DE202004007120U1 - Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes - Google Patents
Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes Download PDFInfo
- Publication number
- DE202004007120U1 DE202004007120U1 DE200420007120 DE202004007120U DE202004007120U1 DE 202004007120 U1 DE202004007120 U1 DE 202004007120U1 DE 200420007120 DE200420007120 DE 200420007120 DE 202004007120 U DE202004007120 U DE 202004007120U DE 202004007120 U1 DE202004007120 U1 DE 202004007120U1
- Authority
- DE
- Germany
- Prior art keywords
- biochemical
- lightening holes
- parts including
- lightweight construction
- including material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1037—Using surface tension, e.g. pins or wires
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Common Mechanisms (AREA)
Abstract
Description
Einleitung:Introduction:
Die Herstellung von Microarrays bestehend aus biochemischen Substanzen ist in der Wissenschaft weit verbreitet. Diese werden in der Regel für die Analytik eingesetzt. Microarrays herzustellen ist ein Unterfangen, das eine hohe Präzision und Genauigkeit verlangt. Bei der Verwendung von Nadeldruckverfahren werden in der Regel Standarddruckköpfe verwendet, wie sie z.B. von den Firmen TeleChem bzw. BioRobotics angeboten werden.The Production of microarrays consisting of biochemical substances is widely used in science. These are usually for the Analytics used. Producing microarrays is an endeavor that a high precision and accuracy demands. When using dot matrix printing typically standard printheads are used, as e.g. offered by the companies TeleChem and BioRobotics.
Unserer Erfahrung nach weisen die Druckköpfe bisher deutliche Schwächen auf. Diese beruhen zum einen der zu grossen Masse des Druckkopfes und der – jeweilgen Halterungen. Zum anderen neigen die Nadeln dazu, sich während des Druckprozesses im Druckkopf festzusetzen, das sogenannte „sticky pin" Problem. Dieses beruht auf einer zu grossen Kontaktfläche der Nadeln mit dem Druckkopf. Wird jedoch die Bohrung der Nadelhalterungen erweitert, so erhalten die Nadeln zu viel Spiel, was zu mangelner Präzision bzw. Genauigkeit führt. Um das „Sicky Pin" Problem zu vermidern, sind aufwendige Reinigungsprozesse notwendig. Ein solcher ist z.B. im Patent US6101946 von der Firma TeleChem beschrieben.our Experience has shown the printheads so far significant weaknesses on. These are based on the one hand too much mass of the print head and the - respectively Holders. On the other hand, the needles tend to move during the To set printing process in the printhead, the so-called "sticky pin "problem. This is due to too large contact area of the needles with the print head. Becomes However, the bore of the needle holders extended so get the Needles too much play, which leads to poor precision or accuracy. Around the "Sicky Pin "problem too reduce the complexity of cleaning processes. Such a is e.g. in patent US6101946 by TeleChem.
Zusammenfassung:Summary:
Der
Druckkopf besteht aus einem gewichtsminimierten Ober und Unterteil
(siehe
Genaue Beschreibung:Precise description:
Der Printkopf nimmt maximal 64 Nadeln auf. Es sind 16 Bohrungen in x Achse und 4 verläuft bis x=3,575-45,425 mm y=17,75 mm und ist lediglich durch die Bohrungen unterbrochen. Es gibt insgesamt 7 Verdickungsleisten mit einem Abstand Mitte zu Mitte von x=4,5 mm, einer Breite von 1,85 mm .Of the Print head takes a maximum of 64 needles. There are 16 holes in x Axis and 4 runs to x = 3.575-45.425 mm y = 17.75 mm and is only through the holes interrupted. There are a total of 7 thickening strips at a distance Center to center of x = 4.5 mm, a width of 1.85 mm.
Der Universaldruckkopf enthält einen Standard Bajonettadapter für Biorobotics Printer und das passende Design für Lage der Pins. Die Distanz der zu befestigenden Printplatten beträgt 5 mm für Telechem Microspotting Pins. Bei Microspot Pins von Biorobotics wird zusätzlich der Distanzblock verwendet.Of the Universal printhead contains a standard bayonet adapter for Biorobotics Printer and the matching design for location of the pins. The distance the PCB to be attached is 5 mm for Telechem Microspotting pins. Microspot pins from Biorobotics also use the spacer block.
Der Distanzblock hat eine Höhe von 17,5 mm, eine Breite von 72 mm und eine Tiefe von 5 mm. Auf der Ober und Unterseite sind längs Leisten von 1 mm Höhe und 1 mm Tiefe, so dass ein Kanal von 5 mm Tiefe die ganze Breite überspannt. An der Position von 4,5 mm Breite befindet sich mittig (2,5 mm) eine 3 mm durchmessende Bohrung. In Abständen von 4,5 mm (Center zu Center) befinden sich 15 weitere 3 mm durchmessende Bohrungen. Die erste und die 16te Bohrung sind 6 mm tief (je von der Ober- bzw. Unterseite gemessen). Die mittleren 14 Bohrungen sind durchgängig.Of the Distance block has a height of 17.5 mm, a width of 72 mm and a depth of 5 mm. On the top and bottom are longitudinal Bars of 1 mm height and 1 mm depth, so that a channel of 5 mm depth spans the entire width. At the position of 4.5 mm width is in the middle (2.5 mm) one 3 mm diameter bore. At intervals of 4.5 mm (center to Center) there are 15 further 3 mm diameter holes. The first and the 16th hole are 6 mm deep (depending on the upper or Underside measured). The middle 14 holes are continuous.
Die Freimasstoleranz beträgt +/-0,1.The Tolerance tolerance is +/- 0.1.
Abb1: Druckkopf ohne Distanzblock:
- 1.1
- Frontansicht
- 1.2
- Seitenansicht
- 1.3
- Aufsicht
- 1.4
- räumliche Ansicht
- a
- Universelle Halterung mit Bajonettadapter
- b
- Oberteil
- c
- Unterteil
- 1.1
- front view
- 1.2
- sideview
- 1.3
- At sight
- 1.4
- spatial view
- a
- Universal mount with bayonet adapter
- b
- top
- c
- lower part
Abb2: Druckkopf mit Distanzblock
- 2.1
- Frontansicht
- 2.2
- Seitenansicht
- 2.3
- Aufsicht
- 3.4
- räumliche Ansicht
- a
- Universelle Halterung mit Bajonettadapter
- b
- Oberteil
- c
- Unterteil
- d
- Distanzblock
- 2.1
- front view
- 2.2
- sideview
- 2.3
- At sight
- 3.4
- spatial view
- a
- Universal mount with bayonet adapter
- b
- top
- c
- lower part
- d
- spacer block
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200420007120 DE202004007120U1 (en) | 2004-05-03 | 2004-05-03 | Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200420007120 DE202004007120U1 (en) | 2004-05-03 | 2004-05-03 | Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes |
Publications (1)
Publication Number | Publication Date |
---|---|
DE202004007120U1 true DE202004007120U1 (en) | 2005-09-29 |
Family
ID=35070725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE200420007120 Expired - Lifetime DE202004007120U1 (en) | 2004-05-03 | 2004-05-03 | Biochemical microarray printer has lightweight construction for all parts including material reductions and lightening holes |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE202004007120U1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2572786A1 (en) * | 2011-09-20 | 2013-03-27 | CyBio AG | Pipetting device with pipette head with a number of pipette channels arranged in a pattern |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5882930A (en) * | 1997-11-10 | 1999-03-16 | Hyseq, Inc. | Reagent transfer device |
WO2000008474A1 (en) * | 1998-08-07 | 2000-02-17 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Dosing head for parallel treatment of a plurality of fluid probes |
US6101946A (en) * | 1997-11-21 | 2000-08-15 | Telechem International Inc. | Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture |
US6146594A (en) * | 1999-02-10 | 2000-11-14 | Robbins Scientific Corporation | Syringe array with adjustable needle spacing |
US20020173048A1 (en) * | 2001-04-26 | 2002-11-21 | Touji Nakazawa | Microarraying head and microarryer |
EP1273347A2 (en) * | 2001-06-28 | 2003-01-08 | Genetix Limited | Microarraying apparatus, pin head therefor and spotting method |
US20030027345A1 (en) * | 2001-07-31 | 2003-02-06 | Friswell David R. | Liquid handling system with automatically interchangeable cannula array |
US6558623B1 (en) * | 2000-07-06 | 2003-05-06 | Robodesign International, Inc. | Microarray dispensing with real-time verification and inspection |
US20030108868A1 (en) * | 2001-09-07 | 2003-06-12 | Affymetrix, Inc. | Apparatus and method for aligning microarray printing head |
US6692701B2 (en) * | 2001-02-01 | 2004-02-17 | V & P Scientific, Inc. | Microarrayer |
WO2004014555A1 (en) * | 2002-08-07 | 2004-02-19 | Perkinelmer Las, Inc. | Dispensing apparatus |
-
2004
- 2004-05-03 DE DE200420007120 patent/DE202004007120U1/en not_active Expired - Lifetime
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5882930A (en) * | 1997-11-10 | 1999-03-16 | Hyseq, Inc. | Reagent transfer device |
US6101946A (en) * | 1997-11-21 | 2000-08-15 | Telechem International Inc. | Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture |
WO2000008474A1 (en) * | 1998-08-07 | 2000-02-17 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Dosing head for parallel treatment of a plurality of fluid probes |
US6146594A (en) * | 1999-02-10 | 2000-11-14 | Robbins Scientific Corporation | Syringe array with adjustable needle spacing |
US6558623B1 (en) * | 2000-07-06 | 2003-05-06 | Robodesign International, Inc. | Microarray dispensing with real-time verification and inspection |
US6692701B2 (en) * | 2001-02-01 | 2004-02-17 | V & P Scientific, Inc. | Microarrayer |
US20020173048A1 (en) * | 2001-04-26 | 2002-11-21 | Touji Nakazawa | Microarraying head and microarryer |
EP1273347A2 (en) * | 2001-06-28 | 2003-01-08 | Genetix Limited | Microarraying apparatus, pin head therefor and spotting method |
US20030027345A1 (en) * | 2001-07-31 | 2003-02-06 | Friswell David R. | Liquid handling system with automatically interchangeable cannula array |
US20030108868A1 (en) * | 2001-09-07 | 2003-06-12 | Affymetrix, Inc. | Apparatus and method for aligning microarray printing head |
WO2004014555A1 (en) * | 2002-08-07 | 2004-02-19 | Perkinelmer Las, Inc. | Dispensing apparatus |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2572786A1 (en) * | 2011-09-20 | 2013-03-27 | CyBio AG | Pipetting device with pipette head with a number of pipette channels arranged in a pattern |
CN103008039A (en) * | 2011-09-20 | 2013-04-03 | 西比欧公司 | Pipetting device with pipette head with a number of pipette channels arranged in a pattern |
US9084993B2 (en) | 2011-09-20 | 2015-07-21 | Analytik Jena Ag | Pipetting apparatus with a pipetting head comprising a multiplicity of pipetting channels disposed in an arrangement pattern |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
R086 | Non-binding declaration of licensing interest | ||
R163 | Identified publications notified | ||
R207 | Utility model specification |
Effective date: 20051103 |
|
R150 | Term of protection extended to 6 years |
Effective date: 20071206 |
|
R151 | Term of protection extended to 8 years |
Effective date: 20101203 |
|
R158 | Lapse of ip right after 8 years |
Effective date: 20121201 |