DE1807604A1 - Feed additive - Google Patents

Description

DR. INC. A. VAN DER WERTH DR. FRANZ LEDERER

al HAMBURG 90 β MÖNCHEN 8O

WlLiTOtFEIl STR. S3 - TEL. (O * 11) 77 0S β I LUCI Ll-CHAH N- * T «. S3 -TEL. 10 "I Il 4 4 0"

'Munich, November 7, 1968

Applicant: Diamalt Aktiengesellschaft, Manchen 13 » Friedrichstrasse 18

Feed additive

The invention particularly relates to a feed additive for non-ruminants and poultry, which is added to the feed shall be.

It is known (see, for example, J, P. Greenstein and M-. Wlnitz, Chemistry of the Amino Acids, John ViIey and Sons, Inc. \ ^ 6i Vol. -I, p. 286) that for full utilization of the Amino acids offered with the feed must be completely available for absorption at the same time. If this is not the case, the smallest amount is present · Amino- dor limiting factor for the entire remaining amino-

Eo is known fex-ner to feed for non-ruminants and For this reason, add certain essential amino acids such as methionine or lysine to poultry. Mainly plant-based feed has protein content in its ice cream Amino acids ntiralieh eJnon deficiency, which one by adding the

009824/0669

8AD ORIGINAL " ^? "

ΥΘ07604

can balance the amino acid concerned. Only through this Measure · the feed will be wholesome. ,

It is also known from DAS t O65 706 instead of methionine the non-wholesome feed is the N-acetyl derivative of Adding methionine, i.e. a methionine derivative that provides this amino acid in the body with a delay. Through this it should be achieved that the methionine etVa is available for absorption at the same time as the rest digested protein free amino acids.

In fact, a significantly better utilization of its methionine content could be proven for the N ~ acetylimethionine: Despite a content of only 70 ° DL ^ methionine, N-acetyl-DL-methionine calcium caused about 100% DL-methionine with the same weight growth increased by a factor of 1.13.

A major disadvantage of the N-Acetylmetfaionixss is that it is difficult to visualize. The effort to obtain this compound by known methods in usable yield and sufficient purity is quite high The rather high solubility of the N-acetyltnethiosis Ib Here, water sets limits to profitable extraction © issdeutig®, The N-acetylmethioiiin and its © salsa is therefore expensive and in spite of its increased effectiveness compared to methionine is its use; as a feed supplement, therefore, amwirtschafteilch. It can therefore be explained that the N-acetylm is stli.ionin despite its better mode of action, that in groüeni used DL ^ Methionir »could not displace.

8 21 0 09/86 0 9 OeAD ORIGINAL

i !!! "Il" I- I "'tills

It has now been found, surprisingly, that simple and cheap catfish can be produced * methionine carbamide and Lyeincarbaaid sur increasing the bare value of Dietary protein is eminently suitable for 1st and growth favorably influenced by poultry and non-ruminants.

The invention therefore relates to a feed additive especially for poultry and non-returners Methionine carbaaid and / or lysine carbaaid or their derivatives «consists or contains these.

While 1 "N" acetylethionine is a carboxylic acid bond like the peptide bond of a food protein and it was therefore to be expected that the N-acyl bond would be split in the gastrointestinal tract instead of the peptide bond «Invention geatfOen · Methionlncarbaald bcw, Lyslnearbaald a urea- bsw. Coals · Hurebindung before, so a very different type of bond, was not expected au of de 'a Possible reactivity Given the Spezifitttt the Ensysie the V _dd rdauungs tract, it was not foreseeable that the Peptidblcdung of Mahrungeprotein · and the urea bond

of methionine bsw. Lysincarbaaids split on the same side Ee nmr therefore surprising that the growth * effect des Methlonincarbaeilde dea des N-Ac «ty! .methionin · corresponds, whereby the molecular weights of the two compounds and therefore your ■ MethloninehaXt are practically identical *

The particular advantage of using the invention MethioninecarbaMids ale feedstuff compared to H-Acetyl aethionln lies in the fact that ίί.ββ * connection is economically

BATH ORIGINAL

can be produced. Because of their heavy = · solubility in aqueous Systemen'erhält you nateh conventional processes in the simplest WeAβ & in nearly quantitative Auebeute a product of high purity ₀ A zueätzliche cleaning about by UmkrietaU isation unnecessary calibration for most applications, "The same goes for dae Lysincarbasjid ₀

It is preferred to use DL-methionine carbamide or DL-lyeincarbamide, anate parts of the free DL-methionine carbamide, or DL-Lysiucarbamida their salts can also be used Calciuneals ·; as well as salts "whose cations verification of so-called trace elements _r derived as Elsen, manganese, copper, cobalt and zinc Salts bit at calibratable known _r biologically valuable organic bases such as choline, arginine, and lysine can be used advantageously ₀ lsi contrast to the free Acid DL-methionine or "lyein carbamide, their salts are readily soluble in water"

The amount of added DL-Methlonincarbaald or »DL-Lysinearb * · Depending on the L-methionine content, id is bsewc DL-Lyein in the feed used 0.03 to 0.1 $ °

example 1

kO day-old chicks were fed into two groups with the following Orunddlttt for 8 weeks "The Futtemslechung was doing full intent of the _r in DAS 1,065,708 Example 1 gegebe recipe

'& ÄD ORIGINAL

"'·· Wl"''"■■:'"'""'"' ^! '':'";' ■ * :! ■ ^l "'''"''^' SiSHlipfi: ¹ :; ': ¹ - .: "i'ij ¹ RII ^ τ ΐτΐπΐ | ΐηιιΐ! Ϊ́ | ΐ | ΐιιιΐ | ΐ !! ΐ ||| ΐ || ||| [|||| ΐ | ΐιιιιΐ | ΐιΐ! ΐ »ιιΐΐΐ || ΐ | ΐ || ^ _::! , .... _:! κιρ ■.,." i !! ; ι |: "; η '.;, ■:''iiiiiFpiiiir ν ■»; ■ τ- ; ■ ■ ■ * ■ ■

Parts corn meal parts barley meal parts wheat meal parts soy meal parts lucerne green meal parts cod meal part skimmed milk powder part dry yeast parts meat feed meal parts mineral mixture r * 3 »3 i * phosphoric acid feed k ^ Sk

29 Ία iodized cattle salt 20 i » white clay (Bolus alba) 2.5 $ magnesium oxide 2 $> spices (fennel) 1 i> sodium phosphate 1 % aluminum sulfate 1 Ίο trace elements (Fe; Cu: Mn: Co =

30: 20: 6: 1)

0.1 i » vitamin mixj

0.01 part of VitaminfiremlDch "Al" (A, B, E and D) 0.063 part of Auryofac 2 A with 8 g of aureomycin / kg

The animals were kept in electrically heated stalls with wooden floors and sand. It was theirs from the start there is limited space available.

Of the two test groups of a 0.025 T _e ile (0.05 $>) "DL-Methionincarbamid calcium ¹¹ (Βία DL-methionincarbaniid Ciilcium) were

ow ,: 1 * 22.55, 70.5 # DL-Mathlonixi.

009824/0860 " ⁶ *

SAD ORfGINAL

the other

0.025 parts (0.05 #) "N-Acetyl-DL Methionine Calcium" (Bie-N-Acetyl-DL-mothionin-calciue)

Molecular Weight: U2O.57. 71 # DL ~ methionine added to the above-mentioned basic diet.

It was broken down into male and female animals after 8 weeks the following average weight gain / animal was determined for the two test groups:

Basic diet + basic diet +

0.05 # N ~ acetyl ~ 0.05 # DL-methio-

DL * methionine «~ Approx. nincarbamide

males: 1.61 kg 1.57 kg

females: 1.33 kg 1.325 kg

Example 2

This example is intended to explain the economic production of DL-methionine carbamide.

75 parts of DL-methionine were ilen in 500 T _e Vaseer with h2,3 Natriuucyanat parts (1.29 equiv.) Umgesetst at 80 ° C. Oi * solution was then mixed with conc. Hydrochloric acid acidified to pH 5, decolorized by carbonation, filtered and the filtrate with conc. Hydrochloric acid acidified to pH 1. 92 parts (95% of theory) of colorless DL-methionine carbamide with a melting point of ik6 ° were obtained. (Lit. Ihk --1 ^ 6 °) The titration with n / 10 sodium hydroxide solution against phenol phthalein showed a content of 99.1 <$ » The nitrogen determination according to KJeldahl gave 13.39 $> (theory: 13, 53 i>)

009S2A / 0669

BATH ORIGINAL

Claims (1)

1107504 Godparents taneprttche 1, Fodder Kusats, in particular for poultry and non-vetted poultry, characterized in that it also contains methionine carbide and / or Lyeincarbaaid or their derivatives baatabt or dl · ·· _o S. PuttaxtBlttalsusatm according to claim 1, characterized in that («can · saiohoat, dafi ar au · Matallaalsan «vorauf ·? ·!. ·· Natriue-, Kaliuai-, Ma ^ naalua ^, Ca Ic luv-i iron, manganese, copper» »Kebalt- or Zi ^ isalaen dee methionine- htm ^ Lysincarbaad.de exists or contains marriage. 3. feed eusat "according to claim 1, characterized eekennaeichnet that he ame bales of methionine bsv" lysine carbaside ait biologically valuable orcanlechen bases, ins special choline, lysine and arginine or such contains. 0 3 32.-I / 0 S ft i: ^c ■■ - 'BAD ORIGINAL