DE2808160A1 - Tablets produced from chewing gum granulate - obtained by cooling chewing gum until it becomes brittle - Google Patents

Tablets produced from chewing gum granulate - obtained by cooling chewing gum until it becomes brittle

Info

Publication number
DE2808160A1
DE2808160A1 DE19782808160 DE2808160A DE2808160A1 DE 2808160 A1 DE2808160 A1 DE 2808160A1 DE 19782808160 DE19782808160 DE 19782808160 DE 2808160 A DE2808160 A DE 2808160A DE 2808160 A1 DE2808160 A1 DE 2808160A1
Authority
DE
Germany
Prior art keywords
chewing gum
granulate
tablet according
granules
tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782808160
Other languages
German (de)
Inventor
Rabbe Dr Nordstroem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VOSS GUNTHER M
Original Assignee
VOSS GUNTHER M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VOSS GUNTHER M filed Critical VOSS GUNTHER M
Priority to DE19782808160 priority Critical patent/DE2808160A1/en
Publication of DE2808160A1 publication Critical patent/DE2808160A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/02—Apparatus specially adapted for manufacture or treatment of chewing gum
    • A23G4/04—Apparatus specially adapted for manufacture or treatment of chewing gum for moulding or shaping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)

Abstract

New tablets are produced from a chewing gum granulate. Tablets based n chewing gum granulates can be produced using conventional tabletting equipment. The chewing gum granulate can be used to achieve prolonged or delayed release of medicament. Furthermore, a sweet chewing gum core can be surrounded with a mantle contg. a bitter active ingredient; in this case, the initial bitter flavour becomes overlaid with the sweetness of the chewing gum, which is more acceptable than the usual case of an initially sweet flavour accompanied by a bitter aftertaste. The chewing gum granulate may contain the active ingredient, or the chewing gum granulate may be compressed together with a conventional tabletting granulate contg. the active ingredient. In an alternative formulation, the tablet may be in several layers, some of which may consist of conventional tabletting granulates.

Description

NEUARTIGE TABLETTE UND DAS VERFAHREN ZUR HERSTELLUNCNOVEL TABLET AND THE METHOD OF MANUFACTURING

EINES SOLCHEN PRESSLINGS. SUCH A PRESSLING.

DIE ERFINDUNG BETRIFFT EINE NEUARTIGE VERABREICHUNGSFORM, DIE GANZ ODER TEILWEISE, AUS EINER KAUGUMMIMASSE BESTEHT, SOWIE DAS VERFAHREN IHRER HERSTELLUNG.THE INVENTION CONCERNS A UNIQUE FORM OF ADMINISTRATION, THE WHOLE OR IN PART, CONSISTS OF A CHEWING GUM, AND THE PROCESS OF THEIR MANUFACTURING.

SEIT LANGEM BESTEHT DER WUNSCH, EINE PHARMAKOLOGISCHE EXAKTE, VOLL REPRODUZIERBARE, VERABREICHUNGSFORM, FÜR DIE ORALE ABSORPTION VON PHARMAKA ZU FINDEN.THE DESIRE FOR PHARMACOLOGICAL EXACT, FULLY HAS BEEN FOR A LONG TIME REPRODUCIBLE DOSAGE FORM TO FIND FOR THE ORAL ABSORPTION OF PHARMACA.

DIES IST VON BESONDERER BEDEUTUNG, WENN MAN DIE, IM VER-GLEICH ZU DER BEKANNTEN RESORPTION AUS DEM MAGEN-DARMTPAKT, VERHPLTNISMPSSIG SCHNELLE RESORPTION ÜBER DIE ORALEN SCHLEIM-HÄUTE VOR AUGEN HALT. WEITERHIN IST ZU BEMERKEN, DASS VON MENSCH ZU MENSCH SEHR ÄHNLICHE VERHÄLTNISSE BEI DER ORALEN RESORPTION BESTEHEN, IM GEGENSATZ ZUR RESORPTION AUS DEM MAGEN- UND DARMTRAKT.THIS IS PARTICULARLY SIGNIFICANT IF YOU'RE THAT, IN COMPARISON TO THE FAMOUS RESORPTION FROM THE STOMACH-INTESTINAL TEST, RELIABLE FAST RESORPTION BEFORE YOUR EYES ABOUT THE ORAL MUCUS. FURTHERMORE, IT SHOULD BE NOTED THAT FROM HUMAN TO HUMAN VERY SIMILAR RELATIONSHIPS EXIST IN ORAL RESORPTION, In contrast to absorption from the gastrointestinal tract.

ES WURDE NUN VERSUCHT, EINE TABLETTE AUS KAUGUMMIMASSE ZU SCHAFFEN, DIE ALLE PHARMAKOLOGISCHE ANFORDERUNGEN ERFÜLLT.IT HAS NOW BEEN TRIED TO CREATE A TABLET FROM CHEWING GUM MASS, THAT MEETS ALL PHARMACOLOGICAL REQUIREMENTS.

KAUGUMMIMASSEN GIBT ES IN DEN VERSCHIEDENSTEN ABFORMUNGEN, WIE STREIFEN, KISSEN, DRAGEES, VOM STRANG EXTP.UDIERT, ALS KERN-MIT EINER -HARTZUCKERDECKE UMGEBEN, FLÜSSIG GEFÜLLT, ODER SOGAR ALS ZIGARETTEN-IMITATION.CHEWING GUM MEASURES ARE AVAILABLE IN VARIOUS IMPRESSIONS, SUCH AS STRIPS, CUSHIONS, DRAGEES, EXTP.UDIED FROM THE ROPE, AS A CORE-SURROUNDED WITH A -HARD SUGAR CEILING, LIQUID, OR EVEN AS A CIGARETTE IMITATION.

DIE KAUGUMMI BASEN EMPFEHLEN SICH IN HOHEM MASSE ZUR WIRK-STOFFAUFNAHME UND BESONDERS LANG ANHALTENDEN WIRKSTOFFAB-GABE. DIE GESCHILDERTEN UND HEUTE BEKANNTEN DAPBIETUNGS-FORA1EN GARANTIEREN JEDOCH NICHT EXAKT DIE BEI DER TABLETTEN-HERSTELLUNG GEFORDERTEN MASS- UND GEWICHTSGENAUIGKEITEN DER ARZNEIMITTELHERSTELLUNG.THE CHEWING GUM BASES ARE HIGHLY RECOMMENDED FOR ABSORBING ACTIVE SUBSTANCES AND PARTICULARLY LONG-LASTING SUBSTANCE DISPENSING. THE DESCRIBED AND KNOWN TODAY HOWEVER, DISCLOSURE FORA1S DO NOT GUARANTEE EXACTLY THAT DURING THE TABLET PRODUCTION REQUIRED DIMENSIONAL AND WEIGHT ACCURACIES IN DRUG MANUFACTURING.

ES WURDE NUN GEFUNDEN, DASS MAN, UM VON KAUGUMMIMASSEN FERTIGE, ZUR ABFORMUNG PRÄPARIERTE KAUGUMMIMASSEN, DIE THERMOPLASTISCH REAGIEREN EIN, FÜR DIE VERPRESSUNG AUF EXZENTER- ODER ROTATIONSPRESSEN ERFORDERLICHES GRANULAT AUS KAUGUMMIMASSE ERHALTEN KANN, WENN MAN DIE FERTIGE CPsUND-MASSE MIT ALLEN INGREDIENZIEN, VORHER AUF CA. 20 MM PLATTEN-STÄRKE AUSWALZT UND AUF ETWA MINUS 10 GRAD CELSIUS HERUNTER-KÜHLT. DIE KAUGUMMIMASSE WIRD HART UND SPRRDE UND EIN FEINSTBRUCH AUF GEEIGNETEN MASCHINEN, ZUM BEISPIEL WALZEN-STUHL, HAMMERSCHLAGMHLE, IST MCGLICH.IT HAS NOW BEEN FOUND TO MANUFACTURE FROM CHEWING GUM MEASUREMENTS IMPRESSION OF PREPARED CHEWING GUM THAT THERMOPLASTIC REACT FOR COMPRESSION ON ECCENTRIC OR ROTARY PRESSES NECESSARY GRANULES MADE OF CHEWING GUM MASS CAN GET IF YOU HAVE THE FINISHED CPsUND DIMENSIONS WITH ALL THE INGREDIENTS, BEFORE ON APPROX. 20 MM PANEL THICKNESS ROLLED OUT AND COOLED DOWN TO AROUND MINUS 10 DEGREES CELSIUS. THE MEASURE OF CHEWING GUM BECOMES HARD AND BRICK AND A FINE FRACTION ON SUITABLE MACHINERY, FOR EXAMPLE, ROLLER CHAIR, HAMMERSHIP MILL, IS MCABLE.

EINE SO HERGESTELLTE TABLETTE HAT VIELE VORTEILE: ES KÖNNEN DIE FÜR EINE TABLETTENHERSTELLUNG ÜBLICHEN ANLAGEN, Z.B.A TABLET MANUFACTURED IN THIS WAY HAS MANY ADVANTAGES: IT CAN BE FOR A TABLET MANUFACTURING SYSTEMS USUAL, E.G.

WERKZEUGE WIE OBER- UND UNTERSTEMPEL EINSCHLIESSLICH MATRIZE, HERSTELLUNGSMASCHINEN UND VERPACKUNGSSTATIONEN BENUTZT WERDEN. WEITERHIN IST ES MIT DIESER TABLETTE MÖGLICH, WIRKSTOFFE SO ZU VERNETZEN, DASS EIN RETARDIERENDER EFFEKT BEIM KAUEN ENTSTEHT. EINER SOLCHEN VERWENDUNG, D.H., UNTER-BRINGUNG VON WIRKSTOFFSUBSTANZEN IN KAUGUMMIMASSEN UND DEREN BISHER BEKANNTEN ABFORMUNGEN, STAND DIE NICHT GENÜGEND EXAKTE UND REPRODUZIERBARE DOSIERUNG ENTGEGEN.TOOLS SUCH AS UPPER AND LOWER STAMPS INCLUDING DIE, MANUFACTURING MACHINERY AND PACKAGING STATIONS ARE USED. IT IS ALSO POSSIBLE WITH THIS TABLET TO CROSS-LINK ACTIVE INGREDIENTS IN A RETARDANT EFFECT WHEN CHEWING. SUCH A USE, I.E., ACCOMMODATION OF ACTIVE SUBSTANCES IN CHEWING GUM MASSES AND THEIR HISTORIC IMPRESSIONS, WERE NOT ENOUGH EXACT AND REPRODUCIBLE DOSAGE AGAINST.

EINE WEITERE METHODE IST DAS DURCHREIBEN DER NOCH WARMEN KAUGUMMIMASSE MITTELS EINER NASSGRANULIERMASCHINE, Z.B ALEXANDERWERK-GRANULIERMASCHINE, HUTTGRANULIERER O.Ä., UM EIN GRANULAT ZU ERHALTEN. IN BEIDEN, OBEN ERWÄHNTEN FÄLLEN, IST ES WICHTIG, DAS SONST ÜBLICHE, FÜR DIE VERPRESSUNG VON GRANULAT ZU TABLETTEN ERFORDERLICHE TPoENN- UND/ODER SCHMIERMITTEL, NICHT UNTERZUMISCHEN. DIE KAUGUMMITABLETTE WÜRDE NACH DER KOMPRESSION SONST AUSEINANDER BUCKELN.ANOTHER METHOD IS TO WRITE THROUGH THE WARM GUM MEASURE BY USING A WET GRANULATING MACHINE, E.G. ALEXANDERWERK GRANULATING MACHINE, HAT GRANULATOR OTHER IN ORDER TO RECEIVE GRANULES. IN BOTH ABOVE-MENTIONED CASES, IT IS IMPORTANT THE OTHER COMMON TYPES REQUIRED FOR COMPRESSING GRANULES TO TABLETS- AND / OR LUBRICANT, DO NOT INTERMEDIATE. THE CHEWING GUM TABLET WOULD BE AFTER THE ELSE COMPRESSION HUMP DOWN.

UM EIN VORZEITIGES ZUSAMMENBACKEN DES PER NASSGRANULATION HERGESTELLTEN KAUGUMMIGRANULATES ZU VERHINDERN, EMPFIEHLT SICH DIE HINZUGABE CKONTINUIERLICH AN DER LOCHWALZE ODER -SCHEIBE ODER IN DIE FERTIGE CHARGE) GEEIGNETER 'tVERBINDUNGS-SUBSTANZEN", Z.B. SACCHAROSE, XYLIT, SORBIT.FOR EARLY BAKING OF THE MADE BY WET GRANULATION TO PREVENT CHEWING GUM GRANULATES, ADDING C CONTINUOUSLY RECOMMENDED THE PUNCH ROLLER OR DISC OR IN THE FINISHED BATCH) OF SUITABLE COMPOUND SUBSTANCES ", E.g. SACCHAROSE, XYLITE, SORBITE.

UM EIN EINWANDFREIES ABLÖSEN UND HERAUSSTOSSEN DER TABLETTE (NACH DER KOMPRESSION) ZU GEWÄHRLEISTEN, KANN DAS KAUGUr1MI-GRANULAT MITTELS DER PRESSKAMMERBESCHICHTUNC- HERGESTELLT WERDEN, VORZUGSWEISE UNTER EINSATZ DES PRESSKAMMERBESCHICHT-TUNGSVERFAHRENS P 27 17 438.5 INFOLGE DER SPEZIELLEN VORBEHANDLUNG DER KAUGUMMIMASSE, UM ZU EINEM PRESSFÄHIGEN GRANULAT ZU GELANGEN, UNTER ZU-HILFENAHME DER INTERMITTIERENDEN MATRIZEN- UND WERKZEUG-BESCHICHTUNG (BZW. DCHMIERUNG), KÖNNEN ALLE BEKANNTEN FORMEN EINER TABLETTE HERGESTELLT WERDEN, WIE MANTELTABLETTE UND SCHICHTTABLETTE, WOBEI AUCH ÜBLICHE GRANULATE MIT ODER OHNE WIRKSTOFFE, UNTER EINBEZIEHUNG DES KAUGUMMIGRANULATES, VER-WENDUNG FINDEN.IN ORDER TO REMOVE AND EJECT THE TABLET PERFECTLY (AFTER THE COMPRESSION), THE KAUGUr1MI GRANULATE CAN BE USED BY THE PRESS CHAMBER COATING PRODUCED, PREFERABLY USING THE PRESS CHAMBER COATING PROCESS P 27 17 438.5 AS A RESULT OF THE SPECIAL PRE-TREATMENT OF THE CHEWING GUM DIMENSIONS IN ORDER TO A TO GET PRESSABLE GRANULES WITH THE HELP OF THE INTERMITTING DIE AND TOOL COATING (OR LUBRICATION), ALL KNOWN SHAPES CAN TABLETS ARE MANUFACTURED SUCH AS COAT-ON TABLETS AND STRATIFIED TABLETS, ALSO USUAL GRANULATES WITH OR WITHOUT ACTIVE INGREDIENTS, INCLUDING THE CHEWING GUM GRANULATES, FIND USING.

DURCH DIE VORLIEGENDE TABLETTE LÄSST SICH AUCH EIN VULLIG NEUER EFFEKT REALISIEREN: BITTERE, AZNEILICHE WIRKSTOFFE, Z.B. IN EINEM DRAGEE UNTERGEBRACHT, LASSEN DEN "ABLAUF" VON SÜSS NACH BITTER ERWARTEN. BEI EINSATZ EINES GESÜSSTEN KAUGUMMIGRANULATES IN VERBINDUNG MIT EINEM ÜBLICHEN GRANU-LAT (ALS SCHICHT- ODER MANTELTABLETTE), WOBEI DER "KERN" AUS DEM GES-ÜSSTEN KAUGUMMIGRANULAT BESTEHEN KÖNNTE), HIER Z.B. MIT BITTER (ODER UNANGENEHM-) SCHMECKENDEN, AR-ZNEI-LICHEN WIRKSTOFFEN VERSEHEN, WIRD DEN UMGEKEHRTEN EFFEKT, BZW. "ABLAUF" ERGEBEN, D.H., ERST WERDEN DIE BITTERSTOFFE AN DEN GESCHMACKSPAPPILLEN WAHRGENOMMEN, MIT EINER, IMMER STÄRKER WERDENDEN SÜSSEN ÜBERLAGERUNG (DES GESÜSSTEN KAU-GUMMIGRANULATES).THIS TABLET ALSO CREATES A COMPLETELY NEW EFFECT REALIZE: BITTER, ACTIONAL INGREDIENTS, E.G. IN A DRAGEE, LET THE "EXPIRY" FROM SWEET TO BITTER EXPECTED. WHEN USING A SWEETED CHEWING GUM GRANULATE IN COMBINATION WITH A USUAL GRANU-LAT (AS A LAYERED OR COATED TABLET), WHICH THE "CORE" COULD CONSIST OF THE GUM-SUSPENDED CHEWING GUM GRANULATE), HERE FOR EXAMPLE WITH BITTER ADDING (OR UNPLEASANT) TASTING AR-ZNEI INGREDIENTS WILL BE THE REVERSE EFFECT, OR RESULTS "EXPIRY", I.E. THE BITTER SUBSTANCES ON THE FLAVORED PAPERS FIRST PERCEIVED, WITH A CUTE OVERLAY EVEN STRENGTHENING (OF THE SWEET CHEW RUBBER GRANULATES).

Claims (9)

PATENTANSPRÜCHE 1. TABLETTE, DADURCH GEKENNZEICHNET, DASS SIE AUS EINEM KAUGUMMIGRANULAT HERGESTELLT IST. PATENT CLAIMS 1. TABLET CHARACTERIZED BY THAT IT IS FROM A CHEWING GUM GRANULATE IS MADE. 2. KAUGUMMITABLETTE NACH ANSPRUCH 1, DADURCH GEKENNZEICHNET, DASS IN DAS KAUGUMMIGRANULAT WIRKSUBSTANZEN EINGEARBEITET WURDEN.2. CHEWING GUM TABLET ACCORDING TO CLAIM 1, CHARACTERIZED BY THAT ACTIVE SUBSTANCES HAVE BEEN INCORPORATED INTO THE CHEWING GUM GRANULES. 3. KAUGUMMITABLETTE NACH ANSPRUCH 1, DADURCH GEKENNZEICHNET, DASS DAS KAUGUMMIGRANULAT MIT EINEM UBLICHEN TABLETTEN-GRANULAT, DEM WIRKSUBSTANZEN ZUGESETZT WURDEN, GEMEIN-SAM VERPRESST WIRD.3. CHEWING GUM TABLET ACCORDING TO CLAIM 1, CHARACTERIZED BY THAT THE CHEWING GUM GRANULES WITH A USUAL TABLET GRANULATE TO THE ACTIVE SUBSTANCES ADDED HAVE BEEN PRESSED, COMMON-SAM. 4. KAUGUMMITABLETTE NACH ANSPRUCH 1, DADURCH GEKENNZEICHNET, DASS DEM GRANULAT PTHERISCHE e;LE ZUGESETZT WURDEN.4. CHEWING GUM TABLET ACCORDING TO CLAIM 1, CHARACTERIZED BY THAT PTHERICAL e; LE HAVE BEEN ADDED TO THE GRANULES. 5. KAUGUMMITABLETTE NACH ANSPRUCH 1, DADURCH GEKENNZEICHNET, DASS SICH DAS KAUGUMMIGRANULAT IN EINER ODER MEHREREN SCHICHTEN BEFINDET UND DAS ES WEITERE SCHICHTEN AUS ÜBLICHEN, VORZUGSWEISE MIT WIRKSUBSTANZEN ANGEREICHERTEN GRANULATEN GIBT.5. CHEWING GUM TABLET ACCORDING TO CLAIM 1, CHARACTERIZED BY THAT THE CHEWING GUM GRANULATE IS IN ONE OR MORE LAYERS AND IT FURTHER Layers of customary granules, preferably enriched with active ingredients GIVES. 6. KAUGUMMITABLETTE NACH ANSPRUCH 1, DADURCH GEKENNZEICHNET, DASS SIE ALS MANTELTABLETTE HERGESTELLT WURDE, WOBEI ENTWEDER DER MANTEL AUS KAUGUMMIGRANULAT BESTEHT ODER DER KERN UND DER REST JEWEILS AUS ÜBLICHEN, VORZUGSWEISE MIT WIRKSUBSTANZEN ANGEREICHERTEN GRANULATEN BESTEHT.6. CHEWING GUM TABLET ACCORDING TO CLAIM 1, CHARACTERIZED BY THAT IT WAS MANUFACTURED AS A COAT TABLET, EITHER THE COAT FROM CHEWING GUM GRANULATE CONSISTS OR THE CORE AND THE REST EACH OF USUAL, PREFERREDLY WITH ACTIVE SUBSTANCES ENRICHED GRANULES EXISTS. 7. VERFAHREN ZUR HERSTELLUNG EINER KAUGUMMITABLETTE NACH ANSPRUCH 1 BIS 6, DADURCH GEKENNZEICHNET, DASS EINE ÜBLICHE KAUGUMMIMASSE, DER BEKANNTEN VISCOSITÄTEN, ZUM ZWECK DER GRANULATHERSTELLUNG GEKÜHLT WIRD.7. METHOD OF MANUFACTURING A CHEWING GUM TABLET ACCORDING TO CLAIMS 1 TO 6, CHARACTERIZED BY THAT A COMMON CHEWING GUM SIZE OF THE KNOWN VISCOSITIES TO BE COOLED FOR THE PURPOSE OF GRANULATE MANUFACTURING. 8. VERFAHREN ZUR HERSTELLUNG EINER KAUGUMMITABLETTE NACH ANSPRUCH I BIS 6, DADURCH GEKENNZEICHNET, DASS DIE FÜR DIE GRANULATION VORGESEHENE MASSE WIE EIN l'NASSGRANULATt' ZERRIEBEN ODER DURCHGEDRÜCKT WIRD, UNTER KONTINUIERLICHER ZUGABE EINER TROCKENEN UND TRENNENDEN SUBSTANZ.8. METHOD OF MANUFACTURING A CHEWING GUM TABLET ACCORDING TO CLAIMS I TO 6, CHARACTERIZED BY THAT THE DIMENSIONS PROVIDED FOR THE GRANULATION HOW A l'NASS GRANULATt 'IS GRINDED OR PRESSED, UNDER CONTINUOUSLY ADDING A DRY AND SEPARATING SUBSTANCE. 9. VERFAHREN ZUR HERSTELLUNG EINER KAUGUMMITABLETTE NACH ANSPRUCH 1 BIS 6, DADURCH GEKENNZEICHNET, DASS F()R DIE HOMOGENE VERPRESSUNG DES GRANULATES KEINE TRENN- UND SCHMIERMITTEL ZUGESETZT WERDEN.9. PROCESS FOR MANUFACTURING A CHEWING GUM TABLET ACCORDING TO CLAIMS 1 TO 6, CHARACTERIZED BY THAT F () R THE HOMOGENOUS COMPRESSION OF THE GRANULATES NO RELEASE AGENTS AND LUBRICANTS ARE ADDED.
DE19782808160 1978-02-25 1978-02-25 Tablets produced from chewing gum granulate - obtained by cooling chewing gum until it becomes brittle Withdrawn DE2808160A1 (en)

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DE19782808160 DE2808160A1 (en) 1978-02-25 1978-02-25 Tablets produced from chewing gum granulate - obtained by cooling chewing gum until it becomes brittle

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DE19782808160 DE2808160A1 (en) 1978-02-25 1978-02-25 Tablets produced from chewing gum granulate - obtained by cooling chewing gum until it becomes brittle

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DE2808160A1 true DE2808160A1 (en) 1979-08-30

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000516A1 (en) * 1983-08-01 1985-02-14 R. P. Scherer Corporation Sustained release method and product
WO1986003967A1 (en) * 1984-12-27 1986-07-17 Gerhard Gergely Chewing gum and production method thereof
US4753805A (en) * 1984-01-31 1988-06-28 Warner-Lambert Company Tabletted chewing gum composition and method of preparation
WO1997021424A1 (en) * 1995-12-09 1997-06-19 Laboratoire Glaxo Wellcome Chewing gum containing ranitidine
WO1999025203A1 (en) * 1997-11-19 1999-05-27 Hosokawa Bepex Gmbh Method for producing chewing gum formed bodies
US6322828B1 (en) * 1999-09-13 2001-11-27 Deseret Laboratories, Inc. Process for manufacturing a pharmaceutical chewing gum
US6582738B2 (en) 1999-09-13 2003-06-24 Deseret Laboratories, Inc. Process for preparing chewing gum containing a nutritional supplement
EP1350434A1 (en) * 2002-04-05 2003-10-08 Gum Base Co. S.p.A. Chewing gum in powder form and method of preparation
WO2004004479A1 (en) * 2002-07-02 2004-01-15 Gumlink A/S Compressed chewing gum
WO2004004480A1 (en) * 2002-07-02 2004-01-15 Gumlink A/S Compressed resin moderated chewing gum
WO2004004478A1 (en) * 2002-07-02 2004-01-15 Gumlink A/S Compressed chewing gum tablet ii
WO2004068964A1 (en) * 2003-02-04 2004-08-19 Gumlink A/S Compressed chewing gum tablet
WO2004068965A1 (en) * 2003-02-04 2004-08-19 Gumlink A/S Compressed chewing gum tablet
EP1449525A1 (en) * 2003-02-20 2004-08-25 Cross Chem Llc chewing gum in the form of multi-layer tablets
EP1554935A1 (en) * 2004-01-19 2005-07-20 Gumlink A/S Layered chewing gum tablet
WO2006079343A1 (en) * 2005-01-28 2006-08-03 Gumlink A/S A compressed chewing gum table
AU2004201099B2 (en) * 1999-09-13 2006-11-02 Deseret Laboratories Inc. Process for manufacturing a pharmaceutical chewing gum
EP1752048A2 (en) * 2002-07-15 2007-02-14 Bagger-Soerensen & Co. A/S A chewing gum tablet comprising at least two integral parts
EP1797770A2 (en) * 2003-02-04 2007-06-20 Gumlink A/S Compressed chewing gum tablet
US8137716B2 (en) 2003-05-06 2012-03-20 Gumlink A/S Method for producing chewing gum granules and compressed gum products, and a chewing gum granulating system
US8329235B2 (en) 2003-05-06 2012-12-11 Gumlink A/S Method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum products
US8734763B2 (en) 2004-07-06 2014-05-27 Gumlink A/S Compressed chewing gum tablet

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000516A1 (en) * 1983-08-01 1985-02-14 R. P. Scherer Corporation Sustained release method and product
US4753805A (en) * 1984-01-31 1988-06-28 Warner-Lambert Company Tabletted chewing gum composition and method of preparation
WO1986003967A1 (en) * 1984-12-27 1986-07-17 Gerhard Gergely Chewing gum and production method thereof
US4737366A (en) * 1984-12-27 1988-04-12 Gerhard Gergely Chewing gum and production method thereof
WO1997021424A1 (en) * 1995-12-09 1997-06-19 Laboratoire Glaxo Wellcome Chewing gum containing ranitidine
WO1999025203A1 (en) * 1997-11-19 1999-05-27 Hosokawa Bepex Gmbh Method for producing chewing gum formed bodies
EP1211951A4 (en) * 1999-09-13 2005-11-02 Deseret Lab Inc Process for manufacturing a pharmaceutical chewing gum
US6322828B1 (en) * 1999-09-13 2001-11-27 Deseret Laboratories, Inc. Process for manufacturing a pharmaceutical chewing gum
EP1211951A1 (en) * 1999-09-13 2002-06-12 Deseret Laboratories, Inc. Process for manufacturing a pharmaceutical chewing gum
US6582738B2 (en) 1999-09-13 2003-06-24 Deseret Laboratories, Inc. Process for preparing chewing gum containing a nutritional supplement
AU2004201099B2 (en) * 1999-09-13 2006-11-02 Deseret Laboratories Inc. Process for manufacturing a pharmaceutical chewing gum
US7101579B2 (en) 1999-09-13 2006-09-05 Deseret Laboratories, Inc. Chewing gum composition containing an active ingredient
EP1350434A1 (en) * 2002-04-05 2003-10-08 Gum Base Co. S.p.A. Chewing gum in powder form and method of preparation
AU2003219129B2 (en) * 2002-04-05 2008-02-21 Gum Base Co. Spa Chewing gum in powder form and a method of preparation
WO2003084338A1 (en) * 2002-04-05 2003-10-16 Gum Base Co. Spa Chewing gum in powder form and a method of preparation
EA010882B1 (en) * 2002-07-02 2008-12-30 Гумлинк А/С Compressed chewing gum tablet ii
EA008858B1 (en) * 2002-07-02 2007-08-31 Гумлинк А/С Compressed chewing gum
EA008845B1 (en) * 2002-07-02 2007-08-31 Гумлинк А/С Compressed resin modulated chewing gum
WO2004004480A1 (en) * 2002-07-02 2004-01-15 Gumlink A/S Compressed resin moderated chewing gum
WO2004004478A1 (en) * 2002-07-02 2004-01-15 Gumlink A/S Compressed chewing gum tablet ii
WO2004004479A1 (en) * 2002-07-02 2004-01-15 Gumlink A/S Compressed chewing gum
EP1776872A1 (en) * 2002-07-15 2007-04-25 Bagger-Soerensen & Co. A/S A chewing gum tablet comprising at least two integral parts
EP1752048A2 (en) * 2002-07-15 2007-02-14 Bagger-Soerensen & Co. A/S A chewing gum tablet comprising at least two integral parts
EP1752048A3 (en) * 2002-07-15 2007-04-18 Bagger-Soerensen & Co. A/S A chewing gum tablet comprising at least two integral parts
EP1797770A2 (en) * 2003-02-04 2007-06-20 Gumlink A/S Compressed chewing gum tablet
WO2004068964A1 (en) * 2003-02-04 2004-08-19 Gumlink A/S Compressed chewing gum tablet
EP1797770A3 (en) * 2003-02-04 2012-03-07 Gumlink A/S Compressed chewing gum tablet
AU2004210498B2 (en) * 2003-02-04 2008-10-09 Gumlink A/S Compressed chewing gum tablet
WO2004068965A1 (en) * 2003-02-04 2004-08-19 Gumlink A/S Compressed chewing gum tablet
EP1967234A1 (en) * 2003-02-04 2008-09-10 Gumlink A/S Compressed chewing gum tablet
EP1449525A1 (en) * 2003-02-20 2004-08-25 Cross Chem Llc chewing gum in the form of multi-layer tablets
US8137716B2 (en) 2003-05-06 2012-03-20 Gumlink A/S Method for producing chewing gum granules and compressed gum products, and a chewing gum granulating system
US8329235B2 (en) 2003-05-06 2012-12-11 Gumlink A/S Method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum products
EP1554935A1 (en) * 2004-01-19 2005-07-20 Gumlink A/S Layered chewing gum tablet
US8734763B2 (en) 2004-07-06 2014-05-27 Gumlink A/S Compressed chewing gum tablet
US9445612B2 (en) 2004-07-06 2016-09-20 Gumlink A/S Compressed chewing gum tablet
WO2006079343A1 (en) * 2005-01-28 2006-08-03 Gumlink A/S A compressed chewing gum table
US8496913B2 (en) 2005-01-28 2013-07-30 Gumlink A/S Compressed chewing gum tablet

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