DE312702C - - Google Patents
Info
- Publication number
- DE312702C DE312702C DENDAT312702D DE312702DA DE312702C DE 312702 C DE312702 C DE 312702C DE NDAT312702 D DENDAT312702 D DE NDAT312702D DE 312702D A DE312702D A DE 312702DA DE 312702 C DE312702 C DE 312702C
- Authority
- DE
- Germany
- Prior art keywords
- water
- caseinate
- casein
- sodium hydroxide
- hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 229940071162 caseinate Drugs 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000005018 casein Substances 0.000 claims description 5
- 235000021240 caseins Nutrition 0.000 claims description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K Aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- 239000000908 ammonium hydroxide Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000006011 modification reaction Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N AI2O3 Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229940080237 Sodium Caseinate Drugs 0.000 description 1
- 230000001476 alcoholic Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229910052570 clay Inorganic materials 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
. Nach, dem Verfahren des Hauptpatents 312222 wird eine wasserlösliche Tonerdenatroneiweißverbindung aus Casein mit Natron und Tonerde erhalten, wenn man auf in. According to the method of main patent 312222, a water-soluble alumina sodium protein compound is obtained obtained from casein with baking soda and clay if you click in
' 5 starkem Alkohol oder einer anderen mit wenig .Wasser mischbaren indifferenten organischen flüssigkeit suspendiertes, feingemahlenes Gasein Natriumhydroxyd und Aluminiumhydroxyd gleichzeitig im molekulareii Verhältnis wie i : 1, wie es zur Bildung von Natriummetaaluminat NaAlO2 erforderlich ist, in Gegenwart geringer Mengen Wasser einwirken läßt, das Lösungsmittel abfiltriert und das Produkt trocknet.5 strong alcohol or another inert organic liquid which is not miscible with much water, finely ground gas suspended in sodium hydroxide and aluminum hydroxide at the same time in a molecular ratio of 1: 1, as is necessary for the formation of sodium metaluminate NaAlO 2 , to act in the presence of small amounts of water, the solvent is filtered off and the product is dried.
Es wurde nun gefunden, daß man das Tonerdenatroncaseinat einfacher, billiger und ohne Anwendung einer organischen Flüssigkeit in konzentrierter wäßriger Lösung, wie sie z. B. für die Herstellung von Pillen oder Dragees unmittelbar und unter Vermeidung der Wiederauflösung des trockenen Tonerdenatroncaseinats verwendbar ist, erhalten kann, wenn man auf in einer geeigneten Menge reinen Wassers suspendiertes, fein verteiltes Casein Natriumhydroxyd und Aluminiumhydroxyd im molekularen Verhältnis ■ wie .1:1 einwirken läßt und erwärmt, bis Lösung eingetreten ist und die Umsetzung sattgefunden hat.It has now been found that the alumina soda caseinate is easier, cheaper and without using an organic liquid in concentrated aqueous solution, such as she z. B. for the production of pills or coated tablets immediately and with avoidance the redissolution of the dry alumina soda caseinate is usable, can be obtained when suspended in an appropriate amount of pure water, fine distributed casein sodium hydroxide and aluminum hydroxide in the molecular ratio ■ like .1: 1 lets act and heats up until Solution has occurred and implementation has taken place.
Das vorliegende Verfahren hat vor dem des Hauptpatents den Vorzug, daß es billiger ausführbar' ist und bei der Weiterverarbeitung, ζ. B. zu Pillen oder Dragees, ein Wiederauflösung des Tonerdenatroncaseinats unnötig macht. r The present process has the advantage over that of the main patent that it can be carried out more cheaply and is easier to process, ζ. B. to pills or coated tablets, a redissolution of the alumina soda caseinate makes unnecessary. r
Die so erhaltene konzentrierte wäßrige. Lösung des Tonerdenatroncaseinats ist auch mit - Alkohol bis zu einem gewissen Grade mischbar; erst bei Gegenwart großer Mengen starken Alkohols scheidet sich das Tonerdenatroncaseinat nach einiger Zeit in weißen Flocken wieder aus, die auf Zusatz von Wasser wieder in. Lösung gehen. Aus der konzentrierten alkoholischen Lösung wird das Tonerdenatroncaseinat durch Äther in weißen 45 Flocken ausgefällt.The concentrated aqueous thus obtained. Alumina sodium caseinate solution is also Miscible with - alcohol to a certain extent; only when large quantities are present strong alcohol, the alumina soda caseinate separates into white after a while Flakes out again, which go back into solution when water is added. From the concentrated In an alcoholic solution, the alumina soda caseinate is precipitated in white flakes by means of ether.
Die Herstellung des Tonerdenatroncaseinats unmittelbar in wäßrig-konzentrierter Lösung geschieht \vie folgt:The production of alumina soda caseinate immediately in aqueous-concentrated Solution happens as follows:
25 kg reines, fein vermahlenes und gesiebtes Casein werden mit 100 1 kaltem Wasser angerührt und mit 3,88 kg einer 25 prozentigen Natronlauge und 1,9 kg Aluminiumhydroxyd versetzt, worauf man die Mischung auf dem Dampfbade erwärmt, bis Lösung eingetreten ist und die Umsetzung stattgefunden hat.25 kg of pure, finely ground and sieved casein are mixed with 100 liters of cold water and mixed with 3.88 kg of a 25 percent sodium hydroxide solution and 1.9 kg of aluminum hydroxide added, whereupon the mixture is heated on the steam bath until solution has occurred and the reaction has taken place Has.
Die so erhaltene Lösung von - Tonerdenatroncaseinat erstarrt in der Kälte zu einer gallertartigen Masse, die sich beim Erwärmen wieder verflüssigt.The resulting solution of - alumina soda caseinate solidifies in the cold to form a gelatinous mass that liquefies again when heated.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE312702C true DE312702C (en) |
Family
ID=565615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT312702D Active DE312702C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE312702C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2721861A (en) * | 1951-10-01 | 1955-10-25 | Laurene O Paterson | Process of preparing an aluminum caseinate |
-
0
- DE DENDAT312702D patent/DE312702C/de active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2721861A (en) * | 1951-10-01 | 1955-10-25 | Laurene O Paterson | Process of preparing an aluminum caseinate |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4029513A (en) | Surface treated silica | |
| DE68908223T2 (en) | Process for the production of very pure, dense, large-scale silica. | |
| DD219023A3 (en) | PROCESS FOR THE PRODUCTION OF SODIUM TAURINATE | |
| DE312702C (en) | ||
| DE2541067C2 (en) | Process for the preparation of the sodium salt of amoxycillin | |
| DE1142851B (en) | Process for the production of finely divided, precipitated calcium carbonate | |
| DE977129C (en) | Process for the production of an extremely finely divided mixture of water-soluble calcium compounds consisting essentially of calcium carbonate | |
| DE968034C (en) | Process for the production of solid sodium metasilicate containing water of crystallization | |
| DE702386C (en) | Process for the production of decoctions from protein splitting bodies | |
| DE1946073A1 (en) | Molding compounds | |
| DE1276635B (en) | Process for the production of potassium sorbate | |
| DE312222C (en) | ||
| DE2006484A1 (en) | New process for the production of the phosphoric acid ester of creatinol (crea tinol orthophosphate) | |
| DE2023571C3 (en) | Process for the production of basic epoxy resins containing nitrogen and hydroxyl groups | |
| DE431580C (en) | Representation of aurosodium thiosulfate | |
| DE661750C (en) | Process for the preparation of gold compounds from keratin breakdown products | |
| DE492244C (en) | Process for the production of pure alumina by saturating an alkali aluminate solution with sulfuric acid gas | |
| DE4236630C2 (en) | Process for the preparation of alkyl and / or alkenyl oligoglucosides | |
| DE977382C (en) | Process for the production of binders for refractory and ceramic products in the form of aqueous solutions of silicates | |
| DE1300927B (en) | Process for the production of aqueous solutions of silicates of guanidine compounds | |
| AT292021B (en) | Process for the preparation of O, O-dialkyl-S-phthaliminomethyl-dithiophosphate | |
| DE2058912A1 (en) | Methyl-xanthine derivs | |
| DD268925A1 (en) | PROCESS FOR PREPARING CAESIUM HYDROXIDE FROM CAESIUM ALAUN | |
| DE2050095C3 (en) | Process for the isolation of triarylphosphines | |
| DE1124956B (en) | Process for the production of surface-active cyanuric acid derivatives |