DE3068533D1 - Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates - Google Patents

Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates

Info

Publication number
DE3068533D1
DE3068533D1 DE8080401315T DE3068533T DE3068533D1 DE 3068533 D1 DE3068533 D1 DE 3068533D1 DE 8080401315 T DE8080401315 T DE 8080401315T DE 3068533 T DE3068533 T DE 3068533T DE 3068533 D1 DE3068533 D1 DE 3068533D1
Authority
DE
Germany
Prior art keywords
primates
interferon
induction
pharmaceutical composition
polyribocytidylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080401315T
Other languages
German (de)
English (en)
Inventor
Kirk A Field
Alfred A Tytell
George P Lampson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3068533D1 publication Critical patent/DE3068533D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE8080401315T 1979-09-17 1980-09-15 Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates Expired DE3068533D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7600479A 1979-09-17 1979-09-17
US15629580A 1980-06-04 1980-06-04

Publications (1)

Publication Number Publication Date
DE3068533D1 true DE3068533D1 (en) 1984-08-16

Family

ID=26757523

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080401315T Expired DE3068533D1 (en) 1979-09-17 1980-09-15 Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates

Country Status (11)

Country Link
EP (1) EP0025766B1 (enExample)
AU (1) AU533471B2 (enExample)
DE (1) DE3068533D1 (enExample)
DK (1) DK391780A (enExample)
ES (1) ES495104A0 (enExample)
FI (1) FI802820A7 (enExample)
GR (1) GR70047B (enExample)
IL (1) IL61006A (enExample)
NO (1) NO802748L (enExample)
NZ (1) NZ194880A (enExample)
PT (1) PT71806B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86884A0 (en) * 1987-07-03 1988-11-30 Nippon Shinyaku Co Ltd Method of preparation of nucleic acid derivatives and method of preparation of medical composition containing the same
IL86863A0 (en) * 1987-07-03 1988-11-30 Nippon Shinyaku Co Ltd Nucleic acid derivatives
US5624912A (en) * 1991-08-21 1997-04-29 Burcoglu; Arsinur Method of treating HIV infection and related secondary infections with defibrotide
US5977083A (en) * 1991-08-21 1999-11-02 Burcoglu; Arsinur Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
RU2175548C2 (ru) * 1998-04-20 2001-11-10 Товарищество с ограниченной ответственностью "Тисет" Средство для профилактики гриппа и других острых респираторных вирусных инфекций
WO1999061032A1 (en) 1998-05-25 1999-12-02 Nippon Shinyaku Co., Ltd. Process for producing composite preparation containing nucleic acid
RU2254861C1 (ru) * 2003-12-01 2005-06-27 Государственный научный центр вирусологии и биотехнологии "Вектор" Индуктор гамма-интерферона
KR101203401B1 (ko) 2005-06-08 2012-11-22 이쉥 바이오파마(싱가포르)피티이 리미티드 폴리이노신산-폴리시티딜산-기초 보조제
US20070166800A1 (en) 2006-01-13 2007-07-19 Haixiang Lin Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
RU2399388C2 (ru) * 2008-12-17 2010-09-20 Учреждение Российской академии наук Институт химической биологии и фундаментальной медицины Сибирского отделения РАН (ИХБФМ СО РАН) Средство для инактивации вирусов, обладающее одновременной рибонуклеазной, мембранолитической и противовирусной активностями
RU2678981C2 (ru) 2014-12-23 2019-02-05 Йишенг Байофарма (Сингапур) Пте Лтд Композиция от бешенства, содержащая адъювант pika

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6801650D0 (pt) * 1968-08-20 1973-03-07 R Maes Processo para preparacao de complexos geradores de interferon
US4024222A (en) * 1973-10-30 1977-05-17 The Johns Hopkins University Nucleic acid complexes

Also Published As

Publication number Publication date
EP0025766B1 (en) 1984-07-11
IL61006A0 (en) 1980-11-30
DK391780A (da) 1981-03-18
EP0025766A2 (en) 1981-03-25
GR70047B (enExample) 1982-07-26
ES8203613A1 (es) 1982-04-16
NO802748L (no) 1981-03-18
EP0025766A3 (en) 1982-03-31
IL61006A (en) 1984-01-31
NZ194880A (en) 1983-07-15
PT71806A (en) 1980-10-01
PT71806B (en) 1982-03-26
ES495104A0 (es) 1982-04-16
FI802820A7 (fi) 1981-03-17
AU533471B2 (en) 1983-11-24
AU6243480A (en) 1981-03-26

Similar Documents

Publication Publication Date Title
MY8500051A (en) Novel 1-aryl-2-acylamido-3-fluoro-1-propanols, theiri preparation and pharmaceutical composition containing them
GB2040292B (en) Type ii interferon and therapeutic and prophylactic compositions
JPS5753449A (en) 2-hydroxy-5-phenylazobenzoic acid derivative, manufacture and medicinal composition
EP0080879A3 (en) Pharmaceutical composition containing interferon in stable state
SG44685G (en) 7-amino-1-cyclopropyl-4-oxo-1,4-dihydronaphthyridine-3-carboxylic acids,process for their preparation and pharmaceutical compositions containing them
IL58765A0 (en) Production of interferon
IL76909A (en) Pharmaceutical compositions comprising tellurium-and selenium-containing compounds,some new telluro-and selenodioxyacycloalkyl halide compounds for the induction of in vivo and in vitro production of cytokines and their preparation
JPS5798281A (en) Azabicyclooctane-carboxylic acid, manufacture and pharmaceutical composition containing same
DE3068533D1 (en) Pharmaceutical composition comprising modified polyriboinosinic-polyribocytidylic acid, for induction of interferon in primates
JPS56140992A (en) Unsaturated benzamides, manufacture and medicinal composition containing them
YU193480A (en) Method of purifying interferon
GB2043644B (en) 3-phosphonocephalosporanic acid derivatives process for preparation thereof and pharmaceutical composition comprising the same
JPS57183772A (en) Aminocyclopentanol acids and esters, manufacture and medicinal composition
GB2036751B (en) Interferon inducers methods for their preparation pharmaceutical compositions containing them and their use as medicaments
DE3262374D1 (en) 2-piperazino-pyrimidine derivatives, processes for their preparation, medicaments containing them and their use as intermediates in the manufacture of medicaments
ZA822571B (en) Derivatives of phenyl aliphatic carboxylic acids, their preparation, their use as medicaments and the compositions containing them
EP0003144A3 (en) 4-pyridone-3-carboxylic acid derivatives, pharmaceutical compositions containing them, processes for their preparation, their application and intermediates in their preparation
IL59514A0 (en) 6- -substituted penicillanic acids,their preparation and pharmaceutical compositions containing them
GB2042555B (en) Interferon inducers methods for their preparation pharmaceutical compositions containing them and their use as medicaments
JPS5692843A (en) Nnsubstituted alphaaamino acids*their manufacture and medicinal composition containing them
GB2042558B (en) Interferon inducers methods for their preparation pharmaceutical compositions containing them and their use as medicaments
PT74994B (en) Improved process for the preparation of new 4-amino benzylamines and of pharmaceutical compositions containing them
MTP873B (en) Homogenous fibroplast interferon and method for manufacture thereof
DE3067008D1 (en) 1-azaxanthone-3-carboxylic acids, their preparation and pharmaceutical compositions containing them
GB2049416B (en) Pharmaceutical composition

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee