DE1929067A1 - Eluent for radioisotope generators - Google Patents

Description

DR. ELISABETH JUNG, DR. VOLKER VOSSIUS, DIPL.-ING. GERHARD COLDEWEY

PATENT LAWYERS MDNCHEN 23 ■ S I EG ESSTHASSE 26- TELEFON 3450 67 · TELEGRAM ADDRESS: INVENT / MÖNCHEN

TELEX 5 29 686

tt «Z .: E 433 (Pl / DP)

Ca »· 742,128-S June 9, 1969

ER · SQUIBB & SONS ₉ Ine.
New York, NY, V.St.A.

Elutionmelttel for radioisotope generators

Priority: 3. JuU I968, V.St.A., Ania © lde ~ No. 742.128

For some years now, radioactive © isotopes such as iodine-132, technetium- ^, yttrium-90, ¹ ^ ¹ J, ⁸⁵ Sr, ⁸⁷ Sr and ⁵² P, have been used in medicine and biology as so-called © trae elements for research and diagnosis and in Bianehan cases also used for therapy *

Many of these radioactive isotopes are delivered to the consumer in the form of a generator, which, bound to an ion exchanger, does not contain the radioactive isotope itself but its Huttereleoent. Using a suitable eluant, the killing element, the desired radioisotope, can be separated from the generator or the cutter element. A solo generator is referred to by Fashaann assist as "Kwh" and the vanity of the isotope of the isotope as "milking".

Ö09883 / 1S01

BAO OfUG (NAL

Recently, new sterile generators have been developed »the are ready in the market * These generators are insofar milked in a different way than previously used, when hypodermic needles and syringes are used, and during milking sterile conditions must be maintained.

ti ''

The invention relates to Elutlonslöeungen that when ί for sterile generators are the ltfnger common for both "non-sterile use.

It was found that by adding an oxidizing agent to the blood solution used to clove a generator can increase the yield of daughter isotopes considerably.

The subject of the invention are therefore eluents for radioiso » Generators »/

top- / which are characterized by a content of an oxidizing agent.

The eluants of the invention are saline solutions that act on known manner can be produced. The saline solution can, for example, be a 0.9% sodium chloride solution or an isotonic one

Be saline. This solution can be used as an oxidizing agent

for example

Add oxygen, which is bubbled through the solution, or

an alkali metal hypochlorite, eg Hatrumhypochlorit »an alkali metal _{permanganate #} eg Kaliuoperraanganat, ferric chloride» hydrogen peroxide or an alkali metal permanganate, eg potassium perchlorate or sodium perbronate. Both organic and inorganic oxidizing agents can be used as oxidizing agents.

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turn, e.g. peracetic acid, copper (II) acetate, iodieobenzene, Fhonanthrenohlnon and pyridine-H-oxide

It has been found that eluting agents old have a p ^ value of

3 # O - 7.0 are particularly effective. Nooh get better results

approximately
is aimed at maintaining the pg between 4 and about 6.8, with best results being achieved when the Py-Vert of the eluate is between about 5 and about 6.5.

The concentration of oxidant should be in the eluents

approximately

According to the invention, between / 0.001 and about 1 VdU - $ . Depending on the oxidizing agent used, a concentration of about 0.01 to 0.1% by volume may be preferred. Oxidant concentrations of from about 0.02 to about 0.05 are particularly preferred

As mentioned above, sterilized water, a sterilized saline solution, an acidic or a basic solvent can be used, depending on what kind of ion exchange resin is used in the cow, and which radioisotope is to be withdrawn or eluted from the generator. The generators are when using Eluants of the invention as with the known bleuers milked.

The examples explain the invention. Unless otherwise stated, temperatures are in each case given in ⁰ C.

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Examples 1-20

The following eluents are used as usual

getting produced:

Solution A - normal isotonic saline solution «it Parabens; Solution B - 0 * 9 $ lge saline; Solution C - 0.9 # Lge saline solution old with a content of 0.5 #

active chlorine and a pj ^ value of 5.3; Solution D - O, 9 $ saline with a content of 0.5 $

active chlorine and a p ^ value of 4.5; Solution E - 0.9 pounds of saline solution with a content of $ 0.01

active chlorine and a p ^ value of 5.5

Solutions C, D and E, containing isotonic, active chlorine Saline solutions are made by adding sodium hypochlorite solutions made into a saline solution, the active chlorine content being calculated beforehand. Then the Pg value of the solution adjusted with hydrochloric acid, and the Solution brought to the desired final volume by diluting with Hasser «

The solutions listed below are then used to elute 4 technetium-99 ^m generators, which «unless otherwise stated, are eluted once a day, giving the results listed in Table I»

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Table I.

9 * Tc yield be Open
rator deduction i Use of different solution solutions Acti
vity »-
target"·
value
. BIu-
■ jtions-
LÖsuni I BC / 25a] ft »,
% of
Intended to
worth Qe
stop Beep. 1. checked
ter
Open «
rator
PS ¹ R? ⁹⁵ 100 B. 105 105 0 1 100 2.
3.
4th 128 78
61
47 B.
B. 72
52 92
85 0
0
0 2
3
4th 5 » 100
78
61 37 B. 34.2 92 0 5 1. 47 200 B. 130 65 0 6th OBC 2.
3. 316 ISO
122 B.
B. 70
47 45
39 0
0 7th
8th 4 · 246
192 95 mi - 0 9 5. 150 74 B. 95 128 0 10 1" 117 421 A. 365 87 0 11th OtfVl 2. 560 200 A. 11th 5.5 0 12th clJU 2 + 266 η C. 165 83 0 13th 3. η 156 Al 170 109 0 14th 4th 207 122 A. 110 90 0 15th 1. 162 632 A. 416 66 0 16 300
■ if * 2. 790 300 A. *> 4.3 0 17th 3 · 375 234 A. 23 10 0 18th 4th 293 183 A. 21 11.5 0 19th 4 + 288 D. 110 60 0 20th _

Atosug

909883/1503

The table above shows the yield an technetium -99 ^ duroh the use of isotonisohem Chlorinated water can be increased considerably.

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Claims (2)

P aten t a η β ρ rti ο h e 1. Elution agent for radiolaotope generators, marked by a content of an oxidation «!, ttel. 2. Elution agent according to Anspmteh 1, characterized in that that it is an organic or an inorganic oxidizing agent contain. 3 · Elution agent according to Anspouoh 1 or Z, characterized in that the oxidizing agent is oxygen, an alkali metal hypochlorite, an alkali metal permangutate, an alkali metal perhalogenate, Eiseu-T, T-chloride, hydrogen peroxide, «ine peracetic acid, phenyl-phenol acetate, iodantl-acetate or pyrldine-N-oxide. 4 eluent according to one of claims 1-3, characterized in that that it buffers one from about 5.0 to about 7 * 0 own. 5 «Elutionsiolttel NaOH to claim 4, characterized in that they contain about O ₁ to about 1.0 OOl Völ.- £ Oxydationaalttel. 0 9 8 8 3/1503