DE202022001505U1 - Inhaler for administering powdered dry substances - Google Patents

Abstract

Inhaler for administering powdered dry substances, characterized in that a piercing nozzle containing one or more piercing elements (32, 33) is used to simultaneously open the active substance cavities (21, 22), and a blow-out nozzle (39) with an integrated filter element (34) which powdered dry substance passed on to the patient via a respiratory path (31) and via a mouthpiece (37), with the respiratory path (31) being perforated with one or more ventilation bores (40) in order to achieve the specified flow rate of the powdered dry substance-air mixture, wherein the blow-out nozzle consists of one component together with the mouthpiece (37) elements.

Description

The present invention relates to an inhaler for administering powdered dry substances.

State of the art

Devices for the administration of powdered dry substances, e.g. pharmaceutical preparations, by inhalation consist in known designs of a device, usually about the size of the palm of a hand, inside which the active substances are stored, for example in a rolled-up blister strip made of deep-drawn aluminum foil or alternatively a substance carrier disc made of plastic sealed cover foil. These strips or these substance carrier disks are moved step by step by relative movement of different housing parts, for example in the form of protective caps or by separate pivoting levers for each application, with the respective cavities containing the substance being opened and the active substances thus being released for inhalation.

Inhalers are also known which use two rolled-up blister strips or two substance-carrier discs for administering two different dry substances, for example pharmaceutical preparations. Such inhalers are for example in the WO 03/061743 1 , in the WO 2005/079727 A2 , in the WO 2005/014089 A1 and in the WO2021/121448 A1 described.

As a rule, 30 or 60 individual doses are accommodated on such inhalers in order to be able to cover the monthly requirement of a patient with one or two inhalations per day. With a double blister strip or a double substance carrier disc inhaler, two different active substances are dosed at the same time. The substance cavities are opened, for example, by gradually pulling off a film covering the cavities, or by piercing the piercing nozzle of the sealed cover film of the covering substance carrier disk cavity.

When inhaling the powdered active substance, the inhaler must be held in a horizontal position. In this case, when opening the active substance cavity, one active substance cavity of the substance carriers arranged in parallel is always opened by gradual removal or by piercing the cover film with forces acting in the direction of gravitation, so that due to the acting gravity, the powdered active substance is released the cavity can fall. In such a case, the very small powdered active substance that has to be dosed precisely would not be able to be administered in the specified dosage. Such an inhaler is from WO 2021/121448 A1 known

It is an object of the present invention to provide an inhaler which enables the simultaneous administration of two powdered dry substances. In particular, no powder should fall out of the cavity into the inhaler in an uncontrolled manner when the piercing nozzle of the cavities filled with active substance is pierced.

A further object of the present invention is to provide an inhaler which prevents uncontrolled emptying of the powdered active substance cavity. In particular, when piercing the piercing nozzle of the cavities filled with active substance, no powder should get into the piercing nozzle and into the respiratory path without inhalation by the patient. Furthermore, the piercing nozzle, the respiratory path and the mouthpiece should consist of one part for reasons of cost.

Description of the invention

It is an object of the present invention to create a powder inhaler with a piercing nozzle which, when the piercing nozzle pierces the cover film, prevents the powdery active substance from escaping uncontrolled from the cavity of the substance carrier, with the resulting annular gap having to be dimensioned accordingly that the cavity for removing the powdered dry substance is sufficiently ventilated, ideally the piercing nozzle, the respiratory path, the piercing elements, the blow-out nozzle and the mouthpiece form one component than the devices known from the prior art.

A further object of the present invention is to design a piercing nozzle in such a way that when the cavity is pierced by means of a piercing nozzle, the active substance in powder form does not get into the piercing nozzle and into the respiratory path in an uncontrolled manner. The implementation of this requirement prevents double dosing of the powdered active substance in the event of the patient accidentally forgetting to inhale.

character list

• 1 zeigt eine isometrische Darstellung der beiden Substanzträger mit gesiegelter Deckfolie mit verschlossener Wirksubstanz Kavität eines Inhalators gemäß einem Ausführungsbeispiel der Erfindung.
• 2 zeigt eine isometrische Darstellung der beiden Substanzträger mit gepiercter Deckfolie mit Einstechdüse in der Endposition eines Inhalators gemäß einem Ausführungsbeispiel der Erfindung.
• 3 zeigt eine isometrische Darstellung eines Mundstücks mit integriertem respiratorischem Pfad und den beiden Anstechelementen eines Inhalators gemäß einem Ausführungsbeispiel der Erfindung.

An embodiment of the invention is shown in the drawings and is explained in more detail in the following description.

• 1 shows an isometric representation of the two substance carriers with a sealed cover film with a closed active substance cavity of an inhaler according to an exemplary embodiment of the invention.
• 2 shows an isometric representation of the two substance carriers with a pierced cover film with a piercing nozzle in the end position of an inhaler according to an exemplary embodiment of the invention.
• 3 shows an isometric view of a mouthpiece with an integrated respiratory path and the two piercing elements of an inhaler according to an embodiment of the invention.

Detailed description of the invention

the 1 and 2 show a first substance carrier disk (1) and a second substance carrier disk (2) which are arranged parallel to one another. The two substance carriers are in the preferred orientation of the patient's inhalation position of an inhaler according to an exemplary embodiment of the invention.

The two substance carrier disks (1,2) are arranged so as to be rotatable on a common axis of rotation. A mouthpiece (37) with an integrated piercing nozzle (3) which has a first piercing element (32) and a second piercing element (33). The piercing element (32) and the piercing element (33) are arranged in such a way that the piercing nozzle (3) is positioned between the cavities of the two substance carrier disks (1, 2). To remove the powdered active substance, the film covering the active substance cavity (21, 22) is pierced by means of piercing elements (32, 33). The two substance carriers (1,2) are moved along the axis of rotation.

the 1 shows the substance carrier discs (1.2) with a closed cavity, the 2 show the two substance carrier discs (1,2) in the open state, the cover of the cavity with the piercing nozzle (3) being opened. A first piercing element (32) and a second piercing element (33) serve to open the drug cavity (21, 22). After the active substance cavity (21, 22) has been opened, the blow-out nozzle (39) removes the active substance in powder form. A filter element (34) is integrated in the shape of a cross in the blow-off nozzle (39). The filter element (34) almost corresponds to the exhaust nozzle (39) in its entire length. Rectangular spacer elements (36) are located on both sides of the piercing nozzle (3). These limit the stroke movement of the substance carrier discs (1,2).

The powdered substance is removed from the active substance cavity of the substance carrier (1,2) by means of a blow-off nozzle (39). The blow-out nozzle (39) is divided into small openings, so-called individual filter surfaces (41), the subdivision takes place via webs arranged in the shape of a cross which are referred to as filter element (34).

the 2 shows how the piercing nozzle (3) pierces the lower and upper active substance cavity (21,22) of the substance carrier disc (1,2) with the aid of the first and second piercing element (32,33). When the active substance cavity (21, 22) is open, the active substance in powder form could penetrate the blow-out nozzle (39) and the respiratory path (31) in an uncontrolled manner. A filter element (34) is designed in size and geometry in such a way that the individual filter surfaces (41) only allow the active substance in powder form to penetrate when the patient inhales it. Here, the knowledge about the behavior of the agglomeration of the powdered active substance is used.

The piercing nozzle (3) consists of a blow-out nozzle at the opposite end of which a respiratory path (31) is arranged, which has an opening. This opening is integrated into a mouthpiece (37).

3 shows a piercing nozzle (3) in side view. The piercing nozzle (3) is constructed symmetrically. The piercing nozzle (3) consists of a mouthpiece, a respiratory path (31) which is penetrated by several symmetrically arranged ventilation bores (40). Furthermore, a peripheral element (35) which, in terms of its geometric shape, corresponds to the shape of the active substance cavity (21, 22). The surrounding element (35) prevents the active substance in powder form from penetrating into the inhaler and at the same time enables the active substance cavity (21, 22) to be ventilated during inhalation.

Reference List

1

Overhead substance carrier disc

2

underlying substance carrier disc

3

piercing nozzle

21

lower active substance cavity

22

upper active substance cavity

31

respiratory pathway

32

first piercing element

33

second piercing element

34

filter element

35

revolving element

36

spacer element

37

mouthpiece

38

annular gap

39

exhaust nozzle

40

vent hole

41

single filter sheet element

QUOTES INCLUDED IN DESCRIPTION

This list of the documents cited by the applicant was generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Patent Literature Cited

• WO 03/0617431 [0003]
• WO 2005/079727 A2 [0003]
• WO 2005/014089 A1 [0003]
• WO 2021/121448 A1 [0003, 0005]

Claims (4)

Inhaler for administering powdered dry substances , characterized in that a piercing nozzle containing one or more piercing elements (32, 33) is used to simultaneously open the active substance cavities (21, 22), and a blow-out nozzle (39) with an integrated filter element (34) which powdered dry substance passed on to the patient via a respiratory path (31) and via a mouthpiece (37), with the respiratory path (31) being perforated with one or more ventilation bores (40) in order to achieve the specified flow rate of the powdered dry substance-air mixture, wherein the blow-out nozzle consists of one component together with the mouthpiece (37) elements. inhaler after claim 1 characterized in that a piercing nozzle (3) contains a blow-out nozzle (39) into which a filter element (34) consisting of several individual filter surfaces (41) is integrated, which is designed in shape and dimensions in such a way that when the active substance cavities (21, 22) the active substance in dry form cannot penetrate into the respiratory path (31), the individual filter surface (41) of the filter element (34) depending on the active substance in powder form having an area of 0.5 mm ² to 1.5 mm ² . inhaler after claim 1 characterized in that a piercing nozzle (3) has a peripheral element (35) which corresponds in geometry to the active substance cavity (21, 22) and produces a reproducible, defined air gap between the substance carrier disk (1, 2) and the peripheral element (35), in order to direct the powdered active substance-air mixture that is produced during inhalation into the respiratory path (31) without loss of the powdered active substance. inhaler after claim 1 characterized in that a piercing nozzle (3) with a peripheral element (35), the piercing elements (32, 33), the respiratory path (31), the blow-out nozzle (39) with an integrated filter element (34), the mouthpiece (37). one component.

Images