DE3368629D1 - Novel chromenes and chromans - Google Patents

Novel chromenes and chromans

Info

Publication number
DE3368629D1
DE3368629D1 DE8383302189T DE3368629T DE3368629D1 DE 3368629 D1 DE3368629 D1 DE 3368629D1 DE 8383302189 T DE8383302189 T DE 8383302189T DE 3368629 T DE3368629 T DE 3368629T DE 3368629 D1 DE3368629 D1 DE 3368629D1
Authority
DE
Germany
Prior art keywords
chromenes
chromans
novel
novel chromenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383302189T
Other languages
German (de)
English (en)
Inventor
Erol A Faruk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3368629D1 publication Critical patent/DE3368629D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE8383302189T 1982-04-28 1983-04-18 Novel chromenes and chromans Expired DE3368629D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8212358 1982-04-28

Publications (1)

Publication Number Publication Date
DE3368629D1 true DE3368629D1 (en) 1987-02-05

Family

ID=10530048

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383302189T Expired DE3368629D1 (en) 1982-04-28 1983-04-18 Novel chromenes and chromans

Country Status (9)

Country Link
US (2) US4510152A (en, 2012)
EP (1) EP0093535B1 (en, 2012)
JP (1) JPS58201776A (en, 2012)
AU (1) AU561551B2 (en, 2012)
CA (1) CA1239930A (en, 2012)
DE (1) DE3368629D1 (en, 2012)
ES (1) ES521894A0 (en, 2012)
NZ (1) NZ203987A (en, 2012)
ZA (1) ZA832890B (en, 2012)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3364145D1 (de) * 1982-04-08 1986-07-24 Beecham Group Plc Antihypertensive benzopyranols
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives
US4808619A (en) * 1983-07-27 1989-02-28 Beecham Group P.L.C. Di/tetra-hydroquinolines
EP0139992B1 (en) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol derivatives
GB8409745D0 (en) * 1984-04-14 1984-05-23 Beecham Group Plc Active compounds
GB8414987D0 (en) * 1984-06-12 1984-07-18 Beecham Group Plc Active compounds
EP0172352B1 (en) * 1984-06-22 1990-08-29 Beecham Group Plc Active benzopyran compounds
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
EP0205292B1 (en) 1985-06-08 1991-11-06 Beecham Group Plc Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
DE3688414D1 (de) * 1985-07-31 1993-06-17 Beecham Group Plc Verwendung von chinolinderivaten zur herstellung von medikamenten zur behandlung von zerebralen gefaesskrankheiten und zerebraler senilitaet.
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
GB8625185D0 (en) * 1986-10-21 1986-11-26 Beecham Group Plc Active compounds
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
FR2639227A1 (fr) * 1988-11-23 1990-05-25 Sanofi Sa Utilisation de derives du chromane pour le traitement des etats depressifs
FR2639349B1 (fr) * 1988-11-23 1991-02-22 Sanofi Sa Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant
ATE120459T1 (de) * 1988-12-13 1995-04-15 Beecham Group Plc Benzopyran und verwandte verbindungen.
GB8902118D0 (en) * 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
US5239090A (en) * 1989-02-01 1993-08-24 Beecham Group P.L.C. Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
ES2041212B1 (es) * 1992-02-17 1994-05-16 Uriach & Cia Sa J Procedimiento para la obtencion de nuevas tetralonas con actividad farmacologica.
BR9206845A (pt) * 1991-12-05 1996-01-02 Smithkline Beecham Plc Composto famacêutico
JP3502403B2 (ja) * 1991-12-16 2004-03-02 アベンティス ファーマ株式会社 骨吸収抑制剤
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US6469753B1 (en) 1996-05-03 2002-10-22 Starsight Telecast, Inc. Information system
CZ24499A3 (cs) * 1996-07-26 1999-05-12 Nissan Chemical Industries, Ltd. Derivát chromanu a farmaceutický prostředek, který ho obsahuje
WO1999062867A1 (en) 1998-06-03 1999-12-09 Nissan Chemical Industries, Ltd. Indan derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2555353A (en) * 1949-01-14 1951-06-05 Sterling Drug Inc 3-tertiaryaminoalkyl-2-pyrrolidones and process for preparing same and related products
DE2965739D1 (en) * 1978-10-04 1983-07-28 Beecham Group Plc Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds

Also Published As

Publication number Publication date
JPS58201776A (ja) 1983-11-24
NZ203987A (en) 1986-06-11
ES8407036A1 (es) 1984-08-16
ZA832890B (en) 1984-03-28
US4510152A (en) 1985-04-09
AU1398283A (en) 1983-11-03
ES521894A0 (es) 1984-08-16
US4647670A (en) 1987-03-03
CA1239930A (en) 1988-08-02
EP0093535B1 (en) 1986-12-30
AU561551B2 (en) 1987-05-14
JPH0561273B2 (en, 2012) 1993-09-06
EP0093535A1 (en) 1983-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee