DE3071727D1 - 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing the same, pharmaceutical compositions containing the same, and intermediates - Google Patents

6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing the same, pharmaceutical compositions containing the same, and intermediates

Info

Publication number
DE3071727D1
DE3071727D1 DE8080107512T DE3071727T DE3071727D1 DE 3071727 D1 DE3071727 D1 DE 3071727D1 DE 8080107512 T DE8080107512 T DE 8080107512T DE 3071727 T DE3071727 T DE 3071727T DE 3071727 D1 DE3071727 D1 DE 3071727D1
Authority
DE
Germany
Prior art keywords
same
carbadethiapen
intermediates
substituted
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080107512T
Other languages
English (en)
Inventor
Burton G Christensen
David H Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/099,275 external-priority patent/US4312871A/en
Priority claimed from US06/099,400 external-priority patent/US4262011A/en
Priority claimed from US06/099,285 external-priority patent/US4262009A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3071727D1 publication Critical patent/DE3071727D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
    • C07C17/275—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of hydrocarbons and halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8080107512T 1979-12-03 1980-12-02 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing the same, pharmaceutical compositions containing the same, and intermediates Expired DE3071727D1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9945179A 1979-12-03 1979-12-03
US06/099,275 US4312871A (en) 1979-12-03 1979-12-03 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US06/099,400 US4262011A (en) 1979-12-03 1979-12-03 1-1-Disubstituted-pen-2-em-3-carboxylic acids
US06/099,285 US4262009A (en) 1979-12-03 1979-12-03 6- And 1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acid

Publications (1)

Publication Number Publication Date
DE3071727D1 true DE3071727D1 (en) 1986-10-02

Family

ID=27493047

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080107512T Expired DE3071727D1 (en) 1979-12-03 1980-12-02 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing the same, pharmaceutical compositions containing the same, and intermediates

Country Status (6)

Country Link
EP (1) EP0030032B1 (de)
DE (1) DE3071727D1 (de)
DK (1) DK512980A (de)
ES (2) ES497383A0 (de)
GR (1) GR72296B (de)
PT (1) PT72136B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE15039T1 (de) * 1979-04-27 1985-09-15 Merck & Co Inc Verfahren zur herstellung von 3-(1-hydroxyaethyl)- azetidinonen.
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
ZA821361B (en) * 1981-03-04 1983-01-26 Beecham Group Plc Beta-lactam antibiotics,their preparation and use
ES514240A0 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
EP0160876A1 (de) * 1984-04-23 1985-11-13 Merck & Co. Inc. 1-Hetero-6-[1-hydroxyethyl]-2-SR8-1-carbadethiapen-2-em-3-carbonsäuren
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
CA2004798A1 (en) * 1988-12-09 1990-06-09 Jacques Banville 6-aminoalkyl carbapenems
US5672701A (en) * 1990-01-16 1997-09-30 Bristol-Myers Squibb Company 4-substituted alkyl carbapenem antibiotics
JP3233434B2 (ja) * 1992-04-01 2001-11-26 塩野義製薬株式会社 カルバペネム誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
DE2732104A1 (de) * 1977-07-15 1979-01-25 Bayer Ag Penicilline, verfahren zu ihrer herstellung und ihre verwendung
EP0004132A1 (de) * 1978-03-04 1979-09-19 Beecham Group Plc Beta-Lactamester Antibiotika, Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
EP0010317B1 (de) * 1978-10-24 1983-12-21 Merck & Co. Inc. 6-,1- und 2-substituierte 1-Carbapen-2-em-3-Carbonsäure, Verfahren zur Herstellung solcher Verbindungen und solche Verbindungen enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
GR72296B (de) 1983-10-18
DK512980A (da) 1981-06-04
EP0030032A3 (en) 1981-09-09
ES507787A0 (es) 1982-10-01
ES8205224A1 (es) 1982-06-01
ES497383A0 (es) 1982-06-01
EP0030032A2 (de) 1981-06-10
ES8207538A1 (es) 1982-10-01
EP0030032B1 (de) 1986-08-27
PT72136B (en) 1982-07-05
PT72136A (en) 1981-01-01

Similar Documents

Publication Publication Date Title
DE2966497D1 (en) 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds
DE3168564D1 (en) Piperidyl - urea, - thiourea and - guanidine derivatives, and intermediates therefor, processes for preparing them and pharmaceutical compositions containing the derivatives
IL57020A (en) Carbazolyl-(4)-oxypropanolamine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA859756B (en) Peptide-aldehydes,process for the preparation thereof and pharmaceutical compositions containing the same
PT74923A (en) Process for preparing substituted 1,2-diaminocyclobutene-3,4-diones and pharmaceutical compositions containing the same
DE3071385D1 (en) Antiinflammatory 5-substituted-2,3-diaryl-thiophenes, processes for their preparation and pharmaceutical compositions containing them
ZA806977B (en) 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
DE3071977D1 (en) Peptides, process for their preparation, their pharmaceutical compositions and their intermediates
DE3061812D1 (en) Process for the preparation of alkoxyalkanoic acids, and alkoxyalkanoic acids so prepared
GB2043644B (en) 3-phosphonocephalosporanic acid derivatives process for preparation thereof and pharmaceutical composition comprising the same
DE3067564D1 (en) 1,2,4-triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
AU542902B2 (en) Substituted carboxylic ceto-acids, process for the preparation thereof, use thereof and medicinal compositions containing them
DE3071727D1 (en) 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing the same, pharmaceutical compositions containing the same, and intermediates
DE3162626D1 (en) Phenylalkanoic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE3061152D1 (en) Pyrazoloindazole derivatives and process for preparing the same and pharmaceutical compositions
DE3065460D1 (en) Benzocycloheptapyrrolealkanoic acids and their derivatives, processes for their preparation and pharmaceutical compositions containing them
PT71411A (en) Process for preparing novel quinazoline derivatives and pharmaceutical compositions thereof
GB2050833B (en) Pharmaceutical compositions and process for the preparation thereof
DE3060161D1 (en) Process for the preparation of urethanes
EP0027260A3 (en) New peptides, processes for their preparation and pharmaceutical compositions containing them
AU533471B2 (en) Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid
IL60907A0 (en) Substituted quinoline-alkanecarboxylic acids,process for their preparation and pharmaceutical compositions containing them
EP0018077A3 (en) Phenylmorphans, processes for their preparation, pharmaceutical compositions containing them, and 4-phenyl-tetrahydro-pyridines
DE3067174D1 (en) Tetrahydro-fluorene compounds, processes for their preparation and pharmaceutical compositions thereof
IL60604A (en) 4-fluoro-3-bromo-benzoyl-fluoride,its preparation and its use for the preparation of the alpha-cyano-4-fluoro-3-phenoxybenzyl ester of permethric acid

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee