DE3063420D1 - Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension - Google Patents

Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension

Info

Publication number
DE3063420D1
DE3063420D1 DE8080300933T DE3063420T DE3063420D1 DE 3063420 D1 DE3063420 D1 DE 3063420D1 DE 8080300933 T DE8080300933 T DE 8080300933T DE 3063420 T DE3063420 T DE 3063420T DE 3063420 D1 DE3063420 D1 DE 3063420D1
Authority
DE
Germany
Prior art keywords
tetrahydroisoquinolines
hypertension
prevention
compounds
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080300933T
Other languages
English (en)
Inventor
Yoshikazu Oka
Kohei Nishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3579279A external-priority patent/JPS55127373A/ja
Priority claimed from JP10151379A external-priority patent/JPS5625164A/ja
Priority claimed from JP13802079A external-priority patent/JPS5661356A/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3063420D1 publication Critical patent/DE3063420D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8080300933T 1979-03-26 1980-03-25 Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension Expired DE3063420D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3579279A JPS55127373A (en) 1979-03-26 1979-03-26 Tetrahydroisoquinoline compound and its preparation
JP10151379A JPS5625164A (en) 1979-08-08 1979-08-08 Tetrahydroisoquinoline compound and its preparation
JP13802079A JPS5661356A (en) 1979-10-24 1979-10-24 Tetrahydroisoquinoline compound and its preparation

Publications (1)

Publication Number Publication Date
DE3063420D1 true DE3063420D1 (en) 1983-07-07

Family

ID=27288874

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080300933T Expired DE3063420D1 (en) 1979-03-26 1980-03-25 Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension

Country Status (2)

Country Link
EP (1) EP0018104B1 (de)
DE (1) DE3063420D1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
GB2048863B (en) * 1979-05-16 1983-06-15 Morton Norwich Products Inc Tetrahydroisoquinoline-3-carboxylic acids
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
DE2937779A1 (de) * 1979-09-19 1981-04-09 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
DE3044236A1 (de) * 1980-11-25 1982-06-16 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2491469A1 (fr) * 1980-10-02 1982-04-09 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4599357A (en) * 1979-12-17 1986-07-08 Ciba-Geigy Corporation 1-mercaptoalkanoylindoline-2-carboxylic acids
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US5200416A (en) * 1980-05-12 1993-04-06 Usv Pharmaceutical Corporation Cyclic amides
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
EP0058567B1 (de) * 1981-02-17 1984-07-25 Warner-Lambert Company Substituierte Acylderivate der Octahydro-1H-isoindol-1-carbonsäure und Ester
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4374246A (en) * 1981-06-18 1983-02-15 Norwich Eaton Pharmaceuticals, Inc. 1-N-[(1-Carboxy-3-phenylpropyl)glycyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
LU88619I2 (fr) * 1981-10-16 1995-07-10 Sandoz Ag QUINAGOLIDE, éventuellement sous forme de sel, par exemple du chlorhydrate
JPS58188847A (ja) * 1982-04-26 1983-11-04 Takeda Chem Ind Ltd ペプチド誘導体
DE3243369A1 (de) * 1982-11-24 1984-05-24 Basf Ag, 6700 Ludwigshafen Bis-(benzoylthio)-carbonsaeuren, ihre herstellung und verwendung zur herstellung von wirkstoffen
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
CN104470930B (zh) * 2012-01-25 2017-02-22 诺华股份有限公司 杂环化合物和它们的使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105776A (en) * 1976-06-21 1978-08-08 E. R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4154935A (en) * 1978-02-21 1979-05-15 E. R. Squibb & Sons, Inc. Halogen substituted mercaptoacylamino acids
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation

Also Published As

Publication number Publication date
EP0018104A3 (en) 1980-11-12
EP0018104B1 (de) 1983-05-25
EP0018104A2 (de) 1980-10-29

Similar Documents

Publication Publication Date Title
DE3063420D1 (en) Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
CY1406A (en) Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
GB2103591B (en) Pharmaceutical compositions and process
PH17194A (en) Novel carbostyril derivatives,and pharmaceutical composition containing the same
IL62082A (en) Beta-lactam derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
PH17552A (en) Novel chloro-and alkoxy-substituted-2,4-diaminoquinazolines,their pharmaceutical compositions and method of use
PH16326A (en) New chemical compounds,pharmaceutical compositions containing the same and method of use
DE3070189D1 (en) Medicament, particularly for the treatment of cholera, and pharmaceutical compositions containing it
PH16758A (en) Quinolone compounds,their pharmaceutical compositions and their use
PH16413A (en) Quinazoline derivatives,their pharmaceutical compositions and use
DE3068803D1 (en) The use of 2-phenyltetralin derivatives, or heterocyclic analogues, in medicine and pharmaceutical compositions containing them
EP0133766A3 (en) Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer
PH23447A (en) B-actam compounds,pharmaceutical compositions containing the same and method of use thereof
IL49424A (en) 1,1,1-triarylalkyl-azabicycloalkanes or azatricycloalkanes, their preparation and pharmaceutical compositions containing them
IL58223A (en) L-proline derivatives having antihypertensive properties and process for the preparation thereof
IL60037A (en) Pyrazinobenzodiazepines,their production and pharmaceutical compositions containing them
IL60025A (en) Process for the preparation of 1,3,7-tri substituted xanthines and certain new such xanthines and pharmaceutical compositions containing them
PH15743A (en) Quinazoline derivatives,their pharmaceutical compositions and their use
PH16253A (en) Dibenzazepine derivatives,pharmaceutical composition containing them and use of the compound
PT76870A (en) Process for the preparation of 1,4-dihydropiridine derivatives and pharmaceutical compositions containing them
EP0084053A4 (de) Arzneimittel und die Verwendung von Sn- oder Cr-Protoporphyrin zu dessen Herstellung.
PT76658B (en) Process for preparing quinazoline derivatives and of pharmaceutical compositions containing the same
PH15625A (en) Pyridazopyridazine derivatives,their pharmaceutical compositions and their use
PH16250A (en) Pharmaceutical composition of therapeutic value in the treatment of some shock conditions
PT71211A (en) Process for the preparation of 3-substituted-tetrahydropyrrolo/1,2-a/pyrimidines and pharmaceutical compositions containing the same and new 3-substituted-tetrahydro-pyrrolo/1,2-a/ pyrimidines

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee