DE3274980D1 - Amino and amido derivatives of chloro nitro amino and alkylamino pyrazines useful as adjuncts to radiation therapy - Google Patents

Amino and amido derivatives of chloro nitro amino and alkylamino pyrazines useful as adjuncts to radiation therapy

Info

Publication number
DE3274980D1
DE3274980D1 DE8282302976T DE3274980T DE3274980D1 DE 3274980 D1 DE3274980 D1 DE 3274980D1 DE 8282302976 T DE8282302976 T DE 8282302976T DE 3274980 T DE3274980 T DE 3274980T DE 3274980 D1 DE3274980 D1 DE 3274980D1
Authority
DE
Germany
Prior art keywords
amino
alkylamino
chloro
produce
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282302976T
Other languages
English (en)
Inventor
George D Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3274980D1 publication Critical patent/DE3274980D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8282302976T 1982-06-09 1982-06-09 Amino and amido derivatives of chloro nitro amino and alkylamino pyrazines useful as adjuncts to radiation therapy Expired DE3274980D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP82302976A EP0096125B1 (de) 1982-06-09 1982-06-09 Amino und Amidoderivate von Chloro-Nitro-Amino und Alkylamino-Pyrazinen als Adjunkten für therapeutischen Strahl verwendbar

Publications (1)

Publication Number Publication Date
DE3274980D1 true DE3274980D1 (en) 1987-02-12

Family

ID=8189695

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282302976T Expired DE3274980D1 (en) 1982-06-09 1982-06-09 Amino and amido derivatives of chloro nitro amino and alkylamino pyrazines useful as adjuncts to radiation therapy

Country Status (3)

Country Link
EP (1) EP0096125B1 (de)
AT (1) ATE24721T1 (de)
DE (1) DE3274980D1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109485916A (zh) * 2018-11-20 2019-03-19 武汉工程大学 一种氨基吡嗪类阻燃剂的合成及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541093A (en) * 1968-08-22 1970-11-17 Merck & Co Inc Process for the preparation of 1h-imidazo(4,5-b)pyrazine-2-ones
NL6911867A (de) * 1968-08-31 1970-03-03
US3660397A (en) * 1970-04-17 1972-05-02 Merck & Co Inc Imidazo(4 5-b)pyrazines

Also Published As

Publication number Publication date
EP0096125A1 (de) 1983-12-21
ATE24721T1 (de) 1987-01-15
EP0096125B1 (de) 1987-01-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee