DE2406164C3 - Growth-promoting feed for farm animals - Google Patents

Description

the compound MYC 8003, now called mocimycin, bacitracin is a polypeptide (cf. Sci., Vol. 102

• found that described in GB-PS 13 25 200 55 [1945], p. 376), which has been specifically considered to be for a long time Is. Zinc complex as a growth-promoting compound

Mocimycin is a promising growth- is used (cf. J. Bacteriol., Vol. 55 [1948], p. 249 promoting agent for animals, especially farm animals. Die and US-PS 28 03 584). Zinc bacitracin is less Invention is based on the surprising finding that it is bitter than bacitracin.

a mixture of mocimycin with bacitracin a 60 The above under (a) and (b) mentioned enhancers has a growth-promoting effect as the bonds can separate in a manner known per se Links. Thus, smaller ones can be mixed. The weight ratio of the compound quantities Both compounds in combination can fertilize in a comparatively broad way should be applied to the same growth-promoting range, namely between 1: 2 to 1:20, To make an impact. 65 in particular about 1: 4 to 1:10.

The invention is therefore a growth The mixture can with conventional, inert physiological

promoting feed for farm animals, which is a mixture of logically compatible carriers or diluents are dispersed or mixed with solvents. the

Strengths or thinners must be taken orally be administrable, they may be used with the growth-promoting Compounds do not react and they are said to be harmless when administered orally The mixture of the growth-promoting compounds or their salts or complexes can be added to the carrier or diluents are incorporated in a manner known per se by grinding, stirring or crushing will. Then this mixture is added to the usual feed ingredients so that the finished feed has the claimed composition. This also applies to concentrates or other feed additives containing the mixture of growth-promoting compounds. as well it is possible to add each of the growth-promoting compounds individually to the feed, the carrier or incorporate the extender.

The amount of growth-promoting mixture added Compounds that are necessary to have a satisfactory growth-promoting effect achieve, is about 3 to 100 ppm, preferably about 5 to 40 ppm, based on the weight of the Animal feed, depending on the species of animal

The administration of the mixture to farm animals,

like chickens, turkeys, pigs and calves, happens in a manner known per se. Preferably the feed is administered to young animals over a period of several weeks.

The example illustrates the invention.

example

The experiments were carried out with chickens. The growth-promoting compounds mocimycin and / or bacitracin as a zinc complex were mixed with chicken feed (wheat flour). The amounts the growth-promoting compounds used are summarized in the table. Likewise shows the Table of the weight of the chickens after 3 and after 5 weeks in absolute numbers and in percentages, based on the weight of the chickens in the control

ao try which no growth promoting compound was administered. Each of the numbers given represents the average of 6 groups of each 15 chickens.

Mocimycin
ppm Zinc-
bacitracin
ppm 3 weeks
I.
G % Π
G % III
G % Through
cut
% 0 0 410 422 413 100.0 1
1.5
3 0
0
0 421
434 102.7
105.9 422
437 100.0
103.6 428
434 103.6
105.1 101.8
102.7
104.9 0
0 10
20th 427
434 104.1
105.9 438 103.8 432 104.6 104.2
105.9 1
1 5
10 433
447 105.6
109.0 451 106.9 439 106.3 105.6
107.4

436

106.3

106.3

(Continuation) Zinc-
bacitracin
ppm 5 weeks
I.
? % Π
G % m
G % Through
cut
% Mocimycin
ppm 0 945 940 957 100.0 0 PPP 950
979 100.5
103.6 938
953 99.8
101.4 946
957 101.0
102.1 100.4
100.5
102.4 1
1.5
3 10
20th 965
972 102.1
102.9 943 100.3 963 102.8 101.7
102.9 0
0 5
10 980
993 103.7
105.1 974 103.6 969 103.4 103.7
304.0 1
1

967

102.3

The table shows the synergistic effect, i.e. far fewer are sufficient in the mixture

borrowed when both growth promoting compounds than half of the single growth promoting

can be used together. Ho corresponds e.g. B. in connections.

an administration of 3 ppm mocimycin or from the use of the invention can be limited by law-20 ppm zinc bacitracin the 'achieved weight gain 5 Liehe determinations, in particular by the feed approximately that with a combination of 1 ppm medium law.
Mocimycin and 5 ppm zinc bacitracin achieved

Claims (3)

(a) Mocimycin or its sodium, potassium or patent claims: calcium salt and (b) bacitracin or a growth-promoting salt or 1. Growth-promoting feed for useful a complex of this compound, animals, characterized in that 5 it is a mixture of whereby the weight ratio of (a) and (b) is about (a) Mocimycin or its sodium, potassium or 1: 2 to about 1:20, in an amount of calcium salt and about 3 to 100 ppm, based on the weight of the (b) contains bacitracin or a growth-promoting salt feed. or a complex of this compound, io mocimycin and its salts have the following where the weight ratio of (a) and (b) physicochemical properties: solid, yellow, about 1: 2 to about 1:20, in an amount of salt-forming, weak acid, containing the egg from about 3 to 100 ppm, based on the weight of menle carbon, hydrogen, nitrogen and acid of the feed. substance, consisting of in equilibrium with each other 2. Feed according to claim 1, characterized by 15 standing compounds, poorly soluble in tetra drawing, that the weight ratio of (a) and chlorocarbon and benzene, soluble in chloroform, (b) is about 1: 4 to about 1:10. Methyl isobutyl ketone, butyl acetate, ethyl acetate, metha- 3. Feed according to claim 1 or 2, characterized in nol and alkaline solutions, with a weak characterized in that the content of (a) and (b) positive reaction when tested for aromatics, red beef about 5 to 40 ppm, based on the weight, colored with concentrated sulfuric acid, dark Feed, lies. brown color in the Pauly reaction, dark red Color and cloudiness with iron (III) chloride, positive periodate reaction, negative Fehlings, Tollens, Molisch, Anthrome and biuret reactions, decomposition 25 when heated, with absorption maxima in the ultraviolet spectral range at 233 and 327 mm and with absorption bands in the infrared spectral range up to 810, 860, 940, 980, 1090, 1215, 1355, 1455, 1540, 1650, for many years it has been common practice to use the 2390 and 3400 cm- ¹ . Forage from farm animals such as chickens, turkeys, 30 The combination of the two components shows Pigs and calves, certain antibiotics in a distinct synergistic effect that point to add small amounts (1 to 50 ppm). The reason for the effect of the individual components showed with at least some antibiotics one that was not predictable. Enhancement of growth and feed- The salt or complex is for oral use. Examples of animals used for this purpose, retains the growth antibiotics are penicillin G (benzylpenicillin), strep-promoting properties and is in the eingetomycin, Tetracyclines, bacitracin, tylosin and their amounts are harmless. Salts and / or their complex compounds. The mixture of the invention has the advantage that In the past few years there has been the use of the growth-promoting properties of Bacitra antibiotics as a feed additive subject of the 40 one, its salts or complexes, which are relatively cheap Criticism in the cases in which these compounds also are, however, only limited growth-promoting for therapeutic purposes, d. H. in medicine, show activity by only very small amounts that to be used. It is generally feared that the growth-promoting agent as described under (a) Pathogenic bacterial strains can develop, is written, is increased, so that the mixture those against these antibiotics or some of them 45 can be used much more sparingly than any are resident, which means that the fight against such bacteria- the compounds on their own. Another advantage lien by the same antibiotics in human can be seen in the fact that in common medicine would be made impossible when delivering the two compounds to animals microin administered in the usual manner. Less likely to be resistance among organisms Taking this problem into account, new 50 bil compounds against both growth-promoting compounds were taken into account with pronounced growth-promoting ones that do not have the same antibiotic spectrum, «Looking for properties that cannot be used as medicinal products, as when one of the two is taken alone; n Fabrics are suitable. That search was going to be among other things.