DE3070872D1 - Process for the preparation of 4-(2-(dimethylamino)-ethoxy)-2-methyl-5-(1-methylethyl)-phenol esters and their salts - Google Patents
Process for the preparation of 4-(2-(dimethylamino)-ethoxy)-2-methyl-5-(1-methylethyl)-phenol esters and their saltsInfo
- Publication number
- DE3070872D1 DE3070872D1 DE8080201200T DE3070872T DE3070872D1 DE 3070872 D1 DE3070872 D1 DE 3070872D1 DE 8080201200 T DE8080201200 T DE 8080201200T DE 3070872 T DE3070872 T DE 3070872T DE 3070872 D1 DE3070872 D1 DE 3070872D1
- Authority
- DE
- Germany
- Prior art keywords
- methylethyl
- dimethylamino
- ethoxy
- salts
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- HJGRPZCEBPNMDU-UHFFFAOYSA-N 4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenol Chemical class CC(C)C1=CC(O)=C(C)C=C1OCCN(C)C HJGRPZCEBPNMDU-UHFFFAOYSA-N 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 abstract 2
- 239000005844 Thymol Substances 0.000 abstract 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000002655 kraft paper Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229960000790 thymol Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT7928251A IT1209160B (it) | 1979-12-20 | 1979-12-20 | Processo per la sintesi di 4-[2-(dimetilammino)-etossi]2-metil-5-81-metiletil)-fenol-este ri |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3070872D1 true DE3070872D1 (en) | 1985-08-14 |
Family
ID=11223231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080201200T Expired DE3070872D1 (en) | 1979-12-20 | 1980-12-15 | Process for the preparation of 4-(2-(dimethylamino)-ethoxy)-2-methyl-5-(1-methylethyl)-phenol esters and their salts |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4336396A (enExample) |
| EP (1) | EP0031184B1 (enExample) |
| JP (1) | JPS56103141A (enExample) |
| AT (1) | ATE14214T1 (enExample) |
| DE (1) | DE3070872D1 (enExample) |
| IT (1) | IT1209160B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0062596B1 (fr) * | 1981-04-06 | 1985-07-03 | Cortial S.A. | Nouveaux dérivés d'aminoéthoxy-4 isopropyl-5 méthyl-2 phénol, leur méthode de préparation et leur emploi en tant que médicaments |
| US5451609A (en) * | 1994-07-27 | 1995-09-19 | Institut De Recherches Chimiques Et Al | Treatment of impotence |
| US6730691B1 (en) | 2000-02-10 | 2004-05-04 | Miles A. Galin | Uses of alpha adrenergic blocking agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE905738C (de) * | 1943-06-11 | 1954-11-02 | Diwag Chemische Fabriken Ag | Verfahren zur Herstellung basischer Thymoldimethylaminoaethylaether |
| GB745070A (en) | 1953-04-28 | 1956-02-22 | Veritas Drug Company Ltd | Improvements in or relating to basic thymol dimethyl-amino ethyl ethers |
| FR332F (enExample) | 1968-08-08 | 1970-10-19 | ||
| GB1164409A (en) | 1968-08-09 | 1969-09-17 | Claude Dufour | Aminoalkoxy-Carvacrol Derivatives |
| DK138316C (da) | 1972-08-02 | 1979-01-22 | Warner Lambert Co | Analogifremgangsmaade til fremstilling af estere af (beta-(4-hydroxy-thymoxy)ethyl)dimethylamin eller syreadditionssalte deraf |
| US3966779A (en) * | 1973-04-30 | 1976-06-29 | Warner-Lambert Company | Thymol derivatives and a process for their preparation |
| GB1535531A (en) | 1976-10-15 | 1978-12-13 | Warmer & Co Ltd W | Pharmaceutical compositions |
-
1979
- 1979-12-20 IT IT7928251A patent/IT1209160B/it active
-
1980
- 1980-12-04 US US06/212,796 patent/US4336396A/en not_active Expired - Lifetime
- 1980-12-15 EP EP80201200A patent/EP0031184B1/en not_active Expired
- 1980-12-15 JP JP17703180A patent/JPS56103141A/ja active Granted
- 1980-12-15 AT AT80201200T patent/ATE14214T1/de not_active IP Right Cessation
- 1980-12-15 DE DE8080201200T patent/DE3070872D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56103141A (en) | 1981-08-18 |
| EP0031184B1 (en) | 1985-07-10 |
| JPS6237620B2 (enExample) | 1987-08-13 |
| ATE14214T1 (de) | 1985-07-15 |
| EP0031184A1 (en) | 1981-07-01 |
| US4336396A (en) | 1982-06-22 |
| IT7928251A0 (it) | 1979-12-20 |
| IT1209160B (it) | 1989-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |