DE3563625D1 - Benzotricyclic nitrogen-containing diones and a process for the production thereof - Google Patents
Benzotricyclic nitrogen-containing diones and a process for the production thereofInfo
- Publication number
- DE3563625D1 DE3563625D1 DE8585300226T DE3563625T DE3563625D1 DE 3563625 D1 DE3563625 D1 DE 3563625D1 DE 8585300226 T DE8585300226 T DE 8585300226T DE 3563625 T DE3563625 T DE 3563625T DE 3563625 D1 DE3563625 D1 DE 3563625D1
- Authority
- DE
- Germany
- Prior art keywords
- radical
- benzotricyclic
- nitrogen
- production
- zero
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000551547 Dione <red algae> Species 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/576,242 US4530929A (en) | 1984-02-02 | 1984-02-02 | Benzotricyclic nitrogen-containing diones and their use in reversing electroconvulsive shock-induced amnesia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3563625D1 true DE3563625D1 (en) | 1988-08-11 |
Family
ID=24303549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585300226T Expired DE3563625D1 (en) | 1984-02-02 | 1985-01-14 | Benzotricyclic nitrogen-containing diones and a process for the production thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4530929A (enExample) |
| EP (1) | EP0153006B1 (enExample) |
| JP (1) | JPS60248687A (enExample) |
| AT (1) | ATE35545T1 (enExample) |
| AU (1) | AU564210B2 (enExample) |
| DE (1) | DE3563625D1 (enExample) |
| DK (1) | DK43585A (enExample) |
| ES (1) | ES8702407A1 (enExample) |
| GR (1) | GR850267B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677112A (en) * | 1984-02-02 | 1987-06-30 | Warner-Lambert Company | 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators |
| US5426191A (en) * | 1993-12-03 | 1995-06-20 | Warner-Lambert Company | Process for the synthesis of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides |
| CN116751151B (zh) * | 2023-05-10 | 2025-10-10 | 瑞弘(天津)科技有限公司 | 一种5-氯-7-甲基靛红的一锅法制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1242175A (en) * | 1969-03-11 | 1971-08-11 | Biorex Laboratories Ltd | A new isoquinoline derivative |
| US4015005A (en) * | 1974-05-28 | 1977-03-29 | Sandoz, Inc. | 1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones |
| US4115555A (en) * | 1976-09-29 | 1978-09-19 | E. R. Squibb & Sons, Inc. | 2-Substituted-1H-benz[de]-isoquinoline-1,3(2H)-diones |
| US4372966A (en) * | 1980-09-15 | 1983-02-08 | Warner-Lambert Company | Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator |
| US4400386A (en) * | 1981-11-06 | 1983-08-23 | Riker Laboratories, Inc. | Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine |
| US4547519A (en) * | 1982-05-24 | 1985-10-15 | Warner-Lambert Company | Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia |
-
1984
- 1984-02-02 US US06/576,242 patent/US4530929A/en not_active Expired - Fee Related
-
1985
- 1985-01-14 EP EP85300226A patent/EP0153006B1/en not_active Expired
- 1985-01-14 DE DE8585300226T patent/DE3563625D1/de not_active Expired
- 1985-01-14 AT AT85300226T patent/ATE35545T1/de not_active IP Right Cessation
- 1985-01-30 GR GR850267A patent/GR850267B/el unknown
- 1985-01-30 ES ES539966A patent/ES8702407A1/es not_active Expired
- 1985-01-31 AU AU38224/85A patent/AU564210B2/en not_active Ceased
- 1985-01-31 DK DK43585A patent/DK43585A/da not_active Application Discontinuation
- 1985-02-01 JP JP60016688A patent/JPS60248687A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GR850267B (enExample) | 1985-05-28 |
| AU3822485A (en) | 1985-08-08 |
| DK43585D0 (da) | 1985-01-31 |
| DK43585A (da) | 1985-08-03 |
| AU564210B2 (en) | 1987-08-06 |
| US4530929A (en) | 1985-07-23 |
| JPS60248687A (ja) | 1985-12-09 |
| ES8702407A1 (es) | 1986-12-16 |
| ES539966A0 (es) | 1986-12-16 |
| EP0153006B1 (en) | 1988-07-06 |
| EP0153006A1 (en) | 1985-08-28 |
| ATE35545T1 (de) | 1988-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU142188A (en) | Process for preparing polyethylenglycolcarbaminates | |
| YU24484A (en) | Process for making new carbacyclines | |
| HUT47099A (en) | Process for producing pyridine derivatives and pharmaceutical compositions comprising such compounds | |
| AU564210B2 (en) | Benzotricyclic nitrogen-containing diones | |
| YU90682A (en) | Process for producing 4'-halo-substituted saccharose derivatives | |
| FR2501676B1 (enExample) | ||
| FR2479831B1 (enExample) | ||
| GR67013B (enExample) | ||
| AU566359B2 (en) | 5-oxo-3/beta (un/substituted phenyl) -2- pyrrolidine propanoic acid | |
| PT77653B (en) | 1-aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters | |
| AU564866B2 (en) | Pyrrolizine 3,5 - dione derivatives | |
| JPS57142982A (en) | N-substituted polyglycidylurazole compound, manufacture and use | |
| TW363967B (en) | Bisquaternary ammonium compound of 2,2'- dimethyl-l, l'-binaphthyl and process for their preparation | |
| SE8008279L (sv) | Bensylidenderivat | |
| ATE40677T1 (de) | Diaminderivate. | |
| GB1545077A (en) | Process for purifying water using bis-isothiouronium salts | |
| YU327980A (en) | Process for preparing new 1-(2-propinyloxy)-2-amino-3-propanol ethers | |
| DE3465737D1 (en) | Process for the preparation of 4-quinolinones | |
| ES8303431A1 (es) | Procedimiento de obtener derivados benzoheteroidicos antialergicos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |