DE2112487A1 - Process for the production of objects which are intended for repeated and long-term contact with living tissues and mucous membranes - Google Patents

Description

PATENT ADVOCATE

March 15, 1971 Anwl file: 75/312

PATENT APPLICATION

Ceskoslovenskä academy ved, Pralia

"Process for the manufacture of objects that are intended for repeated and long-term contact with living tissues and mucous membranes are intended. "

There are known hydrogels which contain, as hydrophilic component units with N-Monoalkylmethakrylamid groups and which are suitable for the production of articles that are to repetitive and long-term contact determined with living tissues and mucous membranes, ie _o for the manufacture of implants, prostheses or their ! share and the like are suitable.

In contrast, the known analogous N-monoalkylakrylamides form no sufficiently stable polymers that are suitable for ugly purposes could prove useful. It is therefore surprising that Ν, Ν-dialkyl acrylamides with regard to their chemical stability and their biological compatibility fully correspond, and hydrogels with good mechanical-physical

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deliver ropes properties »

According to the invention, objects which are intended for repeated and long-term contact with living tissues and mucous membranes are produced in this way by polymerizing hydrophilic monomers or mixtures of hydrophilic or hydrophobic monomers with a small amount (with part of 2f>) of a hardening agent that as the main monomer, which forms at least 50 '- / Ό of the monomer batch, an I \ T, 2r-dialkyl acrylamide is used, the alkyls of which may also have a hydroxyl, polyhydroxyalkyl or amino group, or with two types of this group can be substituted at the same time »It is advantageous to carry out the polymerization in the manner known per se in the presence of water or a water-miscible liquid. -

The amount of Hetzbildners depends on the desired Yernetzungsgrad and thus not only to the i & narrowness of more than zwe if oint ioneilen monomer, Sonders, also according to its kind and its IPfeähigkeit under the circumstances to form with the candidate monomers a crosslinked polymer “Less active bonding agents must therefore be added in larger quantities than more effective bonding agents, in which the optimal range is 0.1 - 2 f> j the content of bonding agents

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BATH ORIGINAL

can be both holier and lower. _O £ own network formers are, for example, N, i \! - i £ ethylene-bis-acrylamide, methylene-bis-methacrylamide, glycol dimethacrylate or the like.

Different dialkyl acrylamides can be used with each other, as well as with other monomers are copolymerized, like Zc-bo with methacrylonitrile, acrylonitrile, acrylamide, JU-substituted or disubstituted methacrylamides and N-monosubstituted acrylic amides. Palls as Ko -?.: Onomer a Ιί, ΙΤ-dialkyl methacrylamide is used, the amount of Ιί, Ιί-dialkyl acrylamide must be essential since dialkyl methacrylamides are not subject to radical polymerization.

The polymerization can be carried out by adding customary initiators for radical polymerizations, e.g. by using various peroxides, peroxosulfates, substituted azo compounds etc., can be initiated.

example 1

A 70-τέ aqueous U, NM / hydroxyethyl / -akrylamid solution with 1 part by weight 5 NC Iriäthylenglykoldimethakrylat and 0.1 wt .- $ of hydrogen peroxide is heated to 7O ⁰ C for 10 hours. A transparent, elastic gel is obtained.

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Example 2

A ähmliches ■ arises when a 80-fö strength 1T, JN-Dipropylakrylamid-solution in n-butanol with 0.7 wt. * - yo Glykoldimethakrylat and 0.05 u-ew, - fi azo-bis-isobutyronitrile 8 ο HOURS ^{is heated to 60 0} O for a long time *

Example 3

Its 80% aqueous 1/2-ethyl-2-hydroxyethylakrylaide solution with 1> 2% by weight methylene-bis-acrylaride and 0.05% m azo-T3is-methyliso'butyrät is 7 hours laiig warmed to ⁰ C 6Q. A hydrogel similar in nature to that described in Example 1 is obtained.

Example 4

An 80 ^ ige solution of Η, ΐί-dipropylakrylamid and liethakrylamid (molar ratio 5 i 2) in ii-butanol with 0 * 4 ■ wt .- ^ -Methylene-bis-methacrylamide and 0.05 wt-y'o diisopropyl percarbonate is heated to 6O ⁰ O for several hours * A hydrogel with good physical properties is obtained, similar gels are also found in the following examples aa,

Example 5

- watery
An 80% strength solution of a mixture of 1, 1 xyethyl / acrylamide and 1/2-bimethyl / ethacrylamide ratio 4: 1) with 0.5% by weight of triethylolpropane methacrylate and 0.1% by weight of azo-bis-isobutyronitrile is heated to 70 ⁰ C for several hours.

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Example 6

A 60 / ί strength aqueous solution of a mixture of JT, U-dimethyl acrylamide and diglycol monomethacrylate (3! 2) with 0.2 wt. / o Diglycol dimethacrylate and 0.05 wt .- ^ diisopropyl percarbonate is ^{heated to 60 0} G for 10 hours.

Example 7

'An 80% ethanol solution of a mixture of Ή, N-di / hydroxyethyl / acrylamide and methyl methacrylate (4: 1) with 0.1% by weight of glycol dimethacrylate and 0.05% by weight of azo Tois- -isobutyronitrile several hours is heated to 60 ⁰ C.

Example 8

A 80 / έ-ethanol solution of a mixture of N, H-Dimethylolakrylamid and Methykrylonitril. (3: l) with 0.9 wt ~ ^ methylene "bis-methacrylamide and 0.1 iiew _o - ^ ~ benzoyl peroxide is Io hours warmed ^{to 60 0} O for a long time.

Example 9

An 80% solution of a mixture of ϊΓ, Ν-dimethylakrylamide and II-hydroxyethyl methacrylamide (3 > 2) in n-butanol with 0.3% by weight of glycol dimethacrylate and 0.05% by weight; o A ^ o -bis-isobutyroriitril 7 hours, heated to 70 ⁰ G

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BATH ORIGINAL

Claims (1)

Patent entitlement Process for the production of objects which are intended for repeated and long-term contact with living tissues and / or mucous membranes by polymerizing hydrophilic monomers with a small amount of a curing agent in the presence of water or of water-miscible liquids, characterized in that ' NjüT dialkyl acrylamides are used as the main monomer, which forms at least 50 % of the monomer batch, the alkyls of which can optionally be substituted by hydroxyl, polyhydroxyalkyl or amino groups or by two types of this group at the same time » PATBiITAIfWALiT 109842/1611