DE3376263D1 - Tetrahydro-3,5-dioxo-1h-pyrrolizine-7a(5h)-carboxylic acids and derivatives as cognition activators - Google Patents

Tetrahydro-3,5-dioxo-1h-pyrrolizine-7a(5h)-carboxylic acids and derivatives as cognition activators

Info

Publication number
DE3376263D1
DE3376263D1 DE8383302897T DE3376263T DE3376263D1 DE 3376263 D1 DE3376263 D1 DE 3376263D1 DE 8383302897 T DE8383302897 T DE 8383302897T DE 3376263 T DE3376263 T DE 3376263T DE 3376263 D1 DE3376263 D1 DE 3376263D1
Authority
DE
Germany
Prior art keywords
pyrrolizine
dioxo
tetrahydro
derivatives
carboxylic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383302897T
Other languages
English (en)
Inventor
Donald E Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE3376263D1 publication Critical patent/DE3376263D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8383302897T 1982-05-24 1983-05-20 Tetrahydro-3,5-dioxo-1h-pyrrolizine-7a(5h)-carboxylic acids and derivatives as cognition activators Expired DE3376263D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38148682A 1982-05-24 1982-05-24
US06/464,193 US4547519A (en) 1982-05-24 1983-02-09 Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia

Publications (1)

Publication Number Publication Date
DE3376263D1 true DE3376263D1 (en) 1988-05-19

Family

ID=27009411

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383302897T Expired DE3376263D1 (en) 1982-05-24 1983-05-20 Tetrahydro-3,5-dioxo-1h-pyrrolizine-7a(5h)-carboxylic acids and derivatives as cognition activators

Country Status (5)

Country Link
US (1) US4547519A (de)
EP (1) EP0095345B1 (de)
DE (1) DE3376263D1 (de)
DK (1) DK228383A (de)
GR (1) GR78308B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581462A (en) * 1983-08-25 1986-04-08 The Upjohn Company Pyrrolizidine-3-ones
US4551470A (en) * 1983-08-29 1985-11-05 Warner-Lambert Company Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid and derivatives, and use for reversing electroconvulsive shock amnesia
US4562195A (en) * 1984-02-02 1985-12-31 Warner-Lambert Company Reversing amnesia with saturated tricyclic nitrogen-containing diones
US4530929A (en) * 1984-02-02 1985-07-23 Warner-Lambert Company Benzotricyclic nitrogen-containing diones and their use in reversing electroconvulsive shock-induced amnesia
JPS60184079A (ja) * 1984-02-29 1985-09-19 Suntory Ltd ピロリチジン誘導体
US4548947A (en) * 1984-05-07 1985-10-22 Warner-Lambert Company 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3,5-[2H,6H-]diones and use for reversing amnesia
US4563469A (en) * 1984-07-20 1986-01-07 Warner-Lambert Company Derivatives of N-[2-(tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]amine as cognition activators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4372966A (en) * 1980-09-15 1983-02-08 Warner-Lambert Company Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator

Also Published As

Publication number Publication date
GR78308B (de) 1984-09-26
DK228383D0 (da) 1983-05-20
US4547519A (en) 1985-10-15
EP0095345A3 (en) 1984-08-01
DK228383A (da) 1983-11-25
EP0095345B1 (de) 1988-04-13
EP0095345A2 (de) 1983-11-30

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee
8364 No opposition during term of opposition