DE3677804D1 - THERAPEUTIC USE OF TIN MESOPORPHYRINE. - Google Patents

THERAPEUTIC USE OF TIN MESOPORPHYRINE.

Info

Publication number
DE3677804D1
DE3677804D1 DE8686104120T DE3677804T DE3677804D1 DE 3677804 D1 DE3677804 D1 DE 3677804D1 DE 8686104120 T DE8686104120 T DE 8686104120T DE 3677804 T DE3677804 T DE 3677804T DE 3677804 D1 DE3677804 D1 DE 3677804D1
Authority
DE
Germany
Prior art keywords
mammals
heme
mesoporphyrine
tin
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686104120T
Other languages
German (de)
Inventor
Attallah Kappas
George S Drummond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Application granted granted Critical
Publication of DE3677804D1 publication Critical patent/DE3677804D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Use of the compound tin mesoporphyrin and compositions containing it to inhibit heme metabolism in mammals, to control the rate of tryptophan metabolism in mammals, and to increase the rate at which heme is excreted by mammals. Effect of Sn-mesoporphyrin on ALA Induced Hyperbilirubinemia and Hepatic Heme Oxygenose Activity in 7day old Neonates
DE8686104120T 1985-03-25 1986-03-25 THERAPEUTIC USE OF TIN MESOPORPHYRINE. Expired - Lifetime DE3677804D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/715,515 US4657902A (en) 1985-03-25 1985-03-25 Therapeutic use of tin mesoporphyrin

Publications (1)

Publication Number Publication Date
DE3677804D1 true DE3677804D1 (en) 1991-04-11

Family

ID=24874343

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686104120T Expired - Lifetime DE3677804D1 (en) 1985-03-25 1986-03-25 THERAPEUTIC USE OF TIN MESOPORPHYRINE.

Country Status (15)

Country Link
US (1) US4657902A (en)
EP (1) EP0196079B1 (en)
JP (1) JPS62500787A (en)
KR (1) KR870700341A (en)
AT (1) ATE61221T1 (en)
AU (1) AU567041B2 (en)
CA (1) CA1293504C (en)
DE (1) DE3677804D1 (en)
DK (1) DK162716C (en)
ES (1) ES8800670A1 (en)
GR (1) GR860768B (en)
IE (1) IE58532B1 (en)
PH (2) PH23102A (en)
WO (1) WO1986005685A1 (en)
ZA (1) ZA861793B (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657902A (en) * 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin
AU603999B2 (en) * 1985-10-23 1990-12-06 Photochemical Co., Ltd. Porphyrin derivatives, and their production and use
EP0249966A1 (en) * 1986-06-20 1987-12-23 The Rockefeller University Tin diiododeuteroporphyrin, its preparation and use, and pharmaceutical compositions thereof
US4782049A (en) * 1986-12-08 1988-11-01 The Rockefeller University Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US4831024A (en) * 1987-10-15 1989-05-16 The Board Of Trustees Of The Leland Stanford Junior University Method to prevent neonatal jaundice
US4997828A (en) * 1989-02-14 1991-03-05 The Rockefeller University Method of weight control by low level administration of cobalt protoporphyrin or cobalt mesoporphyrin
EP0450041B1 (en) * 1989-09-25 1993-11-03 The Rockefeller University Orally administered porphyrins to control intestinal iron absorption
US5010073A (en) * 1989-10-05 1991-04-23 The Rockefeller University Use of liposomes as carriers for metalloporphyrins
US5192757A (en) * 1990-12-20 1993-03-09 Glaxo Inc. Cobalt porphyrins
US5149697A (en) * 1991-04-18 1992-09-22 Glaxo Inc. Cobalt porphyrin pharmaceutical compositions
FR2676738B1 (en) * 1991-05-22 1995-05-05 Ir2M NOVEL ORGANIC TRANSITION METAL WITH PORPHYRINIC STRUCTURE, THERAPEUTIC COMPOSITION CONTAINING SAME, IN PARTICULAR WITH HYPOGLYCEMIC ACTIVITY.
US5371199B1 (en) * 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) * 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
US5599924A (en) * 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5817830A (en) * 1992-08-14 1998-10-06 Trustees Of The University Of Pennsylvania Pyrrolic compounds
WO1994028906A1 (en) * 1993-06-14 1994-12-22 The Rockefeller University Treatment of neonatal hyperbilirubin with metalloporphyrin
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
FI100454B (en) * 1995-01-30 1997-12-15 Leiras Oy New medical use of Hemi products
US5929064A (en) * 1995-08-02 1999-07-27 Warner-Lambert Company Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III) protoporphyrin IX
AU737650B2 (en) 1997-11-03 2001-08-23 Duke University Substituted porphyrins
CN1093541C (en) * 1998-01-19 2002-10-30 徐濂 Metalloporphyrin and production process thereof
ES2162718A1 (en) 1998-07-29 2002-01-01 Const Aeronauticas Sa Lightning protection system for composite aircraft structures
ES2163951B1 (en) 1998-07-29 2003-05-16 Airbus Espana Sl A PROTECTION SYSTEM AGAINST ELECTRIC SHOCK, ESPECIALLY RAYS, OF STRUCTURAL COMPONENTS OF AIRCRAFT.
EP1117384A1 (en) * 1998-10-01 2001-07-25 Elan Pharma International Limited Controlled release nanoparticulate compositions
ATE552260T1 (en) * 1999-01-25 2012-04-15 Nat Jewish Health SUBSTITUTED PORPHYRINS AND THEIR THERAPEUTIC USE
AU2002248366B2 (en) * 2001-01-19 2006-10-26 Aeolus Sciences, Inc. Cancer therapy
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
AU2002312194B8 (en) * 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7011854B2 (en) 2002-02-04 2006-03-14 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
CA2487426C (en) 2002-06-04 2010-09-07 Wellspring Pharmaceutical Corporation Preparation of metal mesoporphyrin halide compounds
US7375216B2 (en) * 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
CA2488500A1 (en) * 2002-06-07 2003-12-18 Duke University Substituted porphyrins
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US20040097481A1 (en) * 2002-11-20 2004-05-20 Benjamin Levinson Water-soluble mesoporphyrin compounds and methods of preparation
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7008937B2 (en) * 2003-06-10 2006-03-07 Frontier Scientific, Inc. Porphyrins and metalloporphyrins for inhibiting heme iron uptake
AU2006232330A1 (en) * 2005-04-01 2006-10-12 Infacare Pharmaceutical Corporation Stannsoporfin compositions and administration
US20060222668A1 (en) * 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
US7960371B2 (en) * 2006-10-04 2011-06-14 Infacare Pharmaceutical Corporation High-purity large-scale preparation of stannsoporfin
RU2506083C2 (en) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Method of treating disorders associated with alkylating agent exposure
US8735574B2 (en) 2011-03-30 2014-05-27 Infacare Pharmaceutical Corporation Methods for synthesizing metal mesoporphyrins
PT2699242T (en) 2011-04-19 2018-01-22 Alfama Inc Carbon monoxide releasing molecules and uses thereof
ES2628634T3 (en) 2011-07-21 2017-08-03 Alfama, Inc. Carbon monoxide-ruthenium releasing molecules and uses thereof
GB201120860D0 (en) 2011-12-05 2012-01-18 Cambridge Entpr Ltd Cancer immunotherapy
RS65182B1 (en) 2014-09-29 2024-03-29 Fred Hutchinson Cancer Center Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
EP3319613B1 (en) 2015-07-07 2023-02-22 The Research Foundation for The State University of New York Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
CN111603472A (en) * 2020-06-09 2020-09-01 上海市闵行区中心医院 Application of tin-mesoporphyrin and artemisinin in preparation of antitumor drugs in combined manner

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579533A (en) * 1968-03-18 1971-05-18 Antioch College Preparation of porphin,substituted porphin and metal chelates thereof
US3687863A (en) * 1970-05-25 1972-08-29 Gen Telephone & Elect Optical filters containing tetraphenyl-porphins and method of making same
US4393071A (en) * 1975-03-17 1983-07-12 Naoharu Fujii Method of treating gastric, mammary, lung and uterus tumors
JPS53109929A (en) * 1977-03-04 1978-09-26 Nippon Oil Co Ltd Medicin for malignant tumor
AU555679B2 (en) * 1981-07-15 1986-10-02 Rockefeller University, The Method of decreasing the rate of heme metabolism and composition used therefor
DE3464252D1 (en) * 1983-06-03 1987-07-23 Hoffmann La Roche Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
US4657902A (en) * 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin

Also Published As

Publication number Publication date
EP0196079A1 (en) 1986-10-01
JPS62500787A (en) 1987-04-02
JPH0317806B2 (en) 1991-03-11
DK565786A (en) 1986-11-25
CA1293504C (en) 1991-12-24
IE58532B1 (en) 1993-10-06
GR860768B (en) 1986-07-22
KR870700341A (en) 1987-12-28
DK565786D0 (en) 1986-11-25
WO1986005685A1 (en) 1986-10-09
ATE61221T1 (en) 1991-03-15
ES553306A0 (en) 1987-11-16
AU5549586A (en) 1986-10-23
ES8800670A1 (en) 1987-11-16
PH24689A (en) 1990-09-07
DK162716C (en) 1992-05-11
US4657902A (en) 1987-04-14
EP0196079B1 (en) 1991-03-06
ZA861793B (en) 1986-10-29
AU567041B2 (en) 1987-11-05
IE860751L (en) 1986-09-25
DK162716B (en) 1991-12-02
PH23102A (en) 1989-04-10

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Legal Events

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