DE3260046D1 - Method of producing hepatitis b surface antigen - Google Patents

Method of producing hepatitis b surface antigen

Info

Publication number
DE3260046D1
DE3260046D1 DE8282400074T DE3260046T DE3260046D1 DE 3260046 D1 DE3260046 D1 DE 3260046D1 DE 8282400074 T DE8282400074 T DE 8282400074T DE 3260046 T DE3260046 T DE 3260046T DE 3260046 D1 DE3260046 D1 DE 3260046D1
Authority
DE
Germany
Prior art keywords
surface antigen
hepatitis
producing hepatitis
hbsag
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282400074T
Other languages
German (de)
English (en)
Inventor
Henri Z Markus
William J Mcaleer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3260046D1 publication Critical patent/DE3260046D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
DE8282400074T 1981-01-16 1982-01-15 Method of producing hepatitis b surface antigen Expired DE3260046D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/225,555 US4416986A (en) 1981-01-16 1981-01-16 Methods of producing HBsAg

Publications (1)

Publication Number Publication Date
DE3260046D1 true DE3260046D1 (en) 1984-04-05

Family

ID=22845332

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282400074T Expired DE3260046D1 (en) 1981-01-16 1982-01-15 Method of producing hepatitis b surface antigen

Country Status (10)

Country Link
US (1) US4416986A (esLanguage)
EP (1) EP0056761B1 (esLanguage)
JP (1) JPS57141294A (esLanguage)
AT (1) ATE6402T1 (esLanguage)
CA (1) CA1175745A (esLanguage)
DE (1) DE3260046D1 (esLanguage)
DK (1) DK15382A (esLanguage)
ES (1) ES508742A0 (esLanguage)
GR (1) GR74755B (esLanguage)
PT (1) PT74246B (esLanguage)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393133A (en) * 1980-06-12 1983-07-12 The Wistar Institute Of Anatomy And Biology Human hepatoma derived cell line, process for preparation thereof, and uses therefor
US5223428A (en) * 1982-12-14 1993-06-29 Baxter International Inc. Method for in vitro culture of mammalian cells
US4742158A (en) * 1986-04-25 1988-05-03 Merck & Co., Inc. Purification of hepatitis pre-S antigens by polymerized serum albumin affinity binding
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5567612A (en) * 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US6309635B1 (en) 1986-11-20 2001-10-30 Children's Medical Center Corp. Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
JP3117994B2 (ja) * 1990-05-16 2000-12-18 ベイラー・カレツジ・オブ・メデイシン 永久的ヒト肝細胞の細胞系および肝臓補助装置（ｌａｄ）におけるその使用
AU2900792A (en) * 1991-10-24 1993-05-21 Children's Medical Center Corporation Neomorphogenesis of urological structures in vivo from cell culture
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5498537A (en) * 1994-03-09 1996-03-12 Cellco, Inc. Serum-free production of packaged viral vector
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US6123727A (en) * 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5741685A (en) * 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
ES2557741T3 (es) * 2002-03-27 2016-01-28 Immunex Corporation Procedimientos para incrementar la producción de polipéptidos
EP2067856A4 (en) * 2006-09-26 2012-11-07 Toyo Boseki METHOD FOR PROLIFERATING A HEPATITIS VIRUS, HOLLOW FIBER FOR CULTURING HEPATITIS VIRUS-INFECTED CELLS AND USE THEREOF

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
PT71739B (en) * 1979-09-04 1982-01-26 Merck & Co Inc Process for preparing a cell culture of hepatitis a virus
US4301250A (en) * 1979-11-02 1981-11-17 Merck & Co., Inc. Method of producing hepatitis B surface antigen
PT72015B (en) * 1979-11-13 1982-06-20 Merck & Co Inc Process for preparing "invitro" cultures of hepatitis b virus
EP0037330B1 (en) * 1980-03-27 1984-03-07 Merck & Co. Inc. Method of growing hepatitis b surface antigen

Also Published As

Publication number Publication date
EP0056761B1 (en) 1984-02-29
ES8300473A1 (es) 1982-11-16
JPS57141294A (en) 1982-09-01
DK15382A (da) 1982-07-17
PT74246B (en) 1984-05-29
ES508742A0 (es) 1982-11-16
EP0056761A1 (en) 1982-07-28
PT74246A (en) 1982-02-01
US4416986A (en) 1983-11-22
CA1175745A (en) 1984-10-09
ATE6402T1 (de) 1984-03-15
GR74755B (esLanguage) 1984-07-11

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee