DE29519982U1 - Induction heating system for metallic implants used in living things - Google Patents
Induction heating system for metallic implants used in living thingsInfo
- Publication number
- DE29519982U1 DE29519982U1 DE29519982U DE29519982U DE29519982U1 DE 29519982 U1 DE29519982 U1 DE 29519982U1 DE 29519982 U DE29519982 U DE 29519982U DE 29519982 U DE29519982 U DE 29519982U DE 29519982 U1 DE29519982 U1 DE 29519982U1
- Authority
- DE
- Germany
- Prior art keywords
- induction heating
- heating system
- living things
- metallic implants
- implants used
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007943 implant Substances 0.000 title claims description 11
- 238000010438 heat treatment Methods 0.000 title claims description 8
- 230000006698 induction Effects 0.000 title claims description 5
- 239000002184 metal Substances 0.000 claims description 10
- 229910052751 metal Inorganic materials 0.000 claims description 10
- 230000003685 thermal hair damage Effects 0.000 claims description 2
- 230000002792 vascular Effects 0.000 description 5
- 206010002329 Aneurysm Diseases 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 101100286286 Dictyostelium discoideum ipi gene Proteins 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/105—Induction heating apparatus, other than furnaces, for specific applications using a susceptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
- A61N1/406—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia using implantable thermoseeds or injected particles for localized hyperthermia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- General Induction Heating (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
Description
Dipi.-Ing. Dr. med. Thomas Schmitz-Rode
Kupferstrasse 5
52070 AachenDipi.-Ing. Dr. med. Thomas Schmitz-Rode
Kupferstrasse 5
52070 Aachen
Professor Dr. med. Rolf W. Günther
Brüsseler Ring 73c
52074 AachenProfessor Dr. med. Rolf W. Günther
Brussels Ring 73c
52074 Aachen
GEBRAUCHSMUSTERANMELDUNGUTILITY MODEL REGISTRATION
Bezeichnung:Designation:
"Induktionserwärmungsanlage für in Lebewesen eingesetzte metal1isehe Imp!antäte""Induction heating system for metallic imp!ants used in living beings"
Tubuläre Endoprothesen ("Stents") werden erfolgreich zur Aufweitung und Schienung von arteriosklerotisch bedingten Engstellungen des menschlichen Gefäßsystems und zur palliativen Behandlung tumorös bedingter Engstellungen anderer Hohlorgane (Speiseröhre, Luftröhre, Gallenwege, ableitende Harnwege etc.) eingesetzt. Problematisch ist Jedoch die früher oder später einsetzende Restenosierung des gestenteten Gefäßsegments durch eine überschießende Gewebereaktion, die sogenannte Intimahyperplasie, und bei den gestenteten tumorbefallenen Hohlorganen die Einengung durch Einwachsen von Tumorzellen in den Stent.Tubular endoprostheses ("stents") are successfully used to widen and splint arteriosclerotic-related narrowing of the human vascular system and for the palliative treatment of tumor-related narrowing of other hollow organs (esophagus, trachea, bile ducts, urinary tract, etc.). However, the problem is the sooner or later onset of restenosis of the stented vascular segment due to an excessive tissue reaction, the so-called intimal hyperplasia, and in the case of stented tumor-affected hollow organs, the narrowing due to the growth of tumor cells into the stent.
Gefäßaussackungen (Aneurysmata), Gefäßleckagen (innere Blutungen) und Tumorgefäße können durch über Katheter eingebrachte Metall imp!antäte (z.B. Metallspiralen) verschlossen werden. Ein gewünschter kompletter Verschluß stellt sich nicht immer ein, mit der Konsequenz, daß das Aneurysma weiter wächst, die Blutung nicht vollständig gestillt ist usw.Vascular bulges (aneurysms), vascular leaks (internal bleeding) and tumor vessels can be closed using metal implants (e.g. metal spirals) inserted via catheters. The desired complete closure does not always occur, with the consequence that the aneurysm continues to grow, the bleeding is not completely stopped, etc.
Der hier beschriebenen Erfindung liegt die Aufgabe zugrunde, ein mit einer Vorrichtung verbundenes Behandlungverfahren zur Verfügung zu stellen, welches ohne invasiven Eingriff in den Körper eines Lebewesens einerseits die überschießende Gewebereaktion bzw. Tumorzellwucherung in der Umgebung metallischer Implantate verringert und andererseits einen unvollständigen Gefäßverschluß durch metallische Implantate komplettiert.The invention described here is based on the object of providing a treatment method connected to a device which, without invasive intervention in the body of a living being, on the one hand reduces the excessive tissue reaction or tumor cell proliferation in the vicinity of metallic implants and, on the other hand, completes an incomplete vascular occlusion by metallic implants.
Zur Lösung dieser Aufgabe wird eine Vorrichtung mit den im kennzeichnenden Teil des Anspruchs 1 angegebenen Merkmalen vorgeschlagen.To solve this problem, a device with the features specified in the characterizing part of claim 1 is proposed.
Der Aufbau und die Handhabung der erfindungsgemäßen Vorrichtung
sind in den Zeichnungen Abb. 1 und 2 dargestellt.
Die Bezeichnung der Bauteile durch Ziffern korrespondiert mit den in der folgenden Beschreibung in Klammern genannten
Ziffern.The structure and handling of the device according to the invention are shown in the drawings Fig. 1 and 2.
The designation of the components by numbers corresponds to the numbers given in brackets in the following description.
Abb. 1 stellt die elektrische Prinzipskizze der Vorrichtung dar.Fig. 1 shows the electrical schematic diagram of the device.
Abb. 2 zeigt eine Ausführungsform der Vorrichtung.Fig. 2 shows an embodiment of the device.
Die wesentlichen Bestandteile der Vorrichtung sind eine Spule (1) und ein zugehöriger Generator (2) (Abb. 1). Die Spule besteht aus mehreren Wicklungen mit einem elektrischen Leiter (vorzugsweise Kupferdraht oder Kupferrohr). Der Generator liefert ein Mittel- oder Hochfrequenzsignal im Mittel- bzw. Langweilenbereich (30 kHz - 1 MHz). Der Spulendurchmesser ist so groß, daß die Körperregion des Patienten, in der sich die MetaIl-Endoprothese (3) befindet, innerhalb der Spule eine zentrale Lage einnehmen kann (Abb. 2). Durch Anlegen des Signals des Generators an die Spule wird in dem Metal!implantat ein Wirbelstrom induziert. Wirbelstromver-The main components of the device are a coil (1) and an associated generator (2) (Fig. 1). The coil consists of several windings with an electrical conductor (preferably copper wire or copper tube). The generator delivers a medium or high frequency signal in the medium or long range (30 kHz - 1 MHz). The coil diameter is so large that the region of the patient's body in which the metal endoprosthesis (3) is located can take up a central position within the coil (Fig. 2). By applying the signal from the generator to the coil, an eddy current is induced in the metal implant. Eddy current
1 uste führen zu einer'ttuf heizt/Hg "des'"InISpT an tats, abhängig von der Frequenz , der Leistung und der Einwirkdauer. In Grundlagenexperimenten konnte gezeigt werden, daß bei einer Frequenz von 300 kHz, einer Generatorieistung von 15 kW, einer 5 cm durchmessenden Spule aus 7 Windungen Kupferrohr und einer Einwirkdauer von 5-20 Sekunden alle üblichen Stenttypen um 2 - 10 Grad erhitzt wurden. Vitale Zellen in Ummgebung der metallischen Stentmatrix wurden abgetötet. Die Ausdehnung des Bereichs getöteter Zellen war durch die Einwirkdauer bei sonst konstanten Parametern einstellbar. Die Zeilabtötung erfolgte durch direkte Wärmeleitung, ausgehend von der Metallmatrix der Stents. Muskel- und Fettgewebe ohne Metal 1 implantat erfuhr bei Exposition zu gleichen Bedingungen keine meßbare Aufheizung. Die Exposition des Körpers eines Lebewesens in einer Induktionserwärmungsanlage führt in dem Frequenzbereich von 30 kHz - 1 MHz zu einer selektiven Aufheizung von Metall imp!antaten. Das normale Körpergewebe erfährt keine meßbare induktive Erwärmung. Das Verfahren kann genutzt werden zur Abtötung vitaler Zellen in direkter Umgebung des Metall Implantats (z.B. Reduktion der Intimahyperplasie bei in die Gefäßwand inkorporierten vaskulären Stents oder des Einwachsens von Tumorzellen bei palliativer Stentung in anderen Hohlorganen). Das Verfahren kann sich auch als sinnvoll erweisen zur Komplettierung eines bewußt herbeigeführten Gefäß-(aneurysma)-Verschlusses, indem durch selektive Erwärmung des Implantats (Metallspirale) im Blutstrom eine lokale thermische Schädigung der Blutzellen herbeigeführt und damit eine Thrombose erzeugt wird.1 usts lead to a 'tuf heats/Hg "of the'"InISpT actually, depending on the frequency, the power and the duration of exposure. In basic experiments it was shown that with a frequency of 300 kHz, a generator power of 15 kW, a 5 cm diameter coil made of 7 turns of copper pipe and an exposure time of 5-20 seconds, all common stent types were heated by 2 - 10 degrees. Vital cells in the vicinity of the metallic stent matrix were killed. The extent of the area of killed cells could be adjusted by the exposure time with otherwise constant parameters. The cell killing occurred through direct heat conduction, starting from the metal matrix of the stents. Muscle and fatty tissue without a metal 1 implant did not experience any measurable heating when exposed under the same conditions. The exposure of the body of a living being to an induction heating system leads to a selective heating of metal implants in the frequency range of 30 kHz - 1 MHz. The normal body tissue does not experience any measurable inductive heating. The process can be used to kill vital cells in the immediate vicinity of the metal implant (e.g. reduction of intimal hyperplasia in vascular stents incorporated into the vessel wall or the growth of tumor cells in palliative stenting in other hollow organs). The process can also prove useful for completing a deliberately induced vessel (aneurysm) closure by causing local thermal damage to the blood cells through selective heating of the implant (metal spiral) in the bloodstream, thus causing thrombosis.
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29519982U DE29519982U1 (en) | 1995-12-16 | 1995-12-16 | Induction heating system for metallic implants used in living things |
| PCT/DE1996/002369 WO1997022290A2 (en) | 1995-12-16 | 1996-12-11 | Inductive heating installation for metal implants in living tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29519982U DE29519982U1 (en) | 1995-12-16 | 1995-12-16 | Induction heating system for metallic implants used in living things |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE29519982U1 true DE29519982U1 (en) | 1996-02-15 |
Family
ID=8016829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE29519982U Expired - Lifetime DE29519982U1 (en) | 1995-12-16 | 1995-12-16 | Induction heating system for metallic implants used in living things |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE29519982U1 (en) |
| WO (1) | WO1997022290A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006005224A1 (en) * | 2006-01-31 | 2007-08-09 | P + P Medical Gmbh | Device for separating an endoprosthesis from biological and / or biocompatible materials |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6397107B1 (en) * | 1998-04-27 | 2002-05-28 | Bokwang Co., Ltd. | Apparatus for embolic treatment using high frequency induction heating |
| AU2003256815A1 (en) * | 2002-07-25 | 2004-02-16 | Triton Biosystems, Inc. | Method and device to treat back pain |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT359178B (en) * | 1976-04-20 | 1980-10-27 | Rodler Ing Hans | DEVICE FOR STUDYING BIOLOGICAL BODIES WITH ELECTROMAGNETIC FIELDS |
| US4574782A (en) * | 1981-11-16 | 1986-03-11 | Corning Glass Works | Radio frequency-induced hyperthermia for tumor therapy |
| DE3406565C2 (en) * | 1984-02-23 | 1995-04-27 | Kraus Werner | Device for generating a low-frequency AC voltage on two tissue electrodes of an implant used for tissue regeneration |
| US4679561A (en) * | 1985-05-20 | 1987-07-14 | The United States Of America As Represented By The United States Department Of Energy | Implantable apparatus for localized heating of tissue |
-
1995
- 1995-12-16 DE DE29519982U patent/DE29519982U1/en not_active Expired - Lifetime
-
1996
- 1996-12-11 WO PCT/DE1996/002369 patent/WO1997022290A2/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006005224A1 (en) * | 2006-01-31 | 2007-08-09 | P + P Medical Gmbh | Device for separating an endoprosthesis from biological and / or biocompatible materials |
| DE102006005224B4 (en) * | 2006-01-31 | 2008-09-04 | P + P Medical Gmbh | Device for separating an existing from an electrically conductive material Gelenkendoprothese of biological and / or biocompatible materials |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997022290A3 (en) | 1997-10-16 |
| WO1997022290A2 (en) | 1997-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R207 | Utility model specification |
Effective date: 19960328 |
|
| R081 | Change of applicant/patentee |
Owner name: TRITON BIOSYSTEMS INC., US Free format text: FORMER OWNER: THOMAS SCHMITZ-RODE,ROLF W. GUENTHER, , DE Effective date: 19971117 |
|
| R150 | Utility model maintained after payment of first maintenance fee after three years |
Effective date: 20000222 |
|
| R081 | Change of applicant/patentee |
Owner name: TRITON BIOSYSTEMS INC., US Free format text: FORMER OWNER: CARDIOTOOLS HERZCHIRURGIETECHNIK GMBH, 23999 INSEL POEL, DE Effective date: 20020724 |
|
| R151 | Utility model maintained after payment of second maintenance fee after six years |
Effective date: 20021127 |
|
| R081 | Change of applicant/patentee |
Owner name: TRITON BIOSYSTEMS INC., US Free format text: FORMER OWNER: RESTENT THERAPEUTICS GMBH, 82024 TAUFKIRCHEN, DE Effective date: 20031210 |
|
| R152 | Utility model maintained after payment of third maintenance fee after eight years |
Effective date: 20031211 |
|
| R071 | Expiry of right |