DE3612622A1 - Medicinal pin for the dermal or transdermal administration, with improved bioavailability, of active substances - Google Patents
Medicinal pin for the dermal or transdermal administration, with improved bioavailability, of active substancesInfo
- Publication number
- DE3612622A1 DE3612622A1 DE19863612622 DE3612622A DE3612622A1 DE 3612622 A1 DE3612622 A1 DE 3612622A1 DE 19863612622 DE19863612622 DE 19863612622 DE 3612622 A DE3612622 A DE 3612622A DE 3612622 A1 DE3612622 A1 DE 3612622A1
- Authority
- DE
- Germany
- Prior art keywords
- medicinal
- dermal
- pen
- active substances
- transdermal administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0282—Compresses or poultices for effecting heating or cooling for particular medical treatments or effects
- A61F2007/0284—Treatment of stings or bites
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Gegenstand der Erfindung ist ein Arzneistift zur dermalen oder transdermalen Applikation mit verbesserter biolo gischer Verfügbarkeit der Arzneistoffe.The invention relates to a medicinal pen for dermal or transdermal application with improved biolo availability of drugs.
Zur dermalen oder transdermalen Applikation von Arznei stoffen werden in einem großen Umfang Arzneiformen wie z.B. Salben, Cremes, Gele und Pflaster eingesetzt. Ebenso sind arzneistoffhaltige Arzneistifte bekannt. Arzneistifte können z.B. zur Behandlung lokaler Haut veränderungen eingesetzt werden. Eine Anwendung von Arzneistiften zur dermalen und transdermalen Wirkstoff applikation ist möglich.For dermal or transdermal application of medication Pharmaceutical forms such as e.g. Ointments, creams, gels and plasters are used. Drug sticks containing medicinal substances are also known. Medicinal pens can e.g. for the treatment of local skin changes are used. An application of Drug pens for dermal and transdermal active ingredient application is possible.
Alle bisher bekannten Arzneistifte weisen den entschei denden Nachteil auf, daß die Wirkstofffreisetzung aus ihnen und die anschließende Permeation des Arzneistoffs aus dem Arzneiträger in die Haut ungerichtet durch pas sive Diffusion erfolgt. Wirkstoffe, die kein ausreichen des Permeationsvermögen durch die Haut aufweisen, können den Wirkort nicht erreichen.All previously known medicinal pens have the decisive factor end disadvantage that the drug release from them and the subsequent permeation of the drug from the drug carrier into the skin undirected by pas sive diffusion takes place. Active ingredients that are not enough of permeability through the skin do not reach the place of action.
Dieser Nachteil wird durch die vorliegende Erfindung dadurch beseitigt, daß der Arzneistoff aktiv aus dem Arzneistift mit Hilfe eines elektrischen Stroms frei gesetzt wird. Dadurch kann gleichzeitig auch der gerich tete aktive Transport des Wirkstoffes in die Haut, bzw. durch die Haut erfolgen.This disadvantage is overcome by the present invention eliminated in that the drug actively from the Drug stick released with the help of an electric current is set. This also allows the court active transport of the active ingredient into the skin or through the skin.
In der Abbildung ist ein nichtbeschränkendes Beispiel für den erfindungsgemäßen Aufbau des Arzneistiftes wiedergegeben.The illustration is a non-limiting example for the construction of the medicinal stick according to the invention reproduced.
Der Stift besteht im vorliegenden Beispiel aus einem Griff teil, der durch eine in ihm enthaltene Batterie (2) als Kathode polarisiert wird. Der Griff (1) besteht aus Alu minium. Der Arzneistoff befindet sich in einem Hydrogel- Arzneiträger (3), der dazu bestimmt ist, auf die zu behan delnde Stelle der Haut, z.B. bei der Anwendung von Anti histaminika nach Insektenstichen, aufgebracht zu werden. Der Arzneiträger wird durch die Batterie als Anode po larisiert.The pin in the present example consists of a handle, which is polarized by a battery ( 2 ) contained in it as a cathode. The handle ( 1 ) is made of aluminum. The drug is in a hydrogel drug carrier ( 3 ) which is intended to be applied to the area of the skin to be treated, for example when using anti-histamines after insect bites. The drug carrier is polarized by the battery as an anode.
Bei der Anwendung des Arzneistifts zur Behandlung von Hautveränderungen am linken Arm wird der Stift mit der rechten Hand am Griff gehalten und mit dem Gelträger auf die zu behandelnde Stelle aufgesetzt. Der Stromkreis wird durch den Arzneistift und den Körper des Patienten gebildet. Die Funktion des Systems wird bei Anwendung über eine elektronische Schaltung (4) angezeigt.When using the medication pen to treat skin changes on the left arm, the pen is held by the handle with the right hand and placed on the area to be treated with the gel carrier. The circuit is formed by the drug stick and the patient's body. The function of the system is indicated by an electronic circuit ( 4 ).
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863612622 DE3612622A1 (en) | 1986-04-15 | 1986-04-15 | Medicinal pin for the dermal or transdermal administration, with improved bioavailability, of active substances |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863612622 DE3612622A1 (en) | 1986-04-15 | 1986-04-15 | Medicinal pin for the dermal or transdermal administration, with improved bioavailability, of active substances |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3612622A1 true DE3612622A1 (en) | 1987-10-22 |
Family
ID=6298703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19863612622 Withdrawn DE3612622A1 (en) | 1986-04-15 | 1986-04-15 | Medicinal pin for the dermal or transdermal administration, with improved bioavailability, of active substances |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE3612622A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3943304A1 (en) * | 1989-12-31 | 1991-07-11 | Broermann Bernard Dr | LOcalised application of pharmaceutical to specific tissue region - by introducing electrodes at opposite ends of tissue, applying d.c. voltage, injecting active agent between electrodes |
DE4130843A1 (en) * | 1991-09-17 | 1993-03-18 | Ruediger Prof Dr Groening | Drug dosage form having variable and controlled drug release - includes drug reservoir under electrochemically generated gas pressure |
DE4316920A1 (en) * | 1993-05-20 | 1994-11-24 | Michael Dr Med Hartmann | Endotracheal tube |
DE29700578U1 (en) * | 1997-01-15 | 1997-03-20 | Rheinmagnet Horst Baermann GmbH, 53819 Neunkirchen-Seelscheid | Patches for the transdermal application of active ingredients |
US11344707B2 (en) | 2016-11-28 | 2022-05-31 | Therma Bright Inc. | Devices for applying a topical treatment |
US11992640B2 (en) | 2016-11-28 | 2024-05-28 | The Jenex Corporation | Devices for applying a topical treatment |
-
1986
- 1986-04-15 DE DE19863612622 patent/DE3612622A1/en not_active Withdrawn
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3943304A1 (en) * | 1989-12-31 | 1991-07-11 | Broermann Bernard Dr | LOcalised application of pharmaceutical to specific tissue region - by introducing electrodes at opposite ends of tissue, applying d.c. voltage, injecting active agent between electrodes |
DE4130843A1 (en) * | 1991-09-17 | 1993-03-18 | Ruediger Prof Dr Groening | Drug dosage form having variable and controlled drug release - includes drug reservoir under electrochemically generated gas pressure |
DE4316920A1 (en) * | 1993-05-20 | 1994-11-24 | Michael Dr Med Hartmann | Endotracheal tube |
DE29700578U1 (en) * | 1997-01-15 | 1997-03-20 | Rheinmagnet Horst Baermann GmbH, 53819 Neunkirchen-Seelscheid | Patches for the transdermal application of active ingredients |
US11344707B2 (en) | 2016-11-28 | 2022-05-31 | Therma Bright Inc. | Devices for applying a topical treatment |
US11992640B2 (en) | 2016-11-28 | 2024-05-28 | The Jenex Corporation | Devices for applying a topical treatment |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8141 | Disposal/no request for examination |