DE1801840A1 - Stable oil-in-water emulsion for skin care - Google Patents

Description

Luzier Incorporated, Kansas City, Missouri / USA Stable Qt-in-water emulsion for skin care

The invention relates to a stable oil-in-water emulsion for skin care, with a water-soluble polypeptide in the aqueous phase

It has long been known that protein hydrolyzates have an effect on the skin Have a beneficial effect by adding these skin creams and lotions. For use in cosmetics of this type, however, they must be more soluble in water Form, usually in the aqueous phase of these mixtures present

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It is also known to advantageously use a skin care product Add a number of other ingredients. As such, for example Mineral oil, lanolin or acetylated lanolin alcohol, purified wax, Squalane (hexamethyltetraeosane) etc. are mentioned, which tend to have a to have a hydrophobic character. Attempts have already been made to combine the beneficial effects of these substances with those of protein hydrolyzates employed to incorporate the latter into the Protelnjösungen. This can usually can be accomplished by using an emulsifier Forms an oil-in-water emulsion, in which the hydrophobic substances form the oil phase.

Although in mixtures of the above-mentioned kind iidiHl in Ql-Wasser-Ümül They locate the protein hydrofysate in the water phase and the others hydrophobic skin care products, humidifiers, etc. contained in the oil phase) naturally are very effective, but exist because of your tendency to some Instability still considerable © Restrictions on use - The main difficulty lies in the fact that these mixtures only very difficult to preserve. This fact has a stronger multiplication of microorganisms that cause the coagulation of the emulsion, guided.

The previous attempts to overcome this problem still have did not lead to the desired goal. For example, the

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formation of a combination of methyl p-hydroxybenzoate, propyl p-hydroxybenzoate and Benzalkaniumchlor Id investigated. However, this combination worked not to a stable system, which also still © In anlonenaktlves Must contain wetting agents. Similarly, a combination was made Methyl p-hydroxybenzoate, propyl p-hydroxybenzoate and 6-ethoxy-2,4-dimothyl-in-dloxane examined. This mixture has also proven to be unsuitable, since it led to a darkening of the products.

Corresponding studies suggest that water-soluble Kosmotic preparations containing polypeptides in one as possible low pH should be stabilized. By this circumstance There is a significant limitation on the ingredients that are mixtures of these Kind could be added, because certain substances of this kind bring an increase in pH with it.

It has now been found that oil-in-water emulsions dlo the protein hydrolysates in the water phase and hydrophobic substances in the oil phase, contain, can be preserved very effectively and thus stabilized if a combination of methyl phydroxybonzoate, Propyl p-hydroxybonzoate and sodium ethyl mercuryl thiosalicylate used. This system is based on anlonlschen wetting agents (e.g. sodium lauryl sulfate) effective. It is also suitable for a pH range up to approx. 8.5 suitable and does not cause any apparent darkening or Oxidation of the product.

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It is therefore a ziol of the invention, o a stable, water-soluble one To provide oil-in-water emulsions containing polypeptides, the opposite of the influence of temperature, the tent and normal storage conditions is stable. It is another object of the invention to provide a To provide a mixture of the type mentioned, as a skin care product is suitable and capable of accelerating the absorption of water and polypeptides through the skin

Still another object of the invention is to provide a mixture of these Kind to provide the skin with permanent, silky smooth films can lend.

In the production of the protein hydrolyzate containing (ie polypeptide containing) oil-in-water emulsions according to the invention, which are used for skin care, the use of a water-soluble polypeptide is necessary. Oa these substances are water-soluble, the solutions obtained have a viscosity that is convenient that won water is the same. Any water-soluble polypeptides can be used for this purpose. These usually have a molecular weight in the range from 1500 to 5000. Of particular interest are those polypeptides which contain those amino acids which are usually also found in the skin and which are generally obtained from animal skins.

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A polypeptide which is particularly suitable for the purposes of the present invention is the hydrolyzate obtained from tanned leather. This generally consists of polypeptides with an average molecular weight of approx. 2500. The amount of the polypeptides which is used according to the invention varies depending on the particular type of mixture desired. In general, however, the proportion of the polypeptides is between 0.8 to 2 <3QW .-%, preferably about 1.5 wt .-% of the total ä mixture.

It has been found to be useful to add to the mixture the aforementioned Polypeptld a number of substances with favorable for skin care To add properties. So it is e.g., zwockmäSlg, Squalan (i.e. Add hexamethyltetracosane). This substance acts as a liquid carrier, which is compatible with the skin and sebum and the percutaneous Penetration and penetration through the cornea are accelerated. This substance is miscible with the sebum and skin oils and stimulates the Skin piracy on.

The proportion of squalane used can vary somewhat. Generally, the content of this material is between about 2 to 3. <3EW, - / 4, preferably 2 _f 5%, the Gesamtmlschung, this substance is hydrophobic and accordingly forms a Toll the oil phase of the emulsion.

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Another material, dor vore I! possibly a component of the can form emulsion according to the invention, is allantoin ,. It has been shown that this connection accelerates tariff proliferation and necrotic Tissue removed * Allantoin protects all skin from drying out and keeps it supple by contributing ,,, the appropriate moisture content Maintaining β allantoin has been shown to be associated with the tissues tolerable, both in the form of creams, lotions or powder. It has also been shown that the protefn-dlspergierde (denaturing) Possesses properties.

The content of the aliantoin present in the mixture according to the invention can likewise be varied depending on the results desired there. The proportion of this compound is usually between 0.15 to 0.50% by weight, preferably 0.20%, of the total mixture. Since the allantoin is hydrophilic, it is contained in the aqueous phase of the mixture. . . · - ·

In addition to the components described above, the components according to the invention Mixtures, the usual additives for skin care preparations contain. So you can use humectants, wetting agents, Fillers, fragrances, emulsifiers and dorg.ieichen contain «Finally you can get medicines, especially medicines that are used to cure small cuts or wounds contribute.

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In the following, various additives which are suitable for the emulsions according to the invention are to be mentioned, _for example:

a) Humidifier:

Glycine, propylene glycol, sorbitol, polyethylene glycol

b) plasticizers:

Lanolin and its derivatives, i. E. acetylated lanolins, ethoxyliorto Lanolin alcohols, fatty acid alcohols and esters "

c) emulsifiers:

Glycerol monostearate, polyoxyethylene glycol, sorbitol sesquioleate

d) Medicines:

Ethyl ami nobenzoate, urea ,,.

As stated earlier, is an important consideration

of the present invention the use of a combination of methyl a

p-hydroxybenzoate, propyl p-hydroxybenzoate and sodium ethyl mercurithio alcylate as a consortium system. The amount of each substance can be vary a little. Suitable Mongon as well as the preferred Antollo of the respective Substances are in the table below, in which the information about relate the percentage to total deletion, indicated.

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Methyl I-p-hydroxybenzoate Propyl p-hydroxybenzoate Sodium ethyl mercuryl thiosalicylate

Weight # 08- 0 , 2 preferred salary
(Wt%) 1 ο, 03- 0 ,1 ο, 05 0, 01 - 0 , 03 0, 02 0, 0,

Usually the propyl p-hydroxybenzoate is in the oil phase of the emulsions. The methyl p-hydroxybenzoate and the sodium methyl morcurithlosallcylate represents a ToM or parts of the aqueous phase. ^ As already mentioned, the pH of the mixtures according to the invention

to about 8.5, however, is usually in the range of approx »6.5 to 8.5» It is preferably approx. 6.8 for creams and approx. 6.8 for lotions approx. 8.2.

The invention is to be explained in more detail below with the aid of specific examples been i

example 1

W A stable cosmetic cream was produced with the following composition,

composition and a pH of 6.5 to 7.0 in the form of an oil-in-water emulsion prepares.

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OI phase

Wt%

Light mineral oil (Saybolt viscosity 50-55) 10.0

Acetulan +) 4.0

Stearic acid 4.0

Cety! Alcohol 2.0

Purified Paraffin Wax 5.0 ™

Lanolin (odorless) 3.0

Squalane 3.0

Propyl p-hydroxybenzoate 0.05

+) acetylated lanol fractlon, pale yellow liquid with a density of 0.867 with a neutral reaction, an acid number of 0.36 and a soaking number of 190.3.

Aqueous phase

Gow .-%

Glycerin 2.0

Borax 0.5

Triethanolamine C | 7

Polypeptide LSN (water soluble) +) 40% aq. 4.0

Mothyi p-hydroxybenzoate 0.1

= -10-

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Continuation of the aqueous phase

Sodium ethyl mercuryl thiosalicyate 0.02

Allantoin 0.20

Distilled water to 100

™ +) Polypeptld LSNi Water-soluble Polypeptld with an average

Molecular weight of approx. 2500 obtained by partial hydrolysis of tanned Leather is preserved »

The components of the oil phase are melted together at 82.degree. The components of the aqueous phase are dissolved at 8.5 ° C. Then the oil phase was added to the aqueous phase at room temperature with moderate mixing.

, Example 2 . ·

The following components became a stable cosmetic Lotion with a pH of 8.0 to 8.5 «.

QI pjiasg

Wt. "-%

Qlycerol monostearate 2.7

Cety I alcohol 1.5

Acetul an 2.0

S qua I at 3.0

Propyl p-hydroxybenzoate 0.05

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Aqueous phase

Gow .-%

Polypeptide LSN (water soluble) 40% aq. 2.0

Sodium lauryl sulfate 0.3

Methyl p-hydroxybenzoate 0.1

Sodium ethyl mercurithio salicylate 0.02

Allantoin 0.2

Distilled water to 100

The oil phase was then, as described in Example 1, to the aqueous Phase given. The allantoin was dissolved in 10 parts by weight of water and added after the formation of the emulsion.

0.3% by weight of sodium lauryl sulfonate was added to this stable mixture (an anionic wetting agent) to determine whether the product Is stable in the presence of an anionic surfactant. aside from that were incorporated into this stable mixture 2 wt .-% acetulan to the To give the skin a silky-soft protective film. As a medicine it was furthermore 0.2% by weight of allantoin was added. The emulsion was at 46 ° C and examined at freezing temperature for 365 days. No rancidity, pre-coloring or separation of the emulsion was observed.

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Claims (1)

Claim 1. Stable Oil-In-Water-Emulslon for skin care with a water-soluble Polypeptld / Öer aqueous phase, characterized by don the content of a preservation system made of methyl p-hydroxybenzoate, Propyl p-hydroxybonzoate and sodium ethyl mercuryl thiosallcylate; 2. Emulsion according to claim 1, characterized in that they, based on the Gowlcht dos total vegetables, a) 0.08 to 0.20 % methyl p-hydroxy bonzoate b) 0.03 to 0.10% propyl p-hydroxybanzoate and c) 0.01 to 0.03% of methyl ethyl mercury thiosallcylate contains. 3. Emulsion according to claim 2, characterized in that that it additionally contains 0.15 to 0.50 % allantoin and 2 to 3% squalane. 4. Emulsion according to claim 1 to 3, characterized g e, k ennzolchnot, that it also contains an ion-active wetting agent. 5. Emulsion according to claim 4, characterized in that the wetting agent is sodium lauryl sulfate. 909824/1270 6. Emulsion according to claim 4, characterized in that g ο k ο η η ζ ο i c h η ο t, that they contain a plasticizer, a humectant and a humidifier contains, Ii emulsion according to claim 6, characterized in that that it contains lanolin or an acetylated lanolin alcohol. Λ 8 «emulsion according to claim 7, characterized by that the polypeptide has a molecular weight of about 1500 to 5000. 9. Emulsion according to claim 8, characterized in that that sio, based on the total weight, a) 2 to 3% squalane, b) 2 to 5% acetylated lanolin alcohol, c) 0.15 to 0.50% allantoin, the like d) 0.10 to 0.40% sodium lauryl sulfate, o) 0.08 to 0.20% methyl p-hydroxybonzoate, f) 0.03 to 0.1% propyl p-hydroxybonzoate and g) 0.01 to 0.03% sodium cithyl mercurithlo salicylate contains ·. 909824/1270