DE19921101A1 - Neue spirocyclische Verbindungen, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung hyperproliferativer Erkrankungen - Google Patents

Neue spirocyclische Verbindungen, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung hyperproliferativer Erkrankungen

Info

Publication number
DE19921101A1
DE19921101A1 DE19921101A DE19921101A DE19921101A1 DE 19921101 A1 DE19921101 A1 DE 19921101A1 DE 19921101 A DE19921101 A DE 19921101A DE 19921101 A DE19921101 A DE 19921101A DE 19921101 A1 DE19921101 A1 DE 19921101A1
Authority
DE
Germany
Prior art keywords
methyl
compounds
methylethenyl
oxy
isoxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19921101A
Other languages
German (de)
English (en)
Inventor
Guenter Neef
Harry Vierhufe
Arwed Cleve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE19921101A priority Critical patent/DE19921101A1/de
Priority to AU45600/00A priority patent/AU4560000A/en
Priority to PCT/EP2000/003915 priority patent/WO2000066593A2/fr
Publication of DE19921101A1 publication Critical patent/DE19921101A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19921101A 1999-05-03 1999-05-03 Neue spirocyclische Verbindungen, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung hyperproliferativer Erkrankungen Ceased DE19921101A1 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19921101A DE19921101A1 (de) 1999-05-03 1999-05-03 Neue spirocyclische Verbindungen, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung hyperproliferativer Erkrankungen
AU45600/00A AU4560000A (en) 1999-05-03 2000-05-03 Novel spirocyclic compounds, method for the production thereof and their use fortreating hyperproliferative diseases
PCT/EP2000/003915 WO2000066593A2 (fr) 1999-05-03 2000-05-03 Nouveaux composes spirocycliques, procede permettant de les preparer et leur utilisation pour traiter des affections hyperproliferatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19921101A DE19921101A1 (de) 1999-05-03 1999-05-03 Neue spirocyclische Verbindungen, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung hyperproliferativer Erkrankungen

Publications (1)

Publication Number Publication Date
DE19921101A1 true DE19921101A1 (de) 2000-11-16

Family

ID=7907317

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19921101A Ceased DE19921101A1 (de) 1999-05-03 1999-05-03 Neue spirocyclische Verbindungen, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung hyperproliferativer Erkrankungen

Country Status (3)

Country Link
AU (1) AU4560000A (fr)
DE (1) DE19921101A1 (fr)
WO (1) WO2000066593A2 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA972195B (en) * 1996-03-15 1998-09-14 Du Pont Merck Pharma Spirocycle integrin inhibitors
EP0888344A1 (fr) * 1996-03-15 1999-01-07 The Du Pont Merck Pharmaceutical Company Inhibiteurs de l'integrine spirocycle

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
. Tetrahedron Lett., 24, 3029, 1983 *
Heterocycles, 36, 1351, 1993 *
J. Am. Chem. Soc., 110, 8242, 1988 *
J. Chem. Soc. Perkin I, 18, 1972 *
J. Chem. Soc. Perkin I, 3121, 1993 *

Also Published As

Publication number Publication date
WO2000066593A2 (fr) 2000-11-09
AU4560000A (en) 2000-11-17
WO2000066593A3 (fr) 2001-05-31

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Legal Events

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OP8 Request for examination as to paragraph 44 patent law
8131 Rejection