DE2158910A1 - Injection device - Google Patents

Description

PATENT LAWYERS

DlPL-ING. BUSCHHOFF

DIPL-ING. HENNICKE

DIPL-ING. VOLLBACH

5 COLOGNE / RH.

KAISER WILHELM RING 24

File:

Registration number.

In IUl 1 COLOGNE, 11/23/71 please specify / O

Patent application

the gentlemen

Howard Merar Yanof, 5224 Eearsdale Road, Toledo , Ohio 43623 (USA)

and

Ben Pansky, 2809 Manchester Boulevard ,! Toledo , Ohio 43606 (USA)

Injection device

The invention relates to an injection device for injecting medicaments, in particular an injection device for so-called Speed sin j ections in which the drug is injected without the use of an injection needle to pierce the skin will.

Injection devices with which a drug can be delivered without the use of a hypodermic needle simply by virtue of the high jet velocity can be injected are known. Such so-called velocity injectors are often used for mass

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209827/0588

vaccinations used! for setting individual more individual However, these devices have syringes in the practice of a doctor or dentist or if they are used by diabetics themselves hardly found widespread.

The main reason for the limitation on speed injection devices for mass vaccination is involved in the intricate, space-consuming, and expensive construction of these devices too see. Numerous attempts have been made to provide an injection device that is simple, compact and relatively inexpensive of this type. However, these attempts have so far been unsuccessful for a number of reasons. For example, it was previously not possible to vary the dosage with the simpler devices, unless with Help of drug ampoules in the various size dimensions. Since, for example, in diabetics, the amount of medication to be injected varies depending on the exposure and food intake can change very strongly at daily intervals, in this case a large number of ampoules would have to be different Sizes are kept in stock. The known injection devices of cheaper design are often difficult to clean and cumbersome to fill up. The well-known injection devices also often have the disadvantage, ' that with them the injection speed is not sufficiently great. This is especially true for such devices which are supplied with injection pressure from a pressurized gas cartridge that is used for multiple injections. When the one

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individual injections are made at longer intervals, this can lead to a pressure drop in the gas cartridge due to the leakage losses, so that during a later injection the jet speed is not high enough. With series injections, the gas pressure in the cartridge drops continuously so that the jet velocity also decreases with each individual injection. To ensure, that In any case, if the jet speed is sufficiently high, the gas cartridges must be replaced more frequently than this would be necessary in itself.

The invention is primarily based on the object of a To create injection device for speed injections with which the aforementioned disadvantages and difficulties at least to be partially resolved. In particular, the invention aims at an injection device, which by simple and compact structure as well as high operational reliability.

The injection device according to the invention is characterized in that it has two housing parts which can move relative to one another , of which one as an injection housing has a spray chamber with at least one injection nozzle and with at least has a piston-like movable wall part for ejecting the injection agent, while the other housing part a carrier for at least one drug ampoule and at least forms a propellant gas cartridge, with channels and a valve between the injection housing and the carrier part

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device for the injection agent and propellant gas supply are provided. The carrier part is preferably designed in such a way that it is able to accommodate a large number of medicament ampoules and propellant gas cartridges. The device is advantageously or the like with a changing or switching device. provided with a selected vial can be contacted with a propellant cartridge from a storage position into the operating position in each case, in which the contents of this vial may be injected using the * contained in the cartridge propellant gas.

Preferably, said carrier part also has a container with a cleaning solution, which is also can be brought into a position in which the container is aligned with respect to the supply channels that the cleaning solution can at least be introduced into the medication-receiving injection chamber of the device to this rinse and clean. According to a preferred embodiment of the invention, the carrier part with the Injek- " tion housing rotatably connected and appropriate in the manner of a drum or the like. formed in a circular arrangement Has holders for the ampoules and the cartridges. It is advisable to provide a safety device in order to to prevent the cleaning solution from being accidentally is released. This can be done in an advantageous manner that the propellant gas cartridge, which is used to expel the Cleaning solution used is only such a low one

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Gas pressure means that no injection can take place here.

The above-mentioned holders for the ampoules and cartridges are appropriate in terms of shape and / or dimensions designed differently from each other. You can choose from reception chambers, Holes or the like. different dimensions or shapes exist. In particular, an execution is expedient in which the housing part forming the ampoule and cartridge carrier is both rotatable and in the direction of The axis of rotation is adjustable on the injection housing.

According to a further feature of the invention, means for opening or piercing the ampoules and cartridges are assigned to the holders or the receiving chambers. The movable wall part of the spray chamber "expediently consists of a piston, although other devices, such as a membrane or the like, could also be provided for this."

According to a further feature of the invention is a device for adjusting the amount to be received by the spray chamber Injectable amount provided. This quantity adjustment device preferably consists of a piston stroke limiting Stroke adjuster.

The valve device provided for actuating the injection device can be arranged on the injection housing. The valve device preferably has only a single valve member, which expediently consists of a rotary slide valve

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or the like. consists.

Furthermore, according to the invention, there is an injection device for speed injections provided, which has a first housing part for receiving a propellant gas cartridge and a drug vial and with one across from it Housing part movable second housing part is provided, which has a spray chamber with a spray nozzle and a piston-like movable wall part. Here is the an-order according to the invention made so that the propellant gas only by a movement of the second housing part relative to the first housing part can be guided in Eichtung onto the spray nozzle behind the movable wall part. In this case it is injecting of the drug is therefore only possible if the second housing part in the stated direction compared to the first housing part is adjusted, which is useful against the restoring force of a spring or the like. he follows. This ■ adjustment movement results from the fact that the injection device with the spray nozzle is pressed against the skin. To the drug To inject, in this case no lever, button or other actuating element needs to be activated. This is particularly advantageous when using the device for self-injections, e.g. by diabetics.

Further features of the invention are listed in the individual claims and are explained below with reference to the in the Drawing illustrated exemplary embodiments of the invention explained in more detail. In the drawing show:

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209827/0568

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1 shows an injection device according to the invention in section} FIG. 2 shows a cross section along line 2-2 of FIG. 1; FIG. 3 shows a view in the direction of line 3-3 of FIG to illustrate the actuation button of the valve device provided in the device according to FIG. 1} 4 shows a perspective illustration of a medicament or propellant gas cartridge which is used in the inventive Injection device is preferably used}

Fig. 5 in perspective, partially in Section, the valve device of the injection device according to Fig. 1}

6A and 6B are a view in the direction of line 6-6 of FIG. 5 with the valve in the filling position or in the injection position} Fig. 7 is a section along line 7-7 of Fig. 1} 8 shows a modified exemplary embodiment of the injection device according to the invention in section} 9 is a view along line 9-9 of FIG. 8; FIG. 10 used in the device according to FIGS. 8 and 9 Valve device in a perspective view.

The drawing, in the preferred embodiments of the He-. Finding are reproduced, shows in Fig. 1 an injection device, which essentially consists of an injection head 10 adjustable in the injection volume, a receiving and feeding

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guide device 12 for the drug and the propellant and a valve device 14 is for adjustment the inflow of medicament and propellant from the device 12 to the device 10 is used.

In Pig. 1 the injection device A is shown somewhat larger than in reality, although of course the shape and / or the dimensions of the device and its parts are different could be.

The aforementioned components 10, 12 and 14 are preferably accommodated in a common housing or housing body 16, made of various materials, such as aluminum, stainless steel, certain plastics and ceramics Substances and the like., Can exist. The injection head 10 is located at the front end of the housing body 16 has a cylindrical chamber 18 which is arranged laterally next to the lower end face of the housing body 16 and one internally threaded at its inlet end Has expanded section 20. In this bore section a thread stopper 22 is screwed, one to the outside protruding threaded collar 24 carries. The plug 22 has on its inside a conical recess 26, which with the The longitudinal axis of the chamber 18 is aligned and widens conically towards the chamber 18. On the threaded collar 24 of the plug is a spray nozzle 28 screwed on. The chamber and all channels are made of one material or with one Lined material that has a non-wettable surface.

2 1 - ⁴ ? 7 / Π568 - ⁹ -

The spray nozzle 28 can be of different shapes and, for example, depending on the type of syringe to be set, outlet nozzles have different dimensions. In the illustrated embodiment, the spray nozzle 28 consists of a machined body which is provided with an opening 30 which narrows conically towards the outlet end and which is connected to the conical bore 26 is aligned and ends in an outlet nozzle 32. The outlet nozzle 32 is conveniently in a nylon socket 34 formed, which is inserted with a press fit into the nozzle and sealed by means of an O-ring. This training of the Nozzle body offers the possibility of providing it with spray nozzles of different dimensions.

In the cylindrical chamber 18 there is a movable wall part in the form of a piston 36, which the chamber into a Drug receiving injection chamber 38 and a propellant gas chamber 40 divided. Instead of the piston could be in certain Cases just as well a fixed membrane or the like. be used. The piston can be made of different materials exist. In the present case it consists of a plastic or polymer material such as polyethylene or polypropylene. The piston 36 is sealed against the cylinder wall of the chamber bore and is in the cylindrical chamber slidably guided. The piston stroke is adjustable in order to be able to adjust the receiving volume of the injection chamber 38. This setting takes place by means of a threaded pin 42 which is screwed into a threaded bore 44, which

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at the top of the housing body 16 in alignment with the chamber 18 is arranged. By turning the pin, the piston stop and thus the upward cap) of the piston to adjust. It is thus possible to determine the volume of the spray chamber 38 and, accordingly, the amount of injection agent to be injected infinitely adjustable. The threaded pin 42 is enclosed at its upper end by a threaded bushing 45. Of the Pin 42 and socket 4 $ have labels or markings and the like and thus the respective setting of the amount of injection agent.

When the injection chamber 38 is filled, the piston 36 moves in the chamber up to the stop at the lower end of the pin 42 upwards. Subsequently, in the upper chamber 40 Propellant gas are introduced to the piston 36 under high Pressure in the chamber 18 to move downwards and thereby the drug from the injection chamber 38 at high injection speed squirt out of the nozzle 32. The friction gas pressure is so great that the injection medium emerging from the nozzle 32 has such a speed that it penetrates the skin tissue of the patient or to the desired level ! Penetrates deep into the muscle meat. It goes without saying that the spray nozzle or the nozzle dimension as well as the The number of nozzles can vary depending on the type of injection to be given and the other requirements.

200027 / 056Ö

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In connection with the injection head described above, different feeding devices can be used Provide propellant gas and injection material. In the illustrated preferred embodiment, this exists Device 12 from a movable housing part, which as a carrier and receiving housing for a larger number of Drug ampoules and propellant cartridges are used. This housing part can be brought into different positions by turning it with respect to the injection head, in each of which an ampoule and a propellant gas cartridge are in the injection position. The housing has a rotatable cylinder on, which is provided with a larger number of receiving chambers in the form of through axial openings. In Small, sealed propellant gas cartridges and injection agent ampoules can be inserted into these receiving chambers. The ones in the The ampoules located in the receiving chambers can be individually connected to the injection chamber via the valve device 14 38 bring. Accordingly, the propellant gas cartridges can be adjusted so that they are individually by means of the valve device 14 · can be connected to the propellant gas chamber 40 of the injection head. In 3pig. 4 is an ampoule or Cartridge expedient design shown, which can be used in the device according to the invention.

As can be seen in particular in FIGS. 2 and 7, the Cylinder drum 48 on two concentric circles said receiving chambers consisting of axial openings.

■? Γι ':' ?. 7 / whether 6 a

There are seven openings on the outer circle 50 for receiving propellant gas cartridges, the openings 50 have the same diameter as one another} their diameter is preferably greater than the diameter on the inner circle lying holes 52. On the inner circle There are also seven bores, each of which has the same diameter and which is used to hold the injection ampoules to serve. The injection agent ampoules are expediently somewhat larger or smaller than the propellant gas cartridges. It will be understood that the openings 50 and 5? could also have the same dimensions «However, in order to prevent that inadvertently a propellant gas cartridge could be inserted into an injection medium opening are those mentioned Openings preferably of different shapes and / or Dimensions.

There is an eighth opening on each of the two rope circles, which is used to hold a cleaning device. The opening 55 on the inner pitch circle is used to receive a Cartridge containing a cleaning agent, such as a buffered physiological saline solution with a disinfectant additive Or the like. Contains. The opening 54, which is located on the outer pitch circle and has a larger diameter, is used for receiving a propellant gas cartridge, the diameter of which is slightly larger than the diameter of the other propellant gas cartridges, wherein However, the propellant gas pressure in this first-mentioned cartridge is appropriately lower than in the one used for the injection.

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the propellant cartridges. The opening 53 ″ has a larger diameter than the openings 52, so that the cartridge containing the cleaning agent cannot be accidentally inserted into one of the injection agent openings Propellant cartridges excluded, so that the cleaning agent is not expelled under any circumstances at a speed at which an injection can occur. To prevent unintentional injection of the cleaning agent, other measures could be taken. For example, the corresponding openings could also have other shapes or with I paint markings and the like.

Like Pig. 1 shows, the cylinder drum 48 is rotatably mounted on a hollow threaded shaft 56 which is connected to the housing body 16 is screwed. The housing body 16 has an axial Peripheral flange 58 on which the rotatable cylinder drum encloses * The cylinder drum 48 has on its inner end face a cover plate 60, which by means of a threaded sleeve 63, is releasably connected to the drum. The cover plate 60 rests against the inner ends of the cartridges and prevents them from moving to the left in the cylinder drum during the advance movement. The cover plate 60 has openings which are aligned with the bores of the cylinder drum, but which are somewhat smaller than the openings openings 50, 52, 53 and 54 of the drum.

The injection device is also provided with devices

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215891Q

to open or pierce the ampoules and cartridges and to bring them into communication with the channels of the valve device 14. This device consists of hollow needles 62 and 64, which are held in bores 66 and 68. The needle 62 is on a threaded part 69 and the needle 64 is on a threaded part 70 attached so that the needle ends into the openings 50 and 52 protrude. In this way, the inner ones Ends of the cartridges and ampoules pierced as they are moved towards the needle tips.

To rotate the cylinder drum 48, a rotary and progressive mechanism is provided, which is a pot-shaped rotating piece 72, which includes the cylindrical housing flange 53 and is connected to the cylinder drum 48. The turning piece 72 consists of the bottom wall 73 and a cylindrical one Shell part 74, which the sleeve-shaped! Flange extension 58 of the housing body 16 tightly encloses. The bottom part 74 is by means of a screw 75 with an inwardly protruding Shank 76 releasably connected. The shaft 76 is guided displaceably in the outer end of the hollow shaft 56. He has a flange 78 which is guided closely in the inner bore of the hollow shaft 56. Between the flange 78 and a The inner flange 81 of the hollow shaft 56 is a compression spring 80 arranged, which presses the shaft 76 and thus the cylinder 48 inward. At the outer end of the shaft 76 is a Snap ring 82 arranged. It is therefore possible to remove the pot-shaped rotating piece 72 by loosening the screw 75, where-

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in the case of the snap ring 82 prevents the shaft from sliding into the interior of the hollow shaft 56 · When the rotating piece is removed 72 become the outer ends of the ampoules and cartridges accessible on receiving openings.

The exact alignment of the cylinder drum 48 and thus the Gas and injection medium cartridges opposite the needles 62 and 64 is effected by a pin 84 attached to the inner surface of the bottom part 73 of the rotating piece and fastened in bores 86 (Pig. 7) on the face of the facing sleeve is insertable. It will be understood that the bores 86 opposite the rows of the ampoules and cartridges receiving openings of the cylinder drum 48 are aligned. To the

CYLINDER DRUM 46 w switch one step forward and therewith

a new set of cartridges aligned with the pins or To bring needles 62 and 64, only the cup-shaped one needs Turning piece 72 into the in Pig. I dot-dash position to be withdrawn. In this position, the needles 62 and 64 are outside the receiving openings of the Cylinder drum 48 so that it can be rotated until the centering pin 84 with the next following centering opening 86 aligns. The cylinder drum 48 with the rotating piece 72 can then be shown in fig. 1 must be pushed back to the left to pierce the new cartridge and ampoule set using needles 62 and 64.

For supplying the propellant gas and the injection agent in the chambers 38 and 40 of the injection head 10 can

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Use devices of different types. With the preferred one Embodiment, a rotary slide valve 90 is provided for this purpose, which, in one between the Components 10 and 12 of the injection device located bore 92 is arranged. The rotary valve is cylindrical and has a larger diameter central section 94 and, in contrast, end sections which are tapered in diameter 96 and 98. In the middle section 94 are ■ the canals that connect with the gas and insect Produce ionic channels. The lower tapered end portion 98 of the rotary valve is rotatable in a plug 100 and displaceably arranged, which is screwed into a threaded bore 102 on the underside of the housing body 16 is. A flange ring 104 is arranged displaceably in the bore 102. A compression spring 106 is supported on the one hand against the flange ring and on the other hand against the inner surface of the threaded plug 100. The flange ring 104 lies down against a shoulder at the transition between sections 94) and 98 of the rotary valve. The rotary valve is therefore normally pushed up into the position shown in FIG.

The upper tapered end portion 96 of the rotary valve 90 has a button or the like. 108 on, which by means of a clamping screw 110 or is releasably connected to the section 96 in some other way. With the help of the button 108 the Turn the rotary valve in the bore 92 and push it against the back

^τ ■ -! ■; ■, G 8

press the actuating force of the spring 106 downwards in the hole, to bring the various channels between the components 10 and 10 in connection. The lower end of the rotary valve 90 is slotted at 93, with a rib (not shown) carried by the plug 100 or the like. in the slot can enclose. The rotary valve can therefore only be pressed down when the slot and the rib are aligned with one another, which in the Ingektionsstellung the Case is. A spring-loaded piston 111 is located under the actuation button 108 and engages in recesses which are arranged on the underside of the button 108. The spring-loaded piston gives a when you turn the knob Display of the respective button setting.

The arrangement of the supply channels for the propellant gas and the Ingektionsmittel to the insect head 10 can be in particular Figs. 3, 5? Refer to 6A and 6B. The valve device 14 connects the needle 62 with a channel 112, via which the injection agent of the injection chamber 38 of the cylinder chamber 18 is fed. Accordingly, the needle 64 is over the valve device can be connected to a channel 114 which is connected to the propellant gas chamber 40 via side channels 116 is. As FIG. 5 in particular shows, the rotary slide valve 90 has a transverse channel 117 in the upper region. When the slide is printed downwards, this transverse channel connects the channel of the needle 64 with the channel 114. In the upper, in The position of the rotary valve shown in FIG. 5 is the channel

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114 connected to an inner channel 118 which leads to the lower end of the slide 90 and here with a channel 120 of the Plug 100 is in communication. In the slide position according to the Mg. 1 and 5 is therefore the propellant gas chamber 40 to the Connected atmosphere, so that there is no internal pressure in the propellant gas chamber.

The rotary slide valve 90 also has a transverse channel 122 which is arranged offset by an angle of 45 ° with respect to the channel 117. If the knob 108 is rotated into a position in which an indicator arrow 124 arranged on it points to the "CLOSED" position, the slide is in its upper position shown in FIGS. Accordingly, the duct 114 is connected to the outside air via the duct 118, while the duct 112 has no connection to the transverse duct 122. In this position, therefore, no propellant gas and no injection agent can get into the cylinder 18 via the needles 62 and 64. If the valve is rotated into a position in which the arrow 124 points to the marking "I ¹ UlLEN", the transverse channel 122 connects the needle 62 with the channel 112. The injection agent can therefore flow from the ampoule into the injection chamber 38. The injection agent is preferably under a low pressure in the ampoule, so that it is pressed out of the ampoule into the chamber 38, lifting the piston 36 up to the stop on the threaded pin 42, thereby filling the chamber by the set volume. As soon as the spray chamber is filled, the rotary

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slide rotated by 45 °, the arrow 124 in the position "SPLASH" arrives. Here, the channel 114 is connected to the channel of the needle 64 via the transverse channel 117, whereby the slide is in the raised position according to FIGS. The propellant gas channel is therefore still closed. In order to carry out the injection, it is only necessary to press the pushbutton 108 downwards in order to do so channel 117 in alignment with needle 64 and channel 114 bring. With the help of a single valve, all filling and injecting processes can be carried out easily Way to perform.

In order to clean the spray chamber of the device, only the cylinder drum 48 needs to be indexed so that that the receiving chambers 53 and 54 in the aligned position to the Needles 62 and 64 arrive. Then the same filling and injecting operations are performed, whereby the Cleaning agent is pressed through the aforementioned channels into the spray chamber and sprayed out of this. The propellant gas pressure of the used for the cleaning process, The propellant gas cartridge located in the chamber 54 is preferably so small that inadvertent injection of the cleaning agent cannot occur. The sleeve-shaped parts 58 and 74 can have markings on their outer circumference and indicators and the like can be provided which the presence of the cleaning cartridges in the channels of the needles 62 and 64 displays.

Although the use of the cylinder drum described above offers particular advantages, but other adjustable or switchable devices such as e.g. Carriages and clamping devices, multiple drums or Elemmhalter, etc. for receiving the cartridges and ampoules can be used. It is understood that instead of the seven receiving rooms shown in the drawing for Propellant and Ing ektionsmittelpatronen also a different number of such rooms could be provided. However, it is "The arrangement of seven receiving chambers for the ampoules and the cartridges is practical, as in this case the device is able to take up a full weekly requirement of a drug.

8 and 9 show a modified embodiment of an injection device according to the invention. This Device differs from that according to FIGS. 1 to 7 both in terms of the injection head and in terms of of the supply part connected to it, which in this case only has a single drug ampoule and holds a single propellant gas ampoule. However, this could also be the case with the injection device described above Embodiment provided storage and supply part 12 can be used.

The injection device according to FIGS. 8 and 9 has an essentially rectangular housing 150 made of metal, plastic or ceramic material. The housing is equipped with a central

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len cylindrical bore 152 of relatively large Provided diameter, which extends from the lower housing side through the housing body inward and at the top is limited by a narrow annular flange 154-. A cylindrical housing part 156 is displaceable in the bore guided. The housing part 156 is rotated by a spring (not shown) which engages in a groove hindered in the cylindrical bore 152. A retaining ring 158 that screws into the threaded lower end of the bore 152 is, secures the housing part 156 in the bore. The housing part is of a relatively weak one Compression spring 160 between a shoulder 162 and the Flange 154- is arranged, held in contact with the ring 158.

The housing part 156 has an axial inner bore 164-, which forms the injection and pressure chamber. At the lower end, the bore 164 has an outlet 166 with a small diameter which connects to an outlet nozzle 168. The outlet nozzle 168 is arranged on a screw cap I70, which is screwed detachably and exchangeably onto the tapered thread end of the housing part 156.

A piston 176 slides in the inner bore 164 and thus the inner bore is divided into the propellant gas pressure chamber 172 and the injection chamber 174- which receives the medicament. The piston 176 seals the two chambers against each other and is

2 0 CC ? 7/0 5 6 a

in the inner bore freely "movable in vertical direction.

In this exemplary embodiment, the amount of injection agent is set by means of a threaded bushing 178, which is screwed into the upper end of the bore 164. By turning the threaded bushing 178, the lower Adjust the piston stop surface 180 and thus the piston stroke or the volume of the injection chamber 174. The setting the threaded bushing 178 can be read on a scale which is located on the housing 150 and the top of the threaded bushing 178 is located.

In this injection device, a special device is provided with which the piston 176 moves into its upper stroke position can bring to then fill the injection chamber 174 with the injection agent. This device has a shaft that can be reciprocated in the vertical direction and has a widening at its lower end, here in Has the shape of a spherical head 184. The upper end of the shaft 182 is connected to a push button 184 which is connected to a radial flange sealing surface 186 is provided, which is against a machined shoulder surface 188 of the inner bore the sleeve 178 places. As a result, the pressure chamber 172 is sealed at the top. A coil spring counteracts this the underside of the push button 184 and thus normally holds the shaft and the push button in the raised position shown in Fig. position shown. The spring 190 is supported with her lower end on a snap ring 192, which is in an inner

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the socket 178 is seated.

To bring the piston 176 into its upper stroke position, the push button 184- is pressed downwards, whereby the Ball head 184 into a correspondingly shaped opening 194 of the Piston 176 engages. When the push button is released, the spring 190 presses the push button together with the shaft and the piston 176 up to the stop of the piston on the surface 180. As soon as the piston hits the stop surface 180 runs, the spring 190 pushes the ball head 184- out of the piston recess 194, whereby the flange 186 of the Push button against the shoulder surface 188 places. The piston is in its upper stroke position due to friction on the inner wall the bore 164 held. With the piston raised, the injection agent can then be introduced into the chamber 174 will.

In the case of the injection device shown, there are drug ampoules and gas cartridges 198 and 199 arranged in respective bores extending from the right end of the housing 154 extend axially into this hdno. The holes will be closed by a closure plate 204 which is connected to the housing by means of a screw 206. By Loosening the screw 206, the closure plate 204 can be removed from the housing in order to remove the used cartridges and insert new cartridges. At the inner ends of the bores receiving the cartridges, needles are arranged,

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which pierce the cartridges when inserted.

The supply of the injection agent from the ampoule 198

follows via a valve device 200 and a channel 202 which is connected to the spray chamber 174 via the channel 166. The ampoule 198 is preferably under a low internal pressure which is sufficient to force the injection agent through the named channels into the injection chamber 174. However, from Mg. 8 it can be seen that the drug vial here a Ψ different shape than in the embodiment according to Fig. 1. It should be understood that also in the apparatus shown in FIGS. 8 and 9, drug vials of in connection with the Fig 1 to 7 described type can be used.

The valve device 200 has a cylindrical valve member 210 which is arranged with a close fit in a cylindrical bore 212 of the housing 150. The valve member 210 is freely rotatable in the bore} it is held in the bore by a locking ring 214. The locking ring 214 w is seated in a groove 216 which encloses the bore 212 on the upper side of the housing. The valve member here has a flange 218 which lies under the disk 214.

For connecting the propellant gas and injection agent supply lines with the two chambers 172 and 174 is the valve member 210 provided with transverse channels. At the lower end of the valve member 210 is a channel 218, which when rotating

203027/0568

of the valve member in the "filling" position according to FIG. 9 The channel of the needle '220 connects to the channel 202. Here is There is no connection between the upper transverse channel 222 and the gas supply needle 224, so that the device cannot be accidentally can be triggered. After the injection chamber 174 has been filled, the valve member 210 is rotated into the "INJECTION" injection position, whereby the transverse channel 222 is in communication with needle 224 and channel 226. In this position, however, the propellant gas chamber 172 cannot yet contain any gas flow in. The connection channel 228 of the chamber 172 leads through the wall of the housing part 156 (FIG. 8). He is aligned in the vertical direction with respect to the channel 226, but is in the normal position of the housing part 156 at a certain distance below the mouth of the channel 226. This means that the housing part 156 and the Inner wall of the bore 152 form a valve which blocks the flow of propellant gas to the chamber 172. Should that Medicines are injected, so only needs the nozzle mouthpiece 170 being pressed against the patient's skin, whereby the housing part 156 is pushed up against the restoring force of the spring 160 and the channel 228 is connected is brought with the channel 226, so that the propellant gas now enter the chamber 172 and that in the spray chamber 174 inject the medication through the nozzle opening can.

It goes without saying that in the above-described configuration

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examples of various changes to the individual parts can be made. For example, instead of of the rotatable valve member shown is another valve, e.g. a slide valve or a toggle or snap valve or the like. , use. Different O-ring seals and other seals can be used to seal the various surfaces are provided.

The cleaning of the injection device described above can be described in connection with FIGS. 1 to 9 Perform this way by placing a pressurized detergent ampoule into the receiving chamber for the Pharmaceutical ampoule 198 is inserted and then the injection chamber is filled and the cleaning agent is sprayed out. However the device according to FIGS. 8 and 9 is provided with a channel 230 through which a cleaning agent is introduced can be to the spray chamber 174 · and the needle 220 as well flush the ampoule 198 through. It can be seen from FIG. 8 that a second needle 232 is connected to the ampoule 198. A connecting channel 234 connects this needle 232 with the Bore 212. The valve member 210 has a transverse channel 236 which, after the valve member has been rotated, into the cleaning area spo si tion establishes the connection between the channels 230 and 234. In the cleaning position is also over a transverse channel 238 establishes a connection between the channel 202 and the needle 220. As a result, the detergent using an injection syringe through the canal

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250 and needle 252 back via needle 220 to the chamber be rinsed.

The nozzle tips 28 and 170 can be of various types of injections together with the drug and propellant ampoules with color markings or the like. be provided. For example can be used for intramuscular injections with a higher gas pressure and with a corresponding diameter sized nozzle. In this case, the appropriate nozzle can be given the same color mark as that Propellant gas cartridge.

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Claims (30)

Expectations Il injection device for speed injections, characterized in that it has two mutually movable housing parts, one of which, as an injection housing, has a spray chamber (38, 174) with at least one injection nozzle (32, 168) and with at least one piston-like movable wall part (36, 176) for ejecting the ', fc injection agent, while the other housing part forms a carrier for at least one drug ampoule and at least one propellant gas cartridge, channels and a valve device (14, 200) for the injection agent and propellant gas supply being provided between the injection housing and the carrier part. 2. Injection device according to claim 1, characterized in that that the carrier part has holders (50, 52) for a plurality of medicament ampoules and propellant gas cartridges and | connected to the injection housing (16) so that it can be switched forward is that in each case a predetermined ampoule cartridge set from a supply position to the injection position is adjustable. 3. Injection device according to claim 1 or 2, characterized in that that the carrier part (48) is rotatably connected to the injection housing (16). 4. Injection device according to claim 3, characterized in that r H that the carrier part (48) is designed in the manner of a drum, the holders (50, 52) for the ampoules and the cartridges. 5- injection device according to claim 4, characterized in that that the holders (50, 52) for the ampoules and the cartridges are arranged distributed on concentric circles are. 6. Injection device according to claim 4 or 5 »characterized in that that the holders (50, 52) for the ampoules and cartridges are designed differently from one another, 7. Injection device according to claim 6, characterized in that the holders (50, 52) for the ampoules and cartridges consist of receiving chambers that have different dimensions and / or shapes. 8. Injection device according to one of claims 3 to 7, characterized in that the carrier part (48) is arranged both rotatably and adjustable in the direction of the axis of rotation on the injection housing (16). 9. Injection device according to one of claims 1 to 8, characterized in that the holders or receiving chambers (50, 52) Means (62, 64, 220, 224) for opening or piercing the ampoules and cartridges are assigned. 10. Injection device according to one of claims 1 to 9, characterized in that the carrier part display means for 2 0 0 Z 2 7/0 5 6 8 show the number of unused ampoules and cartridges still present 11. Injection device according to one of claims 1 to 10, characterized characterized in that the carrier part (48) has a holder or on took ekamm he (53) for one with a cleaning solution Has filled container, which for cleaning at least the spray chamber to the injection medium lines is connectable. 12. Injection device according to one of claims 1 to 11, characterized in that the movable wall part (36, 176) from consists of a piston. 13. Injection device according to one of claims 1 to 12, characterized by a device (42, 178) for adjustment the amount of injection agent to be taken up by the syringe. 14. Injection device according to claim 13, characterized in that the w Mengeneinstellvorrichtung (42, 178) limiting the piston stroke of a stroke adjusting member consists. 15. Injection device according to one of claims 1 to 14, characterized in that the valve device (14) on the injection housing (16) is arranged. 16. Injection device according to one of claims 1 to 15, characterized characterized in that the valve device is a rotatable - 31 2 0-J: '' 7/056 8 Valve member (90, 210), such as in particular a rotary slide valve. 17. Injection device according to claim 16, characterized in that that the rotary slide (90) is rotatable and axially displaceable against a restoring force. 18. Injection device according to one of claims 1 to 17, characterized through a venting device for the spray chamber (38, 174) 19. Injection device according to one of claims 1 to 18, characterized by means by which the diameter, the number and / or the length of the spray nozzles can be varied. 20. Injection device according to one of claims 1 to 19, dadu ', b. characterized in that the spray nozzle is arranged on a removable end wall of the spray chamber (38, 174-). 21. Injection device, in particular according to one or more of claims 1 to 20, characterized in that it is provided with a first housing part (150) which receives the propellant gas and the medicament and a second housing part (156) which is movable relative to this and which has a spray chamber ( 17 * 0 with a spray nozzle (168) and a movably arranged wall part (176), and that the propellant gas only by a movement of the second housing part (156) relative to the first housing part (150) in the direction of the spray nozzle behind the movable wall] (I7 ^f j) is zuüeitbar. ·.) '■ · Ii 22. Injection device according to claim 21, characterized in that the second housing part (156) in the first housing part (150) is arranged displaceably. 23. Injection device according to claim 21 or 22, characterized in that that the propellant gas flow to the second housing part (156) through the two housing parts (150, 156) arranged cooperating valve surfaces is interrupted. 24. Injection device according to one of claims 21 to 23, characterized by a pretensioning device, such as in particular a üfeder (160), which the second housing part (156) holds in the propellant gas blocking position. 25. Injection device according to one of claims 21 to 24, characterized by a device (178) with which the capacity of the spray chamber (174) can be adjusted. 26. Injection device for speed injections, which P in a housing is a spray chamber with an injection nozzle and a piston-like movable wall part which is adjustable for ejecting the injection agent is, characterized in that a pressure vessel is provided to fill the spray chamber (174) in which the Injection agent is under such a pressure that it is when the container is connected to the injection chamber under the Pressure effect flows into the spray chamber. 27 · Injection device, in particular according to one or more of Claims 1 Ms 26, characterized in that it is provided with a container for a cleaning agent that "when the injection agent supply is switched off by. Actuation of an actuator can be introduced into the spray chamber (Γ74-). 28. Injection device according to claim 27, characterized in that that the container with the cleaning agent together with the container or containers for the injection agent on the movable carrier part (48) is arranged. 29. Injection device according to claim 28, characterized. that the receiving space (53) for the container receiving the cleaning agent on the pitch circle of the one Cylindrical drum existing carrier part is on which see the receiving spaces (52) for the ampoules containing the injection agent or the like. are located. 30. Injection device according to one of claims 27 to 29, characterized in that the cleaning agent under a lower pressure can be injected from the injection chamber (174) is called the injection. 2 0 0: · .: '> 7/0 G 6 Empty soap ft