DE29825242U1 - A foaming skin cream - contains special additives which make it useful for treating allergies or preventing skin from absorbing carcinogens - Google Patents

Abstract

A foaming skin cream is obtained by producing a phase I by melting a mixture containing fatty acids, especially 12-22C fatty acids, optionally unsaturated fatty acids and/or polyunsaturated fatty acids, emulsifiers and co-emulsifiers such as triceteareth-4-phosphate at a temperature of 75 [deg]C, then adding a metered quantity of the mixture to a phase II at a temperature of 75 [deg]C while stirring,. The phase II contains an aqueous mixture consisting of moisturiser such as propylene glycol and/or polyvalent alcohols, especially glycerine, emulsifiers such as alkyl sarcosinates, and skin care additives such as allantoin. The two phases are mixed to produce a homogenous mixture, while maintaining the temperature at 75 [deg]C for 5-20 minutes. The temperature of the resulting mixture is lowered to 30-40 [deg]C whilst constantly stirring. The pH value is adjusted to 7.6 to 8.2, preferably with a skin-friendly, basic organic compound. The resulting mixture is filled into presentation containers, adding a propellant gas.

Description

The The invention relates to a foam skin cream, uses of the foam skin protection cream and a process for their preparation.

The galenic principle of an emulsoid 2-phase system by lipophilic or hydrophobic components on the one hand and hydrophilic components On the other hand, is already known for the preparation of foam preparations for skin care. By using these foam preparations on the treated skin, a two-dimensional biphasic network is created, the hydrophilic components bind to the keratin of the horny layer and allow the evaporation of the sweat, while the lipophilic parts on the skin surface the ingress of moisture (including the sweat that has passed through) inhibit. Because the foam, unlike others, is a barrier Anabolic creams in minutes to feed, no grease marks on the Work materials leaves and heat accumulation or even prevents macerating effects through perspiration the foam is rapidly gaining in popularity as a preservative odor-induced moisture. More details about the known foam skin creams are in particular from "skin", Issue 4, 1992 by R. Rudolph, L. Bade, B. Brüggemann, removable.

In "close derm" 10 (1994), 344-351 reported B. Kunze about Fatty skin protection foams that for dry, sensitive skin and chronic eczema are indexed. It also reveals ingredients. The Skin protection foams described there protect against many occupational noxae, such as B. Acid perm in the hairdressing trade, alkalis, oils, Disinfectants, cleaning and rinsing agents, but also against water, Moisture, perspiration, Faeces, urine and mineral dusts.

The EP 0 598 412 also relates to skin protection foams which describe PTFE as an effective principle.

The DE-C-33 30 628 relates to skin protection and care lotions, the silicone oils, partially neutralized stearic acid, Fatty alcohols and their ethoxylated derivatives, ethoxylated wool fat coal, Cetylstearyl alcohol, vaseline, thickener and water contains. These Revealed lotions should be absorbed quickly without affecting the skin longer Time an annoying To leave a greasy film.

information to emulsifiers that can be used in skin care products, find in DE-A-195 42 572. There emulsifiers are proposed, the 43 to 90 wt .-% alkyl and / or Alkenyl oligoglycosides and 10 to 57 wt .-% fatty alcohols. These emulsifiers are particularly suitable for the production of storage-stable high-viscosity, sensory light oil-in-water emulsions. The German Utility model DE-U-9308050 relates to a skin protection foam as Agent against skin-aggressive agents. This foam consists of an aqueous emulsion, the fatty acid esters with good skin compatibility and for producing a water vapor permeable film, polyvalent ones Alcohol for stable dispersion of the active ingredients and regulation of Moisture of the film, emulsifiers to improve foam stability, surfactants for reducing the surface tension and optionally neutralizing agent for resins and emulsifiers. When Blowing agents can gaseous hydrocarbons can be used, such as propane, butane or isobutane as well as their mixtures. The foams described there contain but no free fatty acids.

aerosols are complicated, physico-chemical entities that are not form to arbitrariness. It comes in particular on a special Tuning of the foam-forming components. It already can slight shifts cause the composition to collapse the foam, causing a mixture of effective substances not readily can be formulated as a foam.

skin creams are often, especially in professional applications, as unpleasant felt there too long the "greasy" components on the skin remain and annoying Fingerspuren or in general also lead to an unpleasant feeling. A certain remedies have already created the skin foams known per se, because this is an overload help prevent or reduce the skin with the fatty substances. Nonetheless it is desirable especially with a permanent use of skin protection products, an even stronger one To find acceptance by the user.

Of the The present invention is based on the technical problem that Extend the range of application of skin protection foams by adding a mix which is widely accepted by the user is, allowing a variety of admixtures of other substances, without destroying the aerosol used or the properties of the aerosol.

Surprisingly, the technical problem underlying the invention is solved by a basic mixture of a foam skin cream having the features of claim 1. Preferred embodiments of the foam skin cream according to the invention relate to the subclaims 2 to 12. Claims 13 to 16 relate to uses of the foam skin cream according to the invention, whereas claim 17 relates to a process for the preparation of the basis of the invention for a foam skin cream.

• – Herstellung einer Phase I durch Aufschmelzen bei 75 °C einer Mischung enthaltend Fettsäuren, insbesondere C₁₂-C₂₂ Fettsäuren, ggf. ungesättigte und/oder mehrfach ungesättigte Fettsäuren, Emulgatoren, Coemulgatoren, wie Triceteareth-4-phosphat,

gefolgt von einer dosierten Zugabe unter Rühren zu einer

• – auf 75°C temperierten Phase II, die aus einer wäßrigen Mischung enthaltend Moisturiser, wie Propylenglykol und/oder mehrwertige Alkohole, insbesondere Glycerin, Emulgatoren, wie Alkyl-Sarcosinate, sowie Hautpflegeadditive, wie Allantoin erhalten wird,
• – wobei eine homogene Vermischung der Phasen I und II einzustellen ist und die dosierte Zugabe bei einer Temperatur von 75 °C erfolgt,
• – nach Zugabe die Temperatur für eine Zeit zwischen 5 und 20 Minuten bei 75 °C gehalten wird, wonach
• – die Temperatur der so erhaltenen Mischung unter ständigem Rühren auf eine Temperatur zwischen 30 und 40°C heruntergefahren wird,
• – Einstellung des pH-Wertes auf 7,6 bis 8,2, vorzugsweise mit einer hautverträglichen basischen organischen Verbindung und Abfüllung der erhaltenen Mischung in Darreichungsformen unter Zugabe eines Treibgases.

The foam skin cream according to the invention is obtainable by

• Preparation of a phase I by melting at 75 ° C. of a mixture comprising fatty acids, in particular C ₁₂ -C ₂₂ fatty acids, optionally unsaturated and / or polyunsaturated fatty acids, emulsifiers, coemulsifiers, such as triceteareth 4-phosphate,

followed by a metered addition with stirring to a

• Heated to 75 ° C phase II, which is obtained from an aqueous mixture containing Moisturiser such as propylene glycol and / or polyhydric alcohols, especially glycerol, emulsifiers such as alkyl sarcosinates, and skin care additives such as allantoin
• - whereby a homogeneous mixing of the phases I and II is to be set and the metered addition takes place at a temperature of 75 ° C,
• - After addition, the temperature for a period of between 5 and 20 minutes at 75 ° C is held, after which
• The temperature of the mixture thus obtained is brought down to a temperature between 30 and 40 ° C. with constant stirring,
• - Adjustment of the pH to 7.6 to 8.2, preferably with a skin-compatible basic organic compound and filling of the resulting mixture in dosage forms with the addition of a propellant gas.

The according to the method available Product can be used directly as a foam skin cream in the commercial sector to protect against or reduce absorption of carcinogenic substances, such as polycyclic aromatic hydrocarbons. This mixture is already capable of people whose skin carcinogenic substances, such as polycyclic aromatic compounds is exposed to confer effective protection. Furthermore, the Mixture suitable, persons from the action of acids, alkalis (no over pH 11), rinsing and detergent, sweat, Urine, stool, rubber gloves, dusts, house dust, machinery, Drilling and cooling oils, fats, Paints / varnishes, gypsum and other substances and chemicals, in particular to give protection to aggressive substances and chemicals.

The foam skin cream according to the invention contains fatty acids, in particular C ₁₂ -C ₂₂ -fatty acids, which may optionally additionally contain unsaturated and / or polyunsaturated fatty acids. Suitable fatty acids which are saturated are, in particular, the naturally occurring C ₁₂ -C ₂₀ -fatty acids, in particular stearic acid and palmitic acid. Myristic acid is also usable. Suitable unsaturated fatty acids are, in particular, those having up to three unsaturated bonds in the hydrocarbon chain. Unsaturated fatty acids are found, for example, in fractions of coconut fat. Suitable coemulsifiers are known coemulsifiers, in particular triceteareth-4-phosphate, sodium laureth-4-phosphate or oleth-3 and other lipophilic emulsifiers based on low ethoxylated fatty alcohols.

The Phase I may also contain Paraffinum Liquidum. When emulsifiers to be used in phase I are those based on fatty alcohols and Base of partial esters of fatty acids into consideration. Especially preferred fatty alcohols are cetearyl alcohol. As partial one fatty acid For example, glyceryl stearate is used.

The Moisturizers which can be used in phase II are, in particular, propylene glycol and / or polyhydric alcohols, such as glycerol. As in particular to be used in Phase II Emulsifiers are alkyl sarcosinates such as lauroyl, lauryl, cetyl sarcosinates to call.

The according to claim 1 available Mixture also serves as the basis for further foam skin creams, in many ways to protect the skin and relieve dermatological Malfunctions can be used.

If desired, can the foam skin cream of the invention one or more preservatives are added. As a preservative In particular, substances such as methyldibromoglutaronitrile and / or Phenoxyethanol proven. These substances can in amounts of 0.01 to 1 wt .-% are added.

The emulsifiers, the fatty acids, co-emulsifiers, moisturizers and skincare agents, in particular allantoin, panthenol, etc., are preferably used in the following amounts:
4 to 15% by weight of oil-in-water emulsifier,
1 to 10% by weight of fatty acid, in particular 4 to 7% by weight, preferably 4.5 to 6% by weight
0.4 to 2.3% by weight coemulsifier
1 to 10 wt .-% Moisturizer
0.05 to 1 wt .-% skin care products and water to compensate for 100% wt.%.

A preferred foam skin cream according to the invention has
1 to 3% by weight of glyceryl stearate,
3 to 6% by weight of cetearyl alcohol,
4 to 6% by weight of stearic acid,
0.5 to 2% by weight of paraffin,
0.4 to 2.3% by weight of triceteareth 4-phosphate,
1.5 to 4% by weight of propylene glycol,
1.3 to 4.2% by weight of glycerol,
1 to 3% by weight of cetyl sarcosinate,
0.05 to 1 wt% allantoin as well
Water to compensate for 100 wt .-% on.

In a further preferred embodiment has the foam skin cream according to the invention additionally a silicone-containing substance, such as dimethicone. This substance is added to Phase I. Preferably, it is in amounts of 0.05 to 1 wt .-% before.

The foam skin cream according to the invention furthermore in addition in phase I one or more moisturizing Substances such as decyl oleate, isohexadecane, stearic acid glycol ester, coconut fatty acid ethanolamide, Corn oil, Peanut oil, almond oil, sesame oil, olive oil, jojoba oil, soybean oil, wool wax alcohols, Paraffin, medium chain triglycerides, oleic acid oleyl ester, white petrolatum, Macrogol glycerol hydroxy stearate, hydrogenated castor oil, Ricinus oil communis, Avocado oil, Wheat germ oil, isopropyl palmitate, Cetyl palmitate, Myristinsäuremyristilester and / or octyldodecanol.

Especially the foam-skin cream has amounts of from 0.5 to 2% by weight of decyl oleate and / or 0.5 to 2 wt .-% octyl decanol or another of the above rehydrating Substances on when the product is used on normal skin should. The total amount of moisturizing substances should be calculated in this way be that the Skin protection foam not destroyed becomes. An amount of about 4% by weight of moisturizing substances is sufficient in normal to slightly dry skin. Should dry skin with the Foam skin cream according to the invention be treated, are recommended amounts of 3 to 6 wt .-% of a Component of moisturizing Substances, in particular decyl oleate and / or octyl decanol. Become used more than one component, the total amount should be greasy Components with slightly dry skin are at most about 12%. Becomes even stronger dry skin, the amount of moisturizing substance is when using a Component such as decyl oleate at about 6 to 9 wt .-% and when used from octyldecanol at 6-9% by weight. The amount of greasing Substance can then be up to 20 wt .-% amount.

The The latter foam skin creams are just like the products without silicone-containing substances for the care and protection of the skin, in particular across from aggressive substances, such as rinsing and Detergent, sweat, Urine, stool, rubber gloves, dusts, house dust, machinery, Drilling and cooling oils, fats, Paints / varnishes, gypsum and other substances and chemicals, in particular aggressive substances and chemicals.

The Foam skin creams are also suitable for the treatment of dermatological Diseases or their alleviation. In particular dermatological Diseases such as allergic contact dermatitis type I and IV, cumulative subtoxic Eczema, toxic-irritative eczema, microbial dysregulatory eczema, atopic dermatitis, atopic PalmoPlantar eczema, dyshidrosis, Hyperhidrosis, contact urticaria, intertriginous eczema in hemorrhoids, various weeping Fungal infections, eg. B. Interdigital mycosis, Perleches, psoriasis vulgaris, ulcus cruris, cholinergic urticaria, diaper dermatitis.

It may be displayed next to the greasy Substances also present substances that increase the moisture content of the skin increase can. These hydrating substances include in particular urea, Ethoxydiglycol, sodium chloride, magnesium chloride, sorbitol, dexphanthenol, Sodium lactate, allantoin, hyaluronic acid, vitamin E, linolenic acid. The Amount of these substances may vary according to the severity of the treatment Disease 1 to 20 wt .-% or more of the substances concerned. These quantities are especially valid for urea, which also in quantities from 3 to 15% by weight, or 12.5 -15 Wt .-% may be present. The foam skin cream according to the invention can also be used for psoriasis be used.

One Particularly important field of application opens up in prophylaxis and treatment of the diabetic foot. Due to side effects Diabetics suffer from dry skin during the course of diabetes Diseases damage of the extremities favors, to the necessary Amputation in longtime Diabetics. A prophylactic use of skin protection products, the for an improvement of the skin parameters in diabetics worry, can be prevent the formation of diabetic foot.

Furthermore can the foam skin cream of the invention skin-care substances, such as polyunsaturated fatty acids (PUFA) be added. In particular, omega-6 fatty acids, such as For example, they are known from evening primrose oil and borage oil are eligible. It can both synthetic omega-6 fatty acids as well as those from the mentioned plant extracts are used.

Furthermore are soothing substances, such as chamomile extract as another Fraction, the foam skin cream of the invention can be mixed into consideration.

Even skin-active vitamins, such as vitamins A, E and F, the beige skin cream of the invention in effective amounts beige be mixed. In particular for the treatment and prevention of diaper dermatitis, the admixture of the following substances has proven useful, 3 to 7% by weight of calendula extract, 3 to 7% by weight of witch hazel extract, 3 to 7% by weight of camomile extract, 3-7% by weight of tea tree oil extract, 1-5% by weight of decyl maleate, 1-5% by weight of octyldodecanol.

• – wird eine Phase I durch Aufschmelzen einer Mischung enthaltend Fettsäuren, insbesondere C₁₂–C₂₂ Fettsäuren, ggf. ungesättigte und/oder mehrfach ungesättigte Fettsäuren, Coemulgatoren, wie Triceteareth-4-phosphat, bei 75 °C hergestellt, diese Phase unter Rühren dosiert zu einer
• – bei 75 °C aufgeschmolzenen Phase II, die aus einer wäßrigen Mischung enthaltend Moisturiser, wie Propylenglykol und/oder mehrwertige Alkohole, insbesondere Glycerin, Emulgatoren, wie Alkyl-Sarcosinate, sowie Hautpflegeadditive, wie Allantoin erhalten wird, zugegeben,
• – wobei eine homogene Vermischung der Phasen I und II einzustellen ist und die dosierte Zugabe bei einer Temperatur von 75 °C erfolgt.
• – Nach Zugabe der Phase I zur Phase II wird die Temperatur für eine Zeit zwischen 5 und 20 Minuten bei 75 °C gehalten wird, wonach
• – die Temperatur der so erhaltenen Mischung unter ständigem Rühren auf eine Temperatur zwischen 30 und 40 °C heruntergefahren wird.
• – Die Einstellung des pH-Wertes auf 7,6 bis 8,2 erfolgt, vorzugsweise mit einer hautverträglichen basischen

organischen Verbindung und die Abfüllung unter Zugabe eines Treibgases.The process according to the invention for producing the foam skin protection cream according to the invention comprises the following steps:

• - Is a Phase I by melting a mixture containing fatty acids, in particular C ₁₂ -C ₂₂ fatty acids, optionally unsaturated and / or polyunsaturated fatty acids, Coemulgatoren, such as triceteareth-4-phosphate, prepared at 75 ° C, metering this phase with stirring to a
• Phase II melted at 75 ° C., which is obtained from an aqueous mixture comprising moisturizers, such as propylene glycol and / or polyhydric alcohols, in particular glycerol, emulsifiers, such as alkyl sarcosinates, and skin care additives, such as allantoin,
• - Wherein a homogeneous mixing of the phases I and II is set and the metered addition is carried out at a temperature of 75 ° C.
• After addition of Phase I to Phase II, the temperature is maintained at 75 ° C for a period between 5 and 20 minutes, after which
• - The temperature of the mixture thus obtained with constant stirring to a temperature between 30 and 40 ° C is shut down.
• The pH is adjusted to 7.6 to 8.2, preferably with a skin-compatible basic

organic compound and the filling with the addition of a propellant gas.

The The invention will be explained in more detail with reference to the following example:

example

The Skin protection cream of the invention is in a heatable and coolable closed apparatus with a self-releasing homagenizer and a heated hopper (preferably a Koruma multipurpose machine) produced.

The Phase I is produced in a heatable metering funnel by melting a mixture containing 2% by weight of glyceryl stearate, 4% by weight of cetearyl alcohol, 5% by weight of stearic acid, 1% by weight of paraffin, 1% by weight Triceteareth-4-phosphate 75 ° C. It a metered addition of this phase is added with stirring one in the heatable and coolable closed Apparatus with a self-discharging homogenizer submitted Phase II. This phase consists of an aqueous mixture containing 2.5% by weight of propylene glycol, 2.5% by weight of glycerol, 2% by weight of sodium lauroyl sarcosinate and 0.3% by weight allantoin. The amount of water 79.7 wt .-%. A Homogeneous mixing of phases I and II is to be stopped.

The metered addition of phase I takes place at a temperature of 75 ° C. Both Phases are becoming more and more constant medium stirring speed merged, being on a uniform homogenization activity must be respected. The temperature is between 5 and 20 min. kept at 75 ° C. The resulting mixture is stirred with constant stirring to a temperature between 30 and 40 ° C cooled.

To Reaching a temperature of 40 ° C can then the other substances are added. This can also be the pH be set to a value between 7.8 to 8.0.

For this 2-amino-2-methyl-1-propanol is used. It will be sufficient for a stirred for a long time until stabilization of the pH and then the bottling in suitable storage containers or filled into the corresponding spray container. there 91% active ingredient is filled with 9% butane / propane.

Claims (10)

Foam skin cream comprising - 1 to 20% by weight urea, - C ₁₂ -C ₂₂ fatty acids comprising stearic acid, - ceteryl alcohol, - glyceryl stearate, - alkyl sarcosinate, and - triceteareth-4-phosphate. Foam skin cream according to claim 1, further comprising Allantoin. Foam skin cream according to claim 1 or 2, further comprising glycerin. Foam skin cream according to one of claims 1 to 3, further comprising evening primrose oil. Foam skin cream according to one of claims 1 to 4, further comprising wheat germ oil. Foam skin cream according to one of claims 1 to 5, comprising 3 to 15% by weight Urea. Foam skin cream according to one of claims 1 to 6, comprising lauroyl sarcosinate. Use of a foam skin cream according to a the claims 1 to 7, for a medicine for the prophylaxis and treatment of dry skin. Use of a foam skin cream according to a the claims 1 to 7, for a medicine for the prophylaxis and treatment of diabetic Foot. Use of a foam skin cream according to a the claims 1 to 7, for the prophylaxis and treatment of allergic contact dermatitis, cumulative subtoxic Eczema, toxic-irritative eczema, microbial dysregulatory eczema, atopic dermatitis, atopic PalmoPlantar eczema, dyshidrosis, Hyperhidrosis, contact urticaria, intertriginous eczema in hemorrhoids, weeping Fungal infections, including interdigital mycosis, Perleches, psoriasis vulgaris, leg ulcers, cholinergic urticaria and diaper rash.