DE3463766D1 - Radioprotector agents with an aminothioalkyl structure, and process for their preparation - Google Patents

Radioprotector agents with an aminothioalkyl structure, and process for their preparation

Info

Publication number
DE3463766D1
DE3463766D1 DE8484401296T DE3463766T DE3463766D1 DE 3463766 D1 DE3463766 D1 DE 3463766D1 DE 8484401296 T DE8484401296 T DE 8484401296T DE 3463766 T DE3463766 T DE 3463766T DE 3463766 D1 DE3463766 D1 DE 3463766D1
Authority
DE
Germany
Prior art keywords
radical
aminothioalkyl
radioprotector
agents
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484401296T
Other languages
English (en)
Inventor
Joel Oiry
Jean-Louis Imbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of DE3463766D1 publication Critical patent/DE3463766D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
DE8484401296T 1983-06-22 1984-06-21 Radioprotector agents with an aminothioalkyl structure, and process for their preparation Expired DE3463766D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8310318A FR2549051B1 (fr) 1983-06-22 1983-06-22 Nouveaux agents radioprotecteurs ayant une structure amino-thioalkyle et procede pour leur preparation

Publications (1)

Publication Number Publication Date
DE3463766D1 true DE3463766D1 (en) 1987-06-25

Family

ID=9290052

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484401296T Expired DE3463766D1 (en) 1983-06-22 1984-06-21 Radioprotector agents with an aminothioalkyl structure, and process for their preparation

Country Status (8)

Country Link
US (1) US4816482A (de)
EP (1) EP0131500B1 (de)
JP (1) JPS60501605A (de)
AT (1) ATE27269T1 (de)
CA (1) CA1248298A (de)
DE (1) DE3463766D1 (de)
FR (1) FR2549051B1 (de)
WO (1) WO1985000167A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
FR2654617B1 (fr) * 1989-11-20 1993-10-08 Oreal Composition cosmetique reductrice pour permanente contenant, en tant qu'agent reducteur, de l'aletheine ou l'un de ses sels, et son utilisation dans un procede de deformation permanente des cheveux.
US5643966A (en) * 1990-07-06 1997-07-01 University Of New Mexico β-alethine as anti-tumor agent
US6245561B1 (en) 1990-07-06 2001-06-12 University Of New Mexico β-alethine use in cell culture and therapy
FR2676441B1 (fr) * 1991-05-17 1994-10-28 Oreal Nouveaux alkylamino-mercaptoalkylamides ou l'un de leurs sels cosmetiquement acceptables, et leur utilisation en tant qu'agents reducteurs, dans un procede de deformation permanente des cheveux.
AU3632993A (en) * 1992-02-28 1993-09-13 Consejo Superior De Investigaciones Cientificas Cationic surfactants containing a disulphide in the molecule thereof, production method
US5498616A (en) * 1994-11-04 1996-03-12 Cephalon, Inc. Cysteine protease and serine protease inhibitors
ATE199908T1 (de) 1996-12-16 2001-04-15 Nederlanden Staat Verfahren zur kupplung von polysacchariden und proteinen
EP1143916A2 (de) 1999-01-08 2001-10-17 The Procter & Gamble Company Geschützte funktionelle thiolverbindungen enthaltende topische zusammensetuzungen
US6703007B2 (en) * 1999-01-08 2004-03-09 The Procter & Gamble Company Topical compositions comprising functional nucleophiles protected by phosphorus-containing moieties
KR101579095B1 (ko) * 2008-07-16 2015-12-21 엘지전자 주식회사 세탁물 처리기기
BR112014009789A2 (pt) 2011-10-26 2017-04-25 Seattle Children's Res Inst cisteamina no tratamento da doença fibrótica
CA2851387A1 (en) 2011-11-22 2013-05-30 The Regents Of The University Of California Cysteamine and/or cystamine for treating ischemic injury
CN115724779B (zh) * 2021-09-01 2024-03-29 四川大学 酰胺烷二硫化合物、其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2574996A (en) * 1948-11-18 1951-11-13 Eastman Kodak Co N-(acetylmercaptoacetyl)-n'-n-butylurea
GB710216A (en) * 1952-05-12 1954-06-09 Parke Davis & Co Improvements in or relating to the production of organic disulphides

Also Published As

Publication number Publication date
EP0131500A1 (de) 1985-01-16
WO1985000167A1 (fr) 1985-01-17
EP0131500B1 (de) 1987-05-20
FR2549051A1 (fr) 1985-01-18
FR2549051B1 (fr) 1986-05-16
ATE27269T1 (de) 1987-06-15
JPS60501605A (ja) 1985-09-26
CA1248298A (fr) 1989-01-03
US4816482A (en) 1989-03-28
JPH0523260B2 (de) 1993-04-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee