DE3376320D1 - Mefloquine-hydrochloride and process for its high purity preparation - Google Patents
Mefloquine-hydrochloride and process for its high purity preparationInfo
- Publication number
- DE3376320D1 DE3376320D1 DE8383103632T DE3376320T DE3376320D1 DE 3376320 D1 DE3376320 D1 DE 3376320D1 DE 8383103632 T DE8383103632 T DE 8383103632T DE 3376320 T DE3376320 T DE 3376320T DE 3376320 D1 DE3376320 D1 DE 3376320D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrochloride
- mefloquine
- high purity
- purity preparation
- erythro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WESWYMRNZNDGBX-YLCXCWDSSA-N Mefloquine hydrochloride Chemical compound Cl.C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 WESWYMRNZNDGBX-YLCXCWDSSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960005329 mefloquine hydrochloride Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH225682 | 1982-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3376320D1 true DE3376320D1 (en) | 1988-05-26 |
Family
ID=4229522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8383103632T Expired DE3376320D1 (en) | 1982-04-14 | 1983-04-14 | Mefloquine-hydrochloride and process for its high purity preparation |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4507482A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0092185B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS58188878A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE33647T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE3376320D1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE55387T1 (de) * | 1983-10-07 | 1990-08-15 | Hoffmann La Roche | Mefloquin-hydrochlorid. |
| HUT54363A (en) * | 1989-07-25 | 1991-02-28 | Alkaloida Vegyeszeti Gyar | Process for producing pyridyl-methyl-quinolin derivatives |
| US20030216426A1 (en) * | 2002-05-17 | 2003-11-20 | Regents Of The University Of California | Treatment of cancer with mefloquine, its purified enantiomers, and mefloquine analogs |
| EP2233481A1 (de) | 2009-03-27 | 2010-09-29 | Cilag Ltd. | Verfahren zur Herstellung von Mefloquin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2381044A1 (fr) * | 1977-02-17 | 1978-09-15 | Hoffmann La Roche | Procede pour la preparation de mefloquine |
| DE2940443A1 (de) * | 1979-10-05 | 1981-04-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von erythro-(alpha)-2-piperidyl-2,8-bis-(trifluormethyl)-4-chinolin-methanol |
-
1983
- 1983-04-04 US US06/481,691 patent/US4507482A/en not_active Expired - Lifetime
- 1983-04-13 JP JP58063823A patent/JPS58188878A/ja active Granted
- 1983-04-14 EP EP83103632A patent/EP0092185B1/de not_active Expired
- 1983-04-14 DE DE8383103632T patent/DE3376320D1/de not_active Expired
- 1983-04-14 AT AT83103632T patent/ATE33647T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US4507482A (en) | 1985-03-26 |
| JPH0127070B2 (cg-RX-API-DMAC7.html) | 1989-05-26 |
| EP0092185A3 (en) | 1985-07-03 |
| EP0092185A2 (de) | 1983-10-26 |
| ATE33647T1 (de) | 1988-05-15 |
| EP0092185B1 (de) | 1988-04-20 |
| JPS58188878A (ja) | 1983-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH |