DE2150884A1 - BLOOD TEST AIDS - Google Patents

BLOOD TEST AIDS

Info

Publication number
DE2150884A1
DE2150884A1 DE19712150884 DE2150884A DE2150884A1 DE 2150884 A1 DE2150884 A1 DE 2150884A1 DE 19712150884 DE19712150884 DE 19712150884 DE 2150884 A DE2150884 A DE 2150884A DE 2150884 A1 DE2150884 A1 DE 2150884A1
Authority
DE
Germany
Prior art keywords
blood
glass
blood test
grains
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19712150884
Other languages
German (de)
Other versions
DE2150884B2 (en
DE2150884C3 (en
Inventor
Walter Sarstedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SARSTEDT KUNSTSTOFF
Original Assignee
SARSTEDT KUNSTSTOFF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE789954D priority Critical patent/BE789954A/en
Priority to DE2010830A priority patent/DE2010830C3/en
Priority to DE19702034457 priority patent/DE2034457A1/en
Priority to DE19717111793U priority patent/DE7111793U/en
Application filed by SARSTEDT KUNSTSTOFF filed Critical SARSTEDT KUNSTSTOFF
Priority claimed from DE19712150884 external-priority patent/DE2150884C3/en
Priority to DE19712150884 priority patent/DE2150884C3/en
Priority to GB5361271A priority patent/GB1390621A/en
Priority to DE2245584A priority patent/DE2245584C3/en
Priority to CH1477572A priority patent/CH548765A/en
Priority to CA154,125A priority patent/CA1012023A/en
Priority to US297219A priority patent/US3886928A/en
Priority to NL7213918A priority patent/NL7213918A/xx
Priority to JP10194672A priority patent/JPS575541B2/ja
Priority to FR7236318A priority patent/FR2157471A5/fr
Publication of DE2150884A1 publication Critical patent/DE2150884A1/en
Publication of DE2150884B2 publication Critical patent/DE2150884B2/en
Publication of DE2150884C3 publication Critical patent/DE2150884C3/en
Application granted granted Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A61B5/150519—Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components

Description

Dr. A. Menfael DipUng.W.DahikeDr. A. Menfael DipUng.W.Dahike

Ρί-tenlanwäiteΡί-tenlanwäite

«^:ti» bei Köln Oktober«^: Ti» near Cologne October

ror.kenforst 1o7 ^ror.kenforst 1o7 ^

Firma Walter Sarstedt Kunststoff-SpritzgußwerkWalter Sarstedt plastic injection molding plant

Nümbrecht / RommelsdorfNümbrecht / Rommelsdorf

"Hilfsmittel für Blutuntersuchung" Zusatz zu Patent P 20 34 457.4)"Aid for blood testing" addendum to patent P 20 34 457.4)

Im Hauptpatent wurde als Hilfsmittel für Blutuntersuchungen ein fester, granulatförmiger Träger und eine von diesem getragene, die Oberfläche der einzelnen Körner in einer dünnen Schicht bedeckende, die Blutgerinnung beeinflussende Substanz vorge β chla ge η.The main patent was used as an aid for blood tests a solid, granular carrier and one carried by this, A substance that covers the surface of the individual grains in a thin layer and affects blood coagulation proposed β chla ge η.

303816/0487303816/0487

Insbesondere war dabei vorgesehen, daß der Träger aus einem Kunststoff bestellt, dessen spezifisches Gewicht zwischen dem .des Serums bzw. des Plasmas einerseits und dem des Blutkuchens bzw. der sedimentierten Blutkörperchen andererseits liegt.In particular, it was provided that the carrier ordered from a plastic whose specific weight between the . of the serum or plasma on the one hand and that of the blood cake or sedimented blood cells on the other.

Wie im einzelnen im Hauptpatent ausgeführt wurde, kann es in einigen Fällen erwünscht sein, die Blutgerinnung in einem Ge- ^ fäß durch Zugabe von Körnern der genannten Art zu beschleunigen, in anderen Fällen dagegen, diese zu verlangsamen oder völlig zu verhindern. Es sind verschiedene chemische Substanzen bekannt, die, chemisch in den Blutgerinnungsprozeß eingreifend, diesen beschleunigen oder verlangsamen.As detailed in the main patent, it may be desirable in some cases to prevent blood clotting in a ^ accelerate the vessel by adding grains of the type mentioned, in other cases it is against slowing it down or preventing it entirely. They are different chemical substances known which, chemically intervening in the blood coagulation process, accelerate or slow it down.

Es ist aber auch bekannt, daß die Blutgerinnung ohne Eingriff in den Chemismus der Blutgerinnung, lediglich durch physikalische Mittel, beeinflußt werden kann, beispielsweise durch die Oberflächenspannung einer Grenzfläche zwischen der Substanz W des Behälters und dem Blut. So werden deutlich verlangsamte Blutgerinnungszeiten in Gefäßen aus thermoplastischen Kunststoffen, insbesondere aus Polyäthylen und Polypropylen, gegenüber Gefäßen aus Glas, beobachtet.However, it is also known that the blood coagulation can be influenced without interfering with the blood coagulation chemistry, merely by physical means, for example by the surface tension of an interface between the substance W of the container and the blood. Significantly slowed blood coagulation times are observed in vessels made of thermoplastics, in particular made of polyethylene and polypropylene, compared to vessels made of glass.

χ In manchen Fällen ist diese Verzögerung der Blutgerinnung in ι Kunststoffbehältern ausgesprochen unerwünscht. In solchen Fällen hat man dann bisher auf die Verwendung von Kunststoffgefäßen anstelle von Glasgefäßen verzichtet. χ In some cases, this delay in blood clotting in plastic containers is extremely undesirable. In such cases, the use of plastic vessels instead of glass vessels has hitherto been dispensed with.

309816/0487309816/0487

Ausgehend von der Lehre des Hauptpatents und zur Lösung der dort gestellten Aufgabe für den vorstehend geschilderten besonderen Zweck wird erfindungsgemäß vorgeschlagen, daiB die auf der Oberfläche der Körner befindliche, die Blutgerinnung beeinflussende Substanz Glas in Gestalt feiner, in die oberflächennahen Schichten der Körner eingebetteter leuchen, vorzugsweise Fasern, ist.Based on the teaching of the main patent and to solve the problem set there for the special one described above Purpose is proposed according to the invention that the On the surface of the grains, the substance that affects blood coagulation is glass in a finer shape, in the near-surface Layers of the grains of embedded glow, preferably fibers, is.

Derartige Granulatkörner, insbesondere aus einem hochpolymereη thermoplastischen Kunststoff, die an ihrer Oberfläche mit Glasfasern oder feinen Glasteilchen in anderer Gestalt besetzt sind, bewirken, wenn sie mit Blut in Berührung gebracht v/erden, eine erheblich beschleunigte Blutgerinnung. Dabei besitzt dieses Hilfsmittel noch den besonderen Vorteil, daß es nicht in den eigentlichen Chemismus der Blutgerinnung als Reaktionspartner eingreift, sondern lediglich, wahrscheinlich aufgrund geänderter Oberflächenspannung, von Außen in diesen beschleunigend eingreift. Es können also Blutuntersuchungen jeder Art vorgenommen werden, ohne daß hinzugefügte chemische Substanzen dabei störend wirken*Such granules, in particular from a high polymer thermoplastic material, the surface of which is covered with glass fibers or fine glass particles in a different shape if they come into contact with blood, they cause a considerably accelerated coagulation of the blood. It owns this Aid still has the particular advantage that it does not intervene in the actual blood coagulation chemistry as a reaction partner, but only, probably due to changed surface tension, intervenes from the outside in an accelerating manner. So blood tests of any kind can be used can be carried out without added chemical substances having a disruptive effect *

V/esentlich für die Wirkung des erfindungsgemäß vorgeschlagenen Hilfsmittels ist es, daß die Glasteilchen aus der Oberfläche des sie tragenden Körnchens herausragen, ohne selbst durch die Substanz des Granulats eingehüllt und abgedeckt zu nein.V / aterial for the effect of the inventively proposed aid it is that the glass particles from the surface of the protrude supporting granule encased by the substance itself without the granules and covered to no.

309816/0487309816/0487

Besonders geeignet für diesen Zweck ist ein Kunststoffgranulat üblicher Korngröße, wie es zur Beschickung von kunststoffverarbeitenden Maschinen, beispielsweise Extrudern, verwendet wird. Es eignen sich grundsätzlich alle Kunststoffe, sofern sie nicht aus chemischen Gründen "bedenklich sind und die Blutunter-Buchung stören, für diesen Zweck. In den einzelnen Körnchen des Granulats sollen dann feine Glasteilchen, beispielsweise ™ kurze Pasern aus Glas, enthalten sein. Ein solches Kunststoffgranulat bzw. Halbfabrikate aus Kunststoff, die mit Glasfasern oder Glasteilchen verstärkt sind, sind schon bekannt. Sie sind aber nur dann als Hilfsmittel für Blutuntersuchungen im Sinne der Erfindung geeignet, wenn die Glasteilchen, beispielsweise die Enden der Fasern, aus der Oberfläche der Kunststoffteilchen nach außen vorstehen, und damit physikalisch wirksam werden. Bei der Herstellung eines solchen Granulats, das als Hilfsmittel für Blutuntersuchungen im vorgenannten Sinne geeignet ist, ist also darauf zu achten, daß die Glasteilchen oder zumindest einige derselben aus der Oberfläche nach außen vorstehen. Plastic granules are particularly suitable for this purpose usual grain size, as it is used for feeding plastics processing Machines such as extruders is used. In principle, all plastics are suitable, provided they are not for chemical reasons "are questionable and the blood under-booking bother for this purpose. Fine glass particles, for example ™ short leads made of glass. Such a plastic granulate or semi-finished products made of plastic, which are reinforced with glass fibers or glass particles, are already known. they are but only suitable as an aid for blood tests within the meaning of the invention if the glass particles, for example the ends of the fibers, protrude outward from the surface of the plastic particles, and thus become physically effective. In the production of such granules, which are suitable as an aid for blood tests in the aforementioned sense is, so make sure that the glass particles or at least some of them protrude from the surface to the outside.

• - 5 309818/0487 • - 5 309818/0487

Claims (1)

PatentanspruchClaim Hilfsmittel für Blutuntersuchungen, mit einem festen, granulatförmigen Träger und einer auf der Oberfläche der Körner befindlichen, die Blutgerinnung beeinflussenden Substanz,Aids for blood tests, with a solid, granular form Carrier and a substance on the surface of the grains that affects blood coagulation, nach Hauptpatent (P 20 34 457.4),according to the main patent (P 20 34 457.4), dadurch gekennzeichnet, daßcharacterized in that die Substanz Glas in Gestalt feiner, in die oberflächennahen Schichten der Körner eingebetteter Teilchen, vorzugsweise Fasern, ist.the substance glass in the form of fine particles embedded in the layers of the grains close to the surface, preferably Fibers, is. 309816/0487309816/0487
DE19712150884 1970-03-07 1971-10-13 Tools for blood tests Expired DE2150884C3 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
BE789954D BE789954A (en) 1970-03-07 BLOOD COLLECTION DEVICE
DE2010830A DE2010830C3 (en) 1970-03-07 1970-03-07 Device for taking blood
DE19702034457 DE2034457A1 (en) 1970-03-07 1970-07-11 Tools for blood tests
DE19717111793U DE7111793U (en) 1970-03-07 1971-03-27 STOPPER FOR BLOOD COLLECTION DEVICE
DE19712150884 DE2150884C3 (en) 1971-10-13 Tools for blood tests
GB5361271A GB1390621A (en) 1970-03-07 1972-02-27 Device for the extraction of blood
DE2245584A DE2245584C3 (en) 1970-03-07 1972-09-16 Device for taking blood
CH1477572A CH548765A (en) 1970-03-07 1972-10-10 Device for collecting blood.
CA154,125A CA1012023A (en) 1970-03-07 1972-10-12 Device for the extraction of blood
US297219A US3886928A (en) 1970-03-07 1972-10-13 Device for the extraction of blood
NL7213918A NL7213918A (en) 1970-03-07 1972-10-13
JP10194672A JPS575541B2 (en) 1970-03-07 1972-10-13
FR7236318A FR2157471A5 (en) 1970-03-07 1972-10-13

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2010830A DE2010830C3 (en) 1970-03-07 1970-03-07 Device for taking blood
DE19702034457 DE2034457A1 (en) 1970-03-07 1970-07-11 Tools for blood tests
DE19712150884 DE2150884C3 (en) 1971-10-13 Tools for blood tests
DE2245584A DE2245584C3 (en) 1970-03-07 1972-09-16 Device for taking blood

Publications (3)

Publication Number Publication Date
DE2150884A1 true DE2150884A1 (en) 1973-04-19
DE2150884B2 DE2150884B2 (en) 1975-12-11
DE2150884C3 DE2150884C3 (en) 1976-07-15

Family

ID=

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3036220A1 (en) * 1979-10-04 1981-04-23 Ken Heistad Heimreid METHOD AND DEVICE FOR EXAMINING UNCLOTNED BLOOD
US4477575A (en) * 1980-08-05 1984-10-16 Boehringer Mannheim Gmbh Process and composition for separating plasma or serum from whole blood
US4883764A (en) * 1987-07-20 1989-11-28 Kloepfer Mary A Blood test strip

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3036220A1 (en) * 1979-10-04 1981-04-23 Ken Heistad Heimreid METHOD AND DEVICE FOR EXAMINING UNCLOTNED BLOOD
US4477575A (en) * 1980-08-05 1984-10-16 Boehringer Mannheim Gmbh Process and composition for separating plasma or serum from whole blood
US4883764A (en) * 1987-07-20 1989-11-28 Kloepfer Mary A Blood test strip

Also Published As

Publication number Publication date
US3886928A (en) 1975-06-03
DE2150884B2 (en) 1975-12-11
DE2245584B2 (en) 1979-04-26
JPS4847191A (en) 1973-07-04
DE2010830C3 (en) 1978-05-11
FR2157471A5 (en) 1973-06-01
DE2010830A1 (en) 1971-09-16
NL7213918A (en) 1973-04-17
DE2245584A1 (en) 1974-03-21
JPS575541B2 (en) 1982-01-30
CA1012023A (en) 1977-06-14
BE789954A (en) 1973-02-01
GB1390621A (en) 1975-04-16
DE2034457A1 (en) 1972-02-17
CH548765A (en) 1974-05-15
DE2010830B2 (en) 1977-09-22
DE7111793U (en) 1971-07-01
DE2245584C3 (en) 1980-01-03

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
E77 Valid patent as to the heymanns-index 1977
8339 Ceased/non-payment of the annual fee