DE3378469D1 - Diaminopyrimidines and their production - Google Patents

Diaminopyrimidines and their production

Info

Publication number
DE3378469D1
DE3378469D1 DE8383305229T DE3378469T DE3378469D1 DE 3378469 D1 DE3378469 D1 DE 3378469D1 DE 8383305229 T DE8383305229 T DE 8383305229T DE 3378469 T DE3378469 T DE 3378469T DE 3378469 D1 DE3378469 D1 DE 3378469D1
Authority
DE
Germany
Prior art keywords
diaminopyrimidines
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383305229T
Other languages
German (de)
English (en)
Inventor
Leslie M Werbel
Jocelyn H Hung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE3378469D1 publication Critical patent/DE3378469D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8383305229T 1982-09-09 1983-09-08 Diaminopyrimidines and their production Expired DE3378469D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41640482A 1982-09-09 1982-09-09
US06/520,653 US4532240A (en) 1982-09-09 1983-08-09 Diaminopyrimidines

Publications (1)

Publication Number Publication Date
DE3378469D1 true DE3378469D1 (en) 1988-12-22

Family

ID=27023342

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383305229T Expired DE3378469D1 (en) 1982-09-09 1983-09-08 Diaminopyrimidines and their production

Country Status (9)

Country Link
US (1) US4532240A (OSRAM)
EP (1) EP0103464B1 (OSRAM)
AU (2) AU560971B2 (OSRAM)
CA (1) CA1251447A (OSRAM)
DE (1) DE3378469D1 (OSRAM)
DK (1) DK158310C (OSRAM)
ES (2) ES8502989A1 (OSRAM)
GR (1) GR79058B (OSRAM)
IE (1) IE56148B1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
HUT64323A (en) * 1992-06-09 1993-12-28 Richter Gedeon Vegyeszet Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives
ATE166347T1 (de) * 1993-02-26 1998-06-15 Max Delbrueck Centrum Verfahren zur herstellung von c-nukleosiden und c-nukleosid-analoga, neue c-nukleoside und c- nukleosid-analoga, sowie ihre verwendung
DE4320570C2 (de) * 1993-02-26 2002-07-11 Max Delbrueck Centrum Verfahren zur Herstellung von C-Nukleosiden und C-Nukleosid-Analoga, neue C-Nukleoside und C-Nukleosid-Analoga sowie deren Verwendung
GB9801392D0 (en) * 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
EP1057818A4 (en) 1998-01-30 2003-01-29 Meiji Seika Kaisha PHENYLPIPERAZINE DERIVATIVES AS ANTAGONISTS OF INTEGRIN ALPHAvBETA3
AU4690999A (en) * 1998-08-13 2000-03-06 Warner-Lambert Company Diaminopyrimidines and combination therapies effective for treatment of p-glycoprotein positive cancers
US20040006042A1 (en) * 1998-08-13 2004-01-08 Berry David Allen Diaminopyrimidines and combination therapies effective for treatment of P-glycoprotein positive cancers
EP1389189A2 (en) 2001-05-22 2004-02-18 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
GB0412072D0 (en) * 2004-05-28 2004-06-30 Syngenta Participations Ag Chemical compounds
AU2017213824B9 (en) * 2016-02-05 2021-11-25 Vyera Pharmaceuticals, LLC Compositions and methods for treating infections
US20200270233A1 (en) * 2017-08-07 2020-08-27 Vyera Pharmaceuticais LLC Dhfr inhibitors, compositions, and methods related thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US416404A (en) 1889-12-03 Automatic lath-feeder for paper-carriers
NL72956C (OSRAM) * 1947-11-12
US2748125A (en) * 1954-04-26 1956-05-29 American Cyanamid Co 1-substituted-4-sulfamylpiperazine and method of preparing the same
AT340933B (de) * 1973-08-20 1978-01-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
US4166852A (en) * 1974-08-09 1979-09-04 Produits Chimiques Ugine Kuhlmann Piperazino-pyrimidines and their use as spasmolytic agents
US4287338A (en) * 1980-03-10 1981-09-01 The Upjohn Company Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts
US4351832A (en) * 1980-04-18 1982-09-28 American Home Products Corporation 2-(Piperazinyl)-4-pyrimidinamines

Also Published As

Publication number Publication date
DK158310C (da) 1990-10-15
CA1251447A (en) 1989-03-21
DK158310B (da) 1990-04-30
IE831920L (en) 1984-03-09
AU560971B2 (en) 1987-04-30
EP0103464A3 (en) 1985-07-03
DK407383A (da) 1984-03-10
ES8504775A1 (es) 1985-05-01
GR79058B (OSRAM) 1984-10-02
IE56148B1 (en) 1991-05-08
ES525490A0 (es) 1985-02-01
ES531004A0 (es) 1985-05-01
DK407383D0 (da) 1983-09-08
AU1869983A (en) 1984-03-15
EP0103464B1 (en) 1988-11-17
AU568997B2 (en) 1988-01-14
US4532240A (en) 1985-07-30
ES8502989A1 (es) 1985-02-01
AU6878787A (en) 1987-05-14
EP0103464A2 (en) 1984-03-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition