DE1815865B2 - DEVICE FOR HANDLING LIQUID SAMPLES IN SAMPLE CONTAINERS - Google Patents

Description

The invention relates to a device for treating liquid samples in sample containers,

with at least one reagent input device, with the conveying part moving the sample container and with at least one reading device for reading labels on sample containers.

A device of this type is already known

(Brochure »Auto Chemist? AGA TR LIDINGÖ 1965 from AB Autokemi, Stockholm, Sweden). This device works as follows: that different sample containers are transferred to a roller, with over in the upper area Reagent input devices reagents are supplied. After this addition, the arrangement heated or cooled, after which a measurement is made in the form of a sample identification. The so obtained Data is then recorded and passed on accordingly. In this known arrangement it is now the case that a reagent is added to each sample.

It is still part of the state of the art to analyze To arrange sample vessels on a circular conveyor part (British patent specification 1 055 235). A sample is taken each time with the help of a special part, whereupon due to this extracted sample is automatically evaluated. After a certain period of time the information contained in the evaluation is accessed via a reading device indicating the relevant Sample submitted automatically. The values of the analysis are thus after the end of the investigation process automatically provided with the informative details of the sample container. From this known publication, however, readable information arranged on the sample vessel is already known. In this known device, however, there is no input of a specific reagent.

Furthermore, a method is known (US Pat. No. 3,350,946) in which a sample container a sample is taken in each case with the aid of a device, whereupon this sample is subjected to an analysis

If-

is subjected. After completion of this analysis with sample containers when filling reagents

the information with further details of the pro is in the held capillary tube.

ben container supplemented. In Fig. 1, a sample container 20 is shown,

It is the object of the present invention, which is cast from synthetic resin, to create a device of the type mentioned at the outset compatible with the liquids to be tested, according to which "the is in a specific sample. The container is easy to manufacture, and it Any suitable material can be used for the liquid sample that is present in the holder, and the Beten reagent is to be mixed Instead, it should represent a precise allocation to the recess, although the liquid according to the sample at hand can lie even deeper with a wedge thorough mixing of the reagent must also be achieved at the input of the reagent.

Sample and Reagent Inside the Sample Container The base 26 of the container 20 is flat for resting

he follows. 15 on a flat surface.

According to the invention, this object is achieved by providing a part 28 with a solution to the container 20 in that the sample container is provided with an opening 30 with a rectangular cross-section away from the reader and a readable identifier that the reagent holder 32 has grooves 34 as a result of e ^; forwardly directed input device can be controlled by means of the reader by means of the identification on the pro flanges 36 for receiving a Keurzeichabbenbehälters and 20 cut '. 38 (Fig. 1, 12), which holds by friction that the liquid sample is arranged in each case in a capillary tube stored in the sample container and also via a perforation on a zap container, fen 40 of the container 20 is attached. The section which is connected to the respective reagent input device is längev than the height of the container 20, so that it can be connected to the device. This results in the preliminary placement of the container 20 on the surface 42 (FIG. 12) so that the sample identification device depends on the relevant reagent input device when reading 25 the identification section over the surface 42 from the information (see also FIG. 1 ).

device triggers on the specific signal, so that the rectangular opening 30 can be

The correct reagent is selected and the container 20 is attached to a pin 44 for the correct sample

to be led. The reagent input device conducts (Fig. 12) and secures for the execution of the test,

Now the reagent into the capillary tube and rinses 30 On the container bottom 22 is a shallow recess

this sample is provided along with the predetermined 46. A side rectangular duct 48

Amount of reagent from which a very good one is connected to the bottom 24 of the recess Mixing results. and is deeper than recess 46. A central one

Developments and further developments of the invention are in the stand 50 is inserted into the recess 46, as set out in the subclaims. 35 is rather hollow and forms a drum 52; On-

The invention is described below with reference to a section of a capillary tube. Exemplary embodiments shown in the drawing are explained in more detail between the shaft 48 and the stand 50. In the drawing shows there is a direct connection so that in the

F i g. 1 is a perspective view of a sample stand 50 introduced liquid into the recess

container, 40 mung 22 is passed.

Fig.2 is a plan view of the container according to The stand 50 can be made of inert material such as Fig. 1, glass, synthetic resin or the like. consist or can also consist of 3 shows a section along the line 3-3 made in plastic, whereby it is sufficiently stiff Fig. 1, must be in order to be pressed into the recess 46 F i g. 4 will be a section along line 4-4 in FIG. F i g. 3, The inner diameter of the drum 52 is slightly F i g. 5 a section through a section of a larger than the diameter of the cable to be used Capillary tube, in which a quantity of unpillar tube, so that it can be easily introduced

may contain thin liquid, the ka:, n. The construction of the recess 46 and

F i g. 6 shows a section similar to FIG. 3 in the case of a single 50 of the shaft 48 must be designed in such a way that the un- Container shape with a capillary tube, lower end of the section of a capillary tube,

cut in the opening and a connection between that is inserted in the drum, not axially against

see a reagent source and the opening, with any surface butting and thus blocking the bore.

the liquid will flow through the capillary tube. There is only a very small gap

can to a correspondingly diluted liquid 55 between the section of the capillary tube and

sample to produce the inner surface of the drum.

F i g. 7 shows a broken section through a broken-off In F i g. 5 is a portion of a capillary-tube-converted form of the container to show the chens 54 of predetermined length for connection to the top of the tube, assuming a known volume of the undiluted

F i g. 8 shows a section along line 8-8 in 60 test liquid 56 in the bore. In Fig. 6 is a F i g. 6, broken, simple shape of the container 20 'shown, wherein F i g. 9 shows a plan view of a modified version in which parts 28, 32 and 58 have been omitted. Of the

container shape, stand 50 is attached in the recess 46, so

Fig. 10 is a section along the line 10-10 in that the drum 52 with the shaft 48 in connection Fig. 9, but with the tube inserted, 65 is used to allow the liquid to flow from the F i g. 11 is a perspective view of the container drum in the recess 22.

Carrying device with held capillary tubes, Since part 32 is not present, other

Fig. 12 is a perspective view of a holder fastening means used, such as. B. magnetic. At 60, a magnetic material is shown to remain in it without any further holder. A

Glass tube could also be used on which the identifying information is puffed out. It can-

the can. At 62 a recess can be seen th stand and container cast in one piece

for fastening with a projection 64 (Fig. 11), if this is economical and cheap

around the container 20 'can be guided accordingly on a support part 5.

to keep. In all cases, the stand has the In Fig.7 is a modified form of the stand there would be shown a section of a capillary tube. In this case, the stand 50 'has a increase and with the reagent dispensing protruding mouthpiece 51, which a device to work together. opening S3 forms to accommodate a conical

It is now a section of a capillary tube io plug part 70 'at the end of the line 66, which from 56 leads into the drum 52 of the stand 50 either in the source to the container 20 ". The inlet opening a container 20 or 20 'has been inserted and, there is hole 53 guides the pin part 70' and hold it, the dilution required for the test is now to be achieved. Advantageously, no sealing of the test liquid is carried out. This test is required. The conical bracket can be specified either on the card 38 or in 15 ways z. B. manufacture by grinding ?! and the magnetic surface in the machine or by humans ensures a precise fit. Another advantage readable data. A flexible conduit of the mouthpiece 51 consists in that the inlet 66 leads from the source of the appropriate reagent, tion of the section of the capillary tube easily which is required for dilution and testing, d. that is, the insertion process is facilitated. Are is required to the container. A base 68 is used to provide many containers with these tubes, with as a coupling for the line 66 and has a so that the insertion can also be done by machine Hood 70 or an overhanging part so that can be carried out.

the liquid which enters the containers 20 and 20 'through the line 66 is a shaft 48 is fed, enters the drum 52 and with the laterally next to the recess 46, but deeper than the undiluted liquid 56 through the opening or as water, so that the liquid through the drum 52 in the core of the capillary tube 54 can flow into the recess. The dimensions are like this bold 22 of the container 20 or 20 'flows. On this chosen that the bottom 4? the recess 46 den In this way, the exact amount of dilution in shaft 48 can only be interrupted in part and introduced into a probe. In order to have a perfect most sufficient support surface for the lower part of the Dilution and mixing after inflowing the 30 stand and the capillary tube, wherein Ensure fluid from the reagent source. still a passage opening for the liquid can then a quantity of gas, z. B. Air through which remains. In Fig. 8 is a plan view of this assembly line 66 being inserted. This shows all voltage and the shaft 48. It is the inFluid printed through the capillary bore, and the tere end of the stand 50, the drum 52nd of the if the action of air is continued, the tube 54 and also the opening flows Air bubbling through the liquid in the 56 '. which with the bore 56 of the tube 54 Recess 22 and mixes the liquid. that is usually associated with undiluted Since the dimensions of the device are small, fluid such as blood is filled. The stand and the the pressure for liquid and gas must be low Be enough to achieve the desired functions. However, the opening 56 'is not blocked, so that the ensure and must not allow the liquid out of the liquid via the shaft 48 into the recess Press container. A typical container is less than 22 can flow.

than 25.4 mm high and approximately has a Innendurch- When a reagent liquid into the Kapillarmesser of 17.46 mm on the upper container edge and W. tube introduced under pressure 54 d, the tapered an Innendurch- 45 at the bottom of ser 24 Pressure in the well 48 weakened when measuring about 9.52 mm. The size of the recess, the capacity of the liquid transport through the mung can be increased to a liquid volume of about 2 to 3 well 48, there is still a few milliliters. Likelihood that the liquid will result from this

A seal may be provided around which the container is pushed out. In Fig. 9 and IO Connection between the base 68 and the free so bt represents a further embodiment of the container. To seal the end of the stand 50, namely provided: here radial feet 80 are in the bottom of the

for example with the help of a small diameter 72. Recess 22 of the container 20. W or 20 "

which is cast into a groove within the hood 70. The surface of this FoBe lies in one

can be set. The base 68 can over a plane, which preferably through the bottom 24 of the

Piston and a measuring device with the reagent 55 recess 22 is defined. making four Be connected to the source. Further, automatic quadrant have the shafts 82 resulting m with greater Means for introducing the reagent liquid in front of the feet 80.

be seen. The feet 80 do not run in the center of the

The arrangement for introducing the liquid in the holder together, but are made shorter the container according to FIG. 6 does not require a special 60 and thus creates a rectangular area 84 which Shape of the stand 50. It can be a simple Ab- with the shafts 82 is freely connected. Dk Section of a conventional plastic tube which is inserted into the radially inner ends of the feet 80 at 86 from the recess 46. The container is tiered and thus forms a seat for the lower one Cast in one piece, either in the simple shape of the end of the stand, as previously described 20 or, in the more complicated version, 20. Location points for the lower end of the stand SO in front - The plastic tube should be stiff enough here, as seen at the m (Fig. 10). The length of the feet 80 is so that the recess 46 can be pressed and selected so that the gradations 86 are sufficiently

_lay «, * that

T the liquid km ** £ * £ ™ ^ A are located, B. Cylinder 100, flows and mixes better. If Luttemge ™ ₁₀₂ , _h becomes three different reagent bubbles, «t ^« ^ ^^^^^ »SL ^« an. which according to the air flow to be felt, ^ and there is a good 6 ^ ^ ^^ ^ ^ .. ^ to be _entered schungseffekt This is a possibly inaccurate ^ ^ ^ ^ _{a Tdl a fe} _

α · »ί- - a a

⁸ mi rl Ir wi ^dchlert? rd and de assignment of genz-liquid, regardless of whether the support part 96 r ^ H Lh VoSZb 94 does not move so precisely or not. If, however, the test description container and device y * nicni ο _s ^ ^ ^^^ result in the reader is

It is important that * e Ke ^ eichnung ^ r y fluid through the drum 52 into the recess

of the container, which the resulting g _mu ^ causes here a good diameter

^kel Tn ^tr Fft St Se Volsung for liquid samples schulg and dilution of the liquid to be tested . After the reagent liquid c \ a-

TÄΓΑAM was guided by the support part ⁸ 96 45, the piston pulls the mouthpiece 68

one no point back and the carrying part can move on.

Only aa one or aa can be carried here Uh fh

can only aa

ω «" Ä leads past Siatiooen ^ iideoKarteii The positive keonieidinoiig of samples tad what n »schi makes it necessary here to kill the behilter

IÄ ™ Ϊ £ ΑΚΑΊ ^ γ "Κ5. - = 2 **. Ori ^ v * -τ», «*

one or of places.

FGerzn 1 sheet Zd

Claims (13)

Patent claims: 1. Device for treating liquid samples in sample containers, with at least one reagent input device, with the conveyor part moving the sample container and with at least one reading device for reading off labels on sample containers, characterized in that the sample container (20, 20 ') with the reading device (104) readable identifier is provided that the reagent input device (100, 101, 102) can be controlled by the identifier on the sample container (20, 20 ') by means of the i_ftsgerätes (104) and that the liquid sample (56) is loaded in a sample container (20,200) Capillary tube (54) is arranged, which can be connected to the respective reagent input device (100, 101, 102) . 2. Vonichtung according to claim 1, characterized in that the connection between the vessel of a respective Reageüzeingabevorrichtung (100, 101, 102) and ¹ izm respective sample container is a movable tube (66) and a coupling part (70, 70 ') with a hollow designed as a storage for the capillary tube. other (50, 50 ') of the sample container can be connected in the filling position when a filling signal is present from the reading device (104). 3. Device according to Ansprucu 1 or 2, characterized characterized in that the hollow stand (50, 50 ') is arranged in a sample container recess (22) is, in which from above the bilaterally open and containing a certain sample volume Capillary tube (54) can be inserted, and that from the bottom of the hollow stand to the bottom the sample container recess (22) has a connection (48). 4. Apparatus according to claim 3, characterized in that the sample container (20, 20 ') a fastening device for the hollow stand (50, 50 ') at the bottom of the recess (22) having. 5. Apparatus according to claim 3, characterized in that the capillary tube (54) in the Container can be fastened without interrupting the connection (48). 6. Apparatus according to claim 3, characterized by a Ausspantng (46) on the container bottom for fastening the hollow stand (50) and through at least one shaft (48) as a connection the recess with the inside of the sample container. 7. Apparatus according to claim 3, characterized in that that the hollow stand is designed as a hollow tube and that the connection is a slot (48) in the sample container bottom, which is open to the hollow tube and to the interior of the container. 8. Apparatus according to claim 3, characterized in that the sample container recess (22) is symmetrical about a vertical axis and that the hollow stand (50, 50 ') is coaxial with the Container recess (22) is arranged. 9. The device according to claim 3, characterized in that a plurality of radial feet (80) is arranged on the container bottom, which form a circular bearing (86) for the hollow stand (50, 50 '), with their inner ends at an axial distance of each other and segment ^f örmige shafts (82) form, which communicate with the hollow stand in connection. 10. The device according to claim 2, characterized in that the hollow stand (50, 50 ') on upper end is mouth-shaped (51). 11. The device according to claim 1, characterized in that that a holder (34, 60) is arranged for the readable identifier (38). 12. The device according to claim 2, characterized in that the coupling (70) is cup-shaped is designed to reach over the upper end of the capillary tube: ». 13. The device according to claim 2, characterized in that that the coupling (7C) is conical for insertion into the inner end of the capillary tube.