DE2329752A1 - METHOD AND COMPOSITION FOR DENTAL TREATMENT - Google Patents

Description

μ ·: · t - «on June 12, 194 ^ 29752

DIpI.-hg. K. »11 TSC H ER L ICH Dipl.-Ir.?. K. G J "Jl-CiIKANN

Dr. rer. nat. W. K Ö RBER DH-In ₈ -J-SCHMIDT-EVERS I Mt) NCHEN 22 _£ SMmdoristr. IO

NATIONAL PATENT DEVELOPMENT CORPORATION 375 Park Avenue New-York , New York loo22 / V.St .A.

Procedure and accessories for dental treatment

Patent application

The present invention relates to the treatment of teeth in dentistry and to the cleaning of Teeth in both dentistry and personal hygiene.

An object of the invention is to provide a method of treating teeth in dentistry for elimination of dental plaque and tooth decay and to avoid the formation of lime or limestone.

Another aim is to create a method of treatment of teeth in dentistry for removal

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309885/1394 ORIGINAL INSPECTED

Case 5 <*

. only from plaque and caries, while the rest of the tooth is not touched.

Another aim is to create a method of treating teeth in dentistry by removing plaque and tooth decay, eliminating the need for mechanical removal with the help of drills,
Whetstones and hand tools are reduced to a minimum or eliminated entirely.

Another aim is to create a method of treating teeth in dentistry, with even
then when the treatment happens to be about optimal
Period is extended beyond, only plaque and tooth decay is removed and the rest of the tooth, such as B. dentine or enamel, is left completely untouched.

Another aim is to create a method for treating teeth in dentistry, for removing plaque and tooth decay, which is common to the patient
is absolutely painless, since this procedure resp.
this treatment avoids the vibration due to the use of power tools and the pressure on sensitive parts of a tooth from manually manipulated tools.

Polishing or whitening teeth is an ongoing goal of modern dentistry. The teeth become natural easily dirty and difficult to clean effectively, so it is necessary to use effective detergents to use.

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Known cleaning agents, while effective at cleaning teeth, tend to remove metal parts of dental ones To attack equipment and instruments by corrosion. So z. B. is previously aqueous sodium hypochlorite as a tooth polish but recently it has generally been used as a result of its corrosion - and thus destructive effects is no longer used.

Therefore, an additional object of the present invention is to provide a dental polish which is useful for cleaning the teeth are effective, but not harmful to metal parts due to the effect of corrosion.

Another goal is to create a means of regular Use in personal hygiene, e.g. for daily use, to remove dirt from the teeth remove and / or prevent the formation of stains that whiten teeth.

Another aim is to create a cleaning agent for whitening teeth, which is in the form of tablets can be made and sold for use in water as a mouthwash.

Another object is to provide a teeth whitening detergent which can be used as a mouthwash can be prepared by mixing two solutions while in use.

It has now been found that the above objectives can be achieved by treating teeth to eliminate tooth decay _/

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to dissolve (or otherwise remove) plaque and to avoid the formation of limescale or tartar as well as for Whitening the teeth can be achieved by bringing the teeth into contact with an N-halogenamine, that on a hydroxyl group, a sulfonic acid group, a Contains N-acyl group or a carboxylic acid group. That Halogen has an atomic weight of 35 to 127.

The N-halogen compounds of the present invention are usually used in an aqueous solution, but they can also be used in thicker compositions, such as B. in the form of toothpaste can be used.

Many of the N-halogen compounds are unstable and are conveniently prepared by adding an alkali metal or Alkaline earth metal hypohalite, preferably hypochlorite, is reacted with the amino compounds.

Suitable hypohalites are those of the formula MOX and / or M ² X (OX) and / or M ² (OX) ₉ , in which M Li, Na, K, Rb, or Cs and M Ca, -Sr or Ba or X Cl , Br and / or I, is.

Examples of suitable hypochlorites include sodium hypochlorite, potassium hypobromite, sodium hypoiodite, potassium hypoiodite, Potassium hypobromite, rubidium hypochlorite, cesium hypochlorite, calcium hypobromite, stronitium hypochlorite, and barium hypochlorite.

For reaction with the hypohalite to form the inventive N — Halogen compounds can be either inorganic

309885/1 394

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Connections, like ζ. B. sulfamic acid, or organic compounds are used which contain 2 to 11 carbon atoms, such as. B. glycine, sarcosine, alpha amine butyric acid, Taurine, 2-amine ethanol, N-acetylglycine, alanine, Beta-aanine, serine, phenylalanine, norvaline, leucine, isoleucine proline, hydroxyproline, omega-aminundecanoic acid, aspartic acid, Glutamic acid, asparagine, valine, tyrosine, threonine, cysteine, cystine, methionine, glutamine, tryptophan ^ histidine, Arginine, lysine, alpha-amine butyric acid, gamma-amine butyric acid, Alpha-epsilon-diaminopimelic acid, ornithine, hydroxyllysine, Anthranilic acid, p-aminbenzoic acid, sulfanilic acid, Orthanilic acid, phenylsulfamic acid, aminprοpanesulfonic acid, 2-amine ethanol, 2-amine propanol, diethanolamine ethylenediaminetetraacetic acid (EDTA), nitrile triacetic acid, taurine and amine methanesulfonic acid; Polypeptides e.g. B. glycylglycine, Glycylglycylglycine etc.

Examples of N-halogen compounds include N-chloroglycine, N-bromoglycine, N-iodoglycine, N-chlorosarcosine, N-bromosarcosine, N-iodosarcosine, N-chloro-alpha-aminisobutyric acid, N-chlorotaurine, N-bromotaurine, N-iodotaurine, N-chloramine methanesulfonic acid, N-chloroethanolamine, N-chloro-N-acetylglycine, N ^ bromoethanolamine, N-iodoethanolamine, N-iodine-N-acetylglycine, N-bromo-N-acetylglycine, N-chioralanine, N-chloro-beta-alanine, N-bromo-beta-alanine, N-chloroserine, N-bromserine, N-iodine serine, N-ChIοr-N-Phenylalanine, N-Chlorisoleucine, N-Chlor-Norvaline, N-Chlorleucine, N-Bromleucine, N-Jodleucine, N-Chlorproline, N-Broni proline, N-iodoproline, N-chlorohydroxyproline, N-chloromegaaminundecanoic acid, N-chloraspartic acid, N-bromaspartic acid, N-chiorglutamic acid, N-iodoglutamic acid, N-chlorvaline, N-chlorotyrosine, N-bromotyrosine, N-iodotyrosine, N-chlorothreonine,

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N-chlorocysteine, N-chlorocystine, N-chloromethionine, N-chlorohistidine, N-chloro-arginine, N-chloro-glutamine, N-brom-glutamine, N-chlorolysine, N-chloro-gamma-amine butyric acid, N-chloro-alpha-epsüon-diaminopimelic acid, N-ghlorornithine, N-chlorohydroxylysine, N-chloranthranilic acid, N-chloro-p-aminbenzoic acid, N-chlorosulfanilic acid, N-chlorophenylsulfamic acid, N-chloramine propane sulfonic acid, N-chloropropanolamine, N-chlorinated diethanolamine, N-chloroethylene diamine tetraacetic acid (In this compound the nitrogen atom obviously acts as quaternary nitrogen).

Kalogenamine carboxylic acids are preferably used, z. B. Amine alkanoic acids, which are free from divalent sulfur or from a heterocyclic ring, because then, when the divalent sulfur atom or the heterocyclic ring is present, the N-halogen compound is a very short one Has half life.

The N-bromine and N-iodine compounds are the most effective, but they have a shorter life and half life, respectively than the N-chlorine compounds, so the N-chlorine compounds commonly used. The N-haloamine group is preferably directly on an aliphatic Carbon atom bonded. Compounds that have an unpleasant odor are preferably not used.

Sodium hypochlorite and the other hypochlorites are iridescent the lining of the mouth. Therefore, these hypochlorites are preferably not present in the final solution.

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The parent nitrogen-containing compound is preferred used in excess, the molar ratio of the nitrogen-containing parent compound to the usable X (from the hypochlorite) should, for example, 1: 1 or more and preferably in the range of 2: 1: 15: 1, in particular 7: 1, be. A new set of nitrogenous compounds can be used.

The available active X concentration should preferably be between 0.01 ^ and 6 $ and in particular between 0.0576 and V ₁ -O .

The solutions should have a pH in the range from 8 to 12 and in particular in the range from 10.5 to 11.5 including and in particular 11 to 11.5 used will.

Maintaining the preferred pH range is desirable because hydrogen ions are generated during the cleavage of an N-haloene compound in an aqueous solution to add a buffer system to the solution for dental or whitening treatment. Such a buffer system should be compatible with the N-halide compound, ie it does not have to have any harmful effect on this and it does not have to be non-toxic. Chlorates and phosphates are examples of compatible salts for the formation of buffer systems, such as. B. Na ₂ B ₄ O ₇ , for use as a buffer system, as this allows the pH to be maintained above 10, although in other systems the buffer effect is usually at a lower pH.

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Mixtures of N-halogen compounds can of course can be used.

The stability of the N-halogen compounds in water solutions is limited and generally with the decrease in pH generally enlarged. The stability of the N-halogen compound can expediently be specified with its "half-life" be, d. i.e., the time required to split one half of the N-halogen compound present in solution. A "Half-life" range for solutions to use for removing or dissolving dental plaque or for use as a whitening agent is, for example, 3 to 60 minutes and advantageously between 10 and 20 minutes; to eliminate tooth decay are longer half-lives he wishes. The half-life of the N-chlorine compounds can, for example by using a buffer system of the type mentioned above to maintain the correct pH can be set.

According to the method of the present invention, it is only necessary that the solution be applied to the teeth for a short time correspondingly in contact, so that the plaque is removed or the teeth are whitened.

The removal of the dental plaque can be accelerated by applying the solution in the form of a current to the attacked Tooth is supplied, with an erosive effect achieved during the removal of the dental plaque and the caries material can be. The erosion effect itself can be accelerated by using a pulsating current which

309885/1394

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the deposits of dental plaque and tooth decay due to the alternating Application of force and subsequent relaxation makes you weak, causing mechanical fatigue of the deposits takes place. Using hand tools to scrape off will also help with the elimination the tooth decay.

By adding an appropriate carrier, for example a thickener, such as. B. SiOp, to form a pasta, the solution with an applicator, such as. 3. a toothbrush or derglo, applied more easily will. Such a pasta can be applied to the teeth once or several times a day.

If a solution is used, it is also possible to add one or more pesticides, for example in water or dissolve in an aqueous solution.

The teeth are then pierced or freed from plaque,

by simply introducing part of the formed solution into the mouth as a mouthwash.

If the materials are provided in the form of tablets, it is advantageous to add agents to bring about effervescence or foaming and to increase the rate of dissolution of the tablet material or the tablet materials. For example, equal amounts of adipic acid and sodium bicarbonate in a tablet cause effervescence or foam after dissolution.

Tablets according to the invention can also contain other materials included, such as B. fillers, insofar as they are compatible.

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Repeated use of these solutions over a longer period of time, for example four weeks, can reduce the Teeth get the desired whiteness, whereby the image is prevented from dental plaque. After that, continued daily use of the mouthwash worsens the condition of teeth are maintained.

Unless otherwise specified, all parts and percentages are parts and percentages by weight.

When carrying out the method according to the invention For example, the following solutions have been found to be effective:

Solutions used (the figures are in moles / 1 der

Water solution)

NaOCl NaOH NaCl amine buffer salt pH value *

binding

A 0.008 0.0539 0.050 0.05 Glycine Na ₃ HPO ₄ 11.59

0.0025 B 0.008 0.0640 0.050 0.05 Glycine Na ₃ B ₄ O ₇ 10.77

0.00125 C. 0.008 0.0210 0.050 0.05 Glycine Na ₃ B ₄ O ₇ 9.65

0.00125

D 0.008 0.0537 0.050 0.05 sulfa- none 11.49

mini acid no

E 0.008 0.0520 0.052 0.05 sulfa- none 10.75

mini acid no

P 0.008 0.0548 0.050 0.05 taurine none 11.86

no

* The pH of all investigated solutions remained constant within 0.2 pH value units for at least 1 hour.

309885/1394

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example 1

The following is a first example of preparing a bad tooth given for sealing:

Solutions A through P were applied to a decayed area of a bad tooth in a liquid stream at a temperature of 35-45 ° C, and preferably at a body temperature of about 37 ° C. The solution was applied at either a steady or constant pressure ranging from 10 to 100 pounds / square inch or as a pulsating jet stream, the pressure being between 0 and 10 pounds / square inch or 0 and AO pounds / square inch or 0 and 80 pounds / square. Square inch or 0 and 100 pounds / square inch fluctuates during a cycle at a rate of 100 to 1500 cycles per minute by a hypodermic needle of gauge size 20-23. The pressure can be increased to pounds / square inch in any case.

Each tooth was essentially cleaned and made ready to be sealed within one to 7 minutes, depending on the size of the tooth hole and its location. Judged by qualitative eye observation, the elimination of caries is more effective in living teeth that have not been extracted than in extracted teeth. It has been found that a pulsating jet stream is more effective than a non-pulsating stream, although a greater amount of the cleaning solution was consumed by the non-pulsating jet stream.

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309B8Ö / 1394

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The following table shows the results obtained when using the solutions "A" - ¹ ^ "in extended teeth.

Removal of tooth decay

Solution Temp. Needle Calibration Frequency Pressure (C) size (cycle / min) (psi)

Volume Time for (ml) complete elimination (min)

A. 37 20th A. 37 20th A. 36 20th A. 37 20th A. 37 23 B. 38 20th C. 37 20th D. 39 20th A. 38 23 A. 45 20th A. 35 20th E. 37 20th P. 38 20th

850 0-10 430 3.5 650 0-40 380 4.5 700 0-40 500 4.5 200 0-100 470 6.0 * 40 * 1150 11 100 0-80 480 4.5 1100 0-40 460 5.0 750 0-40 420 5.5 1500 0-100 510 7.0 550 0-40 570 3.5 800 0-80 490 1.0 650 0-40 480 4.5 800 0-80 590 6.0

^ Constant non-pulsating beam current.

A major advantage over this treatment method With conventional drilling operations, even if the treatment is significantly prolonged (i.e., continued, long time all caries material has been removed), no removal or no damage of the substance - dentin or enamel - of healthy teeth. However, this is not the case if a mechanical Bore is extended randomly.

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Example 2

"Here's a second example of how to prepare one bad tooth for sealing:

An active solution was created by mixing equal volumes of 0.1 ^ sodium hypochlorite solution with 0.1 molar solution of ethylenediaminetetraacetic acid. The pH of the ethylenediaminetetraacetic acid solution was adjusted to 10.5 before mixing. The final solution was used at a temperature of 36 ^° C. This solution was applied in the form of a pulsed jet stream, the pressure of which varied between 0 and 80 pounds / square inch during one cycle at a frequency of 700 cycles / minute through a 20 gauge needle. The tooth became essentially clean and ready to be sealed within 5 minutes.

Example 3

The following is an example for carrying out the method according to the invention using the solution as dog water:

Line active solution;. Was made by same!,! Narrow a 0.2 / i-sodium hypochlorite solution and a 0.3-Holdiäthanolamin or ethylenediaminetetraacetic acid solution at room temperature were mixed. L'in part of 20 ml of v.xirde .taken and used to clean the patient's I-junction used. The solution became ver-ν.Ό: ΐ for approximately 1 minute et. The above / organs became one for one. '> Esamtreini-: ■■ -.'; V: 3zeit von 2 Hi nut en. repeated.

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309885/139

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Example 4

A solution for use as a mouthwash, plaque removal and teeth whitening agent prepared by adding equal volumes of aqueous hypohalite and an aqueous nitrogenous compound; 3 solution (or compounds) have been mixed. The initial pH of the nitrogen-containing compound solution was adjusted as necessary using sodium hydroxide. A 20 ml portion of the resulting solution was taken and used as a mouthwash for approximately 1 minute to clean the cavity. Repeated daily use whitened the patient's teeth while maintaining a desirable level of whiteness and removing plaque. The amounts of all ingredients and the conditions are specified in Table I, in which the hypohalite (OX) concentration is given in ^ sets and all other concentrations in Uol /% .

Table I.

Hypohalite solution

NaOCl 0.1

K03r 0.1

GaCl (OGl) 0.16

NaOCl 0.1

nitrogenous ile 0 solution ,1 infa η Connecting 0 X j i 1 Bectandt 0 > ι _ss pH value Glycine 0 »Ι 1 1 > ι HaGl 0 >"' Taurine 0 1 0 , 2 KGx 0 urea I. 1 G i: aOi G .06 SuIfamin- acid Givcin

0 9 8 6 5/1394

Jase 5

jiaüCl

iiaOGl

O ,1 Ethylenediamine 0.16 0.1 11 O Tetraacetic acid 0.1 11 O O ,1 Glycine 0.1 ;; al 0.1 11 2 O ,1 Glycine 0.01 NaCl Na ₃ HPO ₄

Example 2

Dws the same procedure as in Example 1 was used, except that the solution was prepared by adding a solid tablet of Ca (OCL) ₂ (0.005 l.Iol) and a tablet of glycine (0.05 WoI) and NaHCO ^ (0.05 LIoI) was added per liter of the final aqueous solution.

.example 3

Yes, the procedure of Example 2 was repeated, except that each of the solutions was additionally _{thickened using JiO 0} and then equal volumes of the pastes obtained were mixed and applied with a brush.

'Je is viol ■■ -,

Yes / experience of Example 1 was repeated, with the naive off that the hypohalite as a solid (Ca (OCl) _?, 0.004 I. A solution of glycine (0.05 Π), KaCl (0.05) added v. -.u'de, a.-divided to a pH-value of 11.2.

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309805 / Ί39Α

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Example 5

The procedure of Example 1 was repeated, but die'Lös.ung was formed by adding N-chlorosarcosine (0.008 mol / fl ) in the solid state to an aqueous solution of sarcosine (0.042 M), NaCl (0.05 M) and NaOH (0.05M) was added.

Example 6

The procedure of Example 1 was repeated with the exception that a previously formed solution of a stable H — halogen compound was added to a solution with another nitrogen-containing compound. All information is given in Table II. All amounts are in mol / Ä) of each initial solution.

Table II

nitrogen-containing compound solution

Halogen compound Ingredients Initial pH

N-chlorotaurine 0.01 glycine 0.1 11.3

NaCl 0.1

When the amine compound has an asymmetric carbon atom either the DL, the D or the L-Porm can be used. Unless otherwise determined the racemic form is used.

Aqueous used according to the invention formed in situ Compositions containing N-halogen compounds,

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can be seen from the following examples. The half-lives relate to the N-halogen compound and are given in minutes, except when h means hours or d days. All amounts are in moles / liter specified

Example 6

Try nitrogen compound

Amount of NaOH NaCl NaOCl 50 $ Amount Amount Amount split

Glycine

Glycine

Glycine

Glycine

Glycine

Glycine

Glycine

Ethanolamine

Taurine

0.05

0.0444

0.1

0.05

0.025

0.0125

0.005

0.05

0.05

N-Acety glycine 0.0 5
Sarcosine 0.05

SuIfamin- 0.05
acid

L (+) glutamic acid Q q ^

^L ( ⁺ ) "0.05

DL-Aspartic Acid q q ^

L4 lysine

L-seucine

EDTA

DL threonine

L (-) cystine

DL serine

(+) Cystine

0.05
0.05
0.05
0.05
0.05
0.05
0.05

0.05

0.0444

0.1

0.05

0.025

0.0125

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.10

0.10

0.05

0.05

0.10

0.05

0.1

0.05

0.05

0.05

0.0615

0.115

0.065

0.040

0.0279

0.05

0.05

0.05

0.05

0.05

0.05

.0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05

0.0078 0.0069 0.156 0.0073 0.0039 0.0020 0.0078 0.0078 0.0078 0.0078 0.0078 0.0078

53.8

52.3 20.0

44.2 110.2 212.0 6.3 472.0 128.4 h 885.0 108.0 21 d

(for a 25 ^ resolution)

0.0081 0.0081 0.0081 0.0081 0.0081 0.0080 0.0080 0.0080 0.0080

25.3 42.8 32.8 107.0

58.9

13.0

34.9

2.4

51.9

0.008 completely split in less than 1 min.

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Case 5 /

23 L-valine 0.05 0.05 0.05 0.008 75.2

24 4-hydroxyproline 0.05 0.05 0.05 0.008 3.0

25 DL-methionine 0.05 0.05010.05 O ₁ OOG 1.3

26 L (-) proline 0.05 0.05 0.05 0.008 1.8

27 DL - alanine 0.05 0.05 0.05 0.008 54.2

28 L (+) arginine 0.05 0.0657 0.05 0.008 48, o

29 L-histidine 0.05 0.0528 0.05 0.008 39.3

30 L-isoleucine 0.05 0.0509 0.05 0.003 76.5

31 DL-phenylalanine 0.05 0.054 0.05 0.008 37.9

32 L - asparagine 0.05 0.0535 0.05 0.008 13.3

33 L (+) glutamine 0.05 0.0537 0.05 0.008 28.0

34 DL - ornithine 0.05 0.039 0.011 0.008 38.3 hydrochloride

35 aniline - 2 - 0.05 0.05 0.05 0.003 5.0 sulfonic acid

36 sulfanilic acid 0.05 0.05 0.05 0.003 1.1

37 metanilic acid 0.05 NONE 0.05 0.008 1.25 38 * glycine 0.05 0.05 0.05 0.0079 91.4 39 * glycine 0.05 0.025 0.025 0.0033 36.2

40 H- ^{Octadecanylglycine} ° ^{05 OfOb ° 05} 0.008

41 amine methanesulfonic acid ° ^'05 °' ⁰⁵ ° '° ⁵ °' ^Üü8

42 N-Glycylclycine 0.05 0.05 0.05 0.000

3 minutes

43 N, N ¹ -Glyclyglycyl ^ ycine 0.05 0.05 0.05 0.003 less than

* In Experiment 38, sodium compounds were used instead of
the corresponding lithium compounds (LiOK and LiOCl) and in experiment 39 the corresponding calcium compounds (Ca (GH)., CaGIp and Ca (OCl) ₂ ) were used instead of the sodium compounds.

** titration impossible - emulsion developed
** ^x titration impossible - color developed

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Gases 5

Example 7 Toothpaste formulation

Glycerin

water

Saccharin (sodium salt) precipitated lime Magnesium carbonate lvlagne sium hydroxide Soap (powder, neutral, white) gum tragacanth powder N-chlorosarcosine

Toothpaste formulation ^

Na t r ium c yflo r i d sodium bicarbonate calcium carbonate Tricalcium phosphate potassium chloride I.lagne s iumsul fat K-chlorosulfamic acid

- 19 -

47 Parts 3 Il 7, 04 Il ο, ,8th Il 20th , 3 ti 13th 2 Il 4, 35 Il 0, 76 Il ο, Il VJl Parts 44 Il 24 , 5 It 21 ti VJl VJl Il 3, 75 ti 1, Il 5

309685/1394

Claims (10)

Patent application P 2 3 29 752.1 National Patent Development CorD AnsDrüche 1. Composition for the treatment of short teeth in the human mouth, characterized by an aqueous solution of an N-halogen compound, in which the halogen is selected as chlorine, bromine and iodine, the group consisting of N-halogen-sulfamic acid and an organic N-halogen nitrogen compound 2 to 2o carbon atoms, and selected from the group consisting of N-haloamines containing a hydroxyl group, a sulfonic acid group, a carboxylic acid group and an N-acyl or N-amine acyl group, with one to 18 carbon atoms, and one sufficient amount of a buffer system to keep the pH at lo.5 to 11.5. 2. Composition according to claim 1, characterized in that the N-halogen compound is N-haloglycine. 3. Composition according to claim 2, characterized in that the N-haloglycine is N-chloroglycine. 4. A method for dissolving or destroying calcium carbonate or limestone deposits, in particular tartar, characterized in that that the deposits are brought into contact with an aqueous solution of an M-halogen compound, the Halogen is selected from chlorine, bromine and iodine, the group consisting of M-haloglycine, i .'-halosulfamic acid and 3 o 9 a a h / 13 y COPY an organic N-halogenated nitrogen compound with two to 2o carbon atoms, selected from the group which consists of N-haloamines, which have a hydroxyl group, a sulfonic acid group, a carboxylic acid group and an N-acyl or N-aminacyl group with 1 to 18 carbon atoms. 5. The method according to claim 4, characterized in that the solution has a ρΡί value of 8 to 12. 6. The method according to claim 4, characterized in that the pH value lo.5 to 11.5. amounts to. 7. The method according to claim 5, characterized in that the N-halogen compound is selected from the group consisting of N-bromoglycine, N-iodoglycine, N-halosulfamic acid, N-halo-2-amine ethanol, M-halosarcosine, N-halotarine, N-haloamines methanesulfonic acid, N-halo-N-acylglycine, N-haloalpha-amine isobutyric acid and N-haloethylenediaminetetraacetic acid. 8. The method according to claim 5, characterized in that the solution is applied in the oral cavity as a mouthwash. 9. The method according to claim 5, characterized in that the solution is applied to the teeth as a jet stream. 10. The method according to claim 5, characterized in that a thickening agent is present in an amount sufficient to form a pasta and that the pasty solution applied to the teeth by a brush. The patent attorney 309885/1394
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