DE3580317D1 - 2-benzyl-4-(2-(morpholino)-4-pyridyl)thiazol. - Google Patents

2-benzyl-4-(2-(morpholino)-4-pyridyl)thiazol.

Info

Publication number
DE3580317D1
DE3580317D1 DE8585108969T DE3580317T DE3580317D1 DE 3580317 D1 DE3580317 D1 DE 3580317D1 DE 8585108969 T DE8585108969 T DE 8585108969T DE 3580317 T DE3580317 T DE 3580317T DE 3580317 D1 DE3580317 D1 DE 3580317D1
Authority
DE
Germany
Prior art keywords
thiazol
morpholino
pyridyl
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585108969T
Other languages
German (de)
English (en)
Inventor
David A Boulton
Vernon L Moore
Ihor E Kopka
Arsenio A Pessolano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3580317D1 publication Critical patent/DE3580317D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE8585108969T 1984-07-25 1985-07-18 2-benzyl-4-(2-(morpholino)-4-pyridyl)thiazol. Expired - Fee Related DE3580317D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/634,094 US4697012A (en) 1984-07-25 1984-07-25 Morpholino pyridyl thiazole compound

Publications (1)

Publication Number Publication Date
DE3580317D1 true DE3580317D1 (en) 1990-12-13

Family

ID=24542414

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585108969T Expired - Fee Related DE3580317D1 (en) 1984-07-25 1985-07-18 2-benzyl-4-(2-(morpholino)-4-pyridyl)thiazol.

Country Status (12)

Country Link
US (1) US4697012A (US20100223739A1-20100909-C00005.png)
EP (1) EP0169502B1 (US20100223739A1-20100909-C00005.png)
JP (1) JPS6137784A (US20100223739A1-20100909-C00005.png)
KR (1) KR860001105A (US20100223739A1-20100909-C00005.png)
AU (1) AU575666B2 (US20100223739A1-20100909-C00005.png)
DE (1) DE3580317D1 (US20100223739A1-20100909-C00005.png)
DK (1) DK336685A (US20100223739A1-20100909-C00005.png)
ES (1) ES8700255A1 (US20100223739A1-20100909-C00005.png)
GR (1) GR851809B (US20100223739A1-20100909-C00005.png)
IL (1) IL75823A0 (US20100223739A1-20100909-C00005.png)
PT (1) PT80833B (US20100223739A1-20100909-C00005.png)
ZA (1) ZA855581B (US20100223739A1-20100909-C00005.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149884B1 (en) * 1983-09-09 1992-12-16 Takeda Chemical Industries, Ltd. 5-pyridyl-1,3-thiazole derivatives, their production and use
GB9201692D0 (en) * 1992-01-27 1992-03-11 Smithkline Beecham Intercredit Compounds
HUP9801057A3 (en) * 1995-05-26 2000-06-28 Bayer Ag Pyridyl-thiazoles and their use to protect plants against infections by micro-organisms
JP4662764B2 (ja) 2002-06-14 2011-03-30 メルク セローノ ソシエテ アノニム アゾールメチリデンシアニド誘導体およびそれらのタンパク質キナーゼモジュレーターとしての使用
SA04250288B1 (ar) * 2003-09-19 2008-07-19 سولفاي فارماسوتيكالز بي . في مشتقات ثيازول thiazole كمعدلات لمستقبل المكونات الكيميائية للقنب cannabinoid
US7294640B2 (en) 2004-02-06 2007-11-13 Merck & Co., Inc. Mitotic kinesin inhibitors
EP2616441B1 (en) * 2010-09-17 2019-08-07 Purdue Pharma L.P. Pyridine compounds and the uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1112128A (en) * 1965-12-22 1968-05-01 Bellon Labor Sa Roger New thiazolyl-diphenylmethane derivatives
IL28803A (en) * 1966-11-18 1974-05-16 Wyeth John & Brother Ltd Oxazole and thiazole compounds,their preparation and pharmaceutical compositions containing them
CA962269A (en) * 1971-05-05 1975-02-04 Robert E. Grahame (Jr.) Thiazoles, and their use as insecticides
US4153703A (en) * 1977-06-30 1979-05-08 Uniroyal, Inc. Method of controlling insects and acarids with certain aryl-substituted thiazoles
EP0149884B1 (en) * 1983-09-09 1992-12-16 Takeda Chemical Industries, Ltd. 5-pyridyl-1,3-thiazole derivatives, their production and use

Also Published As

Publication number Publication date
EP0169502B1 (en) 1990-10-31
DK336685A (da) 1986-01-26
ZA855581B (en) 1986-03-26
IL75823A0 (en) 1985-11-29
EP0169502A3 (en) 1987-02-25
ES545439A0 (es) 1986-10-01
US4697012A (en) 1987-09-29
JPS6137784A (ja) 1986-02-22
AU575666B2 (en) 1988-08-04
PT80833B (en) 1987-05-27
DK336685D0 (da) 1985-07-24
AU4532085A (en) 1986-01-30
KR860001105A (ko) 1986-02-22
ES8700255A1 (es) 1986-10-01
EP0169502A2 (en) 1986-01-29
GR851809B (US20100223739A1-20100909-C00005.png) 1985-11-26
PT80833A (en) 1985-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee