DE2050072B2 - - Google Patents
Info
- Publication number
- DE2050072B2 DE2050072B2 DE19702050072 DE2050072A DE2050072B2 DE 2050072 B2 DE2050072 B2 DE 2050072B2 DE 19702050072 DE19702050072 DE 19702050072 DE 2050072 A DE2050072 A DE 2050072A DE 2050072 B2 DE2050072 B2 DE 2050072B2
- Authority
- DE
- Germany
- Prior art keywords
- aluminum
- acetyl
- glycyrrhetinate
- tri
- glycyrrhetinic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
3 43 4
Aluminiumhydroxid 16 g SalbeAluminum hydroxide 16 g of ointment
Verdünnungsmittel, wie Nairium-Diluents, such as nairium
alginat, Talk, Magnesiumstearat, Aluminium-tri-S-acetyl-ie/S-gly-alginate, talc, magnesium stearate, aluminum-tri-S-acetyl-ie / S-gly-
Polyoxyäthylenstearat, Stärke cyrrhetinat 2 gPolyoxyethylene stearate, starch cyrrhetinate 2 g
und/oder Lactose bis zu 100 g 5 Lidocain-P-Diäthylamino^'.o'-acet-and / or lactose up to 100 g 5 lidocaine-P-diethylamino ^ '. o'-acet-
oxylidid)-hydrochlorid 2 goxylidide) hydrochloride 2 g
Suppositorien Destilliertes Wasser 14,8 gSuppositories Distilled water 14.8 g
Methyl-p-hydroxybenzoat 0,2 gMethyl p-hydroxybenzoate 0.2 g
Aluminium-tri-3-acetyl-18/3-gly- Verdünnungsmittel, wie Polyäthy-Aluminum tri-3-acetyl-18/3-gly diluents, such as polyethylene
cyrrhetinat 100 mg io lenglykol 4000, Propylenglykolcyrrhetinate 100 mg io lenglykol 4000, propylene glycol
Tri-glyceride von Fettsäuren bis zu 1400 g und/oder Cerylalkohol bis zu .. 100 gTri-glycerides of fatty acids up to 1400 g and / or ceryl alcohol up to .. 100 g
Claims (3)
Aluminium-tri-3-acetyl-18/?-glycyrrhetinat optimal Bei Toxizitätsuntersuchungen hat sich herausge-It was surprisingly found that the most effective substance was found.
Aluminum tri-3-acetyl-18 /? - glycyrrhetinate optimal
dere jedoch bei durch Medikamente bewirkten Die folgenden Beispiele erläutern die Erfindung.Medicinal and anti-inflammatory properties are provided by aluminum tri-3-acetyl-glycyrrhetinate, which is less toxic in the treatment of disorders of the 30 than glycyrrhetinic acid and Na digestive tract, such as gastric and duodenal triumhemisuccinyl-glycyrrhetinate, in particular for ulcers, gastritis and gastroduodenitis, especially intraperitoneal administration,
however, when medicated. The following examples illustrate the invention.
mit 1 bis 4 C-Atomen bei Zimmertemperatur oder 55 Mit der erfindungsgemäßen Verbindung können erhöhter Temperatur, zweckmäßig in Gegenwart eines folgende Rezepturen erhalten werden:
organischen Lösungsmittels, umsetzt. Als organische „ ,The process for the production of aluminum - stirred at room temperature, then on about 50 ml of tri-3-acetyl-18 /? - glycyrrhetinate is thereby marked- concentrated and poured into 200 ml of hexane. Aluminum draws that 3-acetyl-18 /? -Glycyrrhetinic acid in tri-3-acetyl-18/3-glycyrrhetinate was obtained as a white, amoraneously known manner with a lower alkanolate phes, light powder by filtration,
with 1 to 4 carbon atoms at room temperature or 55 With the compound according to the invention at elevated temperature, advantageously in the presence of one of the following formulations, can be obtained:
organic solvent. As organic ",
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19702050072 DE2050072C3 (en) | 1970-10-12 | 1970-10-12 | Aluminum tri-3-acetyl-18 betaglycyrrthetinate, process for its preparation and pharmaceutical preparations containing it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19702050072 DE2050072C3 (en) | 1970-10-12 | 1970-10-12 | Aluminum tri-3-acetyl-18 betaglycyrrthetinate, process for its preparation and pharmaceutical preparations containing it |
Publications (3)
Publication Number | Publication Date |
---|---|
DE2050072A1 DE2050072A1 (en) | 1972-04-20 |
DE2050072B2 true DE2050072B2 (en) | 1974-06-06 |
DE2050072C3 DE2050072C3 (en) | 1975-01-30 |
Family
ID=5784887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19702050072 Expired DE2050072C3 (en) | 1970-10-12 | 1970-10-12 | Aluminum tri-3-acetyl-18 betaglycyrrthetinate, process for its preparation and pharmaceutical preparations containing it |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE2050072C3 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU553789B2 (en) * | 1982-06-30 | 1986-07-24 | Biorex Laboratories Ltd. | Glycyrrhetinic acid derivatives in cream compositions |
SI1663185T1 (en) * | 2003-09-22 | 2009-04-30 | Onepharm Res & Dev Gmbh | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss |
-
1970
- 1970-10-12 DE DE19702050072 patent/DE2050072C3/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2050072A1 (en) | 1972-04-20 |
DE2050072C3 (en) | 1975-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AT389871B (en) | METHOD FOR PRODUCING BETA, GAMMA -DIHYDROPOLYPRENYL ALCOHOL DERIVATIVES | |
DE2003430C3 (en) | p-Benzoylphenoxyisobutyric acid esters, their preparation and pharmaceuticals containing them | |
DE2549783A1 (en) | TRIGLYCERIDE WITH AN ANTI-INFLAMMATORY EFFECT | |
DE2947624A1 (en) | BETA, GAMMA -DIHYDROPOLYPRENYL ALCOHOL AND HEM-PRESSURING MEDICINE CONTAINING THEM | |
EP0029247A1 (en) | Alkenyl thienyl alkane carboxylic acids and their derivatives, process for their preparation and medicaments containing them | |
DE68915269T2 (en) | POLYVALENT ANTI-FLAMMING AGENT. | |
EP0100516B1 (en) | 3-beta-(3'-(carboxypropionyloxy))-ursa-9(11),12-dience-28-carboxylic acid and its salts, process for its preparation and medicines containing these compounds | |
EP0043548B1 (en) | Salt of furosemide or piretanide as acid component and penbutolol as base component and pharmaceutical composition containing both of the said components | |
DE2050072C3 (en) | Aluminum tri-3-acetyl-18 betaglycyrrthetinate, process for its preparation and pharmaceutical preparations containing it | |
DE1192635B (en) | Process for the production of bismuth pectinate | |
DE2748291B2 (en) | Substituted 13-benzodioxan-4ones and processes for their preparation and the use of these compounds in combating inflammation | |
DE2434929A1 (en) | ACETAMINOPHENESTERS OF ARYLSALICYL ACIDS | |
EP0308665B1 (en) | 5-aminosalicylic acid salts and pharmaceutical preparations containing them | |
DE1543733C3 (en) | Aluminum bis-alpha- (p-chlorophenoxy) isobutyrate and brightening agents containing this compound as an active ingredient | |
DE929665C (en) | Process for the preparation of therapeutically active streptomycin and dihydrostreptomycin salts | |
EP0498011B1 (en) | Salts of the 2-(2,6-dichloroanilino)-phenylacetic acid, process for their preparation and their application as pharmaceutical preparations for topical use | |
DE2538292A1 (en) | PHARMACEUTICAL COMPOSITIONS CONTAINING ORGANOSILICIUM COMPOUNDS | |
DE2839311C2 (en) | Anti-ulcer pharmaceutical preparation | |
DE2511852A1 (en) | NEW WIDE-SPECTRUM ANTIBIOTICS | |
DE2436959C2 (en) | ANTIBACTERIAL COMPOSITION CONTAINING A 3-FLUOR-D-ALANINE TYPE COMPOUND AND AN N-SUBSTITUTED CYCLOSERINE COMPOUND | |
DE2141357C3 (en) | Bis (4-chlorophenoxy) acetic acid esters, process for their preparation, medicaments containing these compounds | |
DE1076684B (en) | Process for the preparation of pharmacologically active compounds of glycyrrhetinic acid | |
DE2503135A1 (en) | TERPENS, THE METHOD OF MANUFACTURING IT AND MEDICINAL PRODUCTS CONTAINING THESE PRODUCTS | |
DE1802569C3 (en) | Baicalein esters and process for their preparation | |
DE3037598C2 (en) | Lysine and arginine salts of 5- (2,4-difluorophenyl) -2-hydroxybenzoic acid, process for their preparation and medicaments containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C3 | Grant after two publication steps (3rd publication) | ||
E77 | Valid patent as to the heymanns-index 1977 |