DE1267199B - Keeping substances and mixtures of substances with non-aqueous components moist - Google Patents

Description

FEDERAL REPUBLIC OF GERMANY GERMAN 40J7WW PATENT OFFICE

EDITORIAL

Int. CL:

German class:

Number:
File number:
Registration date:
Display day:

BOIj

A 61k

12 g -1/01

30 h-13/01

30 h-9/04

December 12, 1962

May 2, 1968

The invention relates to the maintenance of moisture which is prone to moisture loss in the air Substances and mixtures of substances and in particular the use of hygroscopic salts organic carboxylic acids as humectants.

A great many preparations that contain both non-aqueous components and some water or moisture contain, tend to be exposed to air at room temperature and even more so at higher temperatures Moisture loss. This decrease in moisture content often has a deleterious effect the desired properties of the preparation. In addition, it is generally after it has occurred Moisture loss very difficult to restore the moisture and the original physical To regain properties of the preparation.

It has been found according to the invention that there is a tendency of such preparations to get moisture in the air to lose, can be significantly reduced by giving them - based on the total preparation weight - at least 2% of a hygroscopic salt certain Carboxylic acids incorporated. The carboxylic acids whose hygroscopic salts are used according to the invention are closely related in terms of their chemical structure and consist of 2-pyrrolidone-5-car bon acid, 2-pyrrolidone-4-methyl-5-carboxylic acid, l-methyl ^ -pyrrolidone-S-carboxylic acid, 1-acetamidobutyric acid, N-acetylglycine and N-acetylalanine.

The hygroscopic salts which can be used according to the invention include the sodium, potassium and Ammonium salts and the alkanolamine salts, such as those of mono-, di- and triethanolamine and des Mono-, di- and triisopropanolamine and mixtures thereof. All of these which can be used according to the invention Salts are so hygroscopic that they can be obtained in a pure state by absorbing moisture from the air gain at least 30% in weight when they are equilibrated with room temperature air 60% relative humidity. They are also entirely water-soluble. Because the free Acid itself is not hygroscopic, it can without special precautionary measures regarding the exclusion of air stored and then converted into the desired hygroscopic salt immediately before use.

The hygroscopic salts which can be used according to the invention must, in order to be effective, be present in an amount of at least 2% based on the total weight of the preparation. However, there is no upper limit to the amount in which they can be present, other than that which imposes economic and aesthetic considerations. Keeping substances and mixtures of substances moist
with non-aqueous components

Applicant:

The Gillette Company, Boston, Mass. (V. St. A.)

Representative:

Dr. phil. G. Henkel

and Dr. rer. nat. W. D. Henkel, patent attorneys,

8000 Munich 90, Eduard-Schmid-Str. 2

Named as inventor:

Karl Laden, Deerfield, JU. (V. St. A.)

Claimed priority:
V. St. v. America December 12, 1961
(158 898)

Under certain conditions, up to 20 percent by weight and even more can be present, however in general, best results are obtained when the humectant is 4 to 10% of the total preparation weight matters.

The humectants that can be used according to the invention can be used for all substances and mixtures of substances, which tend to lose moisture in the air. This doesn't just apply to cosmetic preparations, including those to be applied to the hair or skin, or ointments, but also for products such as cellulosic materials, e.g. B. regenerated cellulose films, paper products, tobacco or toothpaste. Cosmetic articles include, for example, hair sprays, hair care products, talc and body powders, Cleansing cream, shaving cream, shaving powder and such adhesives as used in manufacture lather, shaving prewashes, odor removers, antiperspirants, and the like. Of the many salts which can be used in the present invention, the sodium salt is known because of its cheapness and its known non-toxic properties.

The humectants which can be used according to the invention are primarily for those to be applied to the skin cosmetic preparations and ointments valuable. Such preparations have the effect that when they are applied the skin has a tendency to dry out.

809 574/437

men so that it both continues to feel soft and smooth and loses its slope, in particular to pop open at very low humidity. The humectants can be used with any aqueous or non-aqueous cosmetic or ointment bases are used, but are of particular importance Value in connection with oily preparations of this type, namely those with a content of oils, fats or soft waxes, regardless of whether they are of the water-in-oil or oil-in-water type or in In the form of liquids, pastes, creams or solids.

The following examples are intended to further illustrate the invention. The ones specified in them Parts are parts by weight.

example 1

The following preparation was made:

20 oil phase parts

Stearic acid 18.00

Mineral oil 5.00

Polyoxyethylene (20) propylene glycol

monostearate 5.00 ^{- 5}

Propyl ester of p-hydroxybenzoic acid 0.05

Water phase

Propylene glycol 5.00

Methyl ester of p-hydroxybenzoic acid 0.10

2-pyrrolidone-5-carboxylic acid 5.00

Sodium hydroxide 1.60

Water 59.25

Triethanolamine 1.00

30th

35

The constituents of the oil phase were mixed with vigorous stirring and simultaneous heating to about 75 ^° C. and then mixed with the previously prepared aqueous phase containing the sodium salt of 2-pyrrolidonecarboxylic acid at about the same temperature and with continued stirring. After complete mixing, the emulsion was cooled to about 4O ⁰ C and stirring slowed down to room temperature was reached. The result was a smooth, free-flowing mass that was particularly suitable for skin water.

Equally satisfactory results were obtained when 2-pyrrolidone-5-carboxylic acid was used in the above preparation by an equimolar amount of 2-pyrrolidone-4-methyl-5-carboxylic acid, 1-methyl-pyrrolidone-S-carboxylic acid. 1-acetamido-butyric acid, N-acetylglycine or N-acetylalanine replaced became.

Example 2 The following preparation was made:

The sodium salt of 2-pyrrolidone-5-carboxylic acid was dissolved in a small amount of water, while the remaining ingredients were added to the remaining water with stirring and with heating at 8O ⁰ C. While the emulsion was cooling, the salt solution was added and stirring continued until room temperature was reached. The resulting product turned out to be a viable cream for chapped skin.

The same results are achieved if the sodium salt of 2-pyrrolidone-5-carboxylic acid is used an equal amount by weight of the sodium salt of 2-pyrrolidone-4-methyl-5-carboxylic acid, 1-methyl-2-pyrrolidone-5-carboxylic acid, 1-acetamido-butyric acid, N-acetylglycine or N-acetylalanine are used became.

B e i s ρ i e 1 3

The following preparation was made:

Teüe

Beeswax 74.3

Olive oil 2.6

Lanolin 19.9

Isopropyl myristate 1,2

Sodium salt of 2-pyrrolidone-5-carbon

acid 2.0

55 All of the ingredients are melted together and, after further careful work, the mixture has become Stir in molds to shed cosmetic sticks, which can be used to avoid cracked open Lips are suitable.

Example 4

The following preparation was made:

Parts

Glyceryl monostearate 2.0

Stearic acid 7.0

Oleic acid 3.0

Cetyl alcohol 2.0

Ammonium salt of 2-pyrrolidone

5-carboxylic acid 2.0

Triethanolamine 0.9

Menthyl anthranilate 4.0

Water 78.7

Perfume 0.4

Parts

Cetyl alcohol 1.50

Stearyl alcohol 1.50

Sodium Lauryl Sulphate 0.25

Polyethylene glycol laurate 1.00

Mineral oil 5.00

Lanolin 1.00

2-pyrrolidone-5-carboxylic acid

as the sodium salt 5.00

Water to 100.00

Triethanolamine and 2-pyrrolidone-5-carboxylic acid in the 8O ⁰ C hot water to a solution of the corresponding hygroscopic salt dissolved.

The remaining ingredients except the perfume were also melted at 8O ⁰ C and stirred together, and then melt and aqueous solution were mixed together and stirred thoroughly while cooling. The end product consisted of an emulsion water that is suitable as a sun tanning aid.

. Equally useful results were achieved when in the above approach instead of the ammonium

salt of 2-pyrrolidone-5-carboxylic acid the same amount by weight of the ammonium salt of N-acetylglycine was used.

Example 5

The following preparation was made:

Teüe
Glyceryl monostearate 6.0

Potassium salt of 2-pyrrolidone-5-carbon

acid 5.0

Mineral oil 2.0

Hexachlorophene 0.2

Water 86.2

All of the constituents were ^{heated to 95 to 100 °} C. with constant stirring, resulting in an antiseptic baby water suitable for application to the skin.

If in the above approach instead of the potassium salt of 2-pyrrolidone-5-carboxylic acid, the potassium salt of N-acetylalanine was used, practically the same results were obtained.

Example 6

Different samples of the same unplasticized regenerated cellulose film were each used for 24 hours in 10% aqueous solutions of the sodium salt of 2-pyrrolidone-5-carboxylic acid and immersed in glycerin and then allowed to dry at room temperature. When compared with a untreated specimens, both treated specimens were found to be soft and significantly less on bending "Noisy".

Example 7

The following preparation was made:

Teüe

Sodium lauryl sulfate 2.0

Propylene glycol 12.0

Stearyl alcohol 23.0

White petrolatum 21.0

Sodium salt of 2-pyrrolidone-5-carbon

acid 5.0

Water 37.0

The stearyl alcohol and the white petrolatum were melted together on the water bath and adjusted ^{to about 75 ° C.} The remaining constituents were ^{dissolved in water, which was also warm at 75 °} C., and added to the alcohol-petrolatum mixture while stirring until the batch had reached room temperature. The resulting preparation formed a useful hydrophilic ointment base which, after the addition of the desired medicament, is suitable for application to the skin.

Claims (1)

Claim: The use of - based on total weight - at least 2% of a hygroscopic Salt of 2-pyrrolidone-5-carboxylic acid, 2-pyrrolidone-4-methyl-5-carboxylic acid, l-methyl-2-pyrrolidone-5-carboxylic acid, 1-Acetamidobutyric acid, N-Acetylglycine or N-Acetylalanine to keep you moist of substances and mixtures of substances with non-aqueous components. Considered publications:
Czechoslovak Patent No. 98,238;
Czetsch - Lindenwald, "Pharmazeutische Technologie", 1948, p. 153 and p. 208.