DE2430280A1 - Toothpaste and mouth-wash which are used consecutively - respectively contg urea and anion-active tenside phase and 1,6-di-4'-chlorophenyl-di-guanido-hexane phase - Google Patents

Toothpaste and mouth-wash which are used consecutively - respectively contg urea and anion-active tenside phase and 1,6-di-4'-chlorophenyl-di-guanido-hexane phase

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Publication number
DE2430280A1
DE2430280A1 DE2430280A DE2430280A DE2430280A1 DE 2430280 A1 DE2430280 A1 DE 2430280A1 DE 2430280 A DE2430280 A DE 2430280A DE 2430280 A DE2430280 A DE 2430280A DE 2430280 A1 DE2430280 A1 DE 2430280A1
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Prior art keywords
phase
urea
anion
toothpaste
active
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Pending
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DE2430280A
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German (de)
Inventor
Helmut Dr Raaf
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Blendax GmbH
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Blendax Werke R Schneider and Co GmbH
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Priority to DE19732338177 priority Critical patent/DE2338177A1/en
Priority claimed from DE19732338177 external-priority patent/DE2338177A1/en
Application filed by Blendax Werke R Schneider and Co GmbH filed Critical Blendax Werke R Schneider and Co GmbH
Priority to DE2430280A priority patent/DE2430280A1/en
Publication of DE2430280A1 publication Critical patent/DE2430280A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures

Abstract

Dentifrice of parent patent contains 1,6-di-4'-chlorophenyl di-guanidohexane (I) or its salts (I') and urea. In the addition the dentifrice is present as two phases, separated from one another and used consecutively. One phase, contains 0.5-45 wt % urea and advantageously an anion-active tenside, esp. Na lauryl sulphate or N-lauroyl sarcosinate. The other phase, contains 0.01-7.5 wt % (I) or (I'). Formation of plaque is suppressed, and discolouring effect of (I) is prevented. Restricted compatibility of (I) with anion-active tensides is overcome, allowing full use to be made of their respective +ve properties.

Description

Mittel und Verfahren zur Reinigung und Pflege menschlicher Zähne (Zusatz zur Patentanmeldung P 23 38 177.3) Gegenstand des Hauptpatentes Nr. (Patentanmeldung P 23 38 177.3) ist ein Mittel zur Pflege und Reinigung von menschlichen Zähnen und Zahnprothesen mit einem Gehalt an I,6-Di-4'-chlorphenyldiguanidohexan bzw. dessen Salzen, das darüberhinaus Harnstoff enthält. Preparations and methods for cleaning and caring for human teeth (Addition to patent application P 23 38 177.3) Subject of the main patent no. (Patent application P 23 38 177.3) is a means for the care and cleaning of human teeth and Dental prostheses with a content of 1,6-di-4'-chlorophenyldiguanidohexane or its Salts, which also contain urea.

Durch die Anwendung dieses Mittels kann die Bilduhg von Zahnbelag ohne jedwede störende Nebenwirkungen unterdrückt werden.By using this agent, the formation of plaque can be achieved be suppressed without any annoying side effects.

Es wurde nun gefunden, daß man eine besonders gute Wirkung gegen Zahnbelag und damit eine ausgezeichnete Zahnreinigung und Zahnpflege menschlicher Zähne dann erzielen kann, wenn man diese zunächst mit einem Mittel, das etwa o,5 bis etwa 45 Gew.-% Harnstoff und vorzugsweise ein anionaktives Tensid, beispielsweise Natriumlaurylsulfat oder N-Lauroylsarcosinat, enthält, beispielsweise einer Zahnpasta, behandelt und anschließend mit einem Mittel, das etwa o,ol bis etwa 7,5 Gew.-% 1 ,6-Di-4' -chlorphenyldiguanidohexan enthält, beispielsweise einem Mundwasser, in Berührung bringt.It has now been found that one has a particularly good effect against plaque and with it an excellent tooth cleaning and dental care of human teeth then can be achieved if this is first achieved with an agent that is about 0.5 to about 45 Wt .-% urea and preferably an anionic surfactant, for example sodium lauryl sulfate or N-lauroyl sarcosinate, for example a toothpaste, treated and then with an agent containing about o, ol to about 7.5% by weight 1,6-di-4'-chlorophenyldiguanidohexane contains, for example a mouthwash, in contact.

Auf diese Weise läßt sich ebenfalls die verfärhende Wirkung des Chlorhexidins wirksam verhindern, wobei durch seine Substantivität bei der anschließenden Behandlung die an sich bekannte zahnbelagshemmende Wirksamkeit für einen längeren Zeitraum, jedenfalls bis zum nächsten Zahnpflegevorgang, sichergestellt ist, ohne daß wegen der beschränkten Verträglichkeit des Chiorhexidins mit anionaktiven Tensiden irgendwelche Einschränkungen in dem Einsatz derselben vorgenommen werden braucht.In this way, the harmful effects of chlorhexidine can also be reduced effectively prevent it, by virtue of its substantivity in subsequent treatment the well-known anti-plaque effectiveness for a longer period of time, at least until the next dental care procedure, is ensured without because of the limited compatibility of chlorhexidine with anionic surfactants limitations needs to be made in the use of the same.

Ein wesentliches Hindernis für die allgemeine Anwendung des Zahnbelag entfernenden Wirkstoffes Chlorhexidin in Zahnpasten in größerem Umfang war nebem dem Verfärbungsproblem, das durch die im Hauptpatent vorgeschlagene Maßnahme als gelöst gelten kann, die Tatsache, daß das Chlorhexidin bz. seine Salze nur beschränkt verträglich waren mit den in Zahnpflegemitteln, insbesondere Zahnpasten, üblicherweise eingesetzten anionaktiven Tensiden, die insbesondere zur Hervorrufung des vom Verbraucher sehr geschätzten Schaumeffektes dienen.A major obstacle to the general use of dental plaque The removing agent chlorhexidine in toothpastes to a greater extent was next to it the discoloration problem, which by the measure proposed in the main patent as The fact that chlorhexidine or its salts can only apply to a limited extent were compatible with those in dental care products, in particular toothpastes, usually used anion-active surfactants, in particular to evoke the consumer much appreciated foam effect.

Weiterhin ist es bekannt, daß diese Tenside auch noch eine Reinigungswirkung beim Zähneputzen entfalten.It is also known that these surfactants also have a cleaning effect unfold while brushing your teeth.

Durch die relativ geringe Verträglichkeit des Chlorhexidins mit diesen anionaktiven Tensiden musste in Zahnpasten, die Chlorhexidin enthalten, ein verhältnismäßig niederer Konzentrationsbereich dieser anionaktiven Tenside eingehalten werden.Due to the relatively low compatibility of chlorhexidine with these anion-active surfactants had to be proportionate in toothpastes that contain chlorhexidine lower concentration range of these anionic surfactants are adhered to.

Durch die erfindungsgemäße Maßnahme ist es nunmehr möglich, sowohl die positiven Eigenschaften des Ghlorhexidins als auch diejenigen der anionaktiven Tenside in Zahnpflegemitteln voll auszunutzen.By the measure according to the invention it is now possible both the positive properties of chlorhexidine as well as those of the anion-active ones Make full use of surfactants in dental care products.

Als in der ersten Phase auf die Zähne aufzubringende£Zahnpflegemittel mit einem Gehalt an Harnstoff ist insbesondere eine Zahnpasta üblicher Zusammensetzung geeignet; es kann jedoch auch ein Zahnpflegemittel in Form eines transparenten Gels, eines Mundwassers, etc. gewählt werden Diese Zusammensetzungen enthalten neben den bekannten, im Eauptpatent aufgeführten Stoffen, inshesondere Poliermitteln, Bindemitteln wie insbesondere Carboxymethycellulose , Feuchthaltemitteln, Konservierungsmitteln, Aroma- und Geschmackstoffen vorzugsweise Tenside.As a dental care product to be applied to the teeth in the first phase With a content of urea, a toothpaste of the usual composition is in particular suitable; However, a dentifrice in the form of a transparent gel, a mouthwash, etc. These compositions contain in addition to the known substances listed in the main patent, in particular polishing agents, binders such as in particular carboxymethyl cellulose, humectants, preservatives, Aromas and flavors, preferably surfactants.

Als solche sind insbesondere die anionaktiven Tenside bevorzugt, insbesondere Natriumlaurylsulfat, Salze von höheren aliphatischen Acylamiden niederer aliphatischer Aminosäuren, insbesondere N-Lauroylsarcosinat oder -myristinat, Olefinsulfonate, Alkylbenzolsulfonat und dessen Salze, Eiweissfettsäurekondensate, Sulfate von PolyoxYverbintlungenf beispielsweise Sulfate höherer mehrwertiger Alkohole oder Sulfate partiell veresterter oder verätherter mehrwertiger Alkohole, beispielsweise Monoglyceridsulfate, Sulfate substituierter Polyglykoläther, sog. Xthersulfate, Sulfate acylierter lkanolamine, beispielsweise Fettsäureamidsulfate des Mono- oder Diäthanolamins, Acylamidsulfonate und Alkylamidsulfonate,- Salze der Sulfobernsteinsäure und deren Ester, beispielsweise Natriumdialkylsulfosuccinat, und die Salze der verschiedenen Monoalkylphosphonate und Dialkylphosphonate und -phosphate genannt.As such, the anion-active surfactants are particularly preferred, in particular Sodium lauryl sulfate, salts of higher aliphatic acylamides of lower aliphatic Amino acids, in particular N-lauroyl sarcosinate or myristinate, Olefin sulfonates, alkylbenzenesulfonate and its salts, protein fatty acid condensates, Sulfates of polyoxy compounds, for example, sulfates of higher polyhydric alcohols or sulfates of partially esterified or etherified polyhydric alcohols, for example Monoglyceride sulfates, sulfates of substituted polyglycol ethers, so-called xether sulfates, Sulfates of acylated alkanolamines, for example fatty acid amide sulfates of the mono- or Diethanolamine, acylamide sulphonates and alkylamide sulphonates, - salts of sulphosuccinic acid and their esters, e.g. sodium dialkyl sulfosuccinate, and the salts of the various Monoalkyl phosphonates and dialkyl phosphonates and phosphates called.

Der bevorzugte Anteil der anionaktiven Tenside in den erfindungsgemäß zum Einsatz gelangenden Zahnpflegemittel liegt bei etwa 1 bis maximal etwa lo Gew.-% der Zusammensetzung.The preferred proportion of the anion-active surfactants in the inventive Dental care products used are around 1 to a maximum of around lo% by weight the composition.

Es können natürlich auch verschiedene nichtionogene Tenside enthalten sein, beispielsweise die bekannten oberflächenaktiven Polyhydroxyverbindungen, Zuckerester wie Saccharosemonostearat, Alkylenoxid-Kondensationsprodukte wie Alkylpolyglykoläther, Acylpolyglykoläther, oxäthylierte Fettamine, acylierte Alkanolamine und ihre Addukte sowie Aminoxide, insbesondere Lauryldimethylaminoxid.It can of course also contain various nonionic surfactants be, for example the known surface-active polyhydroxy compounds, sugar esters such as sucrose monostearate, alkylene oxide condensation products such as alkyl polyglycol ethers, Acyl polyglycol ethers, oxethylated fatty amines, acylated alkanolamines and their adducts and amine oxides, especially lauryl dimethyl amine oxide.

Ebenso ist auch der Einsatz der bekannten ampholytischen Tenside wie Betainen und Sulfobetainen sowie den bekannten langkettigen Alkylaminocarbonsäuren möglich, ebenso der Einsatz kationischer Tenside.The use of the known ampholytic surfactants such as Betaines and sulfobetaines and the well-known long-chain alkylaminocarboxylic acids possible, as well as the use of cationic surfactants.

Diese können vorteilhaft auch in der zweiten Phase des Zahnpflegemittels, die erfindungsgemäß das Chlorhexidin enthält, Einsatz finden.These can also be used advantageously in the second phase of the dental care product, which according to the invention contains the chlorhexidine, are used.

Die erfindungsgemäßen Zahnpflege- und Zahnreinigungsmittel können, wie im Hauptpatent ausführlich beschrieben, auch alle sonstigen in Zahnpflegemitteln üblichen Zusätze und Wirkstoffe enthalten.The dental care and cleaning agents according to the invention can, as described in detail in the main patent, also all others in dental care products contain usual additives and active ingredients.

Im folgenden werden einige Beispiele zur näheren Erläuterung der Erfindung gegeben; die angegebenen Zahlen beziehen sich, soweit nichts anderes erwähnt ist, ausschließlich auf Gew.-%.In the following some examples are given to explain the invention in more detail given; Unless otherwise stated, the figures given relate to exclusively to% by weight.

Beispiel 1: a) Zahnpasta Harnstoff 25,00 Gew.-% Carboxymethycellulose 1,20 " Natriumbenzoat o,4o Saccharinnatrium o,15 Sorbit, 70%-ig 10,00 Glycerin, 99,5%-ig 5,00 pyrogenes SiO2 (AerosilR) 2,20 Dicalciumphosphatdihydrat 30,00 Natriumlaurylsulfat 1,40 " ,4o Aromastoffe 1,00 Wasser 23,65 b) Mundwasser Chlorhexidindigluconat 1,80 Gew.-" Saccharin o,o5 1,2-Propandiol 3,50 Fettalkoholäthoxylat 1,20 Äthanol, 95%-ig 8,00 Aromastoffe 0,80 Wasser 84,65 Beispiel 2: a) Zahnpasta Harnstoff 20,00 Gew.-% Natriumalginat 1,20 Methyl-p-hydroxybenzoat o,15 n-Propyl-p-hydroxybenzoat oro5 Sacchar@nnatrium 0,10 " Glycerin, 86%-ig 12,00 " Natriumlauroylsarcosinat 0,75 " Natriumlaurylsulfat o,75 n Natriummonofluorphosphat 0,80 pyrogenes SiO2 (AerosilR) 1,50 Calciumcarbonat 33,00 Aromastoffe 1,10 Wasser 28,60 b) Transparente Zahnpasta Chlorhexidindigluconat 0,90 Gew.-% Hydroxyäthylcellulose 0,80 " Äthyl-p-hydroxybenzoat 0,10 " Sorbit 35,00 " Glycerin, 99,5%-ig 28,oo Polyäthylenglykol 400 2,50 amorphe Kieselsäure 18,50 Polyoxypropylenglykol (MG 8000) 2,20 Aromastoffe 1,10 Wasser 10,90 Beispiel 3: a) Transparente Zahnpasta Harnstoff 12,00 Gew.-% Carboxymethylcellulose 0,50 " Äthyl-p-hydroxybenzoat o,2o Saccharinnatrium 0,10 Sorbit, 7o%-ig 18,oo Glycerin, 99,5%-ig 30,00 Polyäthylenglykol 400 4,oo Siliciumdioxid-Xerogel 21,00 Natriumfluorid o,2o Natriumlaurylsulfoacetat 1,60 Aromastoffe 1,00 Wasser 11,4o b) Mundwasser Chlorhexidindiacetat 1,30 Gew.-% Glycerin, 86%-ig 20,00 " Äthanol, 95%-ig 12,00 " Polyoxypropylenglykol (MG 6000) 1,00 " Aromastoffe o,7o Wasser 65,oo Beispiel 4: a) Mundwasser Harnstoff 20,00 Gew.-% Polyäthylenglykol looo 3,50 " Glycerin, 86%-ig 12,oo Fettalkoholäthoxylat 1,50 Saccharinnatrium o,1o n-Propanol 5,00 Aromastoffe 1,00 Wasser 56,90 b) Zahnpasta Chlorhexidindilactat 0,90 Gew.-" Hydroxyäthylcellulose 0,70 " Saccharinnatrium 0,05 " Glycerin, 86%-ig 35,00 " Bento: t 1,00 " amorphe Kieselsäure 20,00 " TiO2 o,60 Polyoxypropylenglykol (MG 8000) 1,80 Aromastoffe o,9o Wasser 39,05 Beispiel 5: a) Zahnpasta Harnstoff 25,oo Gew.-% Carboxymethylcellulose o,9o Natriumbenzoat 0,20 n-Propyl-p-hydroxybenzoat 0,05 Natriumcyclamat 0,40 Natriumfluorid 0,25 Glycerin, 99,5%-ig 1o,oo Paraffinöl 1,50 Aluminiumhydroxid 32,oo Natriumlaurylsulfat 1,40 Aromastoffe 1,15 Wasser 27,15 b) Kaugummi Naturharzgummigrundlage 40,00 Gew.-% Sorbit 40,00 " Mannit 18,00 " Chlorhexidindihydrofluorid 0,40 " Butylhydroxyanisol 0,10 " Aromastoffe 1,50 Beispiel 6: a) Zahnpasta Harnstoff 35,00 Gew.-% Carboxymethylcellulose 1,30 " Methyl-p-hydroxybenzoat 0,20 " Glycerin, 99,5%-ig 7,00 " amorphe Kieselsäure 17,50 TiO2 0,50 Saccharinnatrium 0,15 Natriumlaurylsulfat 1,oo Natriumlaurolysarcosinat o,50 .Example 1: a) Toothpaste urea 25.00% by weight carboxymethyl cellulose 1.20 "sodium benzoate o, 4 o saccharin sodium o, 15 sorbitol, 70% glycerine, 99.5% pyrogenic SiO2 (AerosilR) 2.20 dicalcium phosphate dihydrate 30.00 sodium lauryl sulfate 1.40 ", 4o flavorings 1.00 water 23.65 b) mouthwash chlorhexidine digluconate 1.80 Weight- "Saccharin o, o5 1,2-propanediol 3.50 fatty alcohol ethoxylate 1.20 ethanol, 95% strength 8.00 Flavorings 0.80 Water 84.65 Example 2: a) Urea toothpaste 20.00% by weight sodium alginate 1.20 methyl p-hydroxybenzoate 0.15 n-propyl p-hydroxybenzoate oro5 Sacchar @ Sodium 0.10 "Glycerine, 86% strength 12.00" Sodium Lauroyl Sarcosinate 0.75 "Sodium lauryl sulfate 0.75 n sodium monofluorophosphate 0.80 pyrogenic SiO2 (AerosilR) 1.50 Calcium carbonate 33.00 Flavorings 1.10 Water 28.60 b) Transparent toothpaste Chlorhexidine digluconate 0.90% by weight hydroxyethyl cellulose 0.80 "ethyl p-hydroxybenzoate 0.10 "Sorbitol 35.00" glycerine, 99.5% strength 28, oo polyethylene glycol 400 2.50 amorphous Silicic acid 18.50 polyoxypropylene glycol (MW 8000) 2.20 flavorings 1.10 water 10.90 example 3: a) Transparent toothpaste urea 12.00% by weight carboxymethyl cellulose 0.50 "Ethyl p-hydroxybenzoate o, 2o sodium saccharine 0.10 sorbitol, 7o% strength 18, oo glycerine, 99.5% 30.00 polyethylene glycol 400 4, oo silicon dioxide xerogel 21.00 sodium fluoride o, 2o sodium lauryl sulfoacetate 1.60 flavorings 1.00 water 11.4o b) mouthwash chlorhexidine diacetate 1.30 wt% glycerin, 86% 20.00 "ethanol, 95% 12.00" polyoxypropylene glycol (MG 6000) 1.00 "Flavorings o.7o Water 65, oo Example 4: a) Mouthwash Urea 20.00% by weight polyethylene glycol, looo 3.50 "glycerine, 86% strength 12, oo fatty alcohol ethoxylate 1.50 Sodium saccharine, 1o n-propanol 5.00 Flavorings 1.00 Water 56.90 b) Toothpaste Chlorhexidine dilactate 0.90% by weight "hydroxyethyl cellulose 0.70" sodium saccharin 0.05 "Glycerine, 86% strength 35.00" Bento: t 1.00 "amorphous silica 20.00" TiO2 o, 60 Polyoxypropylene glycol (MW 8000) 1.80 flavorings o.9o water 39.05 example 5: a) Toothpaste urea 25.0% by weight carboxymethyl cellulose 0.90 sodium benzoate 0.20 n-propyl-p-hydroxybenzoate 0.05 sodium cyclamate 0.40 sodium fluoride 0.25 glycerine, 99.5% strength 1o, oo paraffin oil 1.50 aluminum hydroxide 32, oo sodium lauryl sulfate 1.40 Flavorings 1.15 Water 27.15 b) Chewing gum Natural resin gum base 40.00% by weight sorbitol 40.00 "mannitol 18.00" chlorhexidine dihydrofluoride 0.40 "butyl hydroxyanisole 0.10 "Flavorings 1.50 Example 6: a) Toothpaste urea 35.00% by weight Carboxymethyl cellulose 1.30 "methyl p-hydroxybenzoate 0.20" glycerine, 99.5% 7.00 "amorphous silica 17.50 TiO2 0.50 sodium saccharin 0.15 sodium lauryl sulfate 1, oo sodium laurolysarcosinate o, 50.

Aromastoffe 1,25 Wasser 35,60 b) Zahnreinigungstablette Chlorhexidindihydrochlorid 1,00 Gew.-% Methylcellulose o,5o Polyäthylenglykol 4000 4,oo Milchsäure o,3o Mannit 20,00 " Sorbit 64,70 " Polyvinylpyrrolidon 3,50 " Kieselsäure 6,oo Flavorings 1.25 Water 35.60 b) Tooth cleaning tablet Chlorhexidine dihydrochloride 1.00% by weight methyl cellulose 0.5o polyethylene glycol 4000 4, oo lactic acid 0.3o mannitol 20.00 "Sorbitol 64.70" Polyvinylpyrrolidone 3.50 "Silicic acid 6, oo

Claims (4)

Patentansprüche 0 Zahnpflege- und Zahnreinigungsmittel nach Patent Nr. Claims 0 Dental care and cleaning agents according to the patent No. (Patentanmeldung P 23 38 177.3) mit einem Gehalt an 1,6-Di-4'-chlorphenyldiguanidohexan oder seiner Salze und Harnstoff, dadurch gekennzeichnet, daß dieses Mittel in Form zweier voneinander getrennter Phasen vorliegt, die nacheinander angewendet werden, wobei eine Phase etwa o,5 bis etwa 45 Gew.-% Harnstoff und vorzugsweise ein anionaktives Tensid, insbesondere Natriumlaurylsulfat oder N-Lauroylsarcosinat1 enthält1 und die andere Phase etwa o,o1 bis etwa 7,5 Gew.-t 1 ,6-Di-4' -chlorphenyldiguanidohoxan enthält. (Patent application P 23 38 177.3) with a content of 1,6-di-4'-chlorophenyldiguanidohexane or its salts and urea, characterized in that this agent is in the form there are two separate phases that are applied one after the other, one phase having about 0.5 to about 45% by weight urea and preferably an anion-active one Contains surfactant, in particular sodium lauryl sulfate or N-lauroyl sarcosinate1 and the other phase about o, o1 to about 7.5 t 1, 6-di-4'-chlorophenyldiguanidohoxane contains. 2. Zahnpflege- und Zahnreinigungsmittel nach Anspruch 1, dadurch gekennzeichnet, daß die Harnstoff en4-haltende Phase in Form einer opaken Paste oder eines transparenten Gels vorliegt.2. Dental care and tooth cleaning agent according to claim 1, characterized in that that the urea en4-containing phase in the form of an opaque paste or a transparent one Gels present. 3. Zahnpf lege- und Zahnreinigungsmittel nach Anspruch 1, dadurch gekennzeichnet, daß die 1,6-Di-4'-chlorphenyldiguanidohexan oder seine Salze enthaltende Phase in Form eines Mundwassers vorliegt.3. Dental care and teeth cleaning agent according to claim 1, characterized characterized in that the 1,6-di-4'-chlorophenyldiguanidohexane or its salts containing Phase is in the form of a mouthwash. 4. Verfahren zur Reinigung und Pflege von menschlichen Zähnen, dadurch gekennzeichnet, daß man die Zähne zunächst mit einem etwa o,5 bis etwa 45 Gew.-% Harnstoff- enthaltenden Mittel, beispielsweise einer Zahnpasta'und anschließend mit einem etwa o,o1 bis etwa 7,5 Gew.-% 1,6-Di-4'-chlorphenyldiguanidohexan und/oder seine Salze enthaltenden - Mittel, beispielsweise einem Mundwasser, in Berührung bringt.4. Methods for cleaning and caring for human teeth, thereby characterized in that the teeth are initially treated with an approximately 0.5 to approximately 45% by weight Urea-containing agents, for example a toothpaste 'and then with about 0.01 to about 7.5% by weight 1,6-di-4'-chlorophenyldiguanidohexane and / or agents containing its salts, for example a mouthwash, in contact brings.
DE2430280A 1973-07-27 1974-06-24 Toothpaste and mouth-wash which are used consecutively - respectively contg urea and anion-active tenside phase and 1,6-di-4'-chlorophenyl-di-guanido-hexane phase Pending DE2430280A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19732338177 DE2338177A1 (en) 1973-07-27 1973-07-27 Non-staining dentrifuce compsn - contains urea in addn to chlorohexidine as active ingredients
DE2430280A DE2430280A1 (en) 1973-07-27 1974-06-24 Toothpaste and mouth-wash which are used consecutively - respectively contg urea and anion-active tenside phase and 1,6-di-4'-chlorophenyl-di-guanido-hexane phase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19732338177 DE2338177A1 (en) 1973-07-27 1973-07-27 Non-staining dentrifuce compsn - contains urea in addn to chlorohexidine as active ingredients
DE2430280A DE2430280A1 (en) 1973-07-27 1974-06-24 Toothpaste and mouth-wash which are used consecutively - respectively contg urea and anion-active tenside phase and 1,6-di-4'-chlorophenyl-di-guanido-hexane phase

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2420970A2 (en) * 1978-03-28 1979-10-26 Goupil Jean Jacques Anticariogenic chewing gum compsn. - contg. gum base, water soluble fluorine salt, xylitol and sorbitol
US4206198A (en) 1979-05-16 1980-06-03 Basf Wyandotte Corporation Dentifrice
US4525343A (en) * 1983-04-25 1985-06-25 Blendax-Werke R. Schneider Gmbh & Co. Tooth and mouth care agent
US4532124A (en) * 1981-08-19 1985-07-30 Development Finance Corporation Of New Zealand Dental rinse
EP0181179A2 (en) * 1984-11-02 1986-05-14 The Procter & Gamble Company Antimicrobial lozenges
EP0539811A2 (en) * 1991-10-26 1993-05-05 Ivoclar Ag Chlorhexidine adduct
WO2011094494A2 (en) 2010-01-29 2011-08-04 Colgate-Palmolive Company Fluoride free and anionic surfactant free dentifrice having a high micro efficacy
WO2012128629A1 (en) * 2011-03-23 2012-09-27 Simus B.V. Cleaning composition for dental objects, kit and method

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2420970A2 (en) * 1978-03-28 1979-10-26 Goupil Jean Jacques Anticariogenic chewing gum compsn. - contg. gum base, water soluble fluorine salt, xylitol and sorbitol
US4206198A (en) 1979-05-16 1980-06-03 Basf Wyandotte Corporation Dentifrice
US4532124A (en) * 1981-08-19 1985-07-30 Development Finance Corporation Of New Zealand Dental rinse
US4525343A (en) * 1983-04-25 1985-06-25 Blendax-Werke R. Schneider Gmbh & Co. Tooth and mouth care agent
EP0181179A2 (en) * 1984-11-02 1986-05-14 The Procter & Gamble Company Antimicrobial lozenges
EP0181179A3 (en) * 1984-11-02 1988-10-19 The Procter & Gamble Company Antimicrobial lozenges
EP0539811A2 (en) * 1991-10-26 1993-05-05 Ivoclar Ag Chlorhexidine adduct
EP0539811A3 (en) * 1991-10-26 1993-07-28 Ivoclar Ag Chlorhexidine adduct
WO2011094494A2 (en) 2010-01-29 2011-08-04 Colgate-Palmolive Company Fluoride free and anionic surfactant free dentifrice having a high micro efficacy
WO2011094494A3 (en) * 2010-01-29 2012-04-19 Colgate-Palmolive Company Fluoride free and anionic surfactant free dentifrice having a high micro efficacy
AU2011210800B2 (en) * 2010-01-29 2013-05-30 Colgate-Palmolive Company Fluoride free and anionic surfactant free dentifrice having a high micro efficacy
RU2533461C2 (en) * 2010-01-29 2014-11-20 Колгейт-Палмолив Компани Dental preparation free from fluoride ions and anion surfactant possessing high antimicrobial efficiency
US10258554B2 (en) 2010-01-29 2019-04-16 Colgate-Palmolive Company Fluoride free and anionic surfactant free dentifrice having a high micro efficacy
US11116709B2 (en) 2010-01-29 2021-09-14 Colgate-Palmolive Company Fluoride free and anionic surfactant free dentifrice having a high micro efficacy
WO2012128629A1 (en) * 2011-03-23 2012-09-27 Simus B.V. Cleaning composition for dental objects, kit and method

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