DE3061551D1 - Diphosphonate or phosphate-phosphonate derivatives and pharmaceutical compositions containing them - Google Patents

Diphosphonate or phosphate-phosphonate derivatives and pharmaceutical compositions containing them

Info

Publication number
DE3061551D1
DE3061551D1 DE8080100286T DE3061551T DE3061551D1 DE 3061551 D1 DE3061551 D1 DE 3061551D1 DE 8080100286 T DE8080100286 T DE 8080100286T DE 3061551 T DE3061551 T DE 3061551T DE 3061551 D1 DE3061551 D1 DE 3061551D1
Authority
DE
Germany
Prior art keywords
diphosphonate
phosphate
pharmaceutical compositions
compositions containing
phosphonate derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080100286T
Other languages
English (en)
Inventor
Craig L Bentzen
Mong Lan Nguyen
Eric Niesor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symphar SA
Original Assignee
Symphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7904992A external-priority patent/GB2043073B/en
Application filed by Symphar SA filed Critical Symphar SA
Application granted granted Critical
Publication of DE3061551D1 publication Critical patent/DE3061551D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8080100286T 1979-02-13 1980-01-21 Diphosphonate or phosphate-phosphonate derivatives and pharmaceutical compositions containing them Expired DE3061551D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7904992A GB2043073B (en) 1979-02-13 1979-02-13 Mono-and diphosphonate compounds
GB7933157A GB2043072B (en) 1979-02-13 1979-09-25 Diphosphonate compounds

Publications (1)

Publication Number Publication Date
DE3061551D1 true DE3061551D1 (en) 1983-02-17

Family

ID=26270548

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080100286T Expired DE3061551D1 (en) 1979-02-13 1980-01-21 Diphosphonate or phosphate-phosphonate derivatives and pharmaceutical compositions containing them

Country Status (7)

Country Link
US (2) US4309364A (de)
EP (1) EP0015370B1 (de)
AU (1) AU536326B2 (de)
CA (1) CA1148561A (de)
DE (1) DE3061551D1 (de)
ES (1) ES8105338A1 (de)
GB (1) GB2043072B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
DE3007764A1 (de) * 1980-02-29 1981-10-15 Boehringer Mannheim Gmbh Verfahren und reagens zur bestimmung der beta -lipoproteine
EP0084822B1 (de) 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
IT1195993B (it) * 1984-01-12 1988-11-03 Gentili Ist Spa Forme farmaceutiche a base di difosfonati
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
HU190579B (en) * 1984-07-18 1986-09-29 Nitrokemia Ipartelepek,Hu Plant growth regulating compositions comprising etherified hydroxy-alkyl-phosphonic acid-derivatives as active substance
DE3767998D1 (de) * 1986-12-20 1991-03-14 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
US4822780A (en) * 1987-07-08 1989-04-18 Otsuka Pharmaceutical Factory, Inc. Carboxamide compounds
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (de) * 1988-03-31 1990-09-28 Symphar Sa
FI89364C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
CA2067974A1 (en) * 1991-05-13 1992-11-14 Scott A. Biller Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
ATE164163T1 (de) * 1991-06-19 1998-04-15 Upjohn Co Dialkyl (dialkoxyphosphinyl)methyl phosphate als antientzündungsmittel
US5213154A (en) * 1992-08-17 1993-05-25 Gas Research Institute Liquid desiccant regeneration system
HUT72307A (en) 1993-03-08 1996-04-29 Eisai Co Ltd Phosphonic acid derivatives
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
FR2827289B1 (fr) * 2001-07-16 2004-07-23 Univ Paris 13 Nouveau derive d'acide diphosphonique, son application en therapeutique et procede de preparation
WO2003070179A2 (en) * 2002-02-19 2003-08-28 Ilex Products, Inc. Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
AU2003228990A1 (en) * 2002-05-11 2003-11-11 Ilex Products, Inc. Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
CA2778015C (en) 2009-10-26 2016-08-02 Warner Chilcott Company, Llc Bisphosphonate compounds for treating bone metabolism disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2848475A (en) * 1953-04-20 1958-08-19 Ciba Ltd Substituted methylene bis
FR1394386A (fr) * 1963-04-09 1965-04-02 Monsanto Co Nouveaux acides organo-méthylène diphosphoniques, leurs sels et esters
DE1302557B (de) * 1963-04-09 1971-08-26
US3471406A (en) * 1965-09-07 1969-10-07 Plains Chem Dev Co Detergent compositions containing methane tri and tetra phosphonic acid compounds
US3463835A (en) * 1965-10-05 1969-08-26 Plains Chem Dev Co Aromatic polyphosphonic acids,salts and esters
FR8441M (de) * 1968-04-01 1971-07-15
GB1508772A (en) * 1975-04-04 1978-04-26 Shell Int Research Biologically active compositions
US4067971A (en) * 1976-05-13 1978-01-10 The Procter & Gamble Company Therapeutic composition
US4237165A (en) * 1976-06-04 1980-12-02 Science Union Et Cie Treatment of carbohydrate metabolism disorders
US4137309A (en) * 1976-10-14 1979-01-30 The Procter & Gamble Company Therapeutic treatment
US4113862A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Carboxy phosphonate pharmaceutical composition
US4113861A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Phosphonate pharmaceutical composition
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds

Also Published As

Publication number Publication date
ES488535A0 (es) 1981-05-16
CA1148561A (en) 1983-06-21
AU5495180A (en) 1980-08-21
EP0015370A1 (de) 1980-09-17
GB2043072B (en) 1983-11-23
US4309364A (en) 1982-01-05
GB2043072A (en) 1980-10-01
AU536326B2 (en) 1984-05-03
EP0015370B1 (de) 1983-01-12
ES8105338A1 (es) 1981-05-16
US4371527A (en) 1983-02-01

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee