DE19938960A1 - Test cable connecting probe to test apparatus, e.g. for testing implanted pacemaker, electrotherapy or electro-diagnostics includes crocodile clip and flexible conductor with spring contact - Google Patents

Test cable connecting probe to test apparatus, e.g. for testing implanted pacemaker, electrotherapy or electro-diagnostics includes crocodile clip and flexible conductor with spring contact

Info

Publication number
DE19938960A1
DE19938960A1 DE19938960A DE19938960A DE19938960A1 DE 19938960 A1 DE19938960 A1 DE 19938960A1 DE 19938960 A DE19938960 A DE 19938960A DE 19938960 A DE19938960 A DE 19938960A DE 19938960 A1 DE19938960 A1 DE 19938960A1
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DE
Germany
Prior art keywords
test cable
tube
cable according
test
contact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19938960A
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German (de)
Inventor
Hans-Juergen Bisping
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BISPING HANS JUERGEN
Original Assignee
BISPING HANS JUERGEN
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Filing date
Publication date
Priority claimed from DE19810262A external-priority patent/DE19810262A1/en
Application filed by BISPING HANS JUERGEN filed Critical BISPING HANS JUERGEN
Priority to DE19938960A priority Critical patent/DE19938960A1/en
Publication of DE19938960A1 publication Critical patent/DE19938960A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R31/00—Coupling parts supported only by co-operation with counterpart
    • H01R31/06—Intermediate parts for linking two coupling parts, e.g. adapter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/22—Arrangements of medical sensors with cables or leads; Connectors or couplings specifically adapted for medical sensors
    • A61B2562/225—Connectors or couplings
    • A61B2562/227—Sensors with electrical connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3752—Details of casing-lead connections
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R2201/00—Connectors or connections adapted for particular applications
    • H01R2201/12—Connectors or connections adapted for particular applications for medicine and surgery
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
    • H01R2201/00—Connectors or connections adapted for particular applications
    • H01R2201/20—Connectors or connections adapted for particular applications for testing or measuring purposes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

The test cable includes at least one contact in the form of a crocodile clip. The test cable comprises a fine-stranded flexible conductor (12) and is formed as a disposable component. In addition to the crocodile clip, a spring contact (5) or socket is provided. The spring contact is provided within a carrier member (13) in the form of a tube (26). The tube may be made of transparent material, with a hardness between 70 and 100 Shore A (sic). An Independent claim is included for a test cable for use with two chamber (pacemaker) systems, and having a RJ11 or RJ12 type connector.

Description

Eine gegenüber der bekannten Patentanmeldung De 198 10 262.3 verbesserte Testkabelanordnung, wie sie bei der Bestimmung von elektrophysiologischen Parametern, z. B. in der Elektrotherapie und Elektrodiagnostik verwendet wird, ist Gegenstand dieser Zusatzanmeldung.An improved compared to the known patent application De 198 10 262.3 Test cable arrangement as used in the determination of electrophysiological Parameters, e.g. B. is used in electrotherapy and electrodiagnostics Subject of this additional application.

Es wird eine vorteilhafte, weiter verbesserte Testkabelanordnung beschrieben, bei der das Trägerelement (13) aus einem äußeren Röhrchen (26) - z. B. aus einem etwa 4 cm langen, transparenten PVC-Schlauch - besteht, in dem der Führungskanal (11) für die Federklammer bzw. Krokodilklemme (9) in Form mindestens einer Ausstanzung (27) in der Röhrchenaußenhülle vorliegt. Innerhalb des äußeren Röhrchens (26) befindet sich an seinem proximalen Ende noch ein weiteres inneres Röhrchen (28).An advantageous, further improved test cable arrangement is described in which the carrier element ( 13 ) consists of an outer tube ( 26 ) - e.g. B. from an approximately 4 cm long, transparent PVC hose - in which the guide channel ( 11 ) for the spring clip or crocodile clip ( 9 ) is in the form of at least one punched out ( 27 ) in the outer tube shell. Another inner tube ( 28 ) is located inside the outer tube ( 26 ) at its proximal end.

Die Kontaktfeder (5) ist eingepaßt in das innere Röhrchen (28) und ist in elektrischer Wirkverbindung, z. B. durch Verlötung, mit einem Strang der Zwillingslitze (12).The contact spring ( 5 ) is fitted into the inner tube ( 28 ) and is in electrical operative connection, for. B. by soldering, with a strand of twin strands ( 12 ).

In vorteilhafter Weise tritt der Strang, bzw. die gesamte Zwillingslitze (12) axial aus dem inneren Röhrchen (28) aus.The strand or the entire twin strand ( 12 ) advantageously emerges axially from the inner tube ( 28 ).

Durch entsprechende Dimensionierung des Röhrcheninnendurchmessers des inneren Röhrchens (28) ist die Kontaktfeder (5) gegen Herausrutschen gesichert. The contact spring ( 5 ) is secured against slipping out by appropriate dimensioning of the inner tube diameter of the inner tube ( 28 ).

Dieses innere Röhrchen (28) stellt auch gleichzeitig einen Anschlag für den IS-1 Stecker (1) dar, wenn er in die distale Öffnung des Röhrchens (28) eingeschoben wird.This inner tube ( 28 ) also represents a stop for the IS-1 connector ( 1 ) when it is inserted into the distal opening of the tube ( 28 ).

Die Ausstanzung (27) ist in dem Röhrchen (26) dabei so angeordnet, daß der Elektrodensteckerring (4) des IS-1 Steckers (1) genau unter der Ausstanzung (27) zu liegen kommt, wenn der IS-1 Stecker bis zum Anschlag eingesteckt ist. Die Ausstanzung (27) ist derart dimensioniert, daß ein Schenkel der Federklammer bzw. Krokodilklemme (9), wenn diese über der Ausstanzung plaziert wird, mit dem Elektrodensteckerring (4) elektrischen Kontakt hat. Der zweite Schenkel der Krokodilklemme (9) greift dann auf die Außenhülle des Röhrchens (26).The punched-out ( 27 ) is arranged in the tube ( 26 ) so that the electrode plug ring ( 4 ) of the IS-1 plug ( 1 ) comes to lie exactly under the punched-out ( 27 ) when the IS-1 plug is pushed as far as it will go is plugged in. The cutout ( 27 ) is dimensioned such that one leg of the spring clip or crocodile clip ( 9 ), when it is placed over the cutout, has electrical contact with the electrode plug ring ( 4 ). The second leg of the alligator clip ( 9 ) then grips the outer shell of the tube ( 26 ).

Weiterhin wird vorgeschlagen, daß eine weitere der Ausstanzung (27) gegenüberliegende Ausstanzung vorgesehen ist, um die Möglichkeit der Kontaktierung des zweiten Schenkels der Federklammer bzw. Krokodilklemme (9) mit dem Elektrodensteckerring (4) zu ermöglichen.It is also proposed that a further punching out of the punching ( 27 ) is provided in order to enable the possibility of contacting the second leg of the spring clip or crocodile clip ( 9 ) with the electrode plug ring ( 4 ).

Die oben beschriebene Anordnung hat den Vorteil, daß sie im Wesentlichen rotationssymetrisch ist und gleichzeitig die Merkmale der bereits beschriebenen Testkabelanordnung mit dem Trägerelement (13) z. B. aus Pappe aufweist, nämlich
The arrangement described above has the advantage that it is essentially rotationally symmetrical and at the same time the features of the test cable arrangement already described with the carrier element ( 13 ) z. B. made of cardboard, namely

  • 1. zuverlässige Kontaktierung des Kontaktstiftes (3) durch die Kontaktfeder (5), sowie1. reliable contacting of the contact pin ( 3 ) by the contact spring ( 5 ), as well
  • 2. des Elektrodensteckerringes (4) durch die Krokodilklemme (9), ohne das diese die Dichtringe (2) verletzt.2. the electrode plug ring ( 4 ) through the alligator clip ( 9 ), without this violating the sealing rings ( 2 ).

Die rotationssymetrische Anordnung und der axiale Austritt der Zwillingslitze (12) aus dem Röhrchen (26) erleichtert dem Implanteur die Manipulation der Schrittmachersonde mit aufgestecktem Röhrchen, z. B. durch Anfassen am proximalen oder distalen Ende des Röhrchens (26) und durch Drehen, um eine bessere Elektrodenposition zu erreichen. The rotationally symmetrical arrangement and the axial exit of the twin strands ( 12 ) from the tube ( 26 ) facilitates the manipulator's manipulation of the pacemaker probe with the tube attached, e.g. B. by touching the proximal or distal end of the tube ( 26 ) and by rotating to achieve a better electrode position.

Es ist weiterhin denkbar, am proximalen Ende eine Führungshilfe für einen in die Elektrode einzuführenden Mandrin anzuordnen. Zu diesem Zweck wird vorgeschlagen, ein zylindrisches Plastikteil (29) mit trichterförmiger Einführungshilfe am proximalen Ende des Röhrchens (26) anzuordnen, indem es in das Innere des Röhrchens (28) eingeschoben wird. Die Aussparung (30) dient dabei zur Aufnahme der Lötfahne des Kontaktteils (5) und der Litze (12).It is also conceivable to arrange a guide aid for a stylet to be inserted into the electrode at the proximal end. For this purpose it is proposed to arrange a cylindrical plastic part ( 29 ) with a funnel-shaped insertion aid at the proximal end of the tube ( 26 ) by pushing it into the interior of the tube ( 28 ). The recess ( 30 ) serves to receive the solder tail of the contact part ( 5 ) and the wire ( 12 ).

Um zu verhindern, daß die Testkabelanordnung wiederverwendet wird, wird vorgeschlagen, daß kleine Löcher und/oder Schlitze in dem Röhrchen (26) angeordnet sind, die ein Reinigen von eingedrungenem Blut praktisch unmöglich machen. Auch ist es - wie schon früher vorgetragen - denkbar, daß Teile der Anordnung aus feuchtigkeitabsorbierendem Material hergestellt sind.In order to prevent the test cable arrangement from being reused, it is proposed that small holes and / or slits be arranged in the tube ( 26 ), which make it virtually impossible to clean blood that has penetrated. It is also conceivable, as previously stated, that parts of the arrangement are made of moisture-absorbing material.

Kommen sog. Zweikammerschrittmacher zum Einsatz, so werden zwei Elektroden implantiert, und zwar eine im Vorhof und eine im Ventrikel. Geeignete Testgeräte (24) weisen dementsprechend Anschlüsse für Vorhof als auch Ventrikel auf. Dementsprechend sind auch zwei Meßkabel erforderlich. Es wird daher vorgeschlagen, daß z. B. ein Westernstecker (22) - auch als Modularstecker RJ 11 oder RJ 12 usw. bekannt - mit zwei Zwillingslitzen verbunden ist, die an ihrem distalen Ende jeweils ein Trägerelement (13), (26) mit den notwendigen Kontaktmitteln wie bereits oben beschrieben aufweisen und entsprechende Unterscheidungsmerkmale für die Verwendung an der Vorhof- bzw. Ventrikelelektrode tragen.If so-called two-chamber pacemakers are used, two electrodes are implanted, one in the atrium and one in the ventricle. Suitable test devices ( 24 ) accordingly have connections for the atrium and ventricles. Accordingly, two measuring cables are required. It is therefore proposed that, for. B. a western plug ( 22 ) - also known as modular plug RJ 11 or RJ 12 etc. - is connected to two twin strands, each having a support element ( 13 ), ( 26 ) with the necessary contact means at their distal end as already described above and carry appropriate differentiators for use on the atrial or ventricular electrode.

In vorteilhafter Ausgestaltung der Erfindung wird weiterhin vorgeschlagen, daß die Kontaktbelegung des modularen Steckers (22) so vorgesehen ist, daß an ein Zweikammertestgerät (24) über die Anschlußbuchse (23) sowohl eine erfindungsgemäße Testkabelanordnung für Einkammeranwendung als auch für Zweikammeranwendung anschließbar ist. Denkbar ist z. B. eine Anordnung, bei der die Zwillingslitze für die Vorhofelektrode an die Kontakte 1 und 2 und die Zwillingslitze für die Ventrikelelektrode an die Kontakte 3 und 4 angeschlossen wird. Ein erfindungsgemäßes Testkabel für eine Einkammeranwendung im Ventrikel würde dann nur die Kontaktbelegung 3 und 4 aufweisen.In an advantageous embodiment of the invention, it is further proposed that the contact assignment of the modular plug ( 22 ) is provided in such a way that both a test cable arrangement according to the invention for single-chamber use and for two-chamber use can be connected to a two-chamber test device ( 24 ) via the connection socket ( 23 ). It is conceivable, for. B. an arrangement in which the twin wire for the atrial electrode is connected to contacts 1 and 2 and the twin wire for the ventricular electrode to contacts 3 and 4 . A test cable according to the invention for a single-chamber application in the ventricle would then only have the contact assignment 3 and 4 .

Ein Ausführungsbeispiel der Erfindung ist in der Fig. 1 näher beschrieben, welche eine Röhrchenanordnung im Längsschnitt zeigt. Der IS-1 Stecker (1) ist bis zum Anschlag in das äußere Röhrchen (26) eingeführt. Der Elektrodensteckerring (4) liegt dann genau unter der Ausstanzung (27), in die dann ein Schenkel der Krokodilklemme (9) - in Fig. 1 nicht dargestellt - eingreifen kann.An embodiment of the invention is described in more detail in FIG. 1, which shows a tube arrangement in longitudinal section. The IS-1 connector ( 1 ) is inserted as far as it will go into the outer tube ( 26 ). The electrode plug ring ( 4 ) then lies exactly under the punched-out portion ( 27 ), into which one leg of the alligator clip ( 9 ) - which is not shown in FIG. 1 - can then engage.

Die Fig. 2 zeigt einen Querschnitt des Plastikteils (29) mit der Aussparung (30) für die Lötfahne und die Litze (12). Die zentrisch angeordnete und an der Einführungsseite trichterförmig ausgestaltete Bohrung (31) leitet den Mandrin in die Öffnung des IS1- Steckers. Fig. 2 shows a cross section of the plastic part ( 29 ) with the recess ( 30 ) for the solder tail and the strand ( 12 ). The centrally arranged and funnel-shaped bore ( 31 ) on the inlet side guides the stylet into the opening of the IS1 connector.

Claims (11)

1. Testkabel in mindestens zweiadriger Ausführung für den sterilen Einsatz z. B. bei Schrittmacherimplantationen oder bei der Elektrophysiologischen Untersuchung, das als elektrische Verbindung zwischen Sonde, z. B. Elektrodenstecker (1), und Testgerät (24) dient und dem Testgerät zugeordnete elektrische Verbindungselemente sowie an den elektrischen Kontaktflächen (Kontaktstift (3) und Elektrodensteckerring (4)) der Sonde anschließbare Kontaktelemente aufweist, wobei zumindest ein Kontaktelement als Krokodilklemme ausgebildet ist und das Testkabel eine dünnlitzige flexible Leitungslitze (12) aufweist und als Wegwerfteil ausgebildet und zusätzlich zur Krokodilklemme (9) das zweite Kontaktelement als Kontaktfeder (5) oder Kontakthülse ausgebildet ist, dadurch gekennzeichnet, daß das Trägerelement (13) als Röhrchen (26) ausgebildet ist, in dessen Innerem die Kontaktfeder (5) fixiert ist.1. Test cable in at least two-wire version for sterile use e.g. B. in pacemaker implantations or in electrophysiological examination, which as an electrical connection between the probe, for. B. electrode connector ( 1 ), and test device ( 24 ) is used and the test device has associated electrical connecting elements and on the electrical contact surfaces (contact pin ( 3 ) and electrode connector ring ( 4 )) of the probe connectable contact elements, at least one contact element being designed as an alligator clip and the test cable has a thin-stranded flexible lead ( 12 ) and is designed as a disposable part and, in addition to the alligator clip ( 9 ), the second contact element is designed as a contact spring ( 5 ) or contact sleeve, characterized in that the carrier element ( 13 ) is designed as a tube ( 26 ) inside of which the contact spring ( 5 ) is fixed. 2. Testkabel nach Anspruch 1, dadurch gekennzeichnet, daß das Röhrchen (26) aus transparentem Material hergestellt ist.2. Test cable according to claim 1, characterized in that the tube ( 26 ) is made of transparent material. 3. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß das Röhrchen (26) aus Material mit einer Härte zwischen 70 bis 100 Shore A hergestellt ist. 3. Test cable according to one of the preceding claims, characterized in that the tube ( 26 ) is made of material with a hardness between 70 to 100 Shore A. 4. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß innerhalb des Röhrchens (26) ein Anschlag für den Elektrodenstecker (1) vorhanden ist.4. Test cable according to one of the preceding claims, characterized in that a stop for the electrode plug ( 1 ) is present within the tube ( 26 ). 5. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß der Abstand zwischen Anschlag und Aussparung (27) derart gewählt ist, daß bei bis zum Anschlag eingeschobenem Elektrodenstecker (1) der Elektrodensteckerring (4) im wesentlichen unter der Aussparung (27) zu liegen kommt.5. Test cable according to one of the preceding claims, characterized in that the distance between the stop and the recess ( 27 ) is selected such that when the electrode plug ( 1 ) is pushed in as far as it will go, the electrode plug ring ( 4 ) is substantially below the recess ( 27 ) comes to lie. 6. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß eine der Aussparung (27) gegenüberliegend zweite Aussparung vorgesehen ist.6. Test cable according to one of the preceding claims, characterized in that one of the recess ( 27 ) opposite second recess is provided. 7. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Kontaktierung des Elektrodensteckerringes (4) durch eine Federklemme oder Krokodilklemme (9) erfolgt.7. Test cable according to one of the preceding claims, characterized in that the contacting of the electrode plug ring ( 4 ) by a spring clip or crocodile clip ( 9 ). 8. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Zwillingslitze (12) oder ein Strang derselben axial aus dem Röhrchen (28) austritt.8. Test cable according to one of the preceding claims, characterized in that the twin strands ( 12 ) or a strand thereof exits axially from the tube ( 28 ). 9. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß das Röhrchen (26) mit Schlitzen und/oder 1 Löchern versehen ist. 9. Test cable according to one of the preceding claims, characterized in that the tube ( 26 ) is provided with slots and / or 1 holes. 10. Testkabel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß am proximalen Ende des Röhrchens (26) ein zylindrisches Teil (29) angeordnet ist, welches eine trichterförmige Einführungshilfe (31) und eine Aussparung (30) zur Aufnahme der Lötfahne und/oder Litze aufweist.10. Test cable according to one of the preceding claims, characterized in that a cylindrical part ( 29 ) is arranged at the proximal end of the tube ( 26 ), which has a funnel-shaped insertion aid ( 31 ) and a recess ( 30 ) for receiving the solder tail and / or Strands. 11. Testkabel für die Anwendung bei Zweikammersystemen, dadurch gekennzeichnet, daß in einem Stecker (22), vorzugsweise von einem Typ RJ11 oder RJ12, mindestens zwei Zwillingslitzen angeschlossen sind.11. Test cable for use in two-chamber systems, characterized in that at least two twin strands are connected in a plug ( 22 ), preferably of a type RJ11 or RJ12.
DE19938960A 1998-03-10 1999-08-17 Test cable connecting probe to test apparatus, e.g. for testing implanted pacemaker, electrotherapy or electro-diagnostics includes crocodile clip and flexible conductor with spring contact Withdrawn DE19938960A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19938960A DE19938960A1 (en) 1998-03-10 1999-08-17 Test cable connecting probe to test apparatus, e.g. for testing implanted pacemaker, electrotherapy or electro-diagnostics includes crocodile clip and flexible conductor with spring contact

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19810262A DE19810262A1 (en) 1998-03-10 1998-03-10 Test cable for sterile application e.g. for heart pacemaker implant or electrophysiological investigations
DE19938960A DE19938960A1 (en) 1998-03-10 1999-08-17 Test cable connecting probe to test apparatus, e.g. for testing implanted pacemaker, electrotherapy or electro-diagnostics includes crocodile clip and flexible conductor with spring contact

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DE19938960A1 true DE19938960A1 (en) 2001-02-22

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WO2004101063A1 (en) * 2003-05-13 2004-11-25 Medtronic Inc. Medical lead adaptor assembly
DE102005018806A1 (en) * 2005-04-22 2006-10-26 Biotronik Crm Patent Ag Contact connection adapter for making a temporary electrical contact between two plugs
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US7819842B2 (en) 2006-11-21 2010-10-26 Medtronic, Inc. Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites
US7902352B2 (en) 2005-05-06 2011-03-08 Medtronic, Inc. Isolated nucleic acid duplex for reducing huntington gene expression
US7988668B2 (en) 2006-11-21 2011-08-02 Medtronic, Inc. Microsyringe for pre-packaged delivery of pharmaceuticals
US8119611B2 (en) 2002-11-26 2012-02-21 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of SIRNA
US8258112B2 (en) 2005-05-06 2012-09-04 Medtronic, Inc Methods and sequences to suppress primate huntington gene Expression
US8324367B2 (en) 2006-11-03 2012-12-04 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
US8957198B2 (en) 2003-02-03 2015-02-17 Medtronic, Inc. Compositions, devices and methods for treatment of Huntington's disease through intracranial delivery of sirna
US9133517B2 (en) 2005-06-28 2015-09-15 Medtronics, Inc. Methods and sequences to preferentially suppress expression of mutated huntingtin
US9273356B2 (en) 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
US9375440B2 (en) 2006-11-03 2016-06-28 Medtronic, Inc. Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity
CN111244705A (en) * 2020-01-07 2020-06-05 中国科学院大学宁波华美医院 A test is with connecting wire for artificial heart pacemaker implants

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* Cited by examiner, † Cited by third party
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US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US8618069B2 (en) 2002-11-26 2013-12-31 Medtronic, Inc. Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA
US8415319B2 (en) 2002-11-26 2013-04-09 Medtronic, Inc. Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA
US8058251B2 (en) 2002-11-26 2011-11-15 Kaemmerer William F Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA
US8119611B2 (en) 2002-11-26 2012-02-21 Medtronic, Inc. Treatment of neurodegenerative disease through intracranial delivery of SIRNA
US8957198B2 (en) 2003-02-03 2015-02-17 Medtronic, Inc. Compositions, devices and methods for treatment of Huntington's disease through intracranial delivery of sirna
WO2004101063A1 (en) * 2003-05-13 2004-11-25 Medtronic Inc. Medical lead adaptor assembly
US7917228B2 (en) 2003-05-13 2011-03-29 Medtronic, Inc. Medical lead adaptor assembly
DE102005018806A1 (en) * 2005-04-22 2006-10-26 Biotronik Crm Patent Ag Contact connection adapter for making a temporary electrical contact between two plugs
US7217163B2 (en) 2005-04-22 2007-05-15 Biotronik Crm Patent Ag Contact connection adapter for producing an intermittent electrical contact between two plugs
US8258112B2 (en) 2005-05-06 2012-09-04 Medtronic, Inc Methods and sequences to suppress primate huntington gene Expression
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