DE3584559D1 - Therapeutische antikoerpermittelkonjugate. - Google Patents
Therapeutische antikoerpermittelkonjugate.Info
- Publication number
- DE3584559D1 DE3584559D1 DE8585401776T DE3584559T DE3584559D1 DE 3584559 D1 DE3584559 D1 DE 3584559D1 DE 8585401776 T DE8585401776 T DE 8585401776T DE 3584559 T DE3584559 T DE 3584559T DE 3584559 D1 DE3584559 D1 DE 3584559D1
- Authority
- DE
- Germany
- Prior art keywords
- therapeutic antibody
- antibody conjugates
- conjugates
- therapeutic
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65075484A | 1984-09-13 | 1984-09-13 | |
US06/650,375 US4867973A (en) | 1984-08-31 | 1984-09-13 | Antibody-therapeutic agent conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3584559D1 true DE3584559D1 (de) | 1991-12-05 |
Family
ID=27095841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585401776T Expired - Fee Related DE3584559D1 (de) | 1984-09-13 | 1985-09-13 | Therapeutische antikoerpermittelkonjugate. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0175617B1 (de) |
AU (2) | AU583854B2 (de) |
CA (1) | CA1326834C (de) |
DE (1) | DE3584559D1 (de) |
DK (1) | DK218386A (de) |
GR (1) | GR852217B (de) |
WO (1) | WO1986001720A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5140104A (en) * | 1982-03-09 | 1992-08-18 | Cytogen Corporation | Amine derivatives of folic acid analogs |
US4831122A (en) * | 1986-01-09 | 1989-05-16 | Regents Of The University Of Minnesota | Radioimmunotoxins |
CA1330378C (en) * | 1986-05-08 | 1994-06-21 | Daniel J. Coughlin | Amine derivatives of folic acid analogs |
US4801688A (en) * | 1986-05-27 | 1989-01-31 | Eli Lilly And Company | Hydrazone immunoglobulin conjugates |
GB8628398D0 (en) * | 1986-11-27 | 1986-12-31 | Central Blood Lab Authority | Pharmaceutically-active conjugates |
US4835258A (en) * | 1986-12-24 | 1989-05-30 | Northwestsern University | Conjugation of aromatic amines or nitro-containing compounds with proteins or polypeptides by photoirradiation of the azide derivatives with ultraviolet light in order to produce antibodies against the haptens |
US5079361A (en) * | 1987-01-15 | 1992-01-07 | Celltech Limited | Thiol-reactive cross-linking reagents |
US4920143A (en) * | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
US5283255A (en) * | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
US4883790A (en) * | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5095030A (en) * | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5171749A (en) * | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
FR2610198B1 (fr) * | 1987-02-03 | 1990-06-15 | Ire Celltarg Sa | Conjugues d'hydrazide d'alcaloide de vinca lie a une immunoglobuline, procede de preparation et compositions pharmaceutiques en comprenant |
FR2611141B1 (fr) * | 1987-02-20 | 1991-02-01 | Int Rech Cancer Centre | Ensemble ou kit pour utilisation comme agent pour la destruction selective de cellules transformees ou tumorales |
EP0282057A3 (de) * | 1987-03-11 | 1990-03-07 | The Board Of Regents Of The University Of Michigan | Chemo-Radio-Immunkonjugate |
US4937183A (en) * | 1988-02-03 | 1990-06-26 | Cytogen Corporation | Method for the preparation of antibody-fragment conjugates |
US5047227A (en) * | 1988-02-08 | 1991-09-10 | Cytogen Corporation | Novel and improved antibodies for site specific attachment of compounds |
EP0336383A3 (de) * | 1988-04-07 | 1990-08-16 | Takeda Chemical Industries, Ltd. | Menschliches rekombinantes Lymphotoxin |
USRE39094E1 (en) | 1988-07-20 | 2006-05-09 | Health Research, Inc. | Pyropheophorbides and their use in photodynamic therapy |
USRE38994E1 (en) | 1988-07-20 | 2006-02-28 | Health Research, Inc. | Pyropheophorbides conjugates and their use in photodynamic therapy |
DE3827940A1 (de) * | 1988-08-13 | 1990-03-01 | Schering Ag | 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5066789A (en) * | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
DE68924783T2 (de) * | 1988-09-30 | 1996-03-28 | Neorx Corp | Wässrige additivsysteme, verfahren und polymerteilchen. |
US5270302A (en) * | 1988-12-21 | 1993-12-14 | Abbott Laboratories | Derivatives of tetrapeptides as CCK agonists |
GR890100827A (el) * | 1988-12-21 | 1991-03-15 | Abbott Lab | Μέ?οδος παραγωγής παραγώγων τετραπεπτιδίων ως ανταγωνιστών CCK. |
US5308608A (en) * | 1989-06-07 | 1994-05-03 | University Of British Columbia | Photosensitizing Diels-Alder porphyrin derivatives |
AU641658B2 (en) * | 1989-06-07 | 1993-09-30 | University Of British Columbia, The | Photosensitizing diels-alder porphyrin derivatives |
AU5732290A (en) * | 1989-06-30 | 1991-01-17 | Brunswick Corporation | Antibody-oxidase conjugates with non-systemic substrates |
WO1991009134A1 (en) * | 1989-12-15 | 1991-06-27 | Takeda Chemical Industries, Ltd. | Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics |
WO1991016324A1 (en) * | 1990-04-25 | 1991-10-31 | The Upjohn Company | Novel cc-1065 analogs |
CA2093361C (en) * | 1990-10-05 | 2002-04-23 | Michel Ringuet | Porphyrin derivative |
US5272253A (en) * | 1991-07-01 | 1993-12-21 | Eli Lilly And Company | Cluster conjugates of drugs with antibodies |
GR1001459B (el) * | 1992-10-08 | 1993-12-30 | Lilly Co Eli | Σύμπλεγμα συζυγών φαρμάκων με αντισώματα. |
WO1997033620A2 (de) * | 1996-03-15 | 1997-09-18 | Pulsion Verw. Gmbh & Co. Medical Systems Kg | Verbindungen zur behandlung von tumoren |
US6493570B1 (en) * | 1998-11-02 | 2002-12-10 | Photogen, Inc. | Method for improved imaging and photodynamic therapy |
US7390668B2 (en) | 1996-10-30 | 2008-06-24 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for photodynamic treatment of disease |
ITRM960808A1 (it) * | 1996-11-26 | 1998-05-26 | Rossolini Gianmaria | Immunoconiugati comprendenti anticorpi monoclonali umani o frammenti di essi per diagnosi in vivo e terapia |
DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
US7648695B2 (en) | 1998-08-06 | 2010-01-19 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
WO2000041726A2 (en) * | 1999-01-15 | 2000-07-20 | Light Sciences Corporation | Noninvasive vascular therapy |
US6602274B1 (en) * | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
EP1210078B1 (de) * | 1999-08-13 | 2008-08-27 | Provectus Pharmatech, Inc. | Verbesserte topische medikamente sowie verfahren zur photodynamischer behandlung von krankheiten |
JP2007501811A (ja) * | 2003-08-08 | 2007-02-01 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 治療的な関心対象のタンパク質に対する遅延分子の選択的な化学物質接合のためのガラクトースオキシダーゼの使用。 |
WO2005047507A1 (en) * | 2003-11-12 | 2005-05-26 | The Austin Research Institute | Dna-carrier conjugate |
US7541330B2 (en) | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
EP2380909A1 (de) | 2010-04-26 | 2011-10-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | An Brustkrebs beteiligtes Protein PTK-7 |
JP6017422B2 (ja) | 2010-08-10 | 2016-11-02 | エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ(ウペエフエル)Ecole Polytechnique Federale de Lausanne (EPFL) | 赤血球結合療法 |
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
AU2015233084B2 (en) | 2014-02-21 | 2020-12-17 | Anokion Sa | Glycotargeting therapeutics |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
US20200338128A1 (en) * | 2018-01-05 | 2020-10-29 | Gencyte Therapeutics, Inc. | Precision molecular adaptor system for car-t immunotherapy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3970521A (en) * | 1974-08-07 | 1976-07-20 | Exxon Research And Engineering Company | Immobilized glycoenzymes |
CA1083508A (fr) * | 1975-11-13 | 1980-08-12 | Jacques Grange | Supports porteurs de chaines laterales, procedes d'obtention de ces supports, procedes de fixation de composes organiques comportant un residu glucidique sur lesdits supports, produits et reactifs resultant de ladite fixation chimique |
JPS52141882A (en) * | 1976-05-20 | 1977-11-26 | Hidetoshi Tsuchida | Highhpolymeric complex of covalent type |
CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
-
1985
- 1985-09-10 AU AU48071/85A patent/AU583854B2/en not_active Ceased
- 1985-09-10 WO PCT/US1985/001700 patent/WO1986001720A1/en unknown
- 1985-09-11 CA CA000490424A patent/CA1326834C/en not_active Expired - Lifetime
- 1985-09-12 GR GR852217A patent/GR852217B/el unknown
- 1985-09-13 DE DE8585401776T patent/DE3584559D1/de not_active Expired - Fee Related
- 1985-09-13 EP EP85401776A patent/EP0175617B1/de not_active Expired - Lifetime
-
1986
- 1986-05-12 DK DK218386A patent/DK218386A/da not_active Application Discontinuation
-
1989
- 1989-02-21 AU AU30161/89A patent/AU3016189A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0175617A3 (en) | 1988-06-15 |
AU4807185A (en) | 1986-04-08 |
DK218386D0 (da) | 1986-05-12 |
EP0175617A2 (de) | 1986-03-26 |
DK218386A (da) | 1986-07-11 |
AU583854B2 (en) | 1989-05-11 |
AU3016189A (en) | 1989-07-13 |
EP0175617B1 (de) | 1991-10-30 |
GR852217B (de) | 1986-01-14 |
CA1326834C (en) | 1994-02-08 |
WO1986001720A1 (en) | 1986-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |