DE3270716D1 - Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity - Google Patents
Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activityInfo
- Publication number
- DE3270716D1 DE3270716D1 DE8282300946T DE3270716T DE3270716D1 DE 3270716 D1 DE3270716 D1 DE 3270716D1 DE 8282300946 T DE8282300946 T DE 8282300946T DE 3270716 T DE3270716 T DE 3270716T DE 3270716 D1 DE3270716 D1 DE 3270716D1
- Authority
- DE
- Germany
- Prior art keywords
- guanidino
- histamine
- substituted heterocyclic
- antagonist activity
- heterocyclic derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8106376 | 1981-02-27 | ||
GB8113664 | 1981-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3270716D1 true DE3270716D1 (en) | 1986-05-28 |
Family
ID=26278598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8282300946T Expired DE3270716D1 (en) | 1981-02-27 | 1982-02-24 | Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity |
Country Status (4)
Country | Link |
---|---|
US (2) | US4496571A (de) |
EP (1) | EP0059597B1 (de) |
CA (1) | CA1209999A (de) |
DE (1) | DE3270716D1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR71929B (de) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
DE3270716D1 (en) * | 1981-02-27 | 1986-05-28 | Ici Plc | Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity |
CA1209998A (en) * | 1981-03-09 | 1986-08-19 | David J. Gilman | Amide derivatives as histamine h-2 receptor antagonists |
JPS59104370A (ja) * | 1982-12-03 | 1984-06-16 | Kotobuki Seiyaku Kk | チアゾ−ル誘導体及びその製造方法 |
JPS59167570A (ja) * | 1983-03-04 | 1984-09-21 | バイエル・アクチエンゲゼルシヤフト | グアニジン誘導体 |
DE3334455A1 (de) * | 1983-03-04 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Guanidin - derivate |
US4624958A (en) * | 1983-04-14 | 1986-11-25 | Pfizer Inc. | Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles |
FR2626004B1 (fr) * | 1988-01-20 | 1991-08-02 | Rhone Poulenc Sante | Procede de preparation du (pyridyl-3)-3 1h, 3h-pyrrolo (1,2-c) thiazolecarbonitrile-7 |
US5128140A (en) * | 1991-01-14 | 1992-07-07 | The Procter & Gamble Company | Swallowable pharmaceutical compositions |
US5616722A (en) * | 1995-12-05 | 1997-04-01 | Mcintyre Group, Ltd. | Antimicrobial solution of formaldehyde substituted hydantoin and process for preparation |
DZ3415A1 (fr) * | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
ES2278016T3 (es) * | 2001-04-09 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r). |
JP2005524649A (ja) * | 2002-02-25 | 2005-08-18 | カイロン コーポレーション | Mc4−rアゴニストの鼻腔内投与 |
WO2003099818A1 (en) * | 2002-05-23 | 2003-12-04 | Chiron Corporation | Substituted quinazolinone compounds |
EP1651229A1 (de) * | 2003-05-23 | 2006-05-03 | Chiron Corporation | Guanidino-substituierte chinazolinon-verbindungen als mc4-r agonisten |
US7368453B2 (en) * | 2003-11-19 | 2008-05-06 | Chiron Corporation | Quinazolinone compounds with reduced bioaccumulation |
WO2022034121A1 (en) | 2020-08-11 | 2022-02-17 | Université De Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ186965A (en) * | 1977-04-20 | 1980-02-21 | Ici Ltd | Guanidino derivatives and pharmaceutical compositions |
US4165378A (en) * | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
DE2961923D1 (en) * | 1978-01-18 | 1982-03-11 | Ici Plc | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
DE2963363D1 (en) * | 1978-05-24 | 1982-09-09 | Ici Plc | Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them |
ATE852T1 (de) * | 1978-05-24 | 1982-04-15 | Imperial Chemical Industries Plc | Anti-sekretion oxadiazol-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. |
EP0010893B1 (de) * | 1978-10-16 | 1984-02-08 | Imperial Chemical Industries Plc | Verzweigtkettige heterozyklische Guanidinderivate mit antisekretorischer Wirkung, Verfahren zu ihrer Herstellung, Zwischenprodukte und die genannten Derivate enthaltende pharmazeutische Zusammensetzungen |
EP0014057B1 (de) * | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
US4242351A (en) * | 1979-05-07 | 1980-12-30 | Imperial Chemical Industries Limited | Antisecretory oxadiazoles and pharmaceutical compositions containing them |
GR71929B (de) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
EP0045155B1 (de) * | 1980-07-30 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidinderivate |
DE3270716D1 (en) * | 1981-02-27 | 1986-05-28 | Ici Plc | Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity |
CA1209998A (en) * | 1981-03-09 | 1986-08-19 | David J. Gilman | Amide derivatives as histamine h-2 receptor antagonists |
-
1982
- 1982-02-24 DE DE8282300946T patent/DE3270716D1/de not_active Expired
- 1982-02-24 EP EP82300946A patent/EP0059597B1/de not_active Expired
- 1982-02-25 CA CA000397102A patent/CA1209999A/en not_active Expired
- 1982-03-01 US US06/353,422 patent/US4496571A/en not_active Expired - Fee Related
-
1985
- 1985-02-12 US US06/700,959 patent/US4657908A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0059597B1 (de) | 1986-04-23 |
US4496571A (en) | 1985-01-29 |
US4657908A (en) | 1987-04-14 |
EP0059597A2 (de) | 1982-09-08 |
EP0059597A3 (en) | 1982-11-17 |
CA1209999A (en) | 1986-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZW13185A1 (en) | Heterocyclic derivatives | |
GB2131428B (en) | Amine derivatives having histamine h2-blocking activity | |
EP0182054A3 (en) | Heterocyclic compounds | |
DE3270716D1 (en) | Guanidino-substituted heterocyclic derivatives having histamine h-2 antagonist activity | |
EG17800A (en) | Heterocyclic compounds | |
IL67185A0 (en) | Heterocyclic compounds | |
GB8405368D0 (en) | Heterocyclic compounds | |
DE3274856D1 (en) | Heterocyclic derivatives | |
PT75828A (en) | Heterocyclic compounds | |
GB8408615D0 (en) | Heterocyclic compounds | |
AU1816883A (en) | Thiazole derivatives with histamine h-2 antagonist activity | |
ZA849273B (en) | Pyridone derivatives with histamine h2-receptor antagonist activity | |
EP0181145A3 (en) | Heterocyclic compounds | |
GB8410989D0 (en) | Heterocyclic compounds | |
PH18754A (en) | Benzo-fused heterocyclic derivatives | |
DE3275291D1 (en) | Heterocyclic derivatives | |
ZA821307B (en) | Heterocyclic derivatives | |
GB8401888D0 (en) | Heterocyclic compounds | |
GB8303097D0 (en) | Heterocyclic derivatives | |
ZA825315B (en) | Heterocyclic derivatives | |
ZA824141B (en) | Heterocyclic derivatives | |
ZM1882A1 (en) | Heterocyclic derivatives | |
GB8424251D0 (en) | Heterocyclic derivatives | |
GB8424250D0 (en) | Heterocyclic derivatives | |
ZA855891B (en) | Heterocyclic derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |