DE254530C - - Google Patents
Info
- Publication number
- DE254530C DE254530C DENDAT254530D DE254530DA DE254530C DE 254530 C DE254530 C DE 254530C DE NDAT254530 D DENDAT254530 D DE NDAT254530D DE 254530D A DE254530D A DE 254530DA DE 254530 C DE254530 C DE 254530C
- Authority
- DE
- Germany
- Prior art keywords
- cholic acid
- strontium
- solution
- preparation
- cholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- BHQCQFFYRZLCQQ-OELDTZBJSA-N Cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims description 16
- 239000004380 Cholic acid Substances 0.000 claims description 16
- 229960002471 cholic acid Drugs 0.000 claims description 16
- 235000019416 cholic acid Nutrition 0.000 claims description 16
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 11
- 229910052712 strontium Inorganic materials 0.000 claims description 11
- UUCCCPNEFXQJEL-UHFFFAOYSA-L Strontium hydroxide Chemical compound [OH-].[OH-].[Sr+2] UUCCCPNEFXQJEL-UHFFFAOYSA-L 0.000 claims description 5
- 229910001866 strontium hydroxide Inorganic materials 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000036826 Excretion Effects 0.000 description 2
- 208000001130 Gallstone Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 230000001264 neutralization Effects 0.000 description 2
- BHQCQFFYRZLCQQ-UMZBRFQRSA-N 4-[(3R,5S,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid Chemical class C([C@H]1C[C@H]2O)[C@H](O)CCC1(C)C1C2C2CCC(C(CCC(O)=O)C)C2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-UMZBRFQRSA-N 0.000 description 1
- 229940093761 Bile Salts Drugs 0.000 description 1
- 229940107161 Cholesterol Drugs 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- KJFMBFZCATUALV-UHFFFAOYSA-N Phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 235000012970 cakes Nutrition 0.000 description 1
- 230000005591 charge neutralization Effects 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
- M 254530 KLASSE 12 ο. GRUPPE VQ - M 254530 CLASS 12 ο. GROUP VQ
KNOLL & CO. in LUDWIGSHAFEN a. Rh.KNOLL & CO. in LUDWIGSHAFEN a. Rh.
Verfahren zur Darstellung von cholsaurem Strontium.Process for the preparation of cholic acid strontium.
Patentiert im Deutschen Reiche vom 2. Dezember 1911 ab.Patented in the German Empire on December 2, 1911.
Es wurde durch eingehende, vergleichende therapeutische Versuche an Gallensteinleidenden gefunden, daß gegenüber der besonders in den Anfangsstadien der Erkrankung bewährten Behandlung mit Natriumsalzen der Gallensäuren das bis jetzt noch unbekannte Strontiumsalz der Cholsäure in hervorragenderem Maße geeignet erscheint, die Beschwerden der an Gallenstein leidenden Kranken zuIt was established through in-depth, comparative therapeutic trials on gallstone sufferers found that compared to the proven especially in the early stages of the disease Treatment with sodium salts of bile acids, the hitherto unknown strontium salt of cholic acid, in more excellent form Seems appropriate to the complaints of patients suffering from gallstones
ίο lindern.ίο alleviate.
Es beruht dies wahrscheinlich darauf, daß cholsaures Strontium gleichzeitig nach zwei Richtungen hin zu wirken vermag. Die Cholsäure bietet den integrierenden Bestandteil der weiterer Cholesterinausscheidung vorbeugenden, natürlichen Gallensalze, und das Strontium vermag Entzündungserscheinungen wesentlich herabzusetzen.This is probably due to the fact that cholic acid strontium occurs simultaneously after two Directions. The cholic acid provides the integral part natural bile salts that prevent further cholesterol elimination, and that Strontium can significantly reduce inflammation.
Die Darstellung des cholsauren Strontiums erfolgt nach den bekannten Wegen der Salzdarstellung, z. B. aus Säure und Base. Folgendes Beispiel ist ein gut gangbarer, zu einem Präparat von einheitlicher Zusammensetzung führender Weg.The representation of the cholic acid strontium takes place according to the known ways of the salt representation, z. B. from acid and base. The following example is a viable one, too leading to a preparation of uniform composition.
Einerseits werden 4 kg Cholsäure in 40 1 50 prozentigem Spiritus, andererseits 1,3 kg Strontiumhydroxyd in 60 1 Wasser, beide Ansätze auf dem Wasserbade, gelöst, Hierauf wird die Strontiumhydroxydlösung noch heiß in die ebenfalls heiße Cholsäurelösung unter Rühren hineinfiltriert. Anfänglich etwa auftretende Ausscheidung von Strontiumhydroxyd geht alsbald wieder von selbst in Lösung, später ■— im letzten Drittel der Zumischung — eintretende Ausscheidung von cholsaurem Strontium, die zuweilen auch noch etwas freie Cholsäure eingeschlossen enthält, wird zweckmäßig durch Zugabe von noch 2I Alkohol wieder in Lösung gebracht. Man hört mit dem Zusetzen von Strontiumhydroxydlösung auf, wenn wenige Tropfen Phenolphtaleinlösung durch Farbenumschlag den erreichten Neutralisationspunkt zu erkennen geben. Man läßt, nach Wiedergewinnung des Alkohols durch Abdestillieren, erkalten und erhält so einen Kristallkuchen von cholsaurem Strontium.On the one hand 4 kg of cholic acid in 40 1 50 percent alcohol, on the other hand 1.3 kg Strontium hydroxide in 60 liters of water, both approaches on the water bath, dissolved, then the strontium hydroxide solution is still hot in the likewise hot cholic acid solution Stir filtered in. Initially, about the excretion of strontium hydroxide immediately dissolves again by itself, later ■ - in the last third of the admixture - Occurring excretion of cholic acid strontium, which at times is also somewhat free Contains cholic acid included, is expedient by adding another 2I alcohol again brought into solution. You stop adding strontium hydroxide solution when A few drops of phenolphthalein solution show the neutralization point reached by changing the color. One lets up Recovering the alcohol by distilling it off, cooling it, and getting one Crystal cake of cholic acid strontium.
Cholsaures Strontium kristallisiert in Form farbloser, sehr feiner Haarbüschel und wird durch stärkere Säuren in seine Bestandteile zerlegt.Cholic acid strontium crystallizes in the form of colorless, very fine tufts of hair and becomes broken down into its components by stronger acids.
Das erhaltene cholsäure Strontium ist zusammengesetzt nach der Molekularformel:The obtained cholic acid strontium is composed according to the molecular formula:
^C24 H39 OJ2 Sr, 10 H2O, ^ C 24 H 39 OJ 2 Sr, 10 H 2 O,
ist also neutrales »cholsaures Strontium« und enthält 10 Moleküle über Schwefelsäure entziehbares Wasser.is therefore neutral "cholic acid strontium" and contains 10 molecules that can be extracted via sulfuric acid Water.
5050
5555
Analyse:Analysis:
6060
berechnet:calculated:
6565
10,000.10,000.
10 g enthielten:10 g contained:
1,660H2O,
7,540 Cholsäure
0,792 Strontium 1.660H 2 O,
7,540 cholic acid
0.792 strontium
9.9929,992
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE254530C true DE254530C (en) |
Family
ID=512712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT254530D Active DE254530C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE254530C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0092073A1 (en) * | 1982-04-15 | 1983-10-26 | SCHWARZ ITALIA S.p.A. | Magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid, the process for its preparation, and therapeutic compositions which contain it as active principle |
| US5188995A (en) * | 1992-03-24 | 1993-02-23 | Phillips Petroleum Company | Reactivation and passivation of spent cracking catalysts |
| US6005155A (en) * | 1997-12-03 | 1999-12-21 | Exxon Chemicals Patents Inc. | Modification of molecular sieve catalyst for reduced methane production during conversion of oxygenates to olefins |
-
0
- DE DENDAT254530D patent/DE254530C/de active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0092073A1 (en) * | 1982-04-15 | 1983-10-26 | SCHWARZ ITALIA S.p.A. | Magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid, the process for its preparation, and therapeutic compositions which contain it as active principle |
| US5188995A (en) * | 1992-03-24 | 1993-02-23 | Phillips Petroleum Company | Reactivation and passivation of spent cracking catalysts |
| US6005155A (en) * | 1997-12-03 | 1999-12-21 | Exxon Chemicals Patents Inc. | Modification of molecular sieve catalyst for reduced methane production during conversion of oxygenates to olefins |
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