DE3277532D1 - Process for preparing 1,5-benzothiazepine derivatives - Google Patents

Process for preparing 1,5-benzothiazepine derivatives

Info

Publication number
DE3277532D1
DE3277532D1 DE8282106261T DE3277532T DE3277532D1 DE 3277532 D1 DE3277532 D1 DE 3277532D1 DE 8282106261 T DE8282106261 T DE 8282106261T DE 3277532 T DE3277532 T DE 3277532T DE 3277532 D1 DE3277532 D1 DE 3277532D1
Authority
DE
Germany
Prior art keywords
formula
reacting
preparing
benzothiazepine
benzothiazepine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282106261T
Other languages
German (de)
Inventor
Susumu Nagao
Katsuhiko Kurabayashi
Nobuyuki Futamura
Hidefumi Kinoshita
Toshio Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority claimed from EP82106261A external-priority patent/EP0098892B1/en
Application granted granted Critical
Publication of DE3277532D1 publication Critical patent/DE3277532D1/en
Expired legal-status Critical Current

Links

Landscapes

  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Prepn. of 1,5-benzothiazepines of formula (I) (Ar is phenyl substd. with 1-4C alkoxy; Y is 1-4C alkylene; and R, R1 and R2 are 1-4C alkyl) comprises (i) reacting a 2-hydroxy-3-(2' aminophenylthio)-3-phenylpropionic acid of formula (IV), in the form of a salt with a base, with an acylating agent and (ii) reacting the resulting 1,5-benzothiazepine of formula (II) or its alkali metal salt with an aminoalkyl halide of formula Z-Y-NR1R2 (where Z is halogen). (I) have excellent coronary vasodilating and psychoneurotic activities. They are useful particularly as Ca(2+) antagonistic coronary vasodilators.
DE8282106261T 1982-07-13 1982-07-13 Process for preparing 1,5-benzothiazepine derivatives Expired DE3277532D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP82106261A EP0098892B1 (en) 1982-07-09 1982-07-13 Process for preparing 1,5-benzothiazepine derivatives

Publications (1)

Publication Number Publication Date
DE3277532D1 true DE3277532D1 (en) 1987-12-03

Family

ID=8189129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282106261T Expired DE3277532D1 (en) 1982-07-13 1982-07-13 Process for preparing 1,5-benzothiazepine derivatives

Country Status (3)

Country Link
DE (1) DE3277532D1 (en)
HK (1) HK95588A (en)
MY (1) MY100148A (en)

Also Published As

Publication number Publication date
HK95588A (en) 1988-12-02
MY100148A (en) 1990-01-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee