DE19954490A1 - Reducing salmonellosis in poultry and ornamental birds, by administering competitive lactic acid bacteria isolated from birds - Google Patents

Reducing salmonellosis in poultry and ornamental birds, by administering competitive lactic acid bacteria isolated from birds

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Publication number
DE19954490A1
DE19954490A1 DE19954490A DE19954490A DE19954490A1 DE 19954490 A1 DE19954490 A1 DE 19954490A1 DE 19954490 A DE19954490 A DE 19954490A DE 19954490 A DE19954490 A DE 19954490A DE 19954490 A1 DE19954490 A1 DE 19954490A1
Authority
DE
Germany
Prior art keywords
birds
poultry
salmonella
lactic acid
salmonellosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19954490A
Other languages
German (de)
Inventor
Rudi F Vogel
Matthias Ehrmann
Petra Kurzak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ERNST B?CKER GMBH & CO. KG, 32427 MINDEN, DE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19954490A priority Critical patent/DE19954490A1/en
Publication of DE19954490A1 publication Critical patent/DE19954490A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Abstract

Reducing salmonellosis in poultry and ornamental birds using a lactic acid bacterium (A) isolated from birds is new. (A), especially Lactobacillus animalis TMW1.972 or L. salivarius TMW1.992, are applied by feeding, spraying or other suitable means to reduce colonization, invasion and persistence of Salmonella in the intestinal tract of birds.

Description

Die Erfindung beschreibt den Einsatz von Lactobacillus animalis TMW1.972 und Lactobacillus salivarius TMW1.992 zur Reduktion von Salmonellosen in Geflügel im Sinne einer Prophylaxe als auch einer Therapie.The invention describes the use of Lactobacillus animalis TMW1.972 and Lactobacillus salivarius TMW1.992 for the reduction of salmonellosis in poultry in the sense prophylaxis and therapy.

ZusammenfassungSummary

Salmonellosen stellen eine große Gefahr für Geflügel- und Ziervögelbestände dar, die mit hohen Verlusten sowohl durch Sterben der Tiere als auch durch deren verminderte Produktivität, Gewichtszunahme und Wohlbefinden einhergeht. Eine Prophylaxe und Therapie erfolgt derzeit oft über Antibiotika mit den damit verbundenen Problemen der Resistenzbildung und ggf. Belastung von Nahrungsmitteln aus der Geflügelproduktion. Durch den Einsatz kompetitiver Mikroorganismen kann ein vergleichbarer, jedoch nicht mit diesen Risiken behafteter Effekt erreicht werden. Durch die Entwicklung geeigneter Stämme, die aus den Tieren selbst stammen und somit zur normalen Flora gesunder Tiere gehören, wird die Anwendung und Genehmigung abgeleiteter Präparate und Futtermittel stark vereinfacht.Salmonellosis pose a major threat to poultry and ornamental bird populations that are associated with high losses both from the death of the animals and from their reduced Productivity, weight gain and wellbeing go hand in hand. Prophylaxis and Therapy is currently often carried out via antibiotics with the associated problems of Development of resistance and possibly contamination of food from poultry production. By the use of competitive microorganisms can be compared, but not with them Risky effect can be achieved. By developing suitable strains that come from come from the animals themselves and therefore belong to the normal flora of healthy animals, the Application and approval of derived preparations and animal feed greatly simplified.

Beispielhaft konnte gezeigt werden, daß die Verfütterung von Lactobacillus animalis TMW1.972 und Lactobacillus salivarius TMW1.992 aus Enten zu einer starken Reduktion des Salmonellenbefalls in künstlich infizierten Herden von Hühnern und Enten führt und damit das Salmonellose Risiko vermindert wird.As an example it could be shown that the feeding of Lactobacillus animalis TMW1.972 and Lactobacillus salivarius TMW1.992 from ducks to a strong reduction of Salmonella in artificially infected herds of chickens and ducks and to reduce the risk of salmonellosis.

Einleitungintroduction

Die Pathogenität von Salmonellen und damit die tatsächliche Auslösung einer Krankheit nach dem Befall von Mensch oder Tier wird wesentlich beeinflußt von der Fähigkeit dieser Bakterien sich im Intestinaltrakt aufzuhalten, sich an der Schleimhaut anzuheften und ggf. durch diese in Blutbahn und Lymphsystem einzudringen. Durch das Vorhandensein bestimmter Bakterien im Intestinaltrakt kann eine Kolonisierungsresistenz verursacht werden, die eine Ansiedlung von Pathogenen erschwert oder verhindert (Nurmi and Rantala, 1973). Zusätzlich können bestimmte Bakterienstämme antimikrobielle Substanzen bilden, das Immunsystem stimulieren oder die metabolische Aktivität der Darmmucosazellen beeinflussen. Die Anwendung solcher Organismen ist bisher dadurch erschwert, daß diejenigen, die die gewünschten Effekte zeigen, nicht aus dem Ökosystem (Tier) stammen, in dem sie eingesetzt werden sollen, wenig charakterisiert sind, nicht eindeutig nachweisbar und damit als Verursacher des Effektes beweisbar sind, oder in undefinierten Mischungen vorliegen. Aus diesem Grund wurden Organismen aus Geflügel für die Anwendung in Geflügel isoliert, eingehend charakterisiert und hinsichtlich ihrer Nutzbarkeit zur Reduktion des Salmonellenbefalls bei Geflügel untersucht.The pathogenicity of Salmonella and thus the actual triggering of an illness after The infestation of humans or animals is significantly influenced by their ability Bacteria are in the intestinal tract, attach to the mucous membrane and if necessary through this penetrate into the bloodstream and lymphatic system. By the presence colonization resistance may be caused by certain bacteria in the intestinal tract, which complicates or prevents the settlement of pathogens (Nurmi and Rantala, 1973). In addition, certain strains of bacteria can form antimicrobial substances that Immune system stimulate or the metabolic activity of the intestinal mucosal cells influence. The use of such organisms has so far been complicated by the fact that  those that show the desired effects are not from the ecosystem (animal), in to whom they are to be used, are poorly characterized, cannot be clearly demonstrated and thus provable as the cause of the effect, or in undefined mixtures available. For this reason, poultry organisms have been used in Poultry isolated, thoroughly characterized and in terms of its usefulness for reduction of salmonella in poultry was examined.

Material und Methodenmaterial and methods

Lactobacillus animalis TMW1.972 und Lactobacillus salivarius TMW1.992 wurden hinsichtlich ihrer Physiologie und Taxonomie eingehend nach dem letzten Stand der Technik charakterisiert. Küken von Enten und Hühnern wurden in vier unterschiedlichen Gruppen gefüttert.
Gruppe 1: Gabe von 1010 geflügelpathogenen Salmonellen (Enten)
Gruppe 2: 2 Tage Fütterung mit Laktobazillen, Gabe von 1010 geflügelpathogenen Salmonellen, weitere tägliche Gabe von Laktobazillen (Enten)
Gruppe 3: wie Gruppe 1 (Hühner)
Gruppe 4: wie Gruppe 2 (Hühner)
Kontrollgruppen ohne Bakteriengaben (frei von Salmonellen)
Untersucht wurde die Salmonellenausscheidung im Verlauf von 6 Wochen.Lactobacillus animalis TMW1.972 and Lactobacillus salivarius TMW1.992 have been characterized in terms of their physiology and taxonomy according to the latest state of the art. Chickens from ducks and chickens were fed in four different groups.
Group 1: administration of 10 10 poultry pathogenic salmonella (ducks)
Group 2: 2 days feeding with lactobacilli, administration of 10 10 poultry pathogenic salmonella, further daily administration of lactobacilli (ducks)
Group 3: like group 1 (chickens)
Group 4: like group 2 (chickens)
Control groups without bacteria (free of salmonella)
Salmonella excretion was examined over the course of 6 weeks.

ErgebnisResult

Küken der Gruppe 2 und 4, die mit Lactobacillus animalis TMW1.972 und Lactobacillus salivarius TMW1.992 gefüttert wurden, schieden die applizierten Salmonellen kurzfristig mit erhöhter Keimzahl aus. Sie konnten sich damit nur in stark verminderter Zahl im Intestinaltrakt halten. Bereits am 2. Tag nach Salmonellengabe war die Zahl der ausgeschiedenen Salmonellen stark reduziert und sank nach längerer Applikation gegen Null (Abb. 1 und 2).
Literatur
Nurmi, E., Rantala, M. 1973. New aspects of Salmonella infection in broiler production. Nature, 241: 210-211.Chicks in groups 2 and 4, which were fed with Lactobacillus animalis TMW1.972 and Lactobacillus salivarius TMW1.992, briefly excreted the administered Salmonella with an increased bacterial count. They could only stay in the intestinal tract in a greatly reduced number. Already on the second day after salmonella administration, the number of excreted salmonella was greatly reduced and dropped to zero after prolonged application ( Fig. 1 and 2).
literature
Nurmi, E., Rantala, M. 1973. New aspects of Salmonella infection in broiler production. Nature, 241: 210-211.

Claims (3)

1. Verfahren zur Reduktion von Salmonellosen von Geflügel und Ziervögeln durch Milchsäurebakterien Isolate, dadurch gekennzeichnet, daß Isolate von Milchsäurebakterien aus Geflügel, insbesondere Lactobacillus animalis TMW1.972 und Lactobacillus salivarius TMW1.992, durch Füttern, Aufsprühen oder andere Applikationen die Ansiedlung, Invasion und Persistenz pathogener Salmonellen im Intestinaltrakt von Vögeln im Sinne einer Salmonella-Prophylaxe stark reduzieren.1. A method for reducing salmonellosis of poultry and ornamental birds by lactic acid bacteria isolates, characterized in that isolates of lactic acid bacteria from poultry, in particular Lactobacillus animalis TMW1.972 and Lactobacillus salivarius TMW1.992, by feeding, spraying or other applications to settle and invade Reduce the persistence of pathogenic salmonella in the intestinal tract of birds in the sense of salmonella prophylaxis. 2. Unter 1. genannte Verfahren, dadurch gekennzeichnet, daß die Ausscheidung von im Intestinaltrakt vorhandenen Salmonellen beschleunigt wird und somit eine sukzessive Verdrängung dieser Pathogene auch aus befallenen Vögeln im Sinne einer Salmonella-Therapie unterstützt wird.2. Procedure under 1. characterized, that the excretion of salmonella present in the intestinal tract is accelerated and thus a gradual displacement of these pathogens from infected birds in the sense Salmonella therapy is supported. 3. Unter 1. und 2. genannte Verfahren, dadurch gekennzeichnet, daß Futtermittel in fester oder flüssiger Form, Futtermittelzusätze, medizinische Präparate und andere Anwendungsformen, die solche oder verwandte Organismen oder Präparate daraus, z. B. Enzyme, Proteine oder Zellextrakte, enthalten, zur Behandlung von Tieren, Eiern, oder Einstreu verwendet werden.3. Procedure under 1. and 2., characterized, that feed in solid or liquid form, feed additives, medical preparations and other forms of use, such or related organisms or preparations thereof, e.g. B. Enzymes, proteins or cell extracts, contain, for the treatment of animals, eggs, or Bedding can be used.
DE19954490A 1999-11-11 1999-11-11 Reducing salmonellosis in poultry and ornamental birds, by administering competitive lactic acid bacteria isolated from birds Withdrawn DE19954490A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19954490A DE19954490A1 (en) 1999-11-11 1999-11-11 Reducing salmonellosis in poultry and ornamental birds, by administering competitive lactic acid bacteria isolated from birds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19954490A DE19954490A1 (en) 1999-11-11 1999-11-11 Reducing salmonellosis in poultry and ornamental birds, by administering competitive lactic acid bacteria isolated from birds

Publications (1)

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DE19954490A1 true DE19954490A1 (en) 2001-05-17

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1906754A2 (en) * 2005-05-31 2008-04-09 Limited Wockhardt Novel supplements for poultry and livestock

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1906754A2 (en) * 2005-05-31 2008-04-09 Limited Wockhardt Novel supplements for poultry and livestock
EP1906754A4 (en) * 2005-05-31 2009-03-11 Limited Wockhardt Novel supplements for poultry and livestock

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: ERNST B?CKER GMBH & CO. KG, 32427 MINDEN, DE

8181 Inventor (new situation)

Inventor name: KURZAK, PETRA, 80797 MUENCHEN, DE

Inventor name: VOGEL, RUDI F. PROF.DR., 85414 KIRCHDORF, DE

Inventor name: EHRMANN, MATTHIAS, DR., 85354 FREISING, DE

8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee