DE3465596D1 - (s)-9-(2,3-dihydroxy-1-propoxymethyl) guanine and its acyl derivatives, their preparation and their application as antiherpetic agents - Google Patents

(s)-9-(2,3-dihydroxy-1-propoxymethyl) guanine and its acyl derivatives, their preparation and their application as antiherpetic agents

Info

Publication number
DE3465596D1
DE3465596D1 DE8484401311T DE3465596T DE3465596D1 DE 3465596 D1 DE3465596 D1 DE 3465596D1 DE 8484401311 T DE8484401311 T DE 8484401311T DE 3465596 T DE3465596 T DE 3465596T DE 3465596 D1 DE3465596 D1 DE 3465596D1
Authority
DE
Germany
Prior art keywords
propoxymethyl
guanine
dihydroxy
preparation
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484401311T
Other languages
German (de)
English (en)
Inventor
Wallace T Ashton
Laura F Canning
Arthur K Field
Richard L Tolman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3465596D1 publication Critical patent/DE3465596D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484401311T 1983-06-24 1984-06-22 (s)-9-(2,3-dihydroxy-1-propoxymethyl) guanine and its acyl derivatives, their preparation and their application as antiherpetic agents Expired DE3465596D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50732883A 1983-06-24 1983-06-24
US61691084A 1984-06-06 1984-06-06

Publications (1)

Publication Number Publication Date
DE3465596D1 true DE3465596D1 (en) 1987-10-01

Family

ID=27055802

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484401311T Expired DE3465596D1 (en) 1983-06-24 1984-06-22 (s)-9-(2,3-dihydroxy-1-propoxymethyl) guanine and its acyl derivatives, their preparation and their application as antiherpetic agents

Country Status (10)

Country Link
EP (1) EP0130126B1 (en, 2012)
AU (1) AU564194B2 (en, 2012)
CA (1) CA1225400A (en, 2012)
DE (1) DE3465596D1 (en, 2012)
DK (1) DK306184A (en, 2012)
ES (1) ES8600763A1 (en, 2012)
GR (1) GR82379B (en, 2012)
IL (1) IL72173A0 (en, 2012)
NZ (1) NZ208634A (en, 2012)
PT (1) PT78769A (en, 2012)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152316B1 (en) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituted butyl guanines and their utilization in antiviral compositions
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
MY101126A (en) * 1985-12-13 1991-07-31 Beecham Group Plc Novel compounds
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
AU2641192A (en) * 1991-09-24 1993-04-27 Wellcome Foundation Limited, The Therapeutic nucleosides
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation

Also Published As

Publication number Publication date
AU564194B2 (en) 1987-08-06
DK306184A (da) 1984-12-25
GR82379B (en, 2012) 1984-12-13
EP0130126A1 (en) 1985-01-02
IL72173A0 (en) 1984-10-31
DK306184D0 (da) 1984-06-22
ES533618A0 (es) 1985-10-16
NZ208634A (en) 1988-02-29
ES8600763A1 (es) 1985-10-16
AU2976384A (en) 1985-01-03
CA1225400A (en) 1987-08-11
PT78769A (en) 1984-07-01
EP0130126B1 (en) 1987-08-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee