DE3672133D1 - Wirksame verbindungen. - Google Patents

Wirksame verbindungen.

Info

Publication number
DE3672133D1
DE3672133D1 DE8686306690T DE3672133T DE3672133D1 DE 3672133 D1 DE3672133 D1 DE 3672133D1 DE 8686306690 T DE8686306690 T DE 8686306690T DE 3672133 T DE3672133 T DE 3672133T DE 3672133 D1 DE3672133 D1 DE 3672133D1
Authority
DE
Germany
Prior art keywords
effective connections
connections
effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686306690T
Other languages
English (en)
Inventor
Frederick Cassidy
Geoffrey Stemp
John Morris Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3672133D1 publication Critical patent/DE3672133D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DE8686306690T 1985-09-03 1986-08-29 Wirksame verbindungen. Expired - Fee Related DE3672133D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858521857A GB8521857D0 (en) 1985-09-03 1985-09-03 Active compounds

Publications (1)

Publication Number Publication Date
DE3672133D1 true DE3672133D1 (de) 1990-07-26

Family

ID=10584644

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686306690T Expired - Fee Related DE3672133D1 (de) 1985-09-03 1986-08-29 Wirksame verbindungen.

Country Status (5)

Country Link
US (1) US4782083A (de)
EP (1) EP0214818B1 (de)
JP (1) JPS62111978A (de)
DE (1) DE3672133D1 (de)
GB (1) GB8521857D0 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
EP0301713A3 (de) * 1987-07-07 1990-05-02 Beecham Group Plc Chroman-Derivate zur Behandlung von pulmonaler Hypertonie
FR2621587B1 (fr) * 1987-10-12 1990-02-09 Sanofi Sa Derives du dimethyl-2,2 chromene, procede pour leur preparation et composition pharmaceutiques les contenant
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
FR2632737B1 (fr) * 1988-06-10 1992-12-24 Thomson Csf Procede d'obtention d'une structure generatrice d'effets electrooptiques non lineaires, structure obtenue et applications
US5364878A (en) * 1988-07-19 1994-11-15 Hoechst Aktiengesellschaft Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs
GB8822743D0 (en) * 1988-09-28 1988-11-02 Beecham Group Plc Novel compounds
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
CA2006429A1 (en) * 1988-12-23 1990-06-23 Geoffrey Stemp Compounds
GB8911280D0 (en) * 1989-05-17 1989-07-05 Beecham Group Plc Novel compounds
CA2015296C (en) * 1989-05-31 2001-08-07 Karnail Atwal Pyranyl cyanoguanidine derivatives
US5140031A (en) * 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
DE3924417A1 (de) * 1989-07-24 1991-01-31 Merck Patent Gmbh Chromanderivate
US5095016A (en) * 1989-08-11 1992-03-10 Kaken Pharmaceutical Co., Ltd. Benzopyran compounds, processes for their production and pharmaceutical compositions
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
US5310932A (en) * 1991-04-15 1994-05-10 E. R. Squibb & Sons, Inc. Chromanyl substituted indole potassium channel openers
US5206252A (en) * 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
US5262419A (en) * 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
US5374643A (en) * 1992-09-11 1994-12-20 E. R. Squibb & Sons, Inc. Aryl urea (thiourea) and cyanoguanidine derivatives
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
US5514690A (en) * 1992-11-17 1996-05-07 E. R. Squibb & Sons, Inc. Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline
EP0673374B1 (de) * 1992-12-11 2000-03-01 Smithkline Beecham Plc Pharmazeutische zusammenstellung enthaltende bizyklisch typ verbindungen
US5393771A (en) * 1993-05-12 1995-02-28 Brisol-Myers Squibb Company 4-substituted benzopyran and related compounds
US5401758A (en) * 1993-10-07 1995-03-28 Bristol-Myers Squibb Company Pyridinyl cyanoguanidine compounds
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
WO1995013272A1 (fr) * 1993-11-10 1995-05-18 Japan Tobacco Inc. Derive de chromanne et utilisation therapeutique de ce dernier
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
GB9822024D0 (en) * 1998-10-09 1998-12-02 Novartis Ag Organic compounds
TWI346112B (en) * 2004-02-25 2011-08-01 Nissan Chemical Ind Ltd Benzopyran compound
WO2007027780A2 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091748B1 (de) * 1982-04-08 1986-06-18 Beecham Group Plc Blutdrucksenkende Benzopyranole
DE3368057D1 (en) * 1982-05-21 1987-01-15 Beecham Group Plc Pharmaceutically active aminobenzopyrans
DE3364734D1 (en) * 1982-10-19 1986-08-28 Beecham Group Plc Novel chromans and chromenes
DE3479726D1 (de) * 1983-05-18 1989-10-19 Beecham Group Plc Benzopyran derivatives.
EP0126367B1 (de) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman- und Chromenderivate
GB8313679D0 (en) * 1983-05-18 1983-06-22 Beecham Group Plc Active compounds
EP0139992B1 (de) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol-Derivate
EP0138134B1 (de) * 1983-10-13 1989-04-19 Beecham Group Plc Chroman-Derivate

Also Published As

Publication number Publication date
JPS62111978A (ja) 1987-05-22
GB8521857D0 (en) 1985-10-09
EP0214818A3 (en) 1987-12-16
EP0214818A2 (de) 1987-03-18
EP0214818B1 (de) 1990-06-20
US4782083A (en) 1988-11-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee