DE3063350D1 - 6- and 8-heteroaryl-1,2,4-triazolo(4,3-b)pyridazines - Google Patents

6- and 8-heteroaryl-1,2,4-triazolo(4,3-b)pyridazines

Info

Publication number
DE3063350D1
DE3063350D1 DE8080105842T DE3063350T DE3063350D1 DE 3063350 D1 DE3063350 D1 DE 3063350D1 DE 8080105842 T DE8080105842 T DE 8080105842T DE 3063350 T DE3063350 T DE 3063350T DE 3063350 D1 DE3063350 D1 DE 3063350D1
Authority
DE
Germany
Prior art keywords
pyridazines
triazolo
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080105842T
Other languages
English (en)
Inventor
Daniel Bryan Moran
John Paul Dusza
Jay Donald Albright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE3063350D1 publication Critical patent/DE3063350D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8080105842T 1979-11-15 1980-09-26 6- and 8-heteroaryl-1,2,4-triazolo(4,3-b)pyridazines Expired DE3063350D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/094,628 US4260756A (en) 1979-11-15 1979-11-15 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines

Publications (1)

Publication Number Publication Date
DE3063350D1 true DE3063350D1 (de) 1983-07-07

Family

ID=22246240

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080105842T Expired DE3063350D1 (de) 1979-11-15 1980-09-26 6- and 8-heteroaryl-1,2,4-triazolo(4,3-b)pyridazines

Country Status (4)

Country Link
US (1) US4260756A (de)
EP (1) EP0029103B1 (de)
JP (1) JPS5683490A (de)
DE (1) DE3063350D1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405619A (en) * 1981-09-02 1983-09-20 Diamond Shamrock Corporation Antiinflammatory substituted-1,2,4-triazolo[4,3-b]-1,2,4-triazines
DE3217325A1 (de) * 1982-05-08 1983-11-10 Hoechst Ag, 6230 Frankfurt 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung
US6297235B1 (en) * 1997-08-28 2001-10-02 Merck Sharp & Dohme Ltd. Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en) * 1997-08-28 1997-11-05 Merck Sharp & Dohme Therapeutic agents
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
AU746866B2 (en) 1998-01-14 2002-05-02 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801208D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
WO1999037644A1 (en) 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) * 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
CN1922183B (zh) * 2004-02-18 2010-05-26 万有制药株式会社 含氮的稠合杂芳环衍生物
KR20130083389A (ko) * 2010-05-28 2013-07-22 바이오크리스트파마슈티컬즈,인코포레이티드 야누스 키나아제 억제제로서 헤테로사이클릭 화합물
WO2019236625A1 (en) * 2018-06-04 2019-12-12 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1527537A (fr) * 1966-06-18 1968-05-31 Boehringer & Soehne Gmbh Procédé de préparation de nouveaux dérivés du 5-nitrofurane et du 5-nitrothiophène
DE2113438A1 (de) * 1971-03-19 1972-09-21 Boehringer Mannheim Gmbh Nitrofuryl-triazolo[4,3-b]pyridazinderivate
US3915968A (en) * 1973-09-21 1975-10-28 Lepetit Spa Triazolopyridazines
US4016162A (en) * 1974-08-27 1977-04-05 Gruppo Lepetit S.P.A. 6-Morpholino-3-substituted phenyl-S-triazolo[4,3-b]pyridazines
US3994898A (en) * 1975-10-16 1976-11-30 E. R. Squibb & Sons, Inc. 1,2,4-Triazolo (4,3-b) pyridazin-3-ones
US4112095A (en) * 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents

Also Published As

Publication number Publication date
EP0029103A1 (de) 1981-05-27
JPS5683490A (en) 1981-07-08
EP0029103B1 (de) 1983-05-18
US4260756A (en) 1981-04-07

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee