DE365613T1 - COMBINATION OF TOBRAMYCIN AND STEROIDS FOR TOPICAL OPHTHALMIC USE. - Google Patents

COMBINATION OF TOBRAMYCIN AND STEROIDS FOR TOPICAL OPHTHALMIC USE.

Info

Publication number
DE365613T1
DE365613T1 DE198989903311T DE89903311T DE365613T1 DE 365613 T1 DE365613 T1 DE 365613T1 DE 198989903311 T DE198989903311 T DE 198989903311T DE 89903311 T DE89903311 T DE 89903311T DE 365613 T1 DE365613 T1 DE 365613T1
Authority
DE
Germany
Prior art keywords
composition according
antibiotic
steroid
tobramycin
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198989903311T
Other languages
German (de)
Inventor
D. Gerald Fort Worth Tx 76133 Cagle
O. Thomas Fort Worth Tx 76107 Mcdonald
L. Allan Fort Worth Tx 76109 Rosenthal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Priority claimed from PCT/US1989/000952 external-priority patent/WO1989009057A1/en
Publication of DE365613T1 publication Critical patent/DE365613T1/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (10)

PatentansprüchePatent claims 1. Antibiotische/antiinflammatorische ophthalmische pharmazeutische Zusammensetzung zur topischen Abgabe an das Auge, umfassend eine therapeutisch wirksame Menge Tobramycin und ein Steroid, ausgewählt aus der aus Dexamethason, Fluorometholon und Fluorometholonacetat bestehenden Gruppe, und einen pharmazeutisch annehmbaren Träger für diese.1. An antibiotic/anti-inflammatory ophthalmic pharmaceutical composition for topical delivery to the eye comprising a therapeutically effective amount of tobramycin and a steroid selected from the group consisting of dexamethasone, fluorometholone and fluorometholone acetate, and a pharmaceutically acceptable carrier therefor. 2. Antibiotische/antiinflammatorische ophthalmische pharmazeutische Zusammensetzung nach Anspruch 1, worin das Verhältnis Tobramycin zu Steroid im Bereich von 0,1 : 1,0 bis 10,0 : 1,0 liegt.2. Antibiotic/anti-inflammatory ophthalmic pharmaceutical composition according to claim 1, wherein the ratio of tobramycin to steroid is in the range of 0.1:1.0 to 10.0:1.0. 3. Antibiotische/antiinflammatorische ophthalmische pharmazeutische Zusammensetzung nach Anspruch 1, worin das Steroid Dexamethason ist.3. Antibiotic/anti-inflammatory ophthalmic pharmaceutical composition according to claim 1, wherein the steroid is dexamethasone. 4. Zusammensetzung nach Anspruch 2, worin das Steroid Fluorometholonacetat ist.4. A composition according to claim 2, wherein the steroid is fluorometholone acetate. 5. Zusammensetzung nach Anspruch 1 in Form einer wäßrigen Lösung, Suspension oder Emulsion, die 0,01 bis 2,0 Gew.-% bei einem pH-Wert von 4,5 bis 8,0 enthält.5. Composition according to claim 1 in the form of an aqueous solution, suspension or emulsion containing 0.01 to 2.0% by weight at a pH of 4.5 to 8.0. 0 3 6 66130 3 6 6613 6. Zusammensetzung nach Anspruch 5, die etwa 0,3 Gew.-% Tobramycin und etwa 0,1 Gew.-% Steroid enthält.6. A composition according to claim 5, which contains about 0.3% by weight of tobramycin and about 0.1% by weight of steroid. 7. Zusammensetzung nach Anspruch 1, die außerdem ein oder mehrere Konservierungsmittel, Mischlösungsmittel und Viskositäts-Aufbaustoffe (Viskositäts-Builder) enthält.7. A composition according to claim 1, which further contains one or more preservatives, mixing solvents and viscosity builders. 8. Verfahren zur Behandlung von Augen-Infektionen und -Entzündungen, umfassend die topische Verabreichung einer pharmazeutischen Zusammensetzung nach Anspruch 1 an das betroffene Auge, wenn es für einen antibiotischen/antiinf lammatorischen ophthalmischen Effekt indiziert ist.8. A method for treating ocular infections and inflammations comprising topical administration of a pharmaceutical composition according to claim 1 to the affected eye when indicated for an antibiotic/anti-inflammatory ophthalmic effect. 9. Verfahren zur Behandlung von Augen-Entzündung und Infektionen und Entzündungen, umfassend die topische Verabreichung einer pharmazeutischen Zusammensetzung nach Anspruch 1 an das betroffene Auge, wenn es für einen antibiotischen/antiinflammatorischen ophthalmischen Effekt indiziert ist.9. A method for treating ocular inflammation and infections and inflammations comprising topical administration of a pharmaceutical composition according to claim 1 to the affected eye when indicated for an antibiotic/anti-inflammatory ophthalmic effect. 10. Verfahren nach Anspruch 8, worin die Zusammensetzung dem Auge eines Menschen oder eines Tiers in einer Dosis-Menge von 0,001 bis 5,0 mg pro Auge verabreicht wird.10. The method of claim 8, wherein the composition is administered to the eye of a human or animal in a dosage amount of 0.001 to 5.0 mg per eye.
DE198989903311T 1988-03-09 1989-03-09 COMBINATION OF TOBRAMYCIN AND STEROIDS FOR TOPICAL OPHTHALMIC USE. Pending DE365613T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16595088A 1988-03-09 1988-03-09
US16595288A 1988-03-09 1988-03-09
PCT/US1989/000952 WO1989009057A1 (en) 1988-03-09 1989-03-09 Combination of tobramycin and steroids for topical ophthalmic use

Publications (1)

Publication Number Publication Date
DE365613T1 true DE365613T1 (en) 1990-12-20

Family

ID=27376118

Family Applications (1)

Application Number Title Priority Date Filing Date
DE198989903311T Pending DE365613T1 (en) 1988-03-09 1989-03-09 COMBINATION OF TOBRAMYCIN AND STEROIDS FOR TOPICAL OPHTHALMIC USE.

Country Status (2)

Country Link
DE (1) DE365613T1 (en)
DK (1) DK173326B1 (en)

Also Published As

Publication number Publication date
DK173326B1 (en) 2000-07-24
DK561989A (en) 1989-11-09
DK561989D0 (en) 1989-11-09

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