DE1958555A1 - Device for withdrawing and storing a liquid substance - Google Patents

Description

• miciiifAiiiabiu

DIPL..IN6. H. LEINWEBER dipl ing. H. ZIMMERMANN

PoaiKhtdc-Kofito: MQndwnm «

■ ank account:

Oraidrtar Mnk AO. MOndiw 2, Martenplatz, account no. fftfO

We / Wy / Sd-F 41Ö5 / 4220

Telephone Tal.-Aclr. Mtodwa (MH) MWIf Uhpat Munich

• MQndMii 1, Rotental 7.2.A <rfg. (Kuitermann Panage)

November 21, 1969

COMPAGNIE GBNERALE D'AUTOMATISME Paris, France

"Device for withdrawing and storing a liquid substance"

The invention relates to a device for withdrawing and storing a liquid substance, in particular of blood in several chambers, which enables an automatic multi-analysis of the removed, stored, liquid substance.

There is a device known that a compact unit with a plurality of independent, in comprises a legs of side-by-side containers made of one and the same piece of material and made by Plugs are closed, of which at least a part can easily be pierced with a hollow needle. the Containers are filled at the same time by means of a single hollow needle, which has lateral openings in such a way are arranged at a distance from each other that they open at fiöhe each container and the liquid at the same time in distribute the storage containers. The end of the needle is pointed in such a way that it lies on a line and can be pierced

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Can pierce side parts of the plug. The needle for distributing the liquid in the various individual containers is extended by another part, which is used to remove the substance to be distributed. this part has the same properties as the well-known removal needles.

The aim of the invention is an apparatus for extracting and storing a liquid substance into metireren chambers with an oblong-shaped bearing unit, which is divided into a plurality of chambers, ^and openings are closed at each end by a stopper, a part connected to the bearing unit Luftansaugorgan and on the one hand with a container containing the liquid substance and on the other hand with the storage unit connected line, which is particularly characterized in that the storage unit has a plurality of channels, which each penetrate the inner walls of the storage unit in the area of the openings of a first end and with the plug cooperate to close this end of the chambers of the storage unit, which form a common locking part which can assume two locking positions, wherein in a first position the channels are not closed and allow a connection to the adjacent chamber and in a second position completely are closed and prevent a transfer of liquid stored therein from one chamber to another adjacent chamber.

Further details, advantages and features of the invention emerge from the following description. on the drawing shows the invention for example »and show

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Fig. 1 is a perspective view of a multi-chamber storage unit according to the invention,

Fig. 2 and 3 partial sections through the storage unit at line B and A of Fig. 1,

4 shows a perspective view of a modified embodiment of the storage unit dismantled into its individual parts,

5 shows a section through the storage unit at line C. of Fig. 4,

6 shows a partial section through a further modified form of the bearing unit according to FIG Invention at line D of the * ig, 5,

FIG. 7 is a perspective view of all elements of FIG device according to the invention in the unassembled state,

Fig. 8 on an enlarged scale, a section through a

Element of Fig. 7, and Fig. 9 is a schematic view of one in the - ^ agerein air intake device containing the unit

Fig. 1 shows a warehouse tie it 1, which has, for example, three holes 10 which are arranged in a row and consist of one and the same, preferably transparent block of material. The guides are advantageously made by molding a thermosetting material. ^ü ie each form stock chambers SIOD closed by a stopper. On the upper part of the inner walls of the storage unit 1 channels 11 are provided, which under-

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connect each other * To facilitate the molding process, the channels open, for example, on the side surfaces and are then isolated by attaching a part to the outside.

Advantageously, each set of closure plugs forms a one-piece closure for the upper and lower sides the compact unit. Unit 1 is at its top Part closed by a one-piece plug 2 and at its lower part by a plug 3. The plugs 2 and 3 are made of molded plastic or rubber and have sections 21 and 31 »which fit into the openings of the Engage the tubes and seal them.

According to the embodiment shown, the channels 11 are in the vicinity of the large side surfaces of the unit, parallel to the aligned ears. A first channel provided in the vicinity of one of the large surfaces connects the first and second tubes, and a second channel located near the other large surface connects the second and third bores with one another. In the context of the invention, however, any other arrangement of the Äaneael is also possible, which. connects the tubes to each other at the level of their upper or lower part.

The upper plug 2 can carry provisions, for example a small projection which interacts with another part assigned to it on the bearing unit, for example a groove, so that the sections 21 of the plug assume a first position, a so-called raised position ^H h "(Fig . 2) in which the tubes or chambers are sealed

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are »but communicate in pairs through the channels 11. When the sections 21 of the plug 2 engage deeply in the tube openings, they assume a second position, the so-called. Low position ^M b "(FIG. 2), in which the channels 11 are completely closed and the chambers are not in communication with one another. These parts provided on the plug and the tube unit can be designed and arranged differently and are therefore not shown in the drawing.

Have the storage unit or plugs 2 and 3 also on their sides parts that can be easily pierced by a hollow needle. These parts are arranged so that a hollow needle for distributing a removed Liquid opens into one end chamber while a hollow air aspiration needle opens into the chamber at the other end. if if the plug 2 is in the upper position, the liquid substance flows into the first chamber until it is full, and then flows through the connecting channel into the second tube, while the air is sucked in from the lead chamber, which is connected to the previous one via the channels described.

The pierceable parts can either be on the surface of the common upper part 20 of the upper plug 2 or at the edges 22 of the sections 21 of the plug 2, in both cases these sections

are hollow so that the needle can easily stick into the chamber can, or on the side surfaces of the tube unit

Fig. 2 shows a section at line B of FIG. 1 through an embodiment of the upper plug 2 with pierceable parts 22. The lower plug 3 can be identical. The upper plug can have a pitch "h" occupy, in which the chambers 10 communicate through the channels 11, and a subscript "b" in which the chambers are closed and cannot communicate with each other.

Fig. 3 shows a section at line A of Fig. 1. The storage unit 1 is provided with channels 11 which the Connect chambers 10 with each other

4 shows a modified embodiment of the multi-chamber storage unit 1.

Fig. 5 is a section at line C of the * 'ig. 4 and

6 shows a partial section along line D in FIG. 5. The chambers 10 are connected to one another in pairs through the channels 11 connected and at least the latter chamber (in FIGS. 4 and 5 on the right-hand side) additionally has a channel 12 which opens on the front side.

The first chamber (in Fig. 4 and 5 on the left) can also be stranded with a channel that leads to the front side opens. Through this (not shown) channel you can with a liquid injection needle into the Puncture chamber; the aspiration needle engages through channel 12.

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In particular, the channel 12 is closed by a tape 14, for example made of rubber, with which the element 1 is wrapped around the entire circumference or partially at the height of the channels * so that the unit provided with the plugs 2 and 3 has flat surfaces on the outside the upper portion of relaxed unit in the region of the channels in relation to the middle part, a slight step 15, the layer of the thickness of the rubber 'or of the rubber band corresponds to that of the channel 12 is closed, and the ^r fropfenteilen that f; GFLS. attack on the outer parts of unit 1.

According to a modified embodiment, this can Rubber tape to isolate the connection channels to the outside can be used when these channels, for example to facilitate molding, open onto the side surfaces.

On the lower part is the first chamber (on the left in Fig. 5) provided with a channel 16 on the corresponding undseite of the unit. This channel 16 is through the lower plug 3 closed, which in this figure has the shape of a bottom 33 with a hand 34, which consists of a rubber part 35 ", which is coated with a layer 36 of plastic. The fiand 34 has an opening 37, which is the only plastic layer 36 interspersed, in such a way that it comes with the channel 16 ztuvDe-okung. Volume 34 comes under one To lie step 17, which is provided on the side surface of the tube unit 1. The floor 33 is still in the area the openings of the tubes 10 are provided with openings 38, which only penetrate the plastic layer and a later one Removal of the substance contained in the individual tubes with one of the openings 38 and the rubber part or the sampling needle penetrating the rubber film 35

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enable. In order to ensure a perfect seal between the chambers on the lower part, the inside of the plastic layer 36 has slight bulges 39 (Fig. 6), which engage in the ears and the rubber part Press 35 against the walls of the tubes 10.

When using the multi-chamber storage container, pierce with a hollow needle to distribute the Withdrawal substance, with the beveled end of the rubber part 35 through the opening 37 and the channel 16 through to the first chamber. With a second Hollow needle with beveled end, which is used to suck in the air contained in the chambers and zub suction of the liquid substance is used, the band 14 is pierced at the level of the channel 12 and allowed to open into the last chamber. The upper plug is then in the upper position, so that the chambers can communicate with each other.

The liquid substance rises in the first chamber when the liquid level reaches the channel 11 for connection to the second chamber, flows into the second chamber and so on until the chambers are filled. The needles are then lied out again and there the Kaatschukteil 35 and the band 14 consist of a material that contracts again, the openings created when the needles are inserted close again. The top wad is completely depressed and is in its subscript; the channels are then closed and the substances are stored independently of one another.

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In a modified embodiment (not shown), the unit 1 is completely symmetrical. Of the The lower part is identical to the upper part and they have both connection channels · Furthermore, the lower part is Plug identical to the upper one. In this embodiment, the extracted substance rises slowly in the tubes high, so that a small amount of reagent can be removed from the inside of the parts of the upper plug, which comes into contact with the stored substance when the plug is inserted, without the samples mixing.

Because the substances can be stored without them mixing from one chamber to the other, the storage container according to the invention can be used extremely advantageously for samples which each consist of a mixture of a certain amount of the substance removed and a suitable reagent. In the extracted substance is, for example, - ⁰ IUT for automatic multi analysis. In order to benefit from the distribution of the removed liquid substance in all storage chambers for the samples, the sections 21 of the upper plug 2 are hollow (- ^. 2). A suitable reactant, which is introduced into the inner cavity of each section 21, only mixes with the liquid substance when the distribution of the substance into the chambers has ended in that the sections 21 in the chambers are brought into their lower position b.

In Fig. 2 the sections 21 of the plug 2 are hollow and the inner cavity 23 defined by the lower side walls of the sections 21 is approximately in the shape of a truncated cone, with a small amount of reagent being provided at the apex 25 of the cavity.

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Because of this embodiment of the sections 21 the chambers can be filled up to the level of the channels connecting them without the liquid substance comes into contact with the reactants. Then, when the sections 21 are brought into their subscript b, the substance enters the cavities 25 and the liquid Substance and the reactant are mixed in the individual tubes by the fact that the unit of each under Sealing sealed chambers shakes.

In the embodiment not shown is the Cavity 23 closed until the liquid substance, which is a suitable reagent in the form of a liquid, a powder Od. The like, contains, through a membrane or an easily destructible plate made of plastic or the like., Distributed therethrough is. When it is brought into the deep division, this Plate, for example, by a destructive organ or by friction on the walls of the corresponding chamber, drilled through.

Fig. 7 shows the removal and storage device according to the invention in the unassembled state. The removal and the dispensing needle is a hollow needle 40, the two ends of which are beveled. It is, as in detail in Fig.8 shown, fastened on the side of a needle holder 42 by means of a frustoconical fastening part 41, which is firmly connected to the needle, as well as to a locking system arranged on the face of the needle holder,. which consists, for example, of a part 43 which is displaceable in a groove 44. '

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The (not shown) Luftatisaugnade 1 is a hollow needle, one beveled end in an end chamber opens, and the other end is connected to an intake system via an elastic line. The air suction needle can be permanently connected to a needle carrier or free and is connected to the duct of the air intake system connected »The storage unit 1 can be inserted into a cavity 45 of a carrier 44; the latter has on its edges two grooves 46, in the two tabs 47 of the Hade1träger rs 42 intervene.

The suction system contained in a housing 50 is attached to the carrier 44. It comprises a propeller 51 » a motor (not shown), a switch 52 and the elastic conduit which it operates by means of the air suction needle connected to the storage unit.

The motor, a DC motor, comes from a set Cells or accumulators 56 fed, which are introduced into a container 55. The container 55 is after Container 50 put on.

In a modified form of management (not shown), the intake system consists of one in one Cylinder slidable piston, the effects of which the is the same as that of a syringe

Fig. 9 shows another embodiment in which that Suction system has a suction chamber 60, which by elastic walls 61 limited and via a line 62 with

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1 '958l53'

a barely 63 is connected. The room 63 either protrudes a first slide 65 with the atmosphere or via a second slide 66 with an elastic line 68 in connection.

• * is therefore pressed in the direction of arrow 75, is the air contained in the suction chamber 60 is passed through the slide 65 to the atmosphere, the slide 65 is then closed and the slide 66 is opened and the air in the chambers of the unit 1 is drawn through a suction needle 70, the associated line 68 and sucked through the slide 66 into the chamber 60, the same extent returns to its original volume; this is shown by arrow 76.

In the area of the suction needle 70, the line passes through a device 72 for adjusting the closure of the line 68, which is provided with an organ 71 which can be operated by the laboratory technician. This device serves as a safety device, that any injection of air into the chambers of the unit 1 and the organ for regulating suction is thereby avoided is that it more or less compresses the elastic duct.

Since those used in the orricutung according to FIG If slide 65 and 66 are more well-known, they are only schematic shown. i> he chamber 60 and the slide system are arranged in a carrier 67 and leave part of the space c1 delimiting the chamber 60 free.

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Claims (13)

Claims: Device for removing and storing a liquid Substance in several chambers, with an elongated storage unit that is divided into a number of chambers is, the openings of which are closed by plugs at each end, one connected to the storage unit Air intake member, and one on the one hand with a container containing the liquid substance and on the other hand with the storage unit connected line, characterized in that "the storage unit (1) has a plurality of channels (11), which each penetrate the inner walls of the storage unit (1) in the area of the openings of a first end and with the Plugs (2 or 3) to close this end of the chambers (10) of the storage unit (1) cooperate, which form a one-piece Form closure part which can assume two closure positions, the channels in a first position (h) (11) are not closed and allow a connection to the adjacent chamber, and in a second position (b) are completely closed and a transfer from one chamber to another adjacent chamber from stored therein Prevent liquid. 2. Device according to claim 1, characterized in that that the one-piece element for closing the first end of the storage unit (1) hollow closure parts (21) for Engaging in the individual openings of the chambers (10), as well as at least one pierced by a hollow needle - 14 -009831/1 ble part (22) for the purpose of inserting the needle into one of the closed Chambers (10). 3. Apparatus according to claim 1, characterized in that the storage unit (1) on at least one of its side surfaces has a part made of a material that can be pierced by a hollow needle. 4. Apparatus according to claim 3, characterized in that the part made of a pierceable material of the bearing unit (1) consists of a channel (12) which is introduced into a first side surface essentially in the area of the first end is, opens into an end chamber and is supported by a band (14) made of a material that can be pierced by a hollow needle is locked. 5. Apparatus according to claim 4, characterized in that the closure plug consists of a film (35) an easily pierceable material with substantially square folded edges supported by a plate is covered with openings arranged in each case in the region of the openings of the chambers. 6. Apparatus according to claim 5, characterized in that to ensure the seal between the chambers the film (35) in the region of each opening of the chambers has annular projections of approximately the same size as the openings to engage in these openings. - 15 009831 / U78 7. Apparatus according to claim 5 _t characterized in that the other end chamber defining second side surface of the bearing unit (1) having a channel ISTJ provided (16) of the storage unit provided in the region of the second end and by the edge of the plug for closing the The second end is closed, which has a part which can be pierced by a hollow needle arranged in the region of the channel. : · 8, device according to claim 7, characterized in that it has a carrier for the needle for removing the liquid substance, the end face of which is provided with a locking system (43) provided in the region of the channel of the second side surface, which is provided with one of the needle supported fastening part (41) cooperates, as well as a carrier (44) with a cavity (45) for receiving the Ltgeinheit (1) and with first means for cooperation with ^! second means assigned to them for mutual connection. 9. Apparatus according to claim 8, characterized marked. net that the first means of two grooves (46) in the side surfaces' consist of the carrier delimiting the cavity and that the second means associated with them consist of two There are tabs (47) which are arranged perpendicular to the face of the needle carrier. - 16 - 009831 / U78 10. The device according to claim θ, characterized in that the locking system comprises a part which is along a Groove in the face of the needle carrier is displaceable, which cooperates with the frustoconical fastening part (41) which is firmly connected to the needle. 11. The device according to claim 8, characterized in that the air intake system has a piston which is in a cylinder is slidable, the closed end of which is provided with parts that secure it to the support of the Connect the bearing unit, as well as a conduit running into the tree between the piston and the closed end of the cylinder opens and can be connected to the chambers of the storage unit through a hollow needle which opens through the channel introduced into the first side surface. 12. The device according to claim 9, characterized in that the air intake system has a chamber (60) with elastic! Has walls (61) which via a first slide (65) with the atmosphere and via a second slide (66) with a line (68) can be connected, which is connected to the storage unit (1) via a hollow needle which passes through the channel the first side surface opens, wherein the slide · (65, 66) are mounted in opposite directions, so that when open one slide the other is closed and vice versa. 13. The device according to claim 12, characterized in that it has a device (72) compressing the line (68) for adjusting the closure of the air intake serving line (68) has «, 009831 / U78 Blank page