DE3470743D1 - 4-ALKYL METHYLENE EDIOXY-2-1ÛH¨-QUINAZOLINONES - Google Patents

4-ALKYL METHYLENE EDIOXY-2-1ÛH¨-QUINAZOLINONES

Info

Publication number
DE3470743D1
DE3470743D1 DE8484306668T DE3470743T DE3470743D1 DE 3470743 D1 DE3470743 D1 DE 3470743D1 DE 8484306668 T DE8484306668 T DE 8484306668T DE 3470743 T DE3470743 T DE 3470743T DE 3470743 D1 DE3470743 D1 DE 3470743D1
Authority
DE
Germany
Prior art keywords
edioxy
quinazolinones
alkyl methylene
methylene
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484306668T
Other languages
German (de)
Inventor
Victor T Bandurco
Stanley C Bell
Donald W Combs
Robert Falotico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of DE3470743D1 publication Critical patent/DE3470743D1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8484306668T 1983-09-29 1984-09-28 4-ALKYL METHYLENE EDIOXY-2-1ÛH¨-QUINAZOLINONES Expired DE3470743D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/537,228 US4617392A (en) 1983-09-29 1983-09-29 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents

Publications (1)

Publication Number Publication Date
DE3470743D1 true DE3470743D1 (en) 1988-06-01

Family

ID=24141761

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484306668T Expired DE3470743D1 (en) 1983-09-29 1984-09-28 4-ALKYL METHYLENE EDIOXY-2-1ÛH¨-QUINAZOLINONES

Country Status (11)

Country Link
US (1) US4617392A (en)
EP (1) EP0138490B1 (en)
JP (1) JPS6092290A (en)
KR (1) KR850002271A (en)
AU (1) AU564075B2 (en)
CA (1) CA1244416A (en)
DE (1) DE3470743D1 (en)
DK (1) DK467984A (en)
GR (1) GR80504B (en)
PH (1) PH20296A (en)
ZA (1) ZA847675B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (en) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd Quinazolinone derivative
JP2575078Y2 (en) * 1991-03-05 1998-06-25 ナイルス部品株式会社 Structure of switch mounted on steering wheel pad
US7121421B2 (en) 2003-11-19 2006-10-17 Simplehumer, Llc Trash can assembly
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096144A (en) * 1970-12-08 1978-06-20 Sumitomo Chemical Company, Limited Process for preparing quinazolinone derivatives and their 2-(N-mono-substituted amino)-phenyl ketone intermediate derivatives
DE2134451C3 (en) * 1971-07-09 1982-02-11 Sumitomo Chemical Co., Ltd., Osaka 1,4-Dihydro-1methoxy-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid and process for its preparation
US3838126A (en) * 1972-10-13 1974-09-24 Dow Chemical Co Bronchodilating tetrazolo(1,5-c)quinazolin-5(6h)-ones
JPS5217482A (en) * 1975-07-25 1977-02-09 Sumitomo Chem Co Ltd Preparation of quinazolinone derivatives
JPS5271483A (en) * 1975-12-11 1977-06-14 Sumitomo Chem Co Ltd Synthesis of 2(1h)-quinazolinone derivatives
CH625512A5 (en) * 1976-12-13 1981-09-30 Sandoz Ag
US4164578A (en) * 1977-07-29 1979-08-14 E. R. Squibb & Sons, Inc. Pyrazolo[1,5-c]quinazoline derivatives and related compounds
JPS57197269A (en) * 1981-05-28 1982-12-03 Masayuki Ishikawa Novel 2,4-(1h,3h)-quinazolinedione derivative
JPS57200367A (en) * 1981-06-02 1982-12-08 Masayuki Ishikawa Novel 2(1h)-quinazolinone derivative
US4490374A (en) * 1982-09-30 1984-12-25 Ortho Pharmaceutical Corporation 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use

Also Published As

Publication number Publication date
AU3371684A (en) 1985-04-18
EP0138490A1 (en) 1985-04-24
DK467984D0 (en) 1984-09-28
AU564075B2 (en) 1987-07-30
US4617392A (en) 1986-10-14
ZA847675B (en) 1986-05-28
CA1244416A (en) 1988-11-08
DK467984A (en) 1985-03-30
EP0138490B1 (en) 1988-04-27
PH20296A (en) 1986-11-18
KR850002271A (en) 1985-05-10
JPS6092290A (en) 1985-05-23
GR80504B (en) 1984-11-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee