DE2712078A1 - Pyridine-aldehyde topical compsns. - for treating Acne vulgaris - Google Patents

Pyridine-aldehyde topical compsns. - for treating Acne vulgaris

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Publication number
DE2712078A1
DE2712078A1 DE19772712078 DE2712078A DE2712078A1 DE 2712078 A1 DE2712078 A1 DE 2712078A1 DE 19772712078 DE19772712078 DE 19772712078 DE 2712078 A DE2712078 A DE 2712078A DE 2712078 A1 DE2712078 A1 DE 2712078A1
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Prior art keywords
pyridine
aldehyde
acne vulgaris
compsns
skin
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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DE19772712078
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German (de)
Inventor
Josef Dipl Chem Dr Rer N Klosa
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Individual
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Individual
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Priority to DE19772712078 priority Critical patent/DE2712078A1/en
Priority to ZA00781130A priority patent/ZA781130B/en
Priority to NL7802482A priority patent/NL7802482A/en
Priority to GB9215/78A priority patent/GB1588112A/en
Priority to PH20871A priority patent/PH15053A/en
Priority to JP2782278A priority patent/JPS53145923A/en
Priority to US05/886,820 priority patent/US4189487A/en
Priority to IE534/78A priority patent/IE46583B1/en
Priority to FR7807487A priority patent/FR2400899A1/en
Priority to AU34198/78A priority patent/AU515863B2/en
Priority to IT7867583A priority patent/IT7867583A0/en
Priority to BE186001A priority patent/BE864975A/en
Priority to CA299,236A priority patent/CA1095413A/en
Publication of DE2712078A1 publication Critical patent/DE2712078A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde

Abstract

Therapeutic topical compsn. for treatment of Acne vulgaris contg. as active constituent a pyridine-aldehyde of formula (I) (where n is 0 or 1; the aldehyde is in the 2, 3 or 4 posn. and the Me gp. is in the 2 or 6 posn.). A preferred compsn. contains 0.05-5% pyridine-3-aldehyde and 5-40% ethyllactate and a diluent. The compsns. may be solns. gels, lotions, creams, ointments, or powders. The pref. active agent is pyridine-3-aldehyde at 0.05-5%. Pref. compsns. contain 5-40% ethyl lactate. Treatment is 2-3 times weekly. Improvement is evident in a few days.

Description

Präparate zur lokalen Behandlung der Akne vulgaris Preparations for the local treatment of acne vulgaris

und zur Verschönerung der Haut. and to beautify the skin.

Die Erfindung umfaßt Präparate zur Behandlung der Akne vulgaris auf Basis von Pyridin-aldehyden der nachstehenden Konstitution: insbesondere von Pyridin-3-aldehyd.The invention comprises preparations for the treatment of acne vulgaris based on pyridine aldehydes of the following constitution: especially of pyridine-3-aldehyde.

Es ist bekannt, daß die Akne vulgaris eine Erkrankung des Jugendzeitalters ist, sehr hartnäckig ist und sich über Jahrzehnte bis ins 40. Lebensjahr hinziehen kann. Für die Entstehung der Akne vulgaris sind verschiedene Faktoren, wie hormonelle, didtetisch und konstitutionelle neben Aknebakterien verantwortlich, wobei Corynebacterium acnes vorherrschend ist. Trotzdem ist Akne vulgaris keine Infektionserkrankung. Charakteristisch für die Akne vulgaris sind Hautverunschönerungen infolge von Hautausschlägen, Pusteln, Mitessern und unschönen Eiterherden.It is known that acne vulgaris is a disease of adolescence is, is very persistent and dragging on for decades up to the 40th year of life can. Various factors are responsible for the development of acne vulgaris, such as hormonal, didtetic and constitutional responsible in addition to acne bacteria, being Corynebacterium acnes is predominant. Even so, acne vulgaris is not an infectious disease. Characteristic of acne vulgaris are skin blemishes as a result of skin rashes, Pustules, blackheads and unsightly foci of pus.

Gegen diese Erscheinungen wurden bisher mit mehr oder weniger Erfolg Antibiotika, wie Tetracycline und Erythromycin, verwendet.Against these phenomena were so far with more or less success Antibiotics, such as tetracyclines and erythromycin, are used.

Nachteilig für eine solche Therapie ist eine rasche Antibiotikagewdhnung und unerwünschte Nebenwirkungen, wie Besiedlung der Haut, insbesondere Mund, mit Pilzen, sowie bei Frauen (zu 20 °/0) an den Genitalien.Rapid exposure to antibiotics is disadvantageous for such a therapy and undesirable side effects such as colonization of the skin, especially the mouth Fungi, as well as in women (20%) on the genitals.

Auch die lokale Anwendung von Desinfektionsmitteln ist mit fraglichem Erfolg versucht worden, so mit Chlorhexidin. Endlich aber ist in der Vitamin-A-Säure ein echtes Heilmittel der Akne vulgaris gefunden wordenl Diese Heilwirkung der Vitamin-A-Söure geht allerdings mit einer Reihe unliebsamer Erscheinungen, wie Entzündungen, Hautirritationen und Hautschölungen einher, so daß die Belastung der jugendlichen Akne-Kranken außerordentlich groß ist. Endlich ist die Heilungsquote mittels Vitamin-A-Säure beschränkt; sie schwankt zwischen 25 bis 30 " aller Aknefälle. Diese geringen Erfolge beruhen einerseits auf der yeringen Stabilität der Vitamin-A-Söure, andererseits aber auch auf den unerwünschten und quölenden Nebenwirkungen, also im unfangsstadium der Medikation mit Vitamin-A-Sáure auf dem Auftreten von Entzündungen.The local use of disinfectants is also questionable Success has been attempted, so with chlorhexidine. But finally there is in the vitamin A acid a real cure for acne vulgaris has been foundl This healing effect the vitamin A acid, however, goes with a number of unpleasant phenomena, such as Inflammation, skin irritation and skin lumps, so that the burden of the adolescent acne sufferers is extraordinarily large. The cure rate is finally here limited by means of vitamin A acid; it varies between 25 to 30 "of all acne cases. These minor successes are based on the one hand on the poor stability of the vitamin A acid, on the other hand also on the undesirable and tormenting side effects, that is In the initial stage of the medication with vitamin A acid on the occurrence of inflammation.

Diesem Stand gegenüber wurde die überraschende Beobachtung gemacht, daß Pyridin-aldehydX insbesondere Pyridin-3-aldehyd,in geringen Konzentrationen von 0,05 bis 2 ofi nicht allein Acne vulgaris in kurzer Zeit abheilen, sondern auch die Haut verschönern und umfassend reinigen können. Es ist daher ein weiteres Wesen der Erfindung, daß Pyridin-aldehyde, insbesondere Pyridin-3-aldehyd, in kosmetische Präparate zur Verschönerung der Haut eingearbeitet wtrdss Als Zubereitungen sollen genannt werden alkoholisch-wässrige Lösungen, Lösungen in Alkoholen, Polyglykolenm, Milchsäureestern, Phenylalkoholen, wie Benzylolkohol, Phenyläthanol u.d. oder deren Gemischen.Opposite this stand the surprising observation was made, that pyridine-aldehydeX especially pyridine-3-aldehyde, in low concentrations from 0.05 to 2 ofi not only heal acne vulgaris in a short time, but also can beautify and thoroughly cleanse the skin. It is therefore another being the invention that pyridine aldehydes, especially pyridine-3-aldehyde, in cosmetic Preparations for the beautification of the skin incorporated wtrdss as preparations should alcoholic-aqueous solutions, solutions in alcohols, polyglycols, Lactic acid esters, phenyl alcohols such as benzylol alcohol, phenylethanol, etc. or their Mix.

Als Zusätze können ätherische Öle, wie Azulen, Koniferenöle u.ä.Essential oils such as azulene, coniferous oils and the like can be used as additives.

dienen. In dieser Beziehung ist der Erfindung keine Begrenzung aufgelegt. Die Pyridin-aldehyde können auch in Salben, Cremes, Gele und Lotionen, gegebenenfalls mit Konservierungsmitteln, wie butyliertes Hydroxytoluol oder Tokopherolen, nach konventioneller Art inkorporiert werden Die Pyridin-aldehyde, wie Pyridin-3-aldehyd, Pyridin-2-aldehyd, Pyridin-4-aldehyd, 2-Methyl-pyridin-3-aldehyd, sind bekannt.to serve. In this regard, the invention is not limited. The pyridine aldehydes can also be used in ointments, creams, gels and lotions, if appropriate with preservatives such as butylated hydroxytoluene or tocopherols conventionally be incorporated The pyridine aldehydes, such as Pyridine-3-aldehyde, pyridine-2-aldehyde, pyridine-4-aldehyde, 2-methyl-pyridine-3-aldehyde, are known.

Es war aber bisher nicht bekannt, daß diese Aldehyde sich zur Behandlung von Hautverunschönerungen, insbesondere Akne vulgaris, eignen. Damit ist ein technischer Fortschritt erreicht, und die Erfindung ist neuartig und nicht zu erwarten gewesen.However, it was not previously known that these aldehydes could be used for treatment of skin blemishes, especially acne vulgaris. So that's a technical one Progress has been made and the invention has been novel and not to be expected.

Um welchen Mechanismus es sich bei der Wirkung der Pyridin-aldehyde gegenüber der Akne vulgaris handelt, soll eine offene Frage sein.What is the mechanism behind the action of the pyridine aldehydes about acne vulgaris should be an open question.

Es ist jedoch wahrscheinlich, daß die Paridin-aldehyde, besonders Pyridin-3-aldehyd, mit Corynebacterium acnes reagieren oder mit den Proteinen des gebildeten Eiters, so daß es zur Bildung von Immunkörpern kommt, welche einen echten Heilprozeß einleiten.It is likely, however, that the paridine aldehydes, especially Pyridine-3-aldehyde, react with Corynebacterium acnes or with the proteins of the formed pus, so that it comes to the formation of immune bodies which are genuine Initiate healing process.

Eine weitere Wahrscheinlichkeit für den Wirkungsmechanismus dürfte in dem zusätzlichen durchblutungsfördernden Effekt beruhen.Another probability for the mechanism of action is likely based on the additional blood circulation-promoting effect.

Je nach der Konzentration des Pyridin-3-aldehyds kommt es innerhalb der ersten 15 Minuten nach Applikation der Präparate zu einer Rötung und Erwärmung der Hautpartien bzw. des Gesichts. Dieser Effekt hält ca eine Stunde an. Bei mehrtägigem Auftragen der Lösungen, Gele, Lotionen, Cremes oder Puder, bleibt die gesunde rötliche Hautfarbe der sonst aufdringlich blassen jugendlichen Aknekranken schön rötlich und von gesundem Aussßhen. Die kränkliche Blässe der jugendlichen Aknekranken ist ein typisches und auffallendes Kennzeichen für verschiedene Hautverunreinigungen und endlich die auffallend großen Poren. Zur Sicherung des Heileffektes wurde die Applikation auf zwei- bis dreimalige Applikation wöchentlich beschränkt, da Akne vulgaris auch durch Stoffwechselvorgänge bedingt ist.Depending on the concentration of the pyridine-3-aldehyde, it occurs within the first 15 minutes after application of the preparations to a reddening and warming the skin or the face. This effect lasts for about an hour. For several days Applying the solutions, gels, lotions, creams or powders, the healthy reddish remains The skin color of the otherwise obtrusively pale adolescent acne sufferers is beautifully reddish and of healthy appearance. The sickly pallor of adolescent acne sufferers is a typical and striking indicator of various skin impurities and finally the strikingly large pores. To ensure the healing effect, the Application limited to two to three times a week because of acne vulgaris is also caused by metabolic processes.

Unter der Bah » ung mit den erfindungsgemäßen Pyridin-aldehyden verschwinden demnach innerhalb weniger Tage - in hartnäckigen Fällen spätestens nach 4 bis 6 Wochen - nicht nur die Mitesser, Pusteln und Eiterherde, sondern die Haut wird verschönt, die Blässe geht zurück und die großen unerwünschtenQHuspeschließen sich auffallend zu normaler Größe.Disappear under the path with the pyridine aldehydes according to the invention therefore within a few days - in stubborn cases after 4 to 6 at the latest Weeks - not only the blackheads, pustules and foci of pus, but the skin is beautified, the pallor diminishes and the large, undesirable husks close conspicuously to normal size.

Ein solcher Effekt wird von keienem der bekannten Aknemittel gegeben, weder von der Antibiotika-Therapie noch Vitamin-a-Säure, die im Gegenteil die Gesichtshaut zur schmerzhaften Schälung bringt. Such an effect is given by none of the known acne drugs, neither from antibiotic therapy nor from vitamin a acid, which on the contrary affects the skin of the face causes painful peeling.

Es soll an einigen Beispielen die Herstellung und Zubereitung geeigneter Präparatformen gegeben werden, ohne daß durch diese Beispiele eine Begrenzung der Erfindung entgegensteht, sowie endlich eine Prüfung der erfindungsgemäßen Präparate. A few examples are intended to make the production and preparation more suitable Preparation forms are given, without these examples limiting the Invention contradicts, as well as finally a test of the preparations according to the invention.

Beispiel 1: Pyridin-3-aldehyd 0,5 ml Parfümöl 1 0 ml Äthanol 95 JOig ad 100,0 ml. Example 1: pyridine-3-aldehyde 0.5 ml perfume oil 1 0 ml ethanol 95 JOig ad 100.0 ml.

Herstellungsgang : Hyridin-3-aldehyd (oder an dessen Stelle Pyridin-2-aldehyd, Pyridin-4-aldehyd oder 6-Methyl-pyridin-2-aldehyd) werden zuerst in 50 ml Äthanol gelöst. 1 ml ParfU,öl werden zugesetzt. Production process: Hyridine-3-aldehyde (or in its place pyridine-2-aldehyde, Pyridine-4-aldehyde or 6-methyl-pyridine-2-aldehyde) are first dissolved in 50 ml of ethanol solved. 1 ml of perfume, oil are added.

Alsdann wird mit Äthanol auf loo ml aufgefüllt. Then it is made up to 100 ml with ethanol.

Beispiel 2 Pyridin-3-aldenyd 1,0 ml Polyäthylenglykol 200 50,0 ml Parfümöl 2,0 ml Äthanol 96 %ig ad 100,0 ml Beispiel 3 Pyridin-3-aldehyd 1,0 ml Benzylalkohol 10,0 ml Phenyläthylalkohol 15,0 ml Polyäthylenglykol 200 30,0 ml Parfümöl 3,0 ml Athanol 96 %ig ad 100,0 ml. Example 2 pyridine-3-aldenyde 1.0 ml polyethylene glycol 200 50.0 ml Perfume oil 2.0 ml ethanol 96% ad 100.0 ml Example 3 pyridine-3-aldehyde 1.0 ml benzyl alcohol 10.0 ml phenylethyl alcohol 15.0 ml polyethylene glycol 200 30.0 ml perfume oil 3.0 ml Ethanol 96% to 100.0 ml.

Beispiel2 Pyridin-3-aldehyd 0,5 ml Phenyläthylalkohol 20,0 ml Benzylalkohol tD,o ml Milchsäureäthylester 30,0 ml Polyäthylenlykol 400 ,0 ml Parfümöl 2,0 ml Äthanol 96 ,Oig ad 100,0 ml Beispiel 5 Pyridin-3-aldehyd 0,1 ml Milchsäureäthylester 10,0 ml Äthanol 96 %ig ad 100,0 ml Beispiel 6 : Fettcreme Gewichtsprozente Pyridin-3-aldehyd 0,60 Cetylalk.hol 3¢,00 Spermaceti 10,00 Hydriertes Erdnussöl 86,40 100,00 Herstellungsgrang : Spermaceti und hydriertes Erdnussöl werden unter Erwärmen geschmolzen. Nach Abkühlen wird Pyridin-3-aldehyd eingearbeitet.Example 2 pyridine-3-aldehyde 0.5 ml phenylethyl alcohol 20.0 ml benzyl alcohol tD, o ml lactic acid ethyl ester 30.0 ml polyethylene glycol 400, 0 ml perfume oil 2.0 ml Ethanol 96, Oig ad 100.0 ml Example 5 pyridine-3-aldehyde 0.1 ml lactic acid ethyl ester 10.0 ml of 96% ethanol to 100.0 ml Example 6: Fat cream Percentage by weight of pyridine-3-aldehyde 0.60 Cetylalk.hol 3 [, 00 Spermaceti 10.00 Hydrogenated Peanut Oil 86.40 100.00 Manufacturing process : Spermaceti and hydrogenated peanut oil are melted while heating. After cooling down pyridine-3-aldehyde is incorporated.

Beispiel 7 : Gele Pyridin-3-aldehyd 0,05 g Butyliertes Hydroxyanisol 0,10 g Hydroxypropylcellulose 5,00 g Propylenglykol ad 100,0 g Beispiel 8 : Gel Pyridin-3-aldehyd 1,00 g t -Tocopherol 1,00 g Hydroxyäthylcellulose 3,00 g Äthanol 96 Aig ad 100,0 g Beispiel 9 : Gel Pyridin-3-aldehyd 2,50 g α -Tocopherol 0,50 g Carbopol 940 4'° g Parfümöl 1,00 g Isopropanol ad 100,00 g Herstellungsgang : tt-Tocopherol wird in der halben Menge Isopropanol gelöst. Daraufhin wird Carbopol in kleinen Portionen zugesetzt.Example 7: Gels of pyridine-3-aldehyde 0.05 g of butylated hydroxyanisole 0.10 g of hydroxypropyl cellulose, 5.00 g of propylene glycol to 100.0 g example 8: Gel pyridine-3-aldehyde 1.00 g of t-tocopherol 1.00 g of hydroxyethyl cellulose 3.00 g ethanol 96 Aig ad 100.0 g Example 9: Gel pyridine-3-aldehyde 2.50 g α-tocopherol 0.50 g Carbopol 940 4 ° g perfume oil 1.00 g isopropanol ad 100.00 g production process : tt-tocopherol is dissolved in half the amount of isopropanol. Thereupon Carbopol becomes added in small portions.

Nun wird Pyridin-3-aldehyd zugefügt, es wird gerührt, wobei Solvation eintritt. Man fügt Parfümöl in Isopropanol gelöst hinzu und erhält ein Gele.Now pyridine-3-aldehyde is added, it is stirred, with solvation entry. Perfume oil, dissolved in isopropanol, is added and a gel is obtained.

Beispiel 10 : Gel Pyridin-3-aldehyd 200 y α-Tocopherol ,00 g Hydrocortison 0,50 g Hydroxypropylcellulose 0,50g Propylenglykol 40,00 g Äthanol 96 osig ad 100,00 g Beispiel 71 : 17 Jahre alter Oberschüler.Example 10: Gel pyridine-3-aldehyde 200 y α-tocopherol, 00 g Hydrocortisone 0.50 g hydroxypropyl cellulose 0.50 g propylene glycol 40.00 g ethanol 96 ointments to 100.00 g Example 71: 17 year old high school student.

Seit dem 13.Lebensjahr Akne papulo-pustulosa. Bisherige Behandlung mit Tetracycline und verschiedenen Aknemitteln erfolglos. Zweimal täglich morgens und abends Betupfung des Gesichts mit der Lösung gemäß Beispiel 4. Ab dem zweiten Tage bereits Verschwinden der Mitesser und Einschmelzung der Pusteln, Nachlassen der starken Exerbation der Akne mit Spannungsgefühl der Haut und des Juckreizes. Besserung schritt vor. Ab dem 8.Tage war das Gesicht rein und frei von Pusteln und Mitessern.Papulo-pustular acne since the age of 13. Previous treatment with tetracyclines and various acne drugs unsuccessful. Twice a day in the morning and in the evening dabbing the face with the solution according to Example 4. From the second Days already disappearance of the blackheads and melting of the pustules, subsiding the severe exerbation of acne with a feeling of tension in the skin and itching. Improvement proceeded. From the 8th day the face was clean and free from pustules and Blackheads.

Ähnlich waren die Erfolge bei 1o weiteren Probanden.The successes in 1o other test subjects were similar.

Claims (1)

Patentansprüche.Claims. Präparate zur lokalen Behandluny von Akne vulgaris und zur Verschönerung der Haut, dadurch gekennzeichnet, daß 1. die Pyridin-aldehyde der allgemeinen Konstitution also Pyridin-2-aldehyd, Pyridin-3-aldehyd, Pyridin-4-aldehyd, 6-Methylpyridin-2-aldehyd, in Konzentrationen von 0,05 bis 4 " enthalten; 2. gemäB Anspruch 1, dadurch gekennzeichnet, daß Pyridin-3-aldehyd bevorzugt wird;d 3. gemäß Anspruch 1 und 2, dadurch gekennzeichnet, daß die Pyridin-aldehyde in Lösungen, wie Alkoholen, Glykolen oder Ester, v in CrOmes, Gele und/oder Lotioner., gegebenenfalls in Gegenwart bekannter Konservierungsmittel, wie butylierte Phenolverbindungen oder Tocopherole und/oder Parfümölen eingearbeitet werden.Preparations for the local treatment of acne vulgaris and for the beautification of the skin, characterized in that 1. the pyridine aldehydes of the general constitution thus pyridine-2-aldehyde, pyridine-3-aldehyde, pyridine-4-aldehyde, 6-methylpyridine-2-aldehyde, contained in concentrations of 0.05 to 4 "; 2. according to claim 1, characterized in that pyridine 3-aldehyde is preferred; d 3. according to claim 1 and 2, characterized in that the pyridine aldehydes in solutions such as alcohols, glycols or esters, v in CrOmes, gels and / or lotions., Optionally in the presence of known preservatives, such as butylated phenolic compounds or tocopherols and / or perfume oils are incorporated.
DE19772712078 1977-03-17 1977-03-17 Pyridine-aldehyde topical compsns. - for treating Acne vulgaris Withdrawn DE2712078A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE19772712078 DE2712078A1 (en) 1977-03-17 1977-03-17 Pyridine-aldehyde topical compsns. - for treating Acne vulgaris
ZA00781130A ZA781130B (en) 1977-03-17 1978-02-27 Preparation for prevention and treatment of acne vulgaris and use of pyridine aldehydes for the prevention and treatment of acne vulgaris
NL7802482A NL7802482A (en) 1977-03-17 1978-03-07 PREPARATION FOR ACNE VULGARIS PROPHYLAXIS AND THERAPY AND METHOD FOR ACNE VULGARIS PROPHYLAXIS AND THERAPY USING PYRIDINALDEHYDES.
GB9215/78A GB1588112A (en) 1977-03-17 1978-03-08 Preparation for the prevention and treatment of acne vulgaris
PH20871A PH15053A (en) 1977-03-17 1978-03-10 Preparation for prevention and treatment of acne vulgaris and use of pyridine aldehydes for the prevention and treatment of acne vulgaris
JP2782278A JPS53145923A (en) 1977-03-17 1978-03-13 Protecting and treating agent for acne
US05/886,820 US4189487A (en) 1977-03-17 1978-03-15 Use of pyridine aldehydes for the prevention and treatment of acne vulgaris
IE534/78A IE46583B1 (en) 1977-03-17 1978-03-15 Preparation for the prevention and treatment of acne vulgaris
FR7807487A FR2400899A1 (en) 1977-03-17 1978-03-15 Pyridine-aldehyde topical compsns. - for treating Acne vulgaris
AU34198/78A AU515863B2 (en) 1977-03-17 1978-03-16 Preparation for prevention and treatment of acne
IT7867583A IT7867583A0 (en) 1977-03-17 1978-03-16 PREPARATION FOR ACNE PROPHYLAXIS AND THERAPY
BE186001A BE864975A (en) 1977-03-17 1978-03-16 COMPOSITION FOR THE PROPHYLAXIS AND THERAPEUTIC OF ACNE VULGARIS
CA299,236A CA1095413A (en) 1977-03-17 1978-03-16 Preparation for prevention and treatment of acne vulgaris and use of pyridine aldehydes for the prevention and treatment of acne vulgaris

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772712078 DE2712078A1 (en) 1977-03-17 1977-03-17 Pyridine-aldehyde topical compsns. - for treating Acne vulgaris

Publications (1)

Publication Number Publication Date
DE2712078A1 true DE2712078A1 (en) 1978-09-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772712078 Withdrawn DE2712078A1 (en) 1977-03-17 1977-03-17 Pyridine-aldehyde topical compsns. - for treating Acne vulgaris

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BE (1) BE864975A (en)
DE (1) DE2712078A1 (en)
ZA (1) ZA781130B (en)

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BE864975A (en) 1978-07-17
ZA781130B (en) 1979-02-28

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