DE3506881A1 - Vitamin E spray - Google Patents

Vitamin E spray

Info

Publication number
DE3506881A1
DE3506881A1 DE19853506881 DE3506881A DE3506881A1 DE 3506881 A1 DE3506881 A1 DE 3506881A1 DE 19853506881 DE19853506881 DE 19853506881 DE 3506881 A DE3506881 A DE 3506881A DE 3506881 A1 DE3506881 A1 DE 3506881A1
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DE
Germany
Prior art keywords
skin
spray according
vitamin
spray
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19853506881
Other languages
German (de)
Inventor
Mohamed Roshdy Dr. 5000 Köln Ismail
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RODISMA PHARMA PROD GmbH
Original Assignee
RODISMA PHARMA PROD GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RODISMA PHARMA PROD GmbH filed Critical RODISMA PHARMA PROD GmbH
Priority to DE19853506881 priority Critical patent/DE3506881A1/en
Publication of DE3506881A1 publication Critical patent/DE3506881A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Spray containing vitamin E and agents promoting blood flow for rheumatism and venous disorders and for muscle pain and tiredness of the legs.

Description

Vitamin E Spray Vitamin E spray

Vitamin E Spray ist nicht bekannt. Die Wirkung von Vitamin E auf der Haut ist nicht geklart bzw. die Transdermaleigenschaften sind nicht genau bekannt.Vitamin E spray is not known. The effect of vitamin E on the The skin is not clear or the transdermal properties are not exactly known.

Nach genaueren Untersuchungen wurde gefunden, daß Vitamin E ester kaum einen positiven Einfluss auf die Haut hat. Vitamin E als pflanzliches Öl wie jedes pflanzliche Öl hat positiven Einfluss auf die Haut.After closer investigation, it was found that vitamin E ester hardly has a positive effect on the skin. Vitamin E as a vegetable oil like any vegetable oil has a positive effect on the skin.

Es wurde überraschenderweise gefunden, daß Vitamin E auf der Haut nur Wirksam ist in Gegenwart von Durchblutungsfördernden Mitteln bzw. Hautreizenden Mitteln.It has surprisingly been found that vitamin E is present on the skin Is only effective in the presence of agents that stimulate the blood circulation or irritate the skin Means.

Die Wirkung von Vitamin E wird erheblich gesteigert, so daß man von Synergesin sprechen kann.The effect of vitamin E is considerably increased, so that one of Synergist can speak.

Vitamin E Spray ist bisher unbekannt.Vitamin E spray is so far unknown.

Es aknn als Hautreizend Mittel bzw. Hautdurchblutungsmittel einfach Alcohole vor u.a. Isopropylalkohol und oder Propandiol bzw. Franzbranntwein. Die Verwendung von Spray hat den grossen Vorteil, daß man die Oxidation von Vitamin E verhindert, dies ist ein bedeutender Fortschritt, dei der Verwendung von Vitamin E ausschließlich.It is simply known as a skin irritant or skin blood circulation agent Alcohole before, among other things, isopropyl alcohol and / or propanediol or rubbing alcohol. the Using spray has the great advantage that it prevents the oxidation of the vitamin E prevents, this is a significant advance, the use of vitamin E exclusively.

Die leichte Oxidation von Vitamin E ist der Hauptgrund, daß man Vitaminöl in Lösungen bisher nicht verwendet hat und bzw., daß der Nachweis auf die Wirkung eindeutig fehlt.The easy oxidation of vitamin E is the main reason that you get vitamin oil has not yet been used in solutions and or that evidence of the effect clearly absent.

Als hautreizende Mittel bzw. Hautdurchblutungsmittel sind Öl juniperi Öl pini pulmilionis (Latschenkieferöl) Öl eucalypti Öl rosmarinae Tinct. camphorae bzw. Campher Arnikaextract Extract. Hippocastani Öl calendulae zu nennen.Oil juniperi are used as skin irritants or skin blood circulation agents Oil pini pulmilionis (mountain pine oil) oil eucalypti oil rosmarinae tinct. camphorae or camphor arnica extract. Hippocastani oil to call calendulae.

Es wird bevorzugt als Vitamin die Freie Tocopherole wie z.B dl-alpha-Tocopherol und d-alpha-Tocopherol verwendet, da deren antioxidierende Wirkung höher als der Ester sind.The preferred vitamin is free tocopherols such as dl-alpha-tocopherol and d-alpha-tocopherol used because their antioxidant properties are higher than that Are esters.

Als weitere Durchblutungsfördernde Mittel können Beispielsweise Nicotinsäure und Salicylsäurederivate verwendet.Nicotinic acid, for example, can be used as further blood circulation-promoting agents and salicylic acid derivatives are used.

Als Derivate nennen wir Beisspielsweise Nicotinsäurebenzyl- ester, Nicotinsäure,yHydroxylathylsalcylat, Uimethylsalicylat auch Heparin Natrium kann ebenfalls verwendet werden.As derivatives we name, for example, nicotinic acid benzyl Ester, nicotinic acid, hydroxyl ethyl salicylate, uimethyl salicylate and heparin sodium can also be used.

Herkömmliche Emulgatoren in ca. 1% wie Tween 80, Tween 20, Cremophore, Cetiol,Monoglyceride und ähnliche beschleunigende der Resorption, so daß grössere Mengen Vitamin E durch die Haut eindringen.Conventional emulsifiers in approx. 1% such as Tween 80, Tween 20, Cremophore, Cetiol, monoglycerides and the like accelerate the absorption, so that larger ones Lots of vitamin E penetrate the skin.

Es wurde ebenfalls in dieser Erfindung gefunden, daß Vitamin E als Kombination mit Phosphorlipide, die aus Cholinphosphorsäurediglyceridester mit überwiegend ungesättigten Fettsäuren bestehen, speziell Linolsäure, Linolen und Ölsäure, eine hervorragende Eigenschaft mit Vitamin E besitzt. Es wurde weiterhin festgestellt, daß das Eindringen von Vitamin E durch die Phosphorlipide beschleunigt wird. Es können dadurch größere Mengen Vitamin E durch die Haut eindringen und somit ihre Wirkung gesteigert werden.It was also found in this invention that vitamin E as Combination with phospholipids, consisting of choline phosphoric acid diglyceride ester with predominantly Unsaturated fatty acids, specifically linoleic acid, linolenic acid, and oleic acid, are made up of one has excellent properties with vitamin E. It was also found that the penetration of vitamin E is accelerated by the phospholipids. It As a result, larger amounts of vitamin E can penetrate the skin and thus your skin Effect can be increased.

Die Erfindungsgemäße Produkte finden Verwendung gegen äußerliche Schmerzen. Schmerzen der Muskeln, Beine, Haut und ähnlichen. Sie können als Rheuma, Venenmittel auch bei Muskelentzündungen und Muskelschmerzen wie z.B bei Sportlern und älteren Menschen.The products according to the invention are used against external pain. Pain in muscles, legs, skin and the like. They can be used as rheumatism, venous medication also for muscle inflammation and muscle pain such as in athletes and the elderly People.

Das Vitamin E kann in verschiedenen Mengen verwendet werden, z.B. 2 bis 30 % Gemischt. Vor allem 4 bis 15% Es können für diese Sprays die üblichen Treibmittel wie z.B.The vitamin E can be used in various amounts, e.g. 2 to 30% mixed. Especially 4 to 15% It can be the usual for these sprays Propellants such as

Frigen verwendet werden.Frigen can be used.

Beispiele 1.) Spray 30 Teile D-alpha-Tocopherol Konzentrat 8 Teile Phosphorlipide 120 Teile Isopropylalkohol 2.) Spray 33 Teile D-alpha-Tocopherol Konzentrat 100 Teile Isopropylalkohol 40 Teile Isopropylalkohol 70 % 3.) Spray 25 Teile Dl-alpha-Tocopherol 100 Teile Isopropylalkohol 15 Teile Propandloi 25 Teile Isopropylalkohol 70 % 4.) Wie Beispiel 3 jedoch mit 3 Teilen CetiolR ÖlsäueoleylesterExamples 1.) Spray 30 parts of D-alpha-tocopherol concentrate 8 parts Phospholipids 120 parts isopropyl alcohol 2.) Spray 33 parts D-alpha-tocopherol Concentrate 100 parts isopropyl alcohol 40 parts isopropyl alcohol 70% 3.) Spray 25 Parts of Dl-alpha-tocopherol 100 parts of isopropyl alcohol 15 parts of Propandloi 25 parts Isopropyl alcohol 70% 4.) As in Example 3, but with 3 parts of Cetiol® oleyl ester

Claims (11)

Vitamin E Ansprüche 1.) Spray dadurch gekennzeichnet, daß man Vitamin E zusammen mit Durchblutungsmittel bzw. Hautreizende Mittel und oder Gefäßerweiternde Mittel in Gegenwart der üblichen Hilfsmittel Emulgatoren kombimiert.Vitamin E. Claims 1.) Spray characterized in that vitamin E is combined with blood circulation agents or skin irritants and / or vasodilators in the presence of the usual auxiliaries emulsifiers. 2.) Spray nach Anspruch 1 dadurch gekennzeichnet, daß man als' Durchblutungsfördernde Mittel Alkohole bzw. Hautreizungsmittel insbesondere Isopropylalkohol und oder Propandiol verwendet.2.) Spray according to claim 1, characterized in that one is called 'blood circulation-promoting Means alcohols or skin irritants, in particular isopropyl alcohol and / or propanediol used. 3.) Spray nach Anspruch 1 und 2 dadurch gekennzeichnet, daß man Durchblutungsfördernden Mittel bzw. Hautreizende Mittel bzw.3.) Spray according to claim 1 and 2, characterized in that one stimulates blood flow Agents or skin irritants Hautdurchblutungsmittel Ul Juniperi, Ö Pini pumilionis, (Latschenkieferöl) Ö1 wucaiypti; Öl Rosmarinie, Tinct. Camphorae bzw. Camphen, ArnilXa?xtrakt, Extract. Hi ppocastani e und Öl Calendulae, Extract. Chamomillae deren Gemische verwendet.Skin blood circulation agent Ul Juniperi, Ö Pini pumilionis, (mountain pine oil) Ö1 wucaiypti; Oil rosemary, tinct. Camphorae or camphene, ArnilXa extract, extract. Hi ppocastani e and oil calendulae, extract. Chamomillae uses their mixtures. 4.) Spray nach Anspruch 1-3 dadurch gekennzeichnet, daß man Nicotinsäure bzw. deren Derivate insbesondere Nicotinsäurebenzylester, Nicotinsäuremettylester las Durchblutungsmittel verwendet.4.) Spray according to claims 1-3, characterized in that one nicotinic acid or their derivatives, in particular benzyl nicotinate, methyl nicotinate read circulatory media used. 5.) Spray nach Anspruch 1-4 dadurch gekennzeichnet, daß man Salicylsäure bzw. deren Ester und oder Derivate insbesondere Hydoxyethylsalicylat Dimethylaminsalcylat verwendet.5.) Spray according to claims 1-4, characterized in that one salicylic acid or their esters and or derivatives, in particular hydroxyethyl salicylate, dimethylamine salicylate used. 6.) Spray nach Anspruch 1-5 dadurch gekennzeichnet, daß man die gegen Rheuma, Venenerkrankungen verwendet. 6.) Spray according to claims 1-5, characterized in that the against Used rheumatism, venous diseases. 7.) Spray nach Anspruch 1-5 dadurch gekennzeichnet, daß man die gegen Muskelschmerzen bzw. Muskelermüdungen bzw. gegen Ermüdungen der Beine verwendet vor allem bei Sportlern.7.) Spray according to claims 1-5, characterized in that the against Muscle pain or muscle fatigue or used against fatigue of the legs especially with athletes. 8.) Spray nach Anspruch 1-7 dadurch gekennzeichnet, daß man Emulgatoren verwendet. 8.) Spray according to claims 1-7, characterized in that one emulsifiers used. 9.) Spray nach den Ansprüchen 1-8 dadurch gekennzeichnet, daß man Phosphorlipidc bzw. Lecithin verwendet. 9.) Spray according to claims 1-8, characterized in that one Phosphorlipidc or lecithin used. 10.) Spray nach den Ansprüchen 1-9 dadurch gekennzeichnet, daß man Vitamin E zwischen 2 bis 30 Gewicht % vor allem 4 bis 15 % verwendet. 10.) Spray according to claims 1-9, characterized in that one Vitamin E used between 2 to 30% by weight especially 4 to 15%. 11.) Spray nach den Ansprüchen 1-10 dadurch gekennzeichnet, daß man die als Schutz gegen die Einwirkung von Strahlen vor allem U.V Strahlen, gegen Hautfalten, gegen Pigmentstörungen der Haut bzw. gegen Hautentzündungen bzw. Hauterkrankungen verwendet. 11.) Spray according to claims 1-10, characterized in that one used as protection against the effects of rays, especially UV rays, against skin folds, against pigment disorders of the skin or against skin inflammation or skin diseases used.
DE19853506881 1985-02-27 1985-02-27 Vitamin E spray Withdrawn DE3506881A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19853506881 DE3506881A1 (en) 1985-02-27 1985-02-27 Vitamin E spray

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Application Number Priority Date Filing Date Title
DE19853506881 DE3506881A1 (en) 1985-02-27 1985-02-27 Vitamin E spray

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DE3506881A1 true DE3506881A1 (en) 1986-08-28

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021326A1 (en) * 1993-03-24 1994-09-29 Dominique Douady A therapy method, specifically, an aesthetic therapy method, substances in gel or cream to enhance the effect of the treatment and equipment required for the application of the method
DE4313402A1 (en) * 1993-04-23 1994-10-27 Hexal Pharma Gmbh Transdermal preparation of active compound
DE19904801A1 (en) * 1999-02-05 2000-08-10 Klossner Axel Agent containing urea, sulfur and Calendula extract, useful for topical treatment of skin disorders, especially neurodermatitis
ES2387109A1 (en) * 2012-04-25 2012-09-13 Antonio Ríos Prieto Pharmaceutical spraying (Machine-translation by Google Translate, not legally binding)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021326A1 (en) * 1993-03-24 1994-09-29 Dominique Douady A therapy method, specifically, an aesthetic therapy method, substances in gel or cream to enhance the effect of the treatment and equipment required for the application of the method
DE4313402A1 (en) * 1993-04-23 1994-10-27 Hexal Pharma Gmbh Transdermal preparation of active compound
DE19904801A1 (en) * 1999-02-05 2000-08-10 Klossner Axel Agent containing urea, sulfur and Calendula extract, useful for topical treatment of skin disorders, especially neurodermatitis
ES2387109A1 (en) * 2012-04-25 2012-09-13 Antonio Ríos Prieto Pharmaceutical spraying (Machine-translation by Google Translate, not legally binding)

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