DE3664914D1 - Antihelmintic macrocyclic lactones and their production by fermentation - Google Patents

Antihelmintic macrocyclic lactones and their production by fermentation

Info

Publication number
DE3664914D1
DE3664914D1 DE8686303294T DE3664914T DE3664914D1 DE 3664914 D1 DE3664914 D1 DE 3664914D1 DE 8686303294 T DE8686303294 T DE 8686303294T DE 3664914 T DE3664914 T DE 3664914T DE 3664914 D1 DE3664914 D1 DE 3664914D1
Authority
DE
Germany
Prior art keywords
antihelmintic
fermentation
production
macrocyclic lactones
macrocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8686303294T
Other languages
English (en)
Inventor
Robert T Goegelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3664914D1 publication Critical patent/DE3664914D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dentistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8686303294T 1985-05-02 1986-04-30 Antihelmintic macrocyclic lactones and their production by fermentation Expired DE3664914D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/729,520 US4789684A (en) 1985-05-02 1985-05-02 Anthelmintic fermentation products of microorganisms

Publications (1)

Publication Number Publication Date
DE3664914D1 true DE3664914D1 (en) 1989-09-14

Family

ID=24931427

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686303294T Expired DE3664914D1 (en) 1985-05-02 1986-04-30 Antihelmintic macrocyclic lactones and their production by fermentation

Country Status (7)

Country Link
US (1) US4789684A (de)
EP (1) EP0205251B1 (de)
JP (1) JPS61257989A (de)
AU (1) AU578531B2 (de)
DE (1) DE3664914D1 (de)
NZ (1) NZ215918A (de)
ZA (1) ZA863219B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325462A3 (de) * 1988-01-22 1989-11-02 Beecham Group Plc Milbemycin-Derivate mit anthelmintischer Wirkung
US5008250A (en) * 1988-05-25 1991-04-16 Merck & Co., Inc. Avermectins with a cleaved furan ring and an 8a hydroxy group
US4906619A (en) * 1988-07-22 1990-03-06 Merck & Co., Inc. Alkyl avermectin derivatives
GB9226525D0 (en) * 1992-12-19 1993-02-10 Pfizer Ltd Antiparasitic agents
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug
CN108018324B (zh) * 2016-10-28 2021-04-09 北大方正集团有限公司 一种生产多拉菌素的发酵培养基及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950360A (en) * 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4134973A (en) * 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
NZ186851A (en) * 1977-04-11 1984-12-14 Merck & Co Inc Glycosyloxy derivatives of milbemycin and parasiticidal compositions
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4378353A (en) * 1981-02-17 1983-03-29 Merck & Co., Inc. Novel C-076 compounds
US4427663A (en) * 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
JPS59108785A (ja) * 1982-11-25 1984-06-23 Sankyo Co Ltd ミルベマイシン類の５−オキシム誘導体

Also Published As

Publication number Publication date
AU578531B2 (en) 1988-10-27
AU5708886A (en) 1986-11-06
NZ215918A (en) 1989-10-27
EP0205251A1 (de) 1986-12-17
ZA863219B (en) 1986-12-30
US4789684A (en) 1988-12-06
EP0205251B1 (de) 1989-08-09
JPS61257989A (ja) 1986-11-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee